Cyclophilin B Polyclonal Antibody | Invitrogen PA1-027A product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cyclophilin B Polyclonal Antibody

catalog :

PA1-027A

quantity :

100 µg

price :

US 400

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 8	Bronnimann M, Calton C, Chiquette S, Li S, Lu M, Chapman J, et al. Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins. J Virol. 2016;90:6224-6234 pubmed publisher
western blot; human; 1:2000; fig 4	Rotondi S, Modarelli A, Oliva M, Rostomyan L, Sanità P, Ventura L, et al. Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARÎ±) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH3 cells. Mol Cell Endocrinol. 2016;426:61-72 pubmed publisher
	Sidarala V, Zhu J, Levi D Ancona E, Pearson G, Reck E, Walker E, et al. Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis. Nat Commun. 2022;13:2340 pubmed publisher
	Ho J, Cunningham T, Manara P, Coughlin C, Arumov A, Roberts E, et al. Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome. Cell Rep. 2021;37:109806 pubmed publisher
	Pulimood N, Contreras M, Pruitt M, Tarasiewicz A, Medina A. Phosphorylation of CREB at Serine 142 and 143 Is Essential for Visual Cortex Plasticity. Eneuro. 2021;8: pubmed publisher
	Haataja L, Arunagiri A, Hassan A, Regan K, Tsai B, Dhayalan B, et al. Distinct states of proinsulin misfolding in MIDY. Cell Mol Life Sci. 2021;78:6017-6031 pubmed publisher
	McShan A, Devlin C, Morozov G, Overall S, Moschidi D, Akella N, et al. TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap. Nat Commun. 2021;12:3174 pubmed publisher
	Zhang S, Yuan B, Lam J, Zhou J, Zhou X, Ramos Mandujano G, et al. Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis. Cell Discov. 2021;7:30 pubmed publisher
	Biswas C, Chu N, Burn T, Kreiger P, Behrens E. Amelioration of Murine Macrophage Activation Syndrome by Monomethyl Fumarate in Both a Heme Oxygenase 1-Dependent and Heme Oxygenase 1-Independent Manner. Arthritis Rheumatol. 2021;73:885-895 pubmed publisher
	Yang J, Lee S, Kwon Y, Ma L, Kim J. Tumor suppressive function of Matrin 3 in the basal-like breast cancer. Biol Res. 2020;53:42 pubmed publisher
	Wheeler M, Clark I, Tjon E, Li Z, Zandee S, Couturier C, et al. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020;578:593-599 pubmed publisher
	N Tumba Byn T, Yamada M, Seandel M. Loss of tyrosine kinase receptor Ephb2 impairs proliferation and stem cell activity of spermatogonia in culture†. Biol Reprod. 2020;102:950-962 pubmed publisher
	Ma Lauer Y, Zheng Y, Malesevic M, von Brunn B, Fischer G, von Brunn A. Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication. Antiviral Res. 2020;173:104620 pubmed publisher
	Chiramel A, Meyerson N, McNally K, Broeckel R, Montoya V, Méndez Solís O, et al. TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation. Cell Rep. 2019;27:3269-3283.e6 pubmed publisher
	Terajima M, Taga Y, Cabral W, Liu Y, Nagasawa M, Sumida N, et al. Cyclophilin B control of lysine post-translational modifications of skin type I collagen. PLoS Genet. 2019;15:e1008196 pubmed publisher
	Kim J, Piao H, Kim B, Yao F, Han Z, Wang Y, et al. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018;50:1705-1715 pubmed publisher
	Kim J, Alavi Naini F, Sun Y, Ma L. Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin. Am J Cancer Res. 2018;8:1823-1836 pubmed
	Mancini A, Xavier Magalhães A, Woods W, Nguyen K, Amen A, Hayes J, et al. Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. Cancer Cell. 2018;34:513-528.e8 pubmed publisher
	Peters T, Tillotson J, Yeomans A, Wilmore S, Lemm E, Jiménez Romero C, et al. Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity. Clin Cancer Res. 2018;24:4256-4270 pubmed publisher
	Vera Ramirez L, Vodnala S, Nini R, Hunter K, Green J. Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence. Nat Commun. 2018;9:1944 pubmed publisher
	Pulimood N, Rodrigues W, Atkinson D, Mooney S, Medina A. The Role of CREB, SRF, and MEF2 in Activity-Dependent Neuronal Plasticity in the Visual Cortex. J Neurosci. 2017;37:6628-6637 pubmed publisher

image

image 1 :

Western blot analysis of Cyclophilin B in Rat Liver lysate (25 ug) using anti-Cyclophilin B antibody, PA1-027A at a dilution of 1:2000 (lane 2), 1:1000 (lane 3), 1:2000 (lane 4) and 1:4000 (lane 5).

product information

Product Type :

Antibody

Product Name :

Cyclophilin B Polyclonal Antibody

Catalog # :

PA1-027A

Quantity :

100 µg

Price :

US 400

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Human, Mouse, Rat

Applications :

Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1-2 µg/mL

Species :

Canine, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

Immunogen :

Synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1-2 µg/mL

Aliases :

AA408962; AA553318; AI844835; Cphn2; Cphn-2; Cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP

more info or order :

Invitrogen product webpage