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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
KDEL Polyclonal Antibody
catalog :
PA1-013
quantity :
100 µg
price :
US 430
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
Chinese hamsters, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
Invitrogen product webpage
citations: 11
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; rat; fig 2
González C, Cánovas J, Fresno J, Couve E, Court F, Couve A. Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve. Proc Natl Acad Sci U S A. 2016;113:1823-8 pubmed publisher
Martin C, Murray A, Sala Hamrick K, Mackinder J, Harrison E, Lundgren J, et al. Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization. J Biol Chem. 2021;297:101227 pubmed publisher
Della Flora Nunes G, Wilson E, Marziali L, Hurley E, Silvestri N, He B, et al. Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nat Commun. 2021;12:3285 pubmed publisher
De Vincentiis S, Falconieri A, Mickoleit F, Cappello V, Schüler D, Raffa V. Induction of Axonal Outgrowth in Mouse Hippocampal Neurons via Bacterial Magnetosomes. Int J Mol Sci. 2021;22: pubmed publisher
Bagalkot T, Block E, Bucchin K, Balcita Pedicino J, Calderon M, Sesack S, et al. Dopamine Transporter Localization in Medial Forebrain Bundle Axons Indicates Its Long-Range Transport Primarily by Membrane Diffusion with a Limited Contribution of Vesicular Traffic on Retromer-Positive Compartments. J Neurosci. 2021;41:234-250 pubmed publisher
Mukherjee R, Sallé J, Dmitrieff S, Nelson K, Oakey J, Minc N, et al. The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos. Dev Cell. 2020;54:395-409.e7 pubmed publisher
De Vincentiis S, Falconieri A, Mainardi M, Cappello V, Scribano V, Bizzarri R, et al. Extremely Low Forces Induce Extreme Axon Growth. J Neurosci. 2020;40:4997-5007 pubmed publisher
Tang Y, Lee S, Rahman M, Vanapalli S, Lu H, Schafer W. Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels. Neuron. 2020;107:112-125.e10 pubmed publisher
Stoupa A, Adam F, Kariyawasam D, Strassel C, Gawade S, Szinnai G, et al. TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology. EMBO Mol Med. 2018;10: pubmed publisher
Giese A, Tang Y, Sinha G, Bowl M, Goldring A, Parker A, et al. CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun. 2017;8:43 pubmed publisher
Abbadi A, Lauer M, Swaidani S, Wang A, Hascall V. Hyaluronan Rafts on Airway Epithelial Cells. J Biol Chem. 2016;291:1448-55 pubmed publisher
product information
Product Type :
Antibody
Product Name :
KDEL Polyclonal Antibody
Catalog # :
PA1-013
Quantity :
100 µg
Price :
US 430
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Hamster, Human, Mouse, Rat
Applications :
Flow Cytometry: 1-20 µg/mL, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay dependent, Immunohistochemistry: 1:100-200, Immunoprecipitation: Assay dependent, Western Blot: 8-16 µg/mL
Species :
Hamster, Human, Mouse, Rat
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Immunogen :
Synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP94.
Format :
Lyophilized
Applications w/Dilutions :
Flow Cytometry: 1-20 µg/mL, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay dependent, Immunohistochemistry: 1:100-200, Immunoprecipitation: Assay dependent, Western Blot: 8-16 µg/mL
Aliases :
78 kDa glucose-regulated protein; 8030486F04Rik; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250; AL022860; AU019543; AW215843; baffled; Binding-immunoglobulin protein; BiP; D2Wsu141e; D2Wsu17e; ECGP; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Endoplasmic reticulum resident protein 99; endoplasmin; endoplasmin {ECO:0000250; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; ER lumen protein retaining receptor 1; ER lumen protein-retaining receptor 1; ERD2; ERD2.1; ERp99; glucose regulated protein, 78 kDa; glucose-regulated protein; glucose-regulated protein, 78kDa; gp96; gp96 homolog; GRP 78; GRP78; GRP-78; Grp94; GRP-94; HDEL; heat shock 70 kDa protein 5; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 5; Heat shock protein 70 family protein 5; heat shock protein 90 beta family member 1; heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein family A (Hsp70) member 5; Heat shock protein family A member 5; HEL35; HEL-S-125m; HEL-S-89n; Hsce70; HSP70 family protein 5; Hsp90b1; hsp90b1 {ECO:0000250; Hspa5; I79_019946; I79_020931; immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; KDELR1; Lys-Asp-Glu-Leu; mBiP; MIF2; PM23; Polymorphic tumor rejection antigen 1; putative MAPK-activating protein PM23; RP23-446N16.1; Sez7; SEZ-7; Steroidogenesis-activator polypeptide; stress-inducible tumor rejection antigen gp96; TA-3; Targ2; TRA1; Tra-1; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; tumor rejection antigen 1; Tumor rejection antigen gp96; UniProtKB:P08113}; XAP-1 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA