DRAM Polyclonal Antibody | Invitrogen OSA00052W product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DRAM Polyclonal Antibody

catalog :

OSA00052W

quantity :

150 µL

price :

US 425

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunohistochemistry

product information

Product Type :

Antibody

Product Name :

DRAM Polyclonal Antibody

Catalog # :

OSA00052W

Quantity :

150 µL

Price :

US 425

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Mouse, Rat

Applications :

Immunohistochemistry: 1:200-1:2,000, Western Blot: 1:200-1:2,000

Species :

Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Description :

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Immunogen :

A synthetic peptide from the n-terminal of mouse DRAM (Damage-regulated autophagy modulator) conjugated to an immunogenic carrier protein has been used as the antigen

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry: 1:200-1:2,000, Western Blot: 1:200-1:2,000

Aliases :

1200002N14Rik; Damage-regulated autophagy modulator; DNA damage regulated autophagy modulator 1; DNA damage-regulated autophagy modulator protein 1; DNA-damage regulated autophagy modulator 1; DRAM; Dram1; FLJ11259; hypothetical protein FLJ11259; zgc:101811