Leptin Polyclonal Antibody | Invitrogen PA1-052 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Leptin Polyclonal Antibody

catalog :

PA1-052

quantity :

100 uL

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, pigs

application :

western blot, immunocytochemistry

citations: 2

Reference
Di Vincenzo A, Crescenzi M, Granzotto M, Zancaner S, Fabris R, Foletto M, et al. Body Weight Reduction by Bariatric Surgery Reduces the Plasma Levels of the Novel Orexigenic Gut Hormone Insulin-like Peptide 5 in Patients with Severe Obesity. J Clin Med. 2023;12: pubmed publisher
Stakkestad Ø, Heyward C, Lyngstadaas S, Medin T, Vondrasek J, Lian A, et al. An ameloblastin C-terminus variant is present in human adipose tissue. Heliyon. 2018;4:e01075 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Leptin Polyclonal Antibody

Catalog # :

PA1-052

Quantity :

100 uL

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Rabbit

Reactivity :

Human, Mouse, Porcine

Applications :

Immunocytochemistry: 1:20-1:200, Western Blot: 1:500-1:5,000

Species :

Human, Mouse, Porcine

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure. Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors. Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth. Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension. Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation. Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.

Immunogen :

Synthetic peptide corresponding to residues S(91) R N V I Q I S N D L E N L R D(106) of human Leptin.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:20-1:200, Western Blot: 1:500-1:5,000

Aliases :

CD295 antigen; H-Leptin; HuB219; Lep; LEPD; LEP-R; Leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); leptin precursor; Method: conceptual translation supplied by author.; OB; obese; obese protein; obese, mouse, homolog of; obesity; obesity factor; obesity protein; OB-R; OBS; truncated leptin