Tyrosine Hydroxylase Polyclonal Antibody | Invitrogen P21962 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tyrosine Hydroxylase Polyclonal Antibody

catalog :

P21962

quantity :

100 µL

price :

US 430

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:1000; loading ...; fig 3	Stojakovic A, Paz Filho G, Arcos Burgos M, Licinio J, Wong M, Mastronardi C. Role of the IL-1 Pathway in Dopaminergic Neurodegeneration and Decreased Voluntary Movement. Mol Neurobiol. 2017;54:4486-4495 pubmed publisher
	Fetterly T, Oginsky M, Nieto A, ALONSO CARABALLO Y, Santana Rodriguez Z, Ferrario C. Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release. J Neurosci. 2021;41:2360-2372 pubmed publisher
	Selvakumar G, Ahmed M, Iyer S, Thangavel R, Kempuraj D, Raikwar S, et al. Absence of Glia Maturation Factor Protects from Axonal Injury and Motor Behavioral Impairments after Traumatic Brain Injury. Exp Neurobiol. 2020;29:230-248 pubmed publisher
	Hughes R, Bakhurin K, Petter E, Watson G, Kim N, Friedman A, et al. Ventral Tegmental Dopamine Neurons Control the Impulse Vector during Motivated Behavior. Curr Biol. 2020;30:2681-2694.e5 pubmed publisher
	Wu Y, Yang Z, Li L, Zhu X, Wang Y, Sun W, et al. Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice. Anesthesiology. 2020;133:377-392 pubmed publisher
	Grigoruţă M, Martinez Martinez A, Dagda R, Dagda R. Psychological Stress Phenocopies Brain Mitochondrial Dysfunction and Motor Deficits as Observed in a Parkinsonian Rat Model. Mol Neurobiol. 2020;57:1781-1798 pubmed publisher
	Larsson M, Broman J. Synaptic Organization of VGLUT3 Expressing Low-Threshold Mechanosensitive C Fiber Terminals in the Rodent Spinal Cord. Eneuro. 2019;6: pubmed publisher
	Potdar S, Sheeba V. Wakefulness Is Promoted during Day Time by PDFR Signalling to Dopaminergic Neurons in Drosophila melanogaster. Eneuro. 2018;5: pubmed publisher
	Child K, Herrick D, Schwob J, Holbrook E, Jang W. The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging. J Neurosci. 2018;38:6806-6824 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Tyrosine Hydroxylase Polyclonal Antibody

Catalog # :

P21962

Quantity :

100 µL

Price :

US 430

Clonality :

Polyclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Frozen): 1:1000, Western Blot: 1:1000

Species :

Human, Rat

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Immunogen :

SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Frozen): 1:1000, Western Blot: 1:1000

Aliases :

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase

more info or order :

Invitrogen product webpage