HIF-2 alpha Polyclonal Antibody | Invitrogen PA1-16510 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HIF-2 alpha Polyclonal Antibody

catalog :

PA1-16510

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

Chinese hamsters, human, mouse, rat, domestic sheep, domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 6b	Rychtarčíková Z, Lettlova S, Tomkova V, Korenkova V, Langerova L, Simonova E, et al. Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. Oncotarget. 2017;8:6376-6398 pubmed publisher
immunohistochemistry; mouse; fig s2a	Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2Î± suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher
western blot; human; 1:1000; fig 4	Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed publisher
	Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, et al. CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion. J Clin Invest. 2023;133: pubmed publisher
	Wang T, Dong Y, Huang Z, Zhang G, Zhao Y, Yao H, et al. Antioxidants stimulate BACH1-dependent tumor angiogenesis. J Clin Invest. 2023;133: pubmed publisher
	Wong S, Kardia E, Vijayan A, Umashankar B, Pandzic E, Zhong L, et al. Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia. Int J Mol Sci. 2023;24: pubmed publisher
	Nam J, Kim A, Choi S, Kim J, Han S, Park S, et al. Pharmacologic Inhibition of HIF-1α Attenuates Radiation-Induced Pulmonary Fibrosis in a Preclinical Image Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2021;109:553-566 pubmed publisher
	Wu J, Contratto M, Shanbhogue K, Manji G, O Neil B, NOONAN A, et al. Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma. World J Clin Oncol. 2019;10:149-160 pubmed publisher
	Lin N, Shay J, Xie H, Lee D, Skuli N, Tang Q, et al. Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis. Front Immunol. 2018;9:2565 pubmed publisher
	Altintop I, Tatli M, Karakukcu C, Soyer Sarica Z, Hanım Yay A, Balcioğlu E, et al. Serum and Tissue HIF-2 Alpha Expression in CIN, N-Acetyl Cysteine, and Sildenafil-Treated Rat Models: An Experimental Study. Medicina (Kaunas). 2018;54: pubmed publisher
	Biddlestone J, Batie M, Bandarra D, Munoz I, Rocha S. SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression. Biochem J. 2018;475:2073-2090 pubmed publisher
	Moniz S, Bandarra D, Biddlestone J, Campbell K, Komander D, Bremm A, et al. Cezanne regulates E2F1-dependent HIF2Î± expression. J Cell Sci. 2015;128:3082-93 pubmed publisher
	Sun Y, George J, Rocha S. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS ONE. 2015;10:e0123649 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HIF-2 alpha Polyclonal Antibody

Catalog # :

PA1-16510

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Fish, Hamster, Human, Mouse, Non-human primate, Ovine, Rabbit, Rat, Reptile

Applications :

ChIP Assay: 1:10-1:500, ELISA: 1:100-1:2,000, Flow Cytometry: Assay-Dependent, Gel Shift: Assay-Dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 5 ug/1 mg lysate, In vitro Assay: Assay-Dependent, Western Blot: 1-2 ug/mL

Species :

Fish, Hamster, Human, Mouse, Non-human primate, Ovine, Rabbit, Rat, Reptile

Isotype :

IgG

Storage :

-20 C

Description :

HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.

Immunogen :

A peptide derived from the C-terminus of mouse/human HIF-2 alpha protein.

Format :

Liquid

Applications w/Dilutions :

Aliases :

basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain protein 1b; endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1b; EPAS; Epas1; EPAS-1; epas1b; Hif like protein; HIF1 alpha-like factor; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF-2 alpha; HIF2A; hif-2a; hif-2ab; HIF-2alpha; HIF-2-alpha; HIF2-alpha; HIF-related factor; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2; wu:fq36f01

more info or order :

Invitrogen product webpage