FKBP12 Polyclonal Antibody | Invitrogen PA1-026A product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FKBP12 Polyclonal Antibody

catalog :

PA1-026A

quantity :

100 µL

price :

US 450

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 4c	Daniels B, Snyder A, Olsen T, Orozco S, Oguin T, Tait S, et al. RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation. Cell. 2017;169:301-313.e11 pubmed publisher
immunocytochemistry; human; loading ...; fig 1b western blot; human; loading ...; fig s1a	Gutierrez K, Davis M, Daniels B, Olsen T, Ralli Jain P, Tait S, et al. MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D. J Immunol. 2017;198:2156-2164 pubmed publisher
western blot; mouse; fig 1	Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher
	Hubbard N, Ames J, Maurano M, Chu L, Somfleth K, Gokhale N, et al. ADAR1 mutation causes ZBP1-dependent immunopathology. Nature. 2022;607:769-775 pubmed publisher
	Burclaff J, Bliton R, Breau K, Ok M, Gomez Martinez I, Ranek J, et al. A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics. Cell Mol Gastroenterol Hepatol. 2022;13:1554-1589 pubmed publisher
	Zhou M, Kamarshi V, Arvin A, Oliver S. Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion. PLoS Pathog. 2020;16:e1009022 pubmed publisher
	Tammineni E, Kraeva N, Figueroa L, Manno C, Ibarra C, Klip A, et al. Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes. elife. 2020;9: pubmed publisher
	Ornelas I, Khandker L, Wahl S, Hashimoto H, Macklin W, Wood T. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. 2020;68:1274-1290 pubmed publisher
	Aaes T, Verschuere H, Kaczmarek A, Heyndrickx L, Wiernicki B, Delrue I, et al. Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection. J Immunol. 2020;204:775-787 pubmed publisher
	Cacheux M, Fauconnier J, Thireau J, Osseni A, Brocard J, Roux Buisson N, et al. Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse. Mol Ther. 2020;28:171-179 pubmed publisher
	Bandleon S, Strunz P, Pickel S, Tiapko O, Cellini A, Miranda Laferte E, et al. FKBP52 regulates TRPC3-dependent Ca2+ signals and the hypertrophic growth of cardiomyocyte cultures. J Cell Sci. 2019;132: pubmed publisher
	Chopard C, Tong P, Tóth P, Schatz M, Yezid H, Debaisieux S, et al. Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells. Nat Commun. 2018;9:2251 pubmed publisher
	Xiao Y, Zeng Z, Guan X, Wang L, Wang C, Shi H, et al. FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca2+ /calmodulin-mediated signalling pathways in vivo and in vitro. J Cell Mol Med. 2018;22:3638-3651 pubmed publisher
	Jamison S, Lin Y, Lin W. Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A. PLoS ONE. 2015;10:e0120252 pubmed publisher

image

image 1 :

Western blot detection of purified FKBP12 after immunoprecipatation on a 15% gel.

product information

Product Type :

Antibody

Product Name :

FKBP12 Polyclonal Antibody

Catalog # :

PA1-026A

Quantity :

100 µL

Price :

US 450

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry: 2 µg/mL, Immunoprecipitation: Assay dependent, Western Blot: 1 µg/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

Immunogen :

Synthetic peptide corresponding to the N-terminal residues G(1) V Q V E T I S P G D G R(13) of human FKBP12.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2 µg/mL, Immunoprecipitation: Assay dependent, Western Blot: 1 µg/mL

Aliases :

12 kDa FK506-binding protein; 12 kDa FKBP; calstabin 1; calstabin-1; EC 5.2.1.8; FK506 binding protein 1a; FK506 binding protein 1A, 12kDa; FK506 binding protein 2 (13 kDa); FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 1 (12kD); FK506-binding protein 12; FK506-binding protein 1a; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD; Fkbp; Fkbp1; FKBP12; FKBP-12; FKBP12-Exip3; Fkbp1a; FKBP-1A; Fkbp2; Immunophilin FKBP12; peptidyl-prolyl cis-trans isomerase FKBP1A; PKC12; PKCI2; PPIASE; PPIase FKBP1A; protein kinase C inhibitor 2; Rotamase

more info or order :

Invitrogen product webpage