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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GFAP Polyclonal Antibody
catalog :
PA1-10004
quantity :
100 µL
price :
US 516.00
clonality :
polyclonal
host :
chicken
conjugate :
nonconjugated
reactivity :
human, mouse, rat, bovine, pigs , domestic horse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section
more info or order :
Invitrogen product webpage
citations: 31
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1a
Zhao P, Xu Y, Jiang L, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener. 2022;17:44 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7a
Guimarães Camboa N, Cattaneo P, Sun Y, Moore Morris T, Gu Y, Dalton N, et al. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017;20:345-359.e5 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:2000; fig 4
Morales I, Sánchez A, Rodriguez Sabate C, Rodriguez M. The astrocytic response to the dopaminergic denervation of the striatum. J Neurochem. 2016;139:81-95 pubmed publisher
Szab xf3 V, Cs xe1 k xe1 ny Papp N, G xf6 r xf6 g M, Mad xe1 csy T, Varga x, Kiss A, et al. Orai1 calcium channel inhibition prevents progression of chronic pancreatitis. JCI Insight. 2023;8: pubmed publisher
Cho E, Park J, Hwang E, Kim H, Park J. 14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson's disease-like motor incoordination in mice. Mol Brain. 2023;16:2 pubmed publisher
Snapper D, Reginauld B, Liaudanskaya V, Fitzpatrick V, Kim Y, Georgakoudi I, et al. Development of a novel bioengineered 3D brain-like tissue for studying primary blast-induced traumatic brain injury. J Neurosci Res. 2023;101:3-19 pubmed publisher
Cuenca Ortol xe1 I, Mart xed nez Rojas B, Moreno Manzano V, Garc xed a Castell xf3 M, Monle xf3 n Pradas M, Mart xed nez Ramos C, et al. A Strategy for Magnetic and Electric Stimulation to Enhance Proliferation and Differentiation of NPCs Seeded over PLA Electrospun Membranes. Biomedicines. 2022;10: pubmed publisher
Paul S, Fatihi S, Sharma S, Kutum R, Fields R, Pant H, et al. Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson's Disease. Eneuro. 2022;9: pubmed publisher
Wang W, Liu Z, Jing B, Mai H, Jiao H, Guan T, et al. 4,8-dicarboxyl-8,9-iridoid-1-glycoside Promotes Neural Stem Cell Differentiation Through MeCP2. Dose Response. 2022;20:15593258221112959 pubmed publisher
Duan S, Sawyer T, Sontz R, Wieland B, Diaz A, Merchant J. GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming. Cell Mol Gastroenterol Hepatol. 2022;14:1025-1051 pubmed publisher
Bakaeva Z, Goncharov M, Krasilnikova I, Zgodova A, Frolov D, Grebenik E, et al. Acute and Delayed Effects of Mechanical Injury on Calcium Homeostasis and Mitochondrial Potential of Primary Neuroglial Cell Culture: Potential Causal Contributions to Post-Traumatic Syndrome. Int J Mol Sci. 2022;23: pubmed publisher
Sanchez Petidier M, Guerri C, Moreno Manzano V. Toll-like receptors 2 and 4 differentially regulate the self-renewal and differentiation of spinal cord neural precursor cells. Stem Cell Res Ther. 2022;13:117 pubmed publisher
Jin Y, Shi P, Wang Y, Li J, Zhang J, Zhao X, et al. Precise control of embolic stroke with magnetized red blood cells in mice. Commun Biol. 2022;5:136 pubmed publisher
Sharon A, Shmoel N, Erez H, Jankowski M, Friedmann Y, Spira M. Ultrastructural Analysis of Neuroimplant-Parenchyma Interfaces Uncover Remarkable Neuroregeneration Along-With Barriers That Limit the Implant Electrophysiological Functions. Front Neurosci. 2021;15:764448 pubmed publisher
Levine A, Liktor Busa E, Lipinski A, Couture S, Balasubramanian S, Aicher S, et al. Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats. Biol Sex Differ. 2021;12:60 pubmed publisher
Bonilla P, Hernandez J, Giraldo E, González Pérez M, Alastrue Agudo A, Elkhenany H, et al. Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment. Int J Mol Sci. 2021;22: pubmed publisher
Sharon A, Jankowski M, Shmoel N, Erez H, Spira M. Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and Its Implications. Front Neurosci. 2021;15:646914 pubmed publisher
Jung H, Kim A, Kim S, Park J, Hwang E. AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes. Brain Sci. 2021;11: pubmed publisher
Giraldo E, Palmero Canton D, Martinez Rojas B, Sánchez Martín M, Moreno Manzano V. Optogenetic Modulation of Neural Progenitor Cells Improves Neuroregenerative Potential. Int J Mol Sci. 2020;22: pubmed publisher
Huang S, Shmoel N, Jankowski M, Erez H, Sharon A, Abu Salah W, et al. Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophysiological Recording Quality. Front Neurosci. 2020;14:926 pubmed publisher
Sheng L, Stewart T, Yang D, Thorland E, Soltys D, Aro P, et al. Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis. Acta Neuropathol Commun. 2020;8:102 pubmed publisher
Potratz M, Zaeck L, Christen M, Te Kamp V, Klein A, Nolden T, et al. Astrocyte Infection during Rabies Encephalitis Depends on the Virus Strain and Infection Route as Demonstrated by Novel Quantitative 3D Analysis of Cell Tropism. Cells. 2020;9: pubmed publisher
Hauglund N, Kusk P, Kornum B, Nedergaard M. Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes. J Neurosci. 2020;40:2371-2380 pubmed publisher
Rodríguez Jiménez F, Clemente E, Moreno Manzano V, Erceg S. Organized Neurogenic-Niche-Like Pinwheel Structures Discovered in Spinal Cord Tissue-Derived Neurospheres. Front Cell Dev Biol. 2019;7:334 pubmed publisher
Kim A, Jung H, Kim S, Choi M, Park J, Lee S, et al. Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia. Cell Biochem Funct. 2020;38:167-175 pubmed publisher
Marek V, Reboussin E, Degardin Chicaud J, Charbonnier A, Domínguez López A, Villette T, et al. Implication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo. Front Neurosci. 2019;13:497 pubmed publisher
Petrov A, Lam M, Mast N, Moon J, Li Y, Maxfield E, et al. CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice. Neurotherapeutics. 2019;: pubmed publisher
Mohanty T, Fisher J, Bakochi A, Neumann A, Cardoso J, Karlsson C, et al. Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis. Nat Commun. 2019;10:1667 pubmed publisher
Saadane A, Petrov A, Mast N, El Darzi N, Dao T, Alnemri A, et al. Mechanisms that minimize retinal impact of apolipoprotein E absence. J Lipid Res. 2018;59:2368-2382 pubmed publisher
von Holstein Rathlou S, Petersen N, Nedergaard M. Voluntary running enhances glymphatic influx in awake behaving, young mice. Neurosci Lett. 2018;662:253-258 pubmed publisher
Meyer L, Paisley C, Mohamed E, Bigbee J, Kordula T, Richard H, et al. Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes. Glia. 2017;65:2003-2023 pubmed publisher
product information
Product Type :
Antibody
Product Name :
GFAP Polyclonal Antibody
Catalog # :
PA1-10004
Quantity :
100 µL
Price :
US 516.00
Clonality :
Polyclonal
Host :
Chicken
Reactivity :
Bovine, Equine, Human, Mouse, Porcine, Rat
Applications :
Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:20,000, Western Blot: 1:5,000
Species :
Bovine, Equine, Human, Mouse, Porcine, Rat
Isotype :
IgY
Storage :
4° C
Description :
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Immunogen :
Recombinant full length human GFAP isotype 1 expressed in and purified from E. coli.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:20,000, Western Blot: 1:5,000
Aliases :
6330404F12Rik; 65 kDa glutamic acid decarboxylase; AI836096; ALXDRD; Astrocyte or Intermediate Filament Protein; cb345; class III intermediate filament protein; etID36982.3; FLJ45472; GAD(65); Gad2; Gad-2; GAD65; GAD-65; GFAP; GFAP epsilon; gfap protein; gfapl; glial fibrillary acidic protein; Glial Fibrillary Acidic Protein (GFAP); glial fibrillary acidic protein alpha; glutamate decarboxylase 2; Glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; I79_011607; intermediate filament; intermediate filament protein; intermediate filament protein; GFAP; Unknown (protein for MGC:139638); wu:fb34h11; wu:fk42c12; xx:af506734; zgc:110485; zGFAP; intermediate filament protein; zrf-1 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA