53BP1 Polyclonal Antibody | Invitrogen PA1-16565 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

53BP1 Polyclonal Antibody

catalog :

PA1-16565

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

domestic goat, human, mouse, rat, dogs, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; fig 2	Sears C, Cooney S, Chin Sinex H, Mendonca M, Turchi J. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst). 2016;40:35-46 pubmed publisher
	Zhang L, Hsu J, Braekeleer E, Chen C, Patel T, Urya H, et al. SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells. bioRxiv. 2023;: pubmed publisher
	Roelofs P, Timmermans M, Stefanovska B, den Boestert M, van den Borne A, Balcioglu H, et al. Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase. Cells. 2023;12: pubmed publisher
	Bleiler M, Cyr A, Wright D, Giardina C. Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis. J Cell Sci. 2023;136: pubmed publisher
	Hanu C, Loeliger B, Panyutin I, Maass Moreno R, Wakim P, Pritchard W, et al. Effect of Ionizing Radiation from Computed Tomography on Differentiation of Human Embryonic Stem Cells into Neural Precursors. Int J Mol Sci. 2019;20: pubmed publisher

product information

Product Type :

Antibody

Product Name :

53BP1 Polyclonal Antibody

Catalog # :

PA1-16565

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bat, Bovine, Canine, Fish, Goat, Human, Mouse, Non-human primate, Rat

Applications :

ChIP Assay: Assay-Dependent, Flow Cytometry: 1.5 ug/mL, Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Immunoprecipitation: Assay-Dependent, Western Blot: 1-2 ug/mL

Species :

Bat, Bovine, Canine, Fish, Goat, Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

-20 C

Description :

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Immunogen :

The epitope recognized by this antibody maps to a region between residues 350 and 400 of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1 (GeneID 7158).

Format :

Liquid

Applications w/Dilutions :

Aliases :

53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1

more info or order :

Invitrogen product webpage