This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PROX1 Monoclonal Antibody (5G10)
catalog :
P21936
quantity :
100 uL
price :
US 471.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5G10

The same clone is also sold as:
reactivity :
human, mouse, rat, chicken
application :
immunohistochemistry
citations: 2
Reference
Imig C, López Murcia F, Maus L, García Plaza I, Mortensen L, Schwark M, et al. Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices. Neuron. 2020;108:843-860.e8 pubmed publisher
Kitamura T, Sun C, Martin J, Kitch L, Schnitzer M, Tonegawa S. Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory. Neuron. 2015;87:1317-31 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PROX1 Monoclonal Antibody (5G10)
Catalog # :
P21936
Quantity :
100 uL
Price :
US 471.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Chicken, Human, Mouse, Rat
Applications :
Immunohistochemistry: Assay-dependent
Species :
Chicken, Human, Mouse, Rat
Clone :
5G10
Isotype :
IgG
Storage :
Maintain refrigerated at 2-8 C for up to 1 month. For long term storage store at -20 C
Description :
The expression pattern of the Prox1 homeo box gene suggests that it has a role in a variety of embryonic tissues, including lens. Analysis of mRNA reveals that Prox mRNA is present in many different human tissues and that lens demonstrated the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. The Prox1 gene is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been document to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.
Immunogen :
Recombinant human Prox1 protein.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry: Assay-dependent
Aliases :
A230003G05Rik; homeobox prospero-like protein PROX1; prospero homeobox 1; prospero homeobox protein 1; prospero-related homeobox 1; Prox 1; PROX1; PROX-1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA