53BP1 Polyclonal Antibody | Invitrogen PA1-16566 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

53BP1 Polyclonal Antibody

catalog :

PA1-16566

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig s7	Guo H, Chou W, Lai Y, Liang K, Tam J, Brickey W, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370: pubmed publisher
immunohistochemistry - frozen section; rat; 1:200; loading ...; fig 2c	Suman S, Kumar S, N GOUEMO P, Datta K. Increased DNA double-strand break was associated with downregulation of repair and upregulation of apoptotic factors in rat hippocampus after alcohol exposure. Alcohol. 2016;54:45-50 pubmed publisher
	Dang T, Morales J. Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition. Cancers (Basel). 2021;13: pubmed publisher
	Dang T, Morales J. Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress. Int J Mol Sci. 2020;21: pubmed publisher

product information

Product Type :

Antibody

Product Name :

53BP1 Polyclonal Antibody

Catalog # :

PA1-16566

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bat, Bovine, Canine, Human, Mouse, Rat, Rodent

Applications :

ChIP Assay: Assay-Dependent, Flow Cytometry: 2-5 ug/million cells, Immunocytochemistry: 1:50-1:1,000, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:10-1:500, Western Blot: 1:2,000-1:10,000

Species :

Bat, Bovine, Canine, Human, Mouse, Rat, Rodent

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Immunogen :

Region between residues 1925 and the C-terminus (residue 1972) of human 53BP1

Format :

Liquid

Applications w/Dilutions :

Aliases :

53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1

more info or order :

Invitrogen product webpage