MINT3 Polyclonal Antibody | Invitrogen PA1-072 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MINT3 Polyclonal Antibody

catalog :

PA1-072

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 1

Reference
Wu Q, Dai Q, Jiang L, Wang Y, Yang T, Miao J, et al. Downregulation of microRNA-448 improves isoflurane-induced learning and memory impairment in rats. Mol Med Rep. 2017;16:1578-1583 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MINT3 Polyclonal Antibody

Catalog # :

PA1-072

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 2 ug/mL, Western Blot: 2 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The munc-18 interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that mint3 does not interact with munc-18. Mint3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.

Immunogen :

Synthetic peptide corresponding to residues M(1) E F L P E P Q H P P G P P T M D L E(19) of rat Mint3.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Western Blot: 2 ug/mL

Aliases :

Adapter protein X11gamma; amyloid beta (A4) precursor protein-binding family A member 3 (X11-like 2); amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); amyloid beta (A4) precursor protein-binding, family A, member 3; amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); amyloid beta A4 precursor protein-binding family A member 3; amyloid beta precursor protein binding family A member 3; Amyloid-beta A4 precursor protein-binding family A member 3; Apba3; AW208791; lin 10; lin-10; MGC:15815; Mint 3; MINT3; mint-3; Neuronal Munc18-1-interacting protein 3; neuron-specific X11L2 protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11gamma; X11L2; X11-like 2 protein