SynGAP Polyclonal Antibody | Invitrogen PA1-046 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SynGAP Polyclonal Antibody

catalog :

PA1-046

quantity :

100 µg

price :

US 446

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2a western blot; mouse; 1:5000; loading ...; fig 1c	Sahasrabudhe A, Begum F, Guevara C, Morrison C, Hsiao K, Kezunovic N, et al. Cyfip1 Regulates SynGAP1 at Hippocampal Synapses. Front Synaptic Neurosci. 2020;12:581714 pubmed publisher
western blot; mouse; 1:3,500; loading ...; fig 2s1c	Mastro T, Preza A, Basu S, Chattarji S, Till S, Kind P, et al. A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency. elife. 2020;9: pubmed publisher
western blot; mouse; 1:3,500; fig 11	Walkup W, Mastro T, Schenker L, Vielmetter J, Hu R, Iancu A, et al. A model for regulation by SynGAP-?1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density. elife. 2016;5: pubmed publisher
western blot; mouse; 1:1000; fig s4	Reinhard J, Kriz A, Galic M, Angliker N, Rajalu M, Vogt K, et al. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 2016;7:11613 pubmed publisher
	Chalkiadaki K, Hooshmandi M, Lach G, Statoulla E, Simbriger K, Amorim I, et al. Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1. Brain. 2022;: pubmed publisher
	Kim H, Kim D, Cho Y, Kim K, Roh J, Kim Y, et al. Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming. Nat Commun. 2022;13:5051 pubmed publisher
	Gou G, Roca Fernandez A, Kilinc M, Serrano E, Reig Viader R, Araki Y, et al. SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain. J Neurochem. 2020;154:618-634 pubmed publisher
	Li L, Fan Y, Huang X, Luo J, Zhong L, Shu X, et al. Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas. iScience. 2019;21:1-18 pubmed publisher
	Muheim C, Spinnler A, Sartorius T, D xfc rr R, Huber R, Kabagema C, et al. Dynamic- and Frequency-Specific Regulation of Sleep Oscillations by Cortical Potassium Channels. Curr Biol. 2019;29:2983-2992.e3 pubmed publisher
	Creson T, Rojas C, Hwaun E, Vaissière T, Kilinc M, Jimenez Gomez A, et al. Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior. elife. 2019;8: pubmed publisher
	Ferreira J, Schmidt J, Rio P, Ãguas R, Rooyakkers A, Li K, et al. GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome. J Neurosci. 2015;35:8462-79 pubmed publisher
	Walkup W, Washburn L, Sweredoski M, Carlisle H, Graham R, Hess S, et al. Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. J Biol Chem. 2015;290:4908-27 pubmed publisher
	Aceti M, Creson T, Vaissière T, Rojas C, Huang W, Wang Y, et al. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly. Biol Psychiatry. 2015;77:805-15 pubmed publisher
	Friedman L, Riemslagh F, Sullivan J, Mesias R, Williams F, Huntley G, et al. Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits. J Comp Neurol. 2015;523:75-92 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

SynGAP Polyclonal Antibody

Catalog # :

PA1-046

Quantity :

100 µg

Price :

US 446

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 2 µg/mL, Western Blot: 1 µg/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

Immunogen :

GST fusion protein of a recombinant fragment, residues 947-1167, of rat SynGAP.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 2 µg/mL, Western Blot: 1 µg/mL

Aliases :

DKFZp761G1421; Gm1963; KIAA1938; MRD5; Neuronal R; neuronal RasGAP; OTTHUMP00000209046; p135 SynGAP; Ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP; RASA1; RASA5; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; Syngap; SYNGAP1

more info or order :

Invitrogen product webpage