NFAT5 Polyclonal Antibody | Invitrogen PA1-023 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NFAT5 Polyclonal Antibody

catalog :

PA1-023

quantity :

50 ug

price :

US 465.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 16

Reference
Henrioux F, Navel V, Belville C, Charnay C, Antoine A, Chiambaretta F, et al. Inflammation of Dry Eye Syndrome: A Cellular Study of the Epithelial and Macrophagic Involvement of NFAT5 and RAGE. Int J Mol Sci. 2023;24: pubmed publisher
Ayuzawa N, Nishimoto M, Kawarazaki W, Oba S, Marumo T, Aiba A, et al. Rac1 deficiency impairs postnatal development of the renal papilla. Sci Rep. 2022;12:20310 pubmed publisher
Wang H, Chen W, Huang Y, Hsu S, Tsao Y, Hsu Y, et al. Interleukin-20 is involved in dry eye disease and is a potential therapeutic target. J Biomed Sci. 2022;29:36 pubmed publisher
Fedorov D, Sidorenko S, Yusipovich A, Parshina E, Tverskoi A, Abramicheva P, et al. Na+ i/K+ i imbalance contributes to gene expression in endothelial cells exposed to elevated NaCl. Heliyon. 2021;7:e08088 pubmed publisher
Lunazzi G, Buxade M, Riera Borrull M, Higuera L, Bonnin S, Huerga Encabo H, et al. NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment. J Immunol. 2021;206:2652-2667 pubmed publisher
Kim D, Kim K, Lee T, Eom H, Kim J, Park J, et al. Transcription Factor TonEBP Stimulates Hyperosmolality-Dependent Arginine Vasopressin Gene Expression in the Mouse Hypothalamus. Front Endocrinol (Lausanne). 2021;12:627343 pubmed publisher
Wild J, Jung R, Knopp T, Efentakis P, Benaki D, Grill A, et al. Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect. Acta Physiol (Oxf). 2021;232:e13628 pubmed publisher
Schröder A, Gubernator J, Leikam A, Nazet U, Cieplik F, Jantsch J, et al. Dietary Salt Accelerates Orthodontic Tooth Movement by Increased Osteoclast Activity. Int J Mol Sci. 2021;22: pubmed publisher
Schröder A, Leikam A, Käppler P, Neubert P, Jantsch J, Neuhofer W, et al. Impact of salt and the osmoprotective transcription factor NFAT-5 on macrophages during mechanical strain. Immunol Cell Biol. 2021;99:84-96 pubmed publisher
Brown T, Nicolson N, Man J, Gibson C, Stenman A, Juhlin C, et al. Recurrent Amplification of the Osmotic Stress Transcription Factor NFAT5 in Adrenocortical Carcinoma. J Endocr Soc. 2020;4:bvaa060 pubmed publisher
Neubert P, Homann A, Wendelborn D, Bär A, Krampert L, Trum M, et al. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLoS Biol. 2020;18:e3000722 pubmed publisher
Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand J, et al. HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy. 2019;15:1899-1916 pubmed publisher
Sirtl S, Knoll G, Trinh D, Lang I, Siegmund D, Gross S, et al. Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors. Oncogene. 2018;37:4122-4136 pubmed publisher
Bittner S, Knoll G, Ehrenschwender M. Hyperosmotic stress enhances cytotoxicity of SMAC mimetics. Cell Death Dis. 2017;8:e2967 pubmed publisher
Hoshino A, Costa Silva B, Shen T, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329-35 pubmed publisher
Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, et al. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013;140:3348-59 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NFAT5 Polyclonal Antibody

Catalog # :

PA1-023

Quantity :

50 ug

Price :

US 465.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Gel Shift: Assay-dependent, Immunocytochemistry: 1:1,000, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 3 ug, Western Blot: 1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.

Immunogen :

Synthetic peptide corresponding to residues C D(1439) L L V S L Q N Q G N N L T G S F(1455) of human NFAT5.

Format :

Liquid

Applications w/Dilutions :

Gel Shift: Assay-dependent, Immunocytochemistry: 1:1,000, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 3 ug, Western Blot: 1:1,000

Aliases :

AI225870; B130038B15Rik; CAG-8; CAG80; glutamine rich protein H65; KIAA0827; mKIAA0827; Nfat; Nfat5; NF-AT5; NFATL1; NFAT-like protein 1; nfatz; nuclear factor of activated T cells 5; nuclear factor of activated T-cells 5; nuclear factor of activated T-cells 5, tonicity-responsive; OREBP; osmotic response element-binding protein; rel domain-containing transcription factor NFAT5; T-cell transcription factor NFAT5; TonE-binding protein; TONEBP; tonicity-responsive enhancer binding protein; tonicity-responsive enhancer-binding protein