Cyclophilin B Polyclonal Antibody, Alexa Fluor 488 | Invitrogen PA1-027A-A488 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cyclophilin B Polyclonal Antibody, Alexa Fluor 488

catalog :

PA1-027A-A488

quantity :

50 uL

price :

US 404.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

AF488

reactivity :

human, mouse, rat, dogs

application :

immunocytochemistry

product information

Product Type :

Antibody

Product Name :

Cyclophilin B Polyclonal Antibody, Alexa Fluor 488

Catalog # :

PA1-027A-A488

Quantity :

50 uL

Price :

US 404.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Human, Mouse, Rat

Applications :

Immunocytochemistry: 1-10 ug/mL

Species :

Canine, Human, Mouse, Rat

Isotype :

IgG

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

Immunogen :

Synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1-10 ug/mL

Aliases :

AA408962; AA553318; AI844835; Cphn2; Cphn-2; cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP