product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
RAC1 Polyclonal Antibody
catalog :
PA1-091
quantity :
100 ug
price :
US 471.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2a
Ding Y, Lu L, Xuan C, Han J, Ye S, Cao T, et al. Di-n-butyl phthalate exposure negatively influences structural and functional neuroplasticity via Rho-GTPase signaling pathways. Food Chem Toxicol. 2017;105:34-43 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 8d
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed publisher
  • western blot; human; loading ...; fig 5c
Polusani S, Kalmykov E, Chandrasekhar A, Zucker S, Nicholson B. Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration. J Cell Sci. 2016;129:4399-4410 pubmed
  • flow cytometry; rat; loading ...; fig 4e
  • western blot; human; loading ...; fig 7d
Ubba V, Soni U, Chadchan S, Maurya V, Kumar V, Maurya R, et al. RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model. Reprod Sci. 2017;24:738-752 pubmed publisher
  • western blot; human; 1:1000; fig 3c
Shi D, Shi G, Xie J, Du X, Yang H. MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis. Mol Cells. 2016;39:611-8 pubmed publisher
  • western blot; human; fig 3
Hein A, Post C, Sheinin Y, Lakshmanan I, Natarajan A, Enke C, et al. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016;35:6319-6329 pubmed publisher
Tam S, Islam Khan M, Chen J, Yip J, Yan H, Tam T, et al. Proteomic Profiling of Chemotherapy Responses in FOLFOX-Resistant Colorectal Cancer Cells. Int J Mol Sci. 2023;24: pubmed publisher
Alka K, Mohammad G, Kowluru R. Regulation of serine palmitoyl-transferase and Rac1-Nox2 signaling in diabetic retinopathy. Sci Rep. 2022;12:16740 pubmed publisher
Sun J, Gaidosh G, Xu Y, Mookhtiar A, Man N, Cingaram P, et al. RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells. Oncogene. 2021;40:5950-5962 pubmed publisher
Yoon S, Shin B, Woo H. Endoplasmic Reticulum Stress Induces CAP2 Expression Promoting Epithelial-Mesenchymal Transition in Liver Cancer Cells. Mol Cells. 2021;44:569-579 pubmed publisher
Moon G, Lee J, Jeong S, Jin S, Park Y. NecroX-5 Can Suppress Melanoma Metastasis by Reducing the Expression of Rho-Family GTPases. J Clin Med. 2021;10: pubmed publisher
Misra S, Ghatak S, Moreno Rodriguez R, Norris R, Hascall V, Markwald R. Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction. Front Cell Dev Biol. 2021;9:649862 pubmed publisher
Takeuchi M, Vidigal P, Guerra M, Hundt M, Robert M, Olave Martinez M, et al. Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis. Gut. 2021;70:342-356 pubmed publisher
Hosseini K, Taubenberger A, Werner C, Fischer Friedrich E. EMT-Induced Cell-Mechanical Changes Enhance Mitotic Rounding Strength. Adv Sci (Weinh). 2020;7:2001276 pubmed publisher
Bu F, Min J, Munshi Y, Lai Y, Qi L, Urayama A, et al. Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice. Exp Neurol. 2019;322:113059 pubmed publisher
Mohammad G, Duraisamy A, Kowluru A, Kowluru R. Functional Regulation of an Oxidative Stress Mediator, Rac1, in Diabetic Retinopathy. Mol Neurobiol. 2019;56:8643-8655 pubmed publisher
Rinkenberger N, Schoggins J. Comparative analysis of viral entry for Asian and African lineages of Zika virus. Virology. 2019;533:59-67 pubmed publisher
Wang Z, Li Y, Cai S, Li R, Cao G. Cannabinoid receptor 2 agonist attenuates blood‑brain barrier damage in a rat model of intracerebral hemorrhage by activating the Rac1 pathway. Int J Mol Med. 2018;42:2914-2922 pubmed publisher
Mishra M, Duraisamy A, Bhattacharjee S, Kowluru R. Adaptor protein p66Shc- a link between cytosolic and mitochondrial dysfunction in the development of diabetic retinopathy. Antioxid Redox Signal. 2018;: pubmed publisher
Sivadasan R, Hornburg D, Drepper C, Frank N, Jablonka S, Hansel A, et al. C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. Nat Neurosci. 2016;19:1610-1618 pubmed publisher
Girola N, Matsuo A, Figueiredo C, Massaoka M, Farias C, Arruda D, et al. The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor. Peptides. 2016;85:1-15 pubmed publisher
Rodas P, Álamos Musre A, Álvarez F, Escobar A, Tapia C, Osorio E, et al. The NarE protein of Neisseria gonorrhoeae catalyzes ADP-ribosylation of several ADP-ribose acceptors despite an N-terminal deletion. FEMS Microbiol Lett. 2016;363: pubmed publisher
product information
Product Type :
Antibody
Product Name :
RAC1 Polyclonal Antibody
Catalog # :
PA1-091
Quantity :
100 ug
Price :
US 471.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
Immunocytochemistry: 1:20-1:100, Immunohistochemistry (Paraffin): 1:20-1:50, Western Blot: 1:1,000
Species :
Human, Mouse
Isotype :
IgG
Storage :
-20 C
Description :
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen :
Recombinant Full-length Human Protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:20-1:100, Immunohistochemistry (Paraffin): 1:20-1:50, Western Blot: 1:1,000
Aliases :
AL023026; cell migration-inducing gene 5 protein; D5Ertd559e; GTPase; MGC111543; MIG5; p21-Rac1; Rac 1b; Rac family small GTPase 1; RAC1; Rac-1; Rac2; rac2 GTP-binding protein; ras-like protein TC25; RAS-related C3 botulinum substrate 1; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1; TC25; TC-25
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA