EEA1 Polyclonal Antibody | Invitrogen PA1-063A product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EEA1 Polyclonal Antibody

catalog :

PA1-063A

quantity :

100 µg

price :

US 455

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 5a	Duclos C, Champagne A, Carrier J, Saucier C, Lavoie C, Denault J. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017;3:16100 pubmed publisher
	Hancock Cerutti W, Wu Z, Xu P, Yadavalli N, Leonzino M, Tharkeshwar A, et al. ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling. J Cell Biol. 2022;221: pubmed publisher
	Pan J, Sun D, Lee D, Xiong L, Ren X, Guo H, et al. Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence. Commun Biol. 2021;4:1326 pubmed publisher
	Lu S, Chen M, Atangan L, Killion E, Komorowski R, Cheng Y, et al. GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys. Cell Rep Med. 2021;2:100263 pubmed publisher
	Cejas R, Tamaño Blanco M, Blanco J. Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21). Sci Rep. 2021;11:10981 pubmed publisher
	Maier B, Leader A, Chen S, Tung N, Chang C, LeBerichel J, et al. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020;580:257-262 pubmed publisher
	Puri A, Viard M, Zakrevsky P, Zampino S, Chen A, Isemann C, et al. Photoactivation of sulfonated polyplexes enables localized gene silencing by DsiRNA in breast cancer cells. Nanomedicine. 2020;26:102176 pubmed publisher
	Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, et al. Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration. EMBO J. 2020;39:e103358 pubmed publisher
	Samanta D, Clemente T, Schuler B, Gilk S. Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth. PLoS Pathog. 2019;15:e1007855 pubmed publisher
	Yang M, Chen S, Lin Y, Lee Y, Huang M, Chen K, et al. Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease. J Food Drug Anal. 2019;27:551-564 pubmed publisher
	Aung K, Yoshioka K, Aki S, Ishimaru K, Takuwa N, Takuwa Y. The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells. J Physiol Sci. 2019;69:263-280 pubmed publisher
	Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer E, et al. Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity. elife. 2018;7: pubmed publisher
	Saxena M, Delgado Y, Sharma R, Sharma S, Guzmán S, Tinoco A, et al. Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. PLoS ONE. 2018;13:e0195542 pubmed publisher
	Jiménez Reinoso A, Marin A, Subías M, López Lera A, Román Ortiz E, Payne K, et al. Human plasma C3 is essential for the development of memory B, but not T, lymphocytes. J Allergy Clin Immunol. 2017;: pubmed publisher

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product information

Product Type :

Antibody

Product Name :

EEA1 Polyclonal Antibody

Catalog # :

PA1-063A

Quantity :

100 µg

Price :

US 455

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Western Blot: 2 µg/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.

Immunogen :

Synthetic peptide corresponding to residues T(1391) P S S K K P V R V C D A C F N D L Q G(1410) of human EEA1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Western Blot: 2 µg/mL

Aliases :

A430109M19Rik; B230358H09Rik; early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; zinc finger FYVE domain-containing protein 2

more info or order :

Invitrogen product webpage