PGP9.5 Polyclonal Antibody | Invitrogen PA1-10011 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PGP9.5 Polyclonal Antibody

catalog :

PA1-10011

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine, pigs , domestic horse

application :

western blot, immunocytochemistry

citations: 11

Reference
Stegemann L, Neufeld P, Hecking I, Vorgerd M, Matschke V, Stahlke S, et al. Progesterone: A Neuroprotective Steroid of the Intestine. Cells. 2023;12: pubmed publisher
Hecking I, Stegemann L, Stahlke S, Theis V, Vorgerd M, Matschke V, et al. Methods to Study the Myenteric Plexus of Rat Small Intestine. Cell Mol Neurobiol. 2023;43:315-325 pubmed publisher
Metzner K, Darawsha O, Wang M, Gaur N, Cheng Y, R xf6 diger A, et al. Age-dependent increase of cytoskeletal components in sensory axons in human skin. Front Cell Dev Biol. 2022;10:965382 pubmed publisher
Kupczyk P, Rykala M, Serek P, Pawlak A, Slowikowski B, Holysz M, et al. The cannabinoid receptors system in horses: Tissue distribution and cellular identification in skin. J Vet Intern Med. 2022;36:1508-1524 pubmed publisher
Hecking I, Stegemann L, Theis V, Vorgerd M, Matschke V, Stahlke S, et al. Neuroprotective Effects of VEGF in the Enteric Nervous System. Int J Mol Sci. 2022;23: pubmed publisher
Zinnen A, Vichich J, Metzger J, Gambardella J, Bondarenko V, Simmons H, et al. Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum. PLoS ONE. 2022;17:e0269190 pubmed publisher
Emiliano A, Lopatinsky N, Kraljevi x107 M, Higuchi S, He Y, Haeusler R, et al. Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged mice. Am J Physiol Endocrinol Metab. 2022;323:E107-E121 pubmed publisher
Chen X, Ravindra Kumar S, Adams C, Yang D, Wang T, Wolfe D, et al. Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems. Neuron. 2022;: pubmed publisher
Behrouzi A, Xia H, Thompson E, Kelley M, Fehrenbacher J. Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons. Int J Mol Sci. 2022;23: pubmed publisher
Mancinelli A, Vichich J, Zinnen A, Hugon A, Bondarenko V, Metzger J, et al. Acute Exposure to the Food-Borne Pathogen Listeria monocytogenes Does Not Induce α-Synuclein Pathology in the Colonic ENS of Nonhuman Primates. J Inflamm Res. 2021;14:7265-7279 pubmed publisher
Lu Q, Yang Y, Zhang H, Chen C, Zhao J, Yang Z, et al. Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1. Drug Des Devel Ther. 2021;15:4687-4699 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PGP9.5 Polyclonal Antibody

Catalog # :

PA1-10011

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Host :

Chicken

Reactivity :

Bovine, Equine, Human, Mouse, Porcine, Rat

Applications :

Immunocytochemistry: 1:500-1:1,000, Western Blot: 1:2,000-1:5,000

Species :

Bovine, Equine, Human, Mouse, Porcine, Rat

Isotype :

IgY

Storage :

4 C

Description :

PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.

Immunogen :

Recombinant full length human UCHL1

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:500-1:1,000, Western Blot: 1:2,000-1:5,000

Aliases :

AW822034; C88048; epididymis luminal protein 117; epididymis secretory protein Li 53; gad; gracile axonal dystrophy; HEL-117; HEL-S-53; MGC133697 protein; NDGOA; neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; PARK5; PGP 9.5; PGP9.5; PGP95; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal esterase; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase L1; ubiquitin carboxy-terminal hydrolase L1; ubiquitin C-terminal hydrolase; ubiquitin C-terminal hydrolase 1; ubiquitin C-terminal hydrolase L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1; UCHL; UCHL1; UCH-L1; UCHL-1