BDNF Polyclonal Antibody | Invitrogen OSB00017W product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BDNF Polyclonal Antibody

catalog :

OSB00017W

quantity :

100 µL

price :

US 423

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 7

Reference
Lian H, Zhong X, Xiao Y, Sun Z, Shen Y, Zhao K, et al. Exosomal miR-29b of Gut Origin in Patients With Ulcerative Colitis Suppresses Heart Brain-Derived Neurotrophic Factor. Front Mol Biosci. 2022;9:759689 pubmed publisher
Han G, Choi J, Cha S, Kim B, Kho H, Jang M, et al. Effects of Radix Polygalae on Cognitive Decline and Depression in Estradiol Depletion Mouse Model of Menopause. Curr Issues Mol Biol. 2021;43:1669-1684 pubmed publisher
Tang Y, Kline K, Zhong X, Xiao Y, Lian H, Peng J, et al. Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart. PLoS ONE. 2021;16:e0257280 pubmed publisher
Kim H, Kim S, Park S, Park G, Shin H, Park M, et al. Administration of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI Improves Cognitive and Memory Function in the Mouse Model of Alzheimer's Disease. Front Aging Neurosci. 2021;13:709091 pubmed publisher
Kasemeier Kulesa J, Schnell S, Woolley T, Spengler J, Morrison J, McKinney M, et al. Predicting neuroblastoma using developmental signals and a logic-based model. Biophys Chem. 2018;238:30-38 pubmed publisher
Marwarha G, Claycombe Larson K, Schommer J, Ghribi O. Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring. J Nutr Biochem. 2017;45:54-66 pubmed publisher
Liu X, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, et al. Editing DNA Methylation in the Mammalian Genome. Cell. 2016;167:233-247.e17 pubmed publisher

product information

Product Type :

Antibody

Product Name :

BDNF Polyclonal Antibody

Catalog # :

OSB00017W

Quantity :

100 µL

Price :

US 423

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Description :

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

Immunogen :

A synthetic peptide from n-terminal region of human mature BDNF

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

Aliases :

abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF