CYR61 Polyclonal Antibody | Invitrogen PA1-16580 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CYR61 Polyclonal Antibody

catalog :

PA1-16580

quantity :

100 µL

price :

375 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry

citations: 1

Reference
Kim H, Yoo S, Zhou R, Xu A, Bernitz J, Yuan Y, et al. Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism. Proc Natl Acad Sci U S A. 2018;115:E11128-E11137 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CYR61 Polyclonal Antibody

Catalog # :

PA1-16580

Quantity :

100 µL

Price :

375 USD

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:50-1:100, Immunofluorescence: 1:50-1:100, Western Blot: 1:200

Species :

Human

Isotype :

IgG

Storage :

4° C, do not freeze

Description :

CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

Immunogen :

A synthetic peptide made to the human CYR61 protein sequence (between residues 250-350).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:100, Immunofluorescence: 1:50-1:100, Western Blot: 1:200

Aliases :

3CH61; AI325051; CCN family member 1; Ccn1; Cellular communication network factor 1; Cyr61; cysteine rich angiogenic inducer 61; cysteine rich protein 61; cysteine rich protein 61-like; cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP10; IGFBP-10; insulin-like growth factor binding protein 10; insulin-like growth factor-binding protein 10; intermediate early; LOC100339657; protein CYR61; Protein GIG1