CRM1 Polyclonal Antibody | Invitrogen PA1-083 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CRM1 Polyclonal Antibody

catalog :

PA1-083

quantity :

100 µg

price :

US 500

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

CRM1 Polyclonal Antibody

Catalog # :

PA1-083

Quantity :

100 µg

Price :

US 500

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Human, Mouse

Applications :

Immunoprecipitation: Assay dependent, Western Blot: 1:500-1:5000

Species :

Bovine, Human, Mouse

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Exportin - 1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins. Upon transit of a nuclear complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. The directionality of the nuclear export is thought to be conferred by an asymmetric distribution of the GTP and GDP bound forms of Ran between the cytoplasm and nucleus.

Immunogen :

Synthetic peptide corresponding to residues C R(1043) Q A D E E K H K R Q M S V P G S(1058) of human CRM1.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: Assay dependent, Western Blot: 1:500-1:5000

Aliases :

AA420417; chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; Crm1; emb; exp1; exportin 1; exportin 1 (CRM1 homolog, yeast); exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog; exportin 1, CRM1 homolog (yeast); Exportin-1; exportin-1 (required for chromosome region maintenance); Xpo1