PCSK2 Polyclonal Antibody | Invitrogen PA1-058 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PCSK2 Polyclonal Antibody

catalog :

PA1-058

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 5

Reference
Parchure A, Tian M, Stalder D, Boyer C, Bearrows S, Rohli K, et al. Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules. J Cell Biol. 2022;221: pubmed publisher
Ramzy A, Asadi A, Kieffer T. Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2. Diabetes. 2020;69:1451-1462 pubmed publisher
Bearrows S, Bauchle C, Becker M, Haldeman J, Swaminathan S, Stephens S. Chromogranin B regulates early stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. J Cell Sci. 2019;: pubmed publisher
Ramzy A, Mojibian M, Kieffer T. Insulin-Deficient Mouse β-Cells Do Not Fully Maturebut Can Be Remedied Through Insulin Replacementby Islet Transplantation. Endocrinology. 2018;159:83-102 pubmed publisher
El Ouaamari A, Zhou J, Liew C, Shirakawa J, Dirice E, Gedeon N, et al. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res. 2015;14:3111-3122 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PCSK2 Polyclonal Antibody

Catalog # :

PA1-058

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:20-1:200, Western Blot: 2 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous approximately 10 kDa amino-terminal proregion, a highly conserved approximately 55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

Immunogen :

Synthetic peptide corresponding to residues E(622) L D E A V E R S L Q S I L R K N(638) of mouse PC2.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:20-1:200, Western Blot: 2 ug/mL

Aliases :

6330411F23Rik; AI839700; EC 3.4.21.94; KEX2-like endoprotease 2; NEC 2; NEC2; Nec-2; Neuroendocrine convertase 2; PC2; PC2-like protein; PCSK2; Phpp-2; Prohormone convertase 2; prohormone convertase 2-like protein; propotein convetase subtilisin/kesin type 2; proprotein convertase 2; proprotein convertase subtilisin/kexin type 2; proprotein convertase type 2; Rpc2; SPC2