GFAP Polyclonal Antibody | Invitrogen PA1-10019 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GFAP Polyclonal Antibody

catalog :

PA1-10019

quantity :

100 µL

price :

US 499.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine, pigs , domestic horse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 6, s8	Higgins N, Greenslade J, Wu J, Miranda E, Galliciotti G, Monteiro M. Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD. Brain Pathol. 2021;:e12948 pubmed publisher
immunohistochemistry - frozen section; mouse; loading ...; fig S2G	Huang H, Liu Y, Wang L, Li W. Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. PLoS ONE. 2017;12:e0173716 pubmed publisher
immunohistochemistry; mouse; 1:1000; fig 7	Platt T, Beckett T, Kohler K, Niedowicz D, Murphy M. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. 2016;315:162-74 pubmed publisher
	Kurilova E, Sidorova M, Tuchina O. Single Prolonged Stress Decreases the Level of Adult Hippocampal Neurogenesis in C57BL/6, but Not in House Mice. Curr Issues Mol Biol. 2023;45:524-537 pubmed publisher
	Leng K, Rose I, Kim H, Xia W, Romero Fernandez W, Rooney B, et al. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022;25:1528-1542 pubmed publisher
	Anakor E, Milla V, Connolly O, Martinat C, Pradat P, Dumonceaux J, et al. The Neurotoxicity of Vesicles Secreted by ALS Patient Myotubes Is Specific to Exosome-Like and Not Larger Subtypes. Cells. 2022;11: pubmed publisher
	Scheidmann M, Castro Giner F, Strittmatter K, Krol I, Paasinen Sohns A, Scherrer R, et al. An in vivo CRISPR screen identifies stepwise genetic dependencies of metastatic progression. Cancer Res. 2021;: pubmed publisher
	Aryal S, Neupane K, Masud A, RICHARDS C. Characterization of Astrocyte Morphology and Function Using a Fast and Reliable Tissue Clearing Technique. Curr Protoc. 2021;1:e279 pubmed publisher
	Verma D, Seo B, Ghosh A, Ma S, Hernandez Quijada K, Andersen J, et al. Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models. Cells. 2021;10: pubmed publisher
	Qiang Q, Manalo J, Sun H, Zhang Y, Song A, Wen A, et al. Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming. PLoS Biol. 2021;19:e3001239 pubmed publisher
	Aryal S, Fu X, Sandin J, Neupane K, Lakes J, Grady M, et al. Nicotine induces morphological and functional changes in astrocytes via nicotinic receptor activity. Glia. 2021;69:2037-2053 pubmed publisher
	Song W, Ding H, Dunn T, Gao J, Labastida J, Schlagal C, et al. Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury. Neural Regen Res. 2021;16:2234-2242 pubmed publisher
	Brown M, Gibson K, Schmidt M, Walters D, Arning E, Bottiglieri T, et al. Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase-deficient mice. JIMD Rep. 2020;56:58-69 pubmed publisher
	Ozevren H, Deveci E, Tuncer M. The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of IBA-1 and GFAP expressions. Acta Cir Bras. 2020;35:e202000406 pubmed publisher
	Kruminis Kaszkiel E, Osowski A, Bejer Olenska E, Dziekoński M, Wojtkiewicz J. Differentiation of Human Mesenchymal Stem Cells from Wharton's Jelly Towards Neural Stem Cells Using A Feasible and Repeatable Protocol. Cells. 2020;9: pubmed publisher
	Veraart J, Nunes D, Rudrapatna U, Fieremans E, Jones D, Novikov D, et al. Nonivasive quantification of axon radii using diffusion MRI. elife. 2020;9: pubmed publisher
	Savell K, Bach S, Zipperly M, Revanna J, Goska N, Tuscher J, et al. A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation. Eneuro. 2019;6: pubmed publisher
	Jeong J, Kim D, Lee N, Jeong Y, Kim H, Kim J, et al. Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction. ASN Neuro. 2018;10:1759091418810583 pubmed publisher
	McGrath E, Gao J, Kuo Y, Dunn T, Ray M, Dineley K, et al. Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption. Stem Cell Reports. 2017;9:1916-1930 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

GFAP Polyclonal Antibody

Catalog # :

PA1-10019

Quantity :

100 µL

Price :

US 499.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Bovine, Equine, Human, Mouse, Porcine, Rat

Applications :

Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Western Blot: 1:5,000

Species :

Bovine, Equine, Human, Mouse, Porcine, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.

Immunogen :

Recombinant full length human GFAP isotype 1 expressed in and purified from E. coli.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Western Blot: 1:5,000

Aliases :

6330404F12Rik; 65 kDa glutamic acid decarboxylase; AI836096; ALXDRD; Astrocyte or Intermediate Filament Protein; cb345; class III intermediate filament protein; etID36982.3; FLJ45472; GAD(65); Gad2; Gad-2; GAD65; GAD-65; GFAP; GFAP epsilon; gfap protein; gfapl; glial fibrillary acidic protein; Glial Fibrillary Acidic Protein (GFAP); glial fibrillary acidic protein alpha; glutamate decarboxylase 2; Glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; I79_011607; intermediate filament; intermediate filament protein; intermediate filament protein; GFAP; Unknown (protein for MGC:139638); wu:fb34h11; wu:fk42c12; xx:af506734; zgc:110485; zGFAP; intermediate filament protein; zrf-1 antigen

more info or order :

Invitrogen product webpage