Phospho-GluR1 (Ser845) Polyclonal Antibody | Invitrogen PA1-12749 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-GluR1 (Ser845) Polyclonal Antibody

catalog :

PA1-12749

quantity :

10Miniblots

price :

US 499.00

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:2000	Giralt A, Saavedra A, Carretón O, Arumí H, Tyebji S, Alberch J, et al. PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model. Hippocampus. 2013;23:684-95 pubmed publisher
western blot; mouse	Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, et al. Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron. 2013;77:929-41 pubmed publisher
western blot; mouse; 1:1000	Chen H, Manev H. Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice. Neuropharmacology. 2011;60:1058-63 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-GluR1 (Ser845) Polyclonal Antibody

Catalog # :

PA1-12749

Quantity :

10Miniblots

Price :

US 499.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:1000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct subunits GluR1-4 and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is also potentiated by phosphorylation at Ser831. In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory.

Immunogen :

Sythetic peptide corresponding to amino acid residues surrounding phospho-Ser845 of rat GluR1

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1000

Aliases :

Glutamate Receptor 1, GRIA1, GluRA, HGBR1

PubMed References :

20868701, 23473322, 23576401