CD8 alpha Monoclonal Antibody (OX8), FITC | Invitrogen MR5201 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD8 alpha Monoclonal Antibody (OX8), FITC

catalog :

MR5201

quantity :

1 mL

price :

US 130.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

OX8

reactivity :

rat

application :

immunohistochemistry, flow cytometry

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; rat	Qian B, Tonkonogy S, Sartor R. Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells. Inflamm Bowel Dis. 2008;14:1358-65 pubmed publisher
flow cytometry; rat; tbl 1	Hoentjen F, Tonkonogy S, Qian B, Liu B, Dieleman L, Sartor R. CD4(+) T lymphocytes mediate colitis in HLA-B27 transgenic rats monoassociated with nonpathogenic Bacteroides vulgatus. Inflamm Bowel Dis. 2007;13:317-24 pubmed
flow cytometry; rat; tbl 1	Hoentjen F, Tonkonogy S, Liu B, Sartor R, Taurog J, Dieleman L. Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats. Clin Exp Immunol. 2006;143:474-83 pubmed
flow cytometry; rat	Qian B, Tonkonogy S, Hoentjen F, Dieleman L, Sartor R. Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis. Immunology. 2005;116:112-21 pubmed
flow cytometry; rat; fig 5	Dieleman L, Hoentjen F, Qian B, Sprengers D, Tjwa E, Torres M, et al. Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats. Clin Exp Immunol. 2004;136:30-9 pubmed
immunohistochemistry; rat; 1:25; fig 4	Ito T, Kumamoto T, Horinouchi H, Yukishige K, Sugihara R, Fujimoto S, et al. Adhesion molecule expression in experimental myositis. Muscle Nerve. 2002;25:409-18 pubmed

product information

Product Type :

Antibody

Product Name :

CD8 alpha Monoclonal Antibody (OX8), FITC

Catalog # :

MR5201

Quantity :

1 mL

Price :

US 130.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Rat

Applications :

Flow Cytometry: Assay Dependent

Species :

Rat

Clone :

OX8

Isotype :

IgG1

Storage :

4° C

Description :

CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD38 (T10) is a single chain 46 kDa type II integral glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor.

Immunogen :

Rat CD8.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent

Aliases :

CD8, Leu-2, MAL, p32, CD8b, CD8b, CD8beta