Nanog Polyclonal Antibody | Invitrogen PA1-097X product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Nanog Polyclonal Antibody

catalog :

PA1-097X

quantity :

20 uL

price :

US 187.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 17

Reference
Peeters S, Fedoryshchenko I, Rabaut L, Verstraeten A, Loeys B. Generation of an induced pluripotent stem cell (iPSC) line of a Marfan syndrome patient with a pathogenic FBN1 c.5372G > A (p.Cys1791Tyr) variant. Stem Cell Res. 2023;68:103050 pubmed publisher
Wang P, Li H, Zhu M, Han R, Guo S, Han R. Correction of DMD in human iPSC-derived cardiomyocytes by base-editing-induced exon skipping. Mol Ther Methods Clin Dev. 2023;28:40-50 pubmed publisher
Velchev J, Verstraeten A, Meester J, Ponsaerts P, Richer J, Alaerts M, et al. Generation and validation of an iPSC line (BBANTWi008-A) from a Loeys-Dietz Syndrome type 3 patient. Stem Cell Res. 2022;64:102932 pubmed publisher
Hekman K, Koss K, Ivancic D, He C, Wertheim J. Autophagy Enhances Longevity of Induced Pluripotent Stem Cell-Derived Endothelium via mTOR-Independent ULK1 Kinase. Stem Cells Transl Med. 2022;11:1151-1164 pubmed publisher
Simons E, Nijak A, Loeys B, Alaerts M. Generation of two induced pluripotent stem cell (iPSC) lines (BBANTWi006-A, BBANTWi007-A) from Brugada syndrome patients carrying an SCN5A mutation. Stem Cell Res. 2022;60:102719 pubmed publisher
Majuelos Melguizo J, Rodr xed guez Vargas J, Mart xed nez L xf3 pez N, Delgado Bellido D, Garc xed a D xed az x, Yuste V, et al. Glioblastoma Cells Counteract PARP Inhibition through Pro-Survival Induction of Lipid Droplets Synthesis and Utilization. Cancers (Basel). 2022;14: pubmed publisher
Scaramuzzino L, Lucchino V, Scalise S, Lo Conte M, Zannino C, Sacco A, et al. Uncovering the Metabolic and Stress Responses of Human Embryonic Stem Cells to FTH1 Gene Silencing. Cells. 2021;10: pubmed publisher
Tekel S, Brookhouser N, Standage Beier K, Wang X, Brafman D. Cytosine and adenosine base editing in human pluripotent stem cells using transient reporters for editing enrichment. Nat Protoc. 2021;16:3596-3624 pubmed publisher
Yang X, Ma X, Don O, Song Y, Chen X, Liu J, et al. Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin. Stem Cell Res Ther. 2020;11:182 pubmed publisher
De Angelis M, Santamaria G, Parrotta E, Scalise S, Lo Conte M, Gasparini S, et al. Establishment and characterization of induced pluripotent stem cells (iPSCs) from central nervous system lupus erythematosus. J Cell Mol Med. 2019;23:7382-7394 pubmed publisher
Kolundžić E, Ofenbauer A, Bulut S, Uyar B, Baytek G, Sommermeier A, et al. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Dev Cell. 2018;46:611-626.e12 pubmed publisher
Pisal R, Suchanek J, Siller R, Soukup T, Hrebíková H, Bezrouk A, et al. Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth. Sci Rep. 2018;8:6168 pubmed publisher
El Battrawy I, Lan H, Cyganek L, Zhao Z, Li X, Buljubasic F, et al. Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. J Am Heart Assoc. 2018;7: pubmed publisher
Ventura Ferreira M, Bienert M, Muller K, Rath B, Goecke T, Opländer C, et al. Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta. Stem Cell Res Ther. 2018;9:28 pubmed publisher
De Angelis M, Parrotta E, Santamaria G, Cuda G. Short-term retinoic acid treatment sustains pluripotency and suppresses differentiation of human induced pluripotent stem cells. Cell Death Dis. 2018;9:6 pubmed publisher
Lee M, Huang H, Chang T, Huang H, Hsieh S, Chen Y, et al. Genome-wide analysis of HIF-2? chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep. 2016;6:29311 pubmed publisher
Catanzaro G, Besharat Z, Garg N, Ronci M, Pieroni L, Miele E, et al. MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs. Stem Cells Int. 2016;2016:2683042 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Nanog Polyclonal Antibody

Catalog # :

PA1-097X

Quantity :

20 uL

Price :

US 187.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ChIP Assay: 1-3 uL, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

-20 C

Description :

NANOG (Nanog homeobox) is a divergent homeodomain protein that directs pluripotency and differentiation of undifferentiated embryonic stem cells. NANOG mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Human NANOG protein shares 52% overall amino acid identity with the mouse protein, and 85% identity in the homeodomain. Human NANOG maps to gene locus 12p13.31, while the mouse NANOG maps to gene loci 6 F2. Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst. Research studies have shown that high levels of human NANOG expression in the undifferentiated N-Tera embryonal carcinoma cell line. Further, NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. When overexpressed, NANOG promotes cells to enter into S phase and proliferation. Diseases associated with dysfunction in the NANOG protein include tetracarcinoma and germ cell/embryonal cancer.

Immunogen :

Full-length human recombinant protein expressed in bacteria

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1-3 uL, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:1,000

Aliases :

2410002E02Rik; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein; Ecat4; ENK; ES cell-associated protein 4; FLJ12581; HGNC:20857; hNanog; Homeobox protein NANOG; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; Nanog; Nanog homeobox