Phospho-CRYAB (Ser59) Polyclonal Antibody | Invitrogen PA1-012 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-CRYAB (Ser59) Polyclonal Antibody

catalog :

PA1-012

quantity :

100 µg

price :

US 450

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; mouse; loading ...	Kuipers H, Yoon J, van Horssen J, Han M, Bollyky P, Palmer T, et al. Phosphorylation of Î±B-crystallin supports reactive astrogliosis in demyelination. Proc Natl Acad Sci U S A. 2017;114:E1745-E1754 pubmed publisher
	Reddy V, Jakhotia S, Reddy P, Reddy G. Hyperglycemia induced expression, phosphorylation, and translocation of Î±B-crystallin in rat skeletal muscle. IUBMB Life. 2015;67:291-9 pubmed publisher

image

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product information

Product Type :

Antibody

Product Name :

Phospho-CRYAB (Ser59) Polyclonal Antibody

Catalog # :

PA1-012

Quantity :

100 µg

Price :

US 450

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Human, Rat

Applications :

Immunofluorescence: 8 µg/mL, Immunohistochemistry (Paraffin): 8 µg/mL, Western Blot: 0.5 µg/mL

Species :

Bovine, Human, Rat

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.

Immunogen :

Synthetic phosphopeptide corresponding to residues F(54) L R A P S(p) W I D T G(64) of human alpha-B Crystallin.

Format :

Lyophilized

Applications w/Dilutions :

Immunofluorescence: 8 µg/mL, Immunohistochemistry (Paraffin): 8 µg/mL, Western Blot: 0.5 µg/mL

Aliases :

AACRYA; alpha B-crystallin; alpha crystallin B; alpha(B)-crystallin; alpha-B-crystallin; Alpha-crystallin B chain; alpha-crystallin B chain-like protein; CMD1II; Crya2; Crya-2; CRYAB; CryAB antibody; crystallin alpha B; crystallin, alpha 2; crystallin, alpha B; crystallin, alpha polypeptide 2; CTPP2; CTRCT16; epididymis secretory protein Li 101; heat shock protein beta-5; heat shock protein CryAB; heat shock protein HspB5; heat-shock 20 kD like-protein; HEL-S-101; HSPB5; MFM2; P23; Renal carcinoma antigen NY-REN-27; rosenthal fiber component

more info or order :

Invitrogen product webpage