alpha-1a Adrenergic Receptor Polyclonal Antibody | Invitrogen PA1-047 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

alpha-1a Adrenergic Receptor Polyclonal Antibody

catalog :

PA1-047

quantity :

100 uL

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 10

Reference
Alhamyani A, Napit P, Bheemanapally K, Sylvester P, Briski K. Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex. Transl Neurosci. 2022;13:408-420 pubmed publisher
Maeda S, Minato Y, Kuwahara Otani S, Yamanaka H, Maeda M, Kataoka Y, et al. Morphology of Schwann Cell Processes Supports Renal Sympathetic Nerve Terminals With Local Distribution of Adrenoceptors. J Histochem Cytochem. 2022;70:495-513 pubmed publisher
Yu Z, Yi X, Wang Y, Zeng G, Tan C, Cheng Y, et al. Inhibiting α1-adrenergic receptor signaling pathway ameliorates AD-type pathologies and behavioral deficits in APPswe/PS1 mouse model. J Neurochem. 2022;161:293-307 pubmed publisher
Despain K, Rosenfeld C, Huebinger R, Wang X, Jay J, Radhakrishnan R, et al. Carotid smooth muscle contractility changes after severe burn. Sci Rep. 2021;11:18094 pubmed publisher
Hoffmeister J, Kelm Nelson C, Ciucci M. Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease. Behav Brain Res. 2021;414:113514 pubmed publisher
Ivanova A, Filatova T, Abramochkin D, Atkinson A, Dobrzynski H, Kokaeva Z, et al. Attenuation of inward rectifier potassium current contributes to the α1-adrenergic receptor-induced proarrhythmicity in the caval vein myocardium. Acta Physiol (Oxf). 2021;231:e13597 pubmed publisher
Ibrahim M, Bheemanapally K, Sylvester P, Briski K. Norepinephrine Regulation of Adrenergic Receptor Expression, 5' AMP-Activated Protein Kinase Activity, and Glycogen Metabolism and Mass in Male Versus Female Hypothalamic Primary Astrocyte Cultures. ASN Neuro. 2020;12:1759091420974134 pubmed publisher
Datta D, Yang S, Galvin V, Solder J, Luo F, Morozov Y, et al. Noradrenergic α1-Adrenoceptor Actions in the Primate Dorsolateral Prefrontal Cortex. J Neurosci. 2019;39:2722-2734 pubmed publisher
Neumann V, Knies R, Seidinger A, Simon A, Lorenz K, Matthey M, et al. The ?2 agonist terbutaline specifically decreases pulmonary arterial pressure under normoxia and hypoxia via ? adrenoceptor antagonism. FASEB J. 2018;: pubmed publisher
Rajbhandari A, Baldo B, Bakshi V. Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities. J Neurosci. 2015;35:14270-85 pubmed publisher

product information

Product Type :

Antibody

Product Name :

alpha-1a Adrenergic Receptor Polyclonal Antibody

Catalog # :

PA1-047

Quantity :

100 uL

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Drosophila, Human, Mouse, Rat, Zebrafish

Applications :

Immunocytochemistry: 1:10-1:1,000, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:400

Species :

Drosophila, Human, Mouse, Rat, Zebrafish

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. A1AR subtypes are found in numerous tissues and have been shown to be involved in the regulation of blood pressure due to changes in vascular tone and cardiac output. Effects on uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70), proto-oncogene expression, and mitogenesis have been linked to A1AR activation. Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus by activating alpha-1 AR which may indirectly suppress the release of luteinizing hormone (LH), the androgens, estrogen, and progesterone.

Immunogen :

Synthetic peptide corresponding to residues K(339) F S R E K K A A K T(349) of the 3rd intracellular loop of human A1AR.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:1,000, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:400

Aliases :

ADA1; adra1a; adra1aa; Adra1c; ADRA1L1; adrenergic alpha 1c receptor; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; adrenergic, alpha-1Aa, receptor; adrenoceptor alpha 1A; adrenoceptor alpha 1Aa; alpha 1A-adrenoceptor; alpha 1A-adrenoreceptor; alpha 1C-adrenergic receptor; alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; alpha-1A adrenoreceptor; ALPHA1AAR; Alpha-1C adrenergic receptor; Alpha1C-AR; Alpha-adrenergic receptor 1c; fc18h12; G protein coupled receptor; wu:fc18h12