This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Tyrosine Hydroxylase Polyclonal Antibody
catalog :
OPA1-04050
quantity :
100 uL
price :
US 514.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
citations: 12
Reference
Caldwell M, Ayo Jibunoh V, Mendoza J, Brimblecombe K, Reynolds L, Zhu Jiang X, et al. Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. Brain Struct Funct. 2023;228:1993-2006 pubmed publisher
Grahl M, Andrade B, Perin A, Neves G, Duarte L, Uberti A, et al. Could the Urease of the Gut Bacterium Proteus mirabilis Play a Role in the Altered Gut-Brain Talk Associated with Parkinson's Disease?. Microorganisms. 2023;11: pubmed publisher
Toth B, Chang K, Burgess C. Striatal dopamine regulates sleep states and narcolepsy-cataplexy. bioRxiv. 2023;: pubmed publisher
Trabjerg M, Andersen D, Huntjens P, M xf8 rk K, Warming N, Kullab U, et al. Inhibition of carnitine palmitoyl-transferase 1 is a potential target in a mouse model of Parkinson's disease. NPJ Parkinsons Dis. 2023;9:6 pubmed publisher
Cirnaru M, Song S, Tshilenge K, Corwin C, Mleczko J, Galicia Aguirre C, et al. Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation. elife. 2021;10: pubmed publisher
Valek L, Tegeder I. Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice. Int J Mol Sci. 2021;22: pubmed publisher
Herborg F, Jensen K, Tolstoy S, Arends N, Posselt L, Shekar A, et al. Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease. JCI Insight. 2021;6: pubmed publisher
Yang H, Bari B, Cohen J, O Connor D. Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task. elife. 2021;10: pubmed publisher
Skov L, Ratner C, Hansen N, Thompson J, Egerod K, Burm H, et al. RhoA in tyrosine hydroxylase neurones regulates food intake and body weight via altered sensitivity to peripheral hormones. J Neuroendocrinol. 2019;31:e12761 pubmed publisher
Wolfman S, Gill D, Bogdanic F, Long K, Al Hasani R, McCall J, et al. Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum. Nat Commun. 2018;9:2710 pubmed publisher
Jensen K, Sørensen G, Dencker D, Owens W, Rahbek Clemmensen T, Brett Lever M, et al. PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. Eneuro. 2018;5: pubmed publisher
Depboylu C, Rösler T, de Andrade A, Oertel W, Höglinger G. Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease. J Neurochem. 2015;133:590-7 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Tyrosine Hydroxylase Polyclonal Antibody
Catalog # :
OPA1-04050
Quantity :
100 uL
Price :
US 514.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Many, Mouse, Rat
Applications :
Immunocytochemistry: 1:1,000, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000
Species :
Human, Many, Mouse, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
Immunogen :
SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:1,000, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000
Aliases :
dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA