| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; 1:1000; fig 2
| Petry F, Pelletier J, Bretteville A, Morin F, Calon F, Hébert S, et al. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PLoS ONE. 2014;9:e94251 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig s6a
- western blot; fruit fly ; 1:1000; loading ...; fig s3c
| Subramanian M, Hyeon S, Das T, Suh Y, Kim Y, Lee J, et al. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021;12:3291 pubmed publisher |
| Perez Garcia G, De Gasperi R, Gama Sosa M, Perez G, Otero Pagan A, Pryor D, et al. Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast. Acta Neuropathol Commun. 2021;9:33 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 4c
- western blot; mouse; loading ...; fig 4a
| Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5g
| Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed publisher |
- western blot; human; loading ...; fig 1f
| Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed publisher |
- western blot; mouse; loading ...; fig 4
| Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s5b
| Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 4c
- western blot; mouse; fig 4a
| Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher |
- western blot; human; 1:1000; fig 1a
| Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed publisher |
- immunohistochemistry; mouse; 1:500; fig 5
| Lipton S, Rezaie T, Nutter A, Lopez K, Parker J, Kosaka K, et al. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death Dis. 2016;7:e2499 pubmed publisher |
- western blot; mouse; 1:200; loading ...; fig 3a
| di Meco A, Li J, Blass B, Abou Gharbia M, Lauretti E, Praticò D. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81:92-100 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig ev1
- western blot; human; 1:500; loading ...; fig 8
| Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher |
- western blot; fruit fly ; fig 3
| Dourlen P, Fernandez Gomez F, Dupont C, Grenier Boley B, Bellenguez C, Obriot H, et al. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Mol Psychiatry. 2017;22:874-883 pubmed publisher |
- western blot; human; 1:500; fig 5
| Yetman M, Fowler S, Jankowsky J. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS ONE. 2016;11:e0153724 pubmed publisher |
- western blot; mouse; 1:1000; fig 3
| Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed publisher |
- immunohistochemistry - paraffin section; fruit fly ; 1:1000; fig 4
- western blot; fruit fly ; 1:2000; fig 4
| Chanu S, Sarkar S. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 2017;54:2706-2719 pubmed publisher |
- western blot; mouse; fig 8
| Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200; fig 3
| Nishikawa T, Takahashi T, Nakamori M, Hosomi N, Maruyama H, Miyazaki Y, et al. The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments. Neuropathol Appl Neurobiol. 2016;42:639-653 pubmed publisher |
- western blot; mouse; fig 1
| Lauretti E, Praticò D. Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell. 2015;14:1067-74 pubmed publisher |
- western blot; human; 1:2000
| Hamm M, Bailey R, Shaw G, Yen S, Lewis J, Giasson B. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. J Neurosci Res. 2015;93:1567-80 pubmed publisher |
| Sankaranarayanan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PLoS ONE. 2015;10:e0125614 pubmed publisher |
- western blot; human; fig 1c
| Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed publisher |
- western blot; human; fig 3, 4
| Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed publisher |
- western blot; human; 1:200; fig 6b
| Riise J, Plath N, Pakkenberg B, Parachikova A. Aberrant Wnt signaling pathway in medial temporal lobe structures of Alzheimer's disease. J Neural Transm (Vienna). 2015;122:1303-18 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:100
- western blot; mouse; 1:200
| Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed publisher |
- western blot; human; fig 4
| Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig 1
- western blot; mouse; fig 1
| Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed publisher |
| Yang S, Xia C, Li S, Du L, Zhang L, Hu Y. Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model. Cell Death Dis. 2014;5:e1217 pubmed publisher |
- immunohistochemistry; mouse; 1:500
| Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed publisher |
| Kondadi A, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, et al. Loss of the m-AAA protease subunit AFG?L? causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014;33:1011-26 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed publisher |
- western blot; human; 1:2000
| Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed publisher |
- western blot; mouse; 1:200
| di Meco A, Joshi Y, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging. 2014;35:1813-20 pubmed publisher |
- western blot; mouse; 1:1000
| Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed publisher |
- western blot; mouse; 1:500
| Guo Q, Li H, Cole A, Hur J, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS ONE. 2013;8:e80706 pubmed publisher |
| Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed publisher |
- western blot; mouse; 1:1000
| Rice R, Berchtold N, Cotman C, Green K. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014;35:1002-11 pubmed publisher |
- western blot; human; 1:1000
| Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed publisher |
| Meredith J, Sankaranarayanan S, Guss V, Lanzetti A, Berisha F, Neely R, et al. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. PLoS ONE. 2013;8:e76523 pubmed publisher |
- immunohistochemistry; mouse
| Mannix R, Meehan W, MANDEVILLE J, Grant P, Gray T, Berglass J, et al. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013;74:65-75 pubmed publisher |
| Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed publisher |
- western blot; mouse; 1:1000
| Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed publisher |
- immunohistochemistry; human; 1:200
| Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed publisher |
| Leboucher A, Laurent C, Fernandez Gomez F, Burnouf S, Troquier L, Eddarkaoui S, et al. Detrimental effects of diet-induced obesity on ? pathology are independent of insulin resistance in ? transgenic mice. Diabetes. 2013;62:1681-8 pubmed publisher |
- immunoprecipitation; mouse; 1:5000
| Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, et al. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging Cell. 2013;12:11-23 pubmed publisher |
| Bories C, Guitton M, Julien C, Tremblay C, Vandal M, Msaid M, et al. Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease. PLoS ONE. 2012;7:e46111 pubmed publisher |
- immunohistochemistry; mouse
| Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed publisher |
- immunohistochemistry; mouse; 1:10
| Capsoni S, Carlo A, Vignone D, Amato G, Criscuolo C, Willnow T, et al. SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;33:357-71 pubmed publisher |
- immunohistochemistry; African green monkey; 1:1000
| Engelhardt M, Vorwald S, Sobotzik J, Bennett V, Schultz C. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. Brain Struct Funct. 2013;218:1005-16 pubmed publisher |
| Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed publisher |
| Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed publisher |
| Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed publisher |
- western blot; human; 1:1000
| Bretteville A, Marcouiller F, Julien C, El Khoury N, Petry F, Poitras I, et al. Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors. Sci Rep. 2012;2:480 pubmed publisher |
| Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed publisher |
- western blot; mouse; 1:200
| Joshi Y, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis. 2012;31:167-76 pubmed publisher |
| Löffler T, Flunkert S, Taub N, Schofield E, Ward M, Windisch M, et al. Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci. 2012;47:192-203 pubmed publisher |
| Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed publisher |
- western blot; human; 1:100
| Mouton Liger F, Paquet C, Dumurgier J, Lapalus P, Gray F, Laplanche J, et al. Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease. Biol Psychiatry. 2012;71:829-35 pubmed publisher |
- western blot; mouse; 1:5000
| Burnouf S, Belarbi K, Troquier L, Derisbourg M, Demeyer D, Leboucher A, et al. Hippocampal BDNF expression in a tau transgenic mouse model. Curr Alzheimer Res. 2012;9:406-10 pubmed |
- western blot; rat; 1:1000
- western blot; human; 1:1000
| Jones N, Nguyen T, Corcoran N, Velakoulis D, Chen T, Grundy R, et al. Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. Neurobiol Dis. 2012;45:897-901 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Nijholt D, van Haastert E, Rozemuller A, Scheper W, Hoozemans J. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol. 2012;226:693-702 pubmed publisher |
- immunohistochemistry; mouse
| Ohmi K, Zhao H, Neufeld E. Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. PLoS ONE. 2011;6:e27461 pubmed publisher |
- western blot; human; 1:5000
| Lebbadi M, Julien C, Phivilay A, Tremblay C, Emond V, Kang J, et al. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. J Alzheimers Dis. 2011;27:853-69 pubmed publisher |
- western blot; mouse
- western blot; human
| Minami S, Clifford T, HOE H, Matsuoka Y, Rebeck G. Fyn knock-down increases A?, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012;33:825.e15-24 pubmed publisher |
- immunohistochemistry; human; 1:200
- western blot; human; 1:1000
| Kovacs G, Molnár K, Laszlo L, Strobel T, Botond G, Hönigschnabl S, et al. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol. 2011;122:205-22 pubmed publisher |
| Wu G, Sankaranarayanan S, Hsieh S, Simon A, Savage M. Decrease in brain soluble amyloid precursor protein ? (sAPP?) in Alzheimer's disease cortex. J Neurosci Res. 2011;89:822-32 pubmed publisher |
| Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe D. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011;108:5819-24 pubmed publisher |
- western blot; mouse; 1:1,000
| Koike M, Garcia F, Kitazawa M, Green K, LaFerla F. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011;495:55-9 pubmed publisher |
| Gauthier Kemper A, Weissmann C, Golovyashkina N, Sebö Lemke Z, Drewes G, Gerke V, et al. The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. J Cell Biol. 2011;192:647-61 pubmed publisher |
- immunohistochemistry; mouse; 1:2000
| Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, et al. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci. 2011;31:2511-25 pubmed publisher |
- immunohistochemistry; mouse; 1:100
- western blot; mouse; 1:1,000
| Kudo L, Parfenova L, Ren G, Vi N, Hui M, Ma Z, et al. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Hum Mol Genet. 2011;20:1820-33 pubmed publisher |
- western blot; hamsters; 1:500
| Stieler J, Bullmann T, Kohl F, Tøien Ø, Brückner M, Hartig W, et al. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS ONE. 2011;6:e14530 pubmed publisher |
- immunohistochemistry; mouse
- western blot; mouse
| Niikura T, Sidahmed E, Hirata Fukae C, Aisen P, Matsuoka Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS ONE. 2011;6:e16259 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed publisher |
- western blot; human; 1:100000
| Colodner K, Feany M. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci. 2010;30:16102-13 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Caccamo A, Magrí A, Oddo S. Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to A? oligomers accumulation. Mol Neurodegener. 2010;5:51 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Bose A, Mouton Liger F, Paquet C, Mazot P, Vigny M, Gray F, et al. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol. 2011;21:189-200 pubmed publisher |
- immunohistochemistry; rat; 1:200
| Liu D, Pitta M, Lee J, Ray B, Lahiri D, Furukawa K, et al. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;22:443-57 pubmed publisher |
- immunohistochemistry; human
- immunohistochemistry; mouse
| Hurtado D, Molina Porcel L, Iba M, Aboagye A, Paul S, Trojanowski J, et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol. 2010;177:1977-88 pubmed publisher |
- western blot; fruit fly ; 1:10000
| Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed publisher |
| van Eersel J, Ke Y, Liu X, Delerue F, Kril J, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93 pubmed publisher |
- western blot; human; 1:1000
| Parachikova A, Vasilevko V, Cribbs D, LaFerla F, Green K. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010;21:527-42 pubmed publisher |
- western blot; human; 1:1000
| Koike M, Green K, Blurton Jones M, LaFerla F. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010;177:300-10 pubmed publisher |
- western blot; human
- western blot; rat
| Zilka N, Korenova M, Kovacech B, Iqbal K, Novak M. CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy. Acta Neuropathol. 2010;119:679-87 pubmed publisher |
- western blot; human; 1:1000
| Martinez Coria H, Green K, Billings L, Kitazawa M, Albrecht M, Rammes G, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010;176:870-80 pubmed publisher |
- immunocytochemistry; human; 1:100
- western blot; human
- immunocytochemistry; mouse; 1:100
- western blot; mouse
| Vale C, Alonso E, Rubiolo J, Vieytes M, LaFerla F, Gimenez Llort L, et al. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010;30:577-90 pubmed publisher |
- immunohistochemistry; rat
| Lecanu L, Rammouz G, McCourty A, Sidahmed E, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010;165:427-35 pubmed publisher |
- immunohistochemistry; mouse; 1:1000
| Sobotzik J, Sie J, Politi C, Del Turco D, Bennett V, Deller T, et al. AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci U S A. 2009;106:17564-9 pubmed publisher |
- immunohistochemistry; human; 1:200
- western blot; human; 1:1000
| van Eersel J, Bi M, Ke Y, Hodges J, Xuereb J, Gregory G, et al. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna). 2009;116:1243-51 pubmed publisher |
- immunohistochemistry; human
| Rahman A, Ting K, Cullen K, Braidy N, Brew B, Guillemin G. The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS ONE. 2009;4:e6344 pubmed publisher |
- immunohistochemistry; mouse
- western blot; mouse
| Ittner L, Ke Y, Götz J. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem. 2009;284:20909-16 pubmed publisher |
- immunohistochemistry; mouse
| Ohmi K, Kudo L, Ryazantsev S, Zhao H, Karsten S, Neufeld E. Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy. Proc Natl Acad Sci U S A. 2009;106:8332-7 pubmed publisher |
- immunohistochemistry; human; 1:10
| Covaceuszach S, Capsoni S, Ugolini G, Spirito F, Vignone D, Cattaneo A. Development of a non invasive NGF-based therapy for Alzheimer's disease. Curr Alzheimer Res. 2009;6:158-70 pubmed |
| Run X, Liang Z, Zhang L, Iqbal K, Grundke Iqbal I, Gong C. Anesthesia induces phosphorylation of tau. J Alzheimers Dis. 2009;16:619-26 pubmed publisher |
- western blot; fruit fly ; 1:2,000
| Chatterjee S, Sang T, Lawless G, Jackson G. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet. 2009;18:164-77 pubmed publisher |
- immunohistochemistry; mouse; 1:500
| Takahashi R, Capetillo Zarate E, Lin M, Milner T, Gouras G. Co-occurrence of Alzheimer's disease ß-amyloid and ? pathologies at synapses. Neurobiol Aging. 2010;31:1145-52 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Mastrangelo M, Bowers W. Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. BMC Neurosci. 2008;9:81 pubmed publisher |
- ELISA; human; 1:2000
- western blot; human
| Woltjer R, Sonnen J, Sokal I, Rung L, Yang W, Kjerulf J, et al. Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly. Brain Pathol. 2009;19:365-74 pubmed publisher |
- immunohistochemistry; mouse
- western blot; mouse
| Lim J, Balastik M, Lee T, Nakamura K, Liou Y, Sun A, et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008;118:1877-89 pubmed publisher |
| Matsuoka Y, Jouroukhin Y, Gray A, Ma L, Hirata Fukae C, Li H, et al. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther. 2008;325:146-53 pubmed publisher |
- western blot; rat; 1:4000
| Selenica M, Jensen H, Larsen A, Pedersen M, Helboe L, Leist M, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007;152:959-79 pubmed |
- western blot; rat
- western blot; roundworm
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- immunohistochemistry; mouse
- western blot; mouse
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- immunohistochemistry; mouse
- western blot; mouse
| Caccamo A, Oddo S, Tran L, LaFerla F. Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol. 2007;170:1669-75 pubmed |
- western blot; human; 1:1,000
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- western blot; fruit fly ; 1:2,000
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- immunohistochemistry; mouse
- western blot; mouse; 1:1,000
| Green K, Billings L, Roozendaal B, McGaugh J, LaFerla F. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006;26:9047-56 pubmed |
- western blot; mouse; fig 7
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