proBDNF Polyclonal Antibody | Invitrogen OSB00016G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

proBDNF Polyclonal Antibody

catalog :

OSB00016G

quantity :

500 µg

price :

US 425

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 1

Reference
Fyk Kolodziej B, Mueller P. Sedentary Conditions Promote Subregionally Specific Changes in Brain-Derived Neurotrophic Factor in the Rostral Ventrolateral Medulla. Front Physiol. 2021;12:756542 pubmed publisher

product information

Product Type :

Antibody

Product Name :

proBDNF Polyclonal Antibody

Catalog # :

OSB00016G

Quantity :

500 µg

Price :

US 425

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: 10-50 µg/mL, Western Blot: 10-50 µg/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Description :

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimers and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

Immunogen :

A synthetic peptide from mouse pro BDNF conjugated to blue carrier protein was used as the antigen.

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry: 10-50 µg/mL, Western Blot: 10-50 µg/mL

Aliases :

abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; neurotrophin; pro BDNF; ProBDNF