product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-Tau (Thr231) Monoclonal Antibody (AT180)
catalog :
MN1040
quantity :
100 µg
price :
US 536
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
AT180
reactivity :
hamsters, human, mouse, rat, dogs, cat, fruit fly , domestic rabbit, roundworm , domestic horse, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, western blot knockout validation
more info or order :
Invitrogen product webpage
citations: 403
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; fig 2
Petry F, Pelletier J, Bretteville A, Morin F, Calon F, Hébert S, et al. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PLoS ONE. 2014;9:e94251 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Nies S, Takahashi H, Herber C, Huttner A, Chase A, Strittmatter S. Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. J Biol Chem. 2021;297:101159 pubmed publisher
  • western blot; fruit fly ; 1:1000; loading ...; fig s3c
  • immunohistochemistry; mouse; 1:200; loading ...; fig s6a
Subramanian M, Hyeon S, Das T, Suh Y, Kim Y, Lee J, et al. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021;12:3291 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...
Lin L, Petralia R, Lake R, Wang Y, Hoffman D. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1c
  • immunohistochemistry; human; loading ...; fig 7e
Wander C, Tseng J, Song S, Al Housseiny H, Tart D, Ajit A, et al. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. 2020;23:101255 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4c
  • western blot; mouse; loading ...; fig 4a
Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig s2b
  • western blot; human; 1:500-1:1000; loading ...; fig 5, 6
Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig s4
He Z, McBride J, Xu H, Changolkar L, Kim S, Zhang B, et al. Transmission of tauopathy strains is independent of their isoform composition. Nat Commun. 2020;11:7 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Fan Q, He W, Gayen M, Benoit M, Luo X, Hu X, et al. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. J Neurosci. 2020;40:1133-1144 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1b
  • immunocytochemistry; human; loading ...; fig 3b
Wheeler J, McMillan P, Strovas T, Liachko N, Amlie Wolf A, Kow R, et al. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Sci Transl Med. 2019;11: pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 3a
di Meco A, Pratico D. Early-life exposure to high-fat diet influences brain health in aging mice. Aging Cell. 2019;18:e13040 pubmed publisher
  • western blot; roundworm ; fig 9d
Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig s15a
Sartori M, Mendes T, Desai S, Lasorsa A, Herledan A, Malmanche N, et al. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation. Acta Neuropathol. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4e
Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson M. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiol Aging. 2018;70:160-169 pubmed publisher
  • western blot; human; loading ...; fig 1f
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2c
Brici D, G tz J, Nisbet R. A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles. J Alzheimers Dis. 2018;61:899-905 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s5b
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4c
  • western blot; mouse; fig 4a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Maphis N, Jiang S, Binder J, Wright C, Gopalan B, Lamb B, et al. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Front Mol Neurosci. 2017;10:69 pubmed publisher
  • western blot; human; loading ...; fig 4a
Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed publisher
  • western blot; human; 1:1000; fig 1a
Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3b
  • western blot; mouse; 0.2 ug/ml; loading ...; fig 2b
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig 1a
Fu H, Rodriguez G, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. 2017;93:533-541.e5 pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; fig 7d
Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed publisher
  • immunohistochemistry; mouse; 1:250; loading ...; fig 5b
  • western blot; mouse; 1:1000; loading ...; fig 5c
Wang A, Jensen E, Rexach J, Vinters H, Hsieh Wilson L. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:15120-15125 pubmed publisher
  • western blot; human; loading ...; fig 4a
Rueli R, Torres D, Dewing A, Kiyohara A, Barayuga S, Bellinger M, et al. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. J Alzheimers Dis. 2017;55:749-762 pubmed
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 6b
Zimova I, Brezovakova V, Hromádka T, Weisová P, Cubinkova V, Valachova B, et al. Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy. J Alzheimers Dis. 2016;54:831-43 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:50; fig 6
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:1000; fig 5
McAteer K, Corrigan F, Thornton E, Turner R, Vink R. Short and Long Term Behavioral and Pathological Changes in a Novel Rodent Model of Repetitive Mild Traumatic Brain Injury. PLoS ONE. 2016;11:e0160220 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 3a
di Meco A, Li J, Blass B, Abou Gharbia M, Lauretti E, Praticò D. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81:92-100 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig ev1
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 3
Kolisnyk B, Al Onaizi M, Soreq L, Barbash S, Bekenstein U, Haberman N, et al. Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology. Cereb Cortex. 2017;27:3553-3567 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 3
  • western blot; mouse; 1:500; fig 6
Baker S, Götz J. A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta Neuropathol Commun. 2016;4:32 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed publisher
  • western blot; fruit fly ; fig 2
Ando K, Maruko Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima K. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity. PLoS Genet. 2016;12:e1005917 pubmed publisher
  • immunohistochemistry - paraffin section; fruit fly ; 1:1000; fig 4
  • western blot; fruit fly ; 1:2000; fig 4
Chanu S, Sarkar S. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 2017;54:2706-2719 pubmed publisher
  • western blot; mouse; fig 8
Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 1
Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed publisher
  • immunohistochemistry; human; fig 3
  • western blot; human; 1:1000; fig 3
  • immunohistochemistry; mouse; fig 3
  • western blot; mouse; 1:1000; fig 3
Jiang T, Zhang Y, Chen Q, Gao Q, Zhu X, Zhou J, et al. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. 2016;105:196-206 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
  • western blot; human; 1:1000; tbl 1
Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
El Khoury N, Gratuze M, Petry F, Papon M, Julien C, Marcouiller F, et al. Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice. Neurobiol Dis. 2016;88:55-65 pubmed publisher
  • western blot; human; 1:100; fig 2
Platt T, Beckett T, Kohler K, Niedowicz D, Murphy M. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. 2016;315:162-74 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed publisher
  • western blot; human; fig 7
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, et al. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Mol Brain. 2015;8:82 pubmed publisher
  • western blot; human; fig 3
Hromadkova L, Kolarova M, Jankovicova B, Bartos A, Ricny J, Bilkova Z, et al. Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product. J Neuroimmunol. 2015;289:121-9 pubmed publisher
  • western blot; human; fig 2
Taniguchi Watanabe S, Arai T, Kametani F, Nonaka T, Masuda Suzukake M, Tarutani A, et al. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol. 2016;131:267-280 pubmed publisher
  • ELISA; human; fig 2
  • ELISA; mouse; fig 2
Yamada K, Patel T, Hochgräfe K, Mahan T, Jiang H, Stewart F, et al. Analysis of in vivo turnover of tau in a mouse model of tauopathy. Mol Neurodegener. 2015;10:55 pubmed publisher
  • western blot; human; 1:1000; fig 3
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, et al. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol. 2015;130:619-31 pubmed publisher
  • western blot; human; fig s2
Richter M, Mewes A, Fritsch M, Krügel U, Hoffmann R, Singer D. Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation. Vaccines (Basel). 2014;2:601-23 pubmed publisher
  • immunohistochemistry; hamsters; 1:10,000; fig 2
Bullmann T, Seeger G, Stieler J, Hanics J, Reimann K, Kretzschmann T, et al. Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters. Hippocampus. 2016;26:301-18 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed publisher
  • immunohistochemistry; human
  • immunohistochemistry - paraffin section; dogs; 1:1000; fig 3
Smolek T, Madari A, Farbáková J, Kandrac O, Jadhav S, Cente M, et al. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. J Comp Neurol. 2016;524:874-95 pubmed publisher
  • western blot; mouse; fig 1
Lauretti E, Praticò D. Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell. 2015;14:1067-74 pubmed publisher
  • western blot; rat; fig 3
Chesser A, Ganeshan V, Yang J, Johnson G. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutr Neurosci. 2016;19:21-31 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
Kim J, Kim S, Lee Y. Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice. Neuroreport. 2015;26:767-72 pubmed publisher
  • western blot; mouse; 1:200; fig 3
Di Meco A, Joshi Y, Lauretti E, Praticò D. Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry. 2016;21:403-10 pubmed publisher
  • western blot; human; fig 1b
Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed publisher
  • western blot; human; fig 3, 4
Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed publisher
  • western blot; human; 1:2500; fig 1a
Maphis N, Xu G, Kokiko Cochran O, Jiang S, Cardona A, Ransohoff R, et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015;138:1738-55 pubmed publisher
  • western blot; rat; 1:1000; fig 1
Li R, Xu D, Ma T. Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience. 2015;294:14-20 pubmed publisher
  • immunohistochemistry - free floating section; human; 1:500
Jay T, Miller C, Cheng P, Graham L, Bemiller S, Broihier M, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015;212:287-95 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000
Kaufman A, Salazar S, Haas L, Yang J, Kostylev M, Jeng A, et al. Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann Neurol. 2015;77:953-71 pubmed publisher
  • western blot; mouse; fig s4
Carret Rebillat A, Pace C, Gourmaud S, Ravasi L, Montagne Stora S, Longueville S, et al. Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation. Sci Rep. 2015;5:8489 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500
Xu H, Rösler T, Carlsson T, de Andrade A, Fiala O, Höllerhage M, et al. Tau silencing by siRNA in the P301S mouse model of tauopathy. Curr Gene Ther. 2014;14:343-51 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:400
Wu Z, Yang B, Liu C, Liang G, Eckenhoff M, Liu W, et al. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer Dis Assoc Disord. 2015;29:184-191 pubmed publisher
  • western blot; mouse
Mouton Liger F, Rebillat A, Gourmaud S, Paquet C, Leguen A, Dumurgier J, et al. PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model. Cell Death Dis. 2015;6:e1594 pubmed publisher
  • western blot; mouse; fig s2
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro G, Liu D, et al. DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. Nucleic Acids Res. 2015;43:943-59 pubmed publisher
  • western blot; mouse
Iliff J, Chen M, Plog B, Zeppenfeld D, Soltero M, Yang L, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. 2014;34:16180-93 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
  • western blot; mouse; 1:100
Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
  • western blot; mouse; 1:500
Höllerhage M, Deck R, de Andrade A, Respondek G, Xu H, Rösler T, et al. Piericidin A aggravates Tau pathology in P301S transgenic mice. PLoS ONE. 2014;9:e113557 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 2
  • western blot; human; 1:250; fig 4
Ohia Nwoko O, Montazari S, Lau Y, Eriksen J. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54 pubmed publisher
  • western blot; mouse
  • immunohistochemistry; fruit fly
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S. Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40. Mol Neurodegener. 2014;9:52 pubmed publisher
  • immunohistochemistry - paraffin section; rat; fig 2
  • western blot; rat; fig 1
Huang C, Ho Y, Ng O, Irwin M, Chang R, Wong G. Dexmedetomidine directly increases tau phosphorylation. J Alzheimers Dis. 2015;44:839-50 pubmed publisher
  • western blot; mouse; fig 2
Castro Alvarez J, Uribe Arias S, Kosik K, Cardona Gómez G. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Front Aging Neurosci. 2014;6:243 pubmed publisher
  • western blot; human; fig 4
Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
  • western blot; mouse; fig 1
Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed publisher
  • western blot; human; 1:1000
Jiang T, Yu J, Zhu X, Zhang Q, Cao L, Wang H, et al. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. 2014;85:121-30 pubmed publisher
  • immunohistochemistry; mouse; 1:250
  • western blot; mouse; 1:500
Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher
  • immunohistochemistry; mouse
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed publisher
  • western blot; mouse
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3?/?. Eur J Neurosci. 2014;40:2442-53 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
  • western blot; mouse; 1:1000
Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed publisher
  • western blot; human; 1:2000
Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed publisher
  • western blot; mouse; 1:200
di Meco A, Joshi Y, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging. 2014;35:1813-20 pubmed publisher
  • western blot; human
Chabrier M, Cheng D, Castello N, Green K, LaFerla F. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiol Dis. 2014;64:107-17 pubmed publisher
  • western blot; mouse; 1:1000
Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed publisher
  • immunohistochemistry; mouse; 1:100
  • western blot; mouse; 1:1000
Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed publisher
  • western blot; mouse; 1:1000
Farr S, Ripley J, Sultana R, Zhang Z, Niehoff M, Platt T, et al. Antisense oligonucleotide against GSK-3? in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radic Biol Med. 2014;67:387-95 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed publisher
  • western blot; mouse; 1:500
Guo Q, Li H, Cole A, Hur J, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS ONE. 2013;8:e80706 pubmed publisher
  • western blot; mouse
Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed publisher
  • western blot; human; 1:1000
Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed publisher
  • western blot; mouse; 1:1000
Rothman S, Herdener N, Frankola K, Mughal M, Mattson M. Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease. Brain Res. 2013;1529:200-8 pubmed publisher
  • immunohistochemistry; mouse
Maurin H, Seymour C, Lechat B, Borghgraef P, Devijver H, Jaworski T, et al. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PLoS ONE. 2013;8:e63589 pubmed publisher
  • immunohistochemistry; human; 1:100
Bomba M, Ciavardelli D, Silvestri E, Canzoniero L, Lattanzio R, Chiappini P, et al. Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals. Cell Death Dis. 2013;4:e612 pubmed publisher
  • immunohistochemistry; rat; 1:100
  • ELISA; rat; 1:1000
  • western blot; rat; 1:1000
Hawkins B, Krishnamurthy S, Castillo Carranza D, Sengupta U, Prough D, Jackson G, et al. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem. 2013;288:17042-50 pubmed publisher
  • immunocytochemistry; fruit fly ; fig s4
Wu T, Lu Y, Chuang C, Wu C, Chiang A, Krantz D, et al. Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. Acta Neuropathol. 2013;125:711-25 pubmed publisher
  • western blot; rat
Georgievska B, Sandin J, Doherty J, Mörtberg A, Neelissen J, Andersson A, et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013;125:446-56 pubmed publisher
  • immunohistochemistry; human; 1:1000
Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed publisher
  • western blot; mouse
Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed publisher
  • western blot; mouse; 1:1000
Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed publisher
  • western blot; mouse; 1:2000
Desrumaux C, Pisoni A, Meunier J, Deckert V, Athias A, Perrier V, et al. Increased amyloid-? peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice. Neuropsychopharmacology. 2013;38:817-25 pubmed publisher
  • immunohistochemistry; human; 1:50
Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Kashiwaya Y, Bergman C, Lee J, Wan R, King M, Mughal M, et al. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging. 2013;34:1530-9 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; mouse
Liu D, Pitta M, Jiang H, Lee J, Zhang G, Chen X, et al. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol Aging. 2013;34:1564-80 pubmed publisher
  • immunohistochemistry; mouse; 1:2400
Morcinek K, Kohler C, Götz J, Schröder H. Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Res. 2013;1497:73-84 pubmed publisher
  • western blot; mouse
Leboucher A, Laurent C, Fernandez Gomez F, Burnouf S, Troquier L, Eddarkaoui S, et al. Detrimental effects of diet-induced obesity on ? pathology are independent of insulin resistance in ? transgenic mice. Diabetes. 2013;62:1681-8 pubmed publisher
  • western blot; rat; 1:1000
Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed publisher
  • immunohistochemistry; mouse
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed publisher
  • western blot; fruit fly ; fig 3
Iijima Ando K, Sekiya M, Maruko Otake A, Ohtake Y, Suzuki E, Lu B, et al. Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS Genet. 2012;8:e1002918 pubmed publisher
  • western blot; human
Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, et al. Hyperphosphorylation of Tau induced by naturally secreted amyloid-? at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3? signaling pathway. J Biol Chem. 2012;287:35222-33 pubmed publisher
  • western blot; mouse
Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed publisher
  • immunocytochemistry; human; 1:100
Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed publisher
  • western blot; mouse
Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed publisher
  • immunohistochemistry; human; 1:100
  • western blot; mouse
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed publisher
  • western blot; mouse; 1:1000
Julien C, Marcouiller F, Bretteville A, El Khoury N, Baillargeon J, Hébert S, et al. Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation. PLoS ONE. 2012;7:e40020 pubmed publisher
  • western blot; human; 1:1000
Bretteville A, Marcouiller F, Julien C, El Khoury N, Petry F, Poitras I, et al. Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors. Sci Rep. 2012;2:480 pubmed publisher
  • western blot; human
Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed publisher
  • immunohistochemistry; mouse
Barten D, Fanara P, Andorfer C, Hoque N, Wong P, Husted K, et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci. 2012;32:7137-45 pubmed publisher
  • western blot; mouse; 1:500
Cancino G, Miller F, Kaplan D. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013;34:387-99 pubmed publisher
  • immunohistochemistry; human; 1:1000
  • western blot; human; 1:500
Van der Jeugd A, Hochgräfe K, Ahmed T, Decker J, Sydow A, Hofmann A, et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol. 2012;123:787-805 pubmed publisher
  • western blot; mouse; 1:200
Joshi Y, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis. 2012;31:167-76 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Keilani S, Lun Y, Stevens A, Williams H, Sjoberg E, Khanna R, et al. Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-? peptide. J Neurosci. 2012;32:5223-36 pubmed publisher
  • western blot; rat; 1:1000
Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed publisher
  • western blot; mouse; 1:1000
de Calignon A, Polydoro M, Suarez Calvet M, William C, Adamowicz D, Kopeikina K, et al. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 2012;73:685-97 pubmed publisher
  • western blot; human
Löffler T, Flunkert S, Taub N, Schofield E, Ward M, Windisch M, et al. Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci. 2012;47:192-203 pubmed publisher
  • western blot; mouse; 1:1000
Sudduth T, Wilson J, Everhart A, Colton C, Wilcock D. Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS ONE. 2012;7:e31993 pubmed publisher
  • immunohistochemistry; human; 1:200
Lee S, Kim W, Li Z, Hall G. Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model. Int J Alzheimers Dis. 2012;2012:172837 pubmed publisher
  • western blot; human
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed publisher
  • western blot; rat; 1:1000
  • western blot; human; 1:1000
Jones N, Nguyen T, Corcoran N, Velakoulis D, Chen T, Grundy R, et al. Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. Neurobiol Dis. 2012;45:897-901 pubmed publisher
  • western blot; rat
Krüger U, Wang Y, Kumar S, Mandelkow E. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging. 2012;33:2291-305 pubmed publisher
  • immunohistochemistry; human; 1:300
Perez S, Getova D, He B, Counts S, Geula C, Désiré L, et al. Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease. Am J Pathol. 2012;180:526-40 pubmed publisher
  • immunohistochemistry; human; 1:200
Ho Y, Yang X, Lau J, Hung C, Wuwongse S, Zhang Q, et al. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. J Alzheimers Dis. 2012;28:839-54 pubmed publisher
  • western blot; human
Kitazawa M, Cheng D, Tsukamoto M, Koike M, Wes P, Vasilevko V, et al. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ?-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011;187:6539-49 pubmed publisher
  • western blot; human
Maarouf C, Daugs I, Kokjohn T, Walker D, Hunter J, Kruchowsky J, et al. Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging. PLoS ONE. 2011;6:e27291 pubmed publisher
  • immunocytochemistry; mouse
Lee S, Lemere C, Frost J, Shea T. Dietary supplementation with S-adenosyl methionine delayed amyloid-? and tau pathology in 3xTg-AD mice. J Alzheimers Dis. 2012;28:423-31 pubmed publisher
  • immunohistochemistry; human
McMillan P, Kraemer B, Robinson L, Leverenz J, Raskind M, Schellenberg G. Truncation of tau at E391 promotes early pathologic changes in transgenic mice. J Neuropathol Exp Neurol. 2011;70:1006-19 pubmed publisher
  • western blot; mouse
Jeong Y, Kim J, Yoo J, Lee S, Kim H, Suh Y. Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model. J Neurochem. 2011;119:1282-93 pubmed publisher
  • immunocytochemistry; mouse
Milner T, Waters E, Robinson D, Pierce J. Degenerating processes identified by electron microscopic immunocytochemical methods. Methods Mol Biol. 2011;793:23-59 pubmed publisher
  • immunohistochemistry; mouse; 1:500
  • western blot; mouse; 1:1000
Tang J, Mardini F, Caltagarone B, Garrity S, Li R, Bianchi S, et al. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement. 2011;7:521-531.e1 pubmed publisher
  • western blot; mouse
  • western blot; human
Minami S, Clifford T, HOE H, Matsuoka Y, Rebeck G. Fyn knock-down increases A?, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012;33:825.e15-24 pubmed publisher
  • immunohistochemistry; human; 1 ug/ml
Tran H, LaFerla F, Holtzman D, Brody D. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-? accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011;31:9513-25 pubmed publisher
  • immunohistochemistry; human; 1:200
  • western blot; human; 1:500
Kovacs G, Molnár K, Laszlo L, Strobel T, Botond G, Hönigschnabl S, et al. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol. 2011;122:205-22 pubmed publisher
  • immunohistochemistry; mouse
Maeda J, Zhang M, Okauchi T, Ji B, Ono M, Hattori S, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci. 2011;31:4720-30 pubmed publisher
  • immunohistochemistry; human; 1:400
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, et al. Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice. PLoS ONE. 2011;6:e17971 pubmed publisher
  • western blot; rat
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe D. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011;108:5819-24 pubmed publisher
  • western blot; mouse; 1:1,000
Koike M, Garcia F, Kitazawa M, Green K, LaFerla F. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011;495:55-9 pubmed publisher
  • immunohistochemistry; human; 1:250
Jayadev S, Nochlin D, Poorkaj P, Steinbart E, Mastrianni J, Montine T, et al. Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Ann Neurol. 2011;69:712-20 pubmed publisher
  • immunohistochemistry; human; 1:200
  • western blot; human; 1:3000
Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, et al. Apomorphine treatment in Alzheimer mice promoting amyloid-? degradation. Ann Neurol. 2011;69:248-56 pubmed publisher
  • immunohistochemistry; human; 1:400
Corona C, Masciopinto F, Silvestri E, Viscovo A, Lattanzio R, Sorda R, et al. Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction. Cell Death Dis. 2010;1:e91 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
To A, Ribe E, Chuang T, Schroeder J, Lovestone S. The ?3 and ?4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice. PLoS ONE. 2011;6:e16991 pubmed publisher
  • immunohistochemistry; mouse; 1:25
  • western blot; mouse; 1:200
Kudo L, Parfenova L, Ren G, Vi N, Hui M, Ma Z, et al. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Hum Mol Genet. 2011;20:1820-33 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Garcia Mesa Y, López Ramos J, Gimenez Llort L, Revilla S, Guerra R, Gruart A, et al. Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. J Alzheimers Dis. 2011;24:421-54 pubmed publisher
  • western blot; hamsters; 1:500
Stieler J, Bullmann T, Kohl F, Tøien Ø, Brückner M, Hartig W, et al. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS ONE. 2011;6:e14530 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; mouse
Niikura T, Sidahmed E, Hirata Fukae C, Aisen P, Matsuoka Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS ONE. 2011;6:e16259 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed publisher
  • immunohistochemistry; rat
  • western blot; rat
Filipcik P, Zilka N, Bugos O, Kučerák J, Koson P, Novak P, et al. First transgenic rat model developing progressive cortical neurofibrillary tangles. Neurobiol Aging. 2012;33:1448-56 pubmed publisher
  • immunohistochemistry; human; 1:250
Ringman J, Gylys K, Medina L, Fox M, Kepe V, Flores D, et al. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neurosci Lett. 2011;487:287-92 pubmed publisher
  • immunocytochemistry; human; 1:500
Takahashi R, Tobiume M, Sato Y, Sata T, Gouras G, Takahashi H. Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain. Neuropathology. 2011;31:208-14 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Bose A, Mouton Liger F, Paquet C, Mazot P, Vigny M, Gray F, et al. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol. 2011;21:189-200 pubmed publisher
  • immunohistochemistry; mouse
Gimenez Llort L, García Y, Buccieri K, Revilla S, Suñol C, Cristofol R, et al. Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice. Int J Alzheimers Dis. 2010;2010:128354 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Andrews Zwilling Y, Bien Ly N, Xu Q, Li G, Bernardo A, Yoon S, et al. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010;30:13707-17 pubmed publisher
  • immunohistochemistry; rat
Stozicka Z, Zilka N, Novak P, Kovacech B, Bugos O, Novak M. Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease. J Neuroinflammation. 2010;7:64 pubmed publisher
  • western blot; mouse; 1:500
Peethumnongsin E, Yang L, Kallhoff Munoz V, Hu L, Takashima A, Pautler R, et al. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010;30:13409-18 pubmed publisher
  • immunohistochemistry; mouse; 1:200
  • western blot; mouse; 1:5000
Bhaskar K, Konerth M, Kokiko Cochran O, Cardona A, Ransohoff R, Lamb B. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010;68:19-31 pubmed publisher
  • western blot; mouse
Minami S, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, et al. Therapeutic versus neuroinflammatory effects of passive immunization is dependent on A?/amyloid burden in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2010;7:57 pubmed publisher
  • immunohistochemistry; mouse
  • immunohistochemistry; human
Hurtado D, Molina Porcel L, Iba M, Aboagye A, Paul S, Trojanowski J, et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol. 2010;177:1977-88 pubmed publisher
  • immunohistochemistry; rat; 1:500
Ramirez J, Poulton W, Knelson E, Barton C, King M, Klein R. Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behav Brain Res. 2011;216:332-40 pubmed publisher
  • immunohistochemistry; human; 1:20
  • western blot; human; 1:100
Hamilton L, Aumont A, Julien C, Vadnais A, Calon F, Fernandes K. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci. 2010;32:905-20 pubmed publisher
  • immunohistochemistry; human; 1:2,000
McKee A, Gavett B, Stern R, Nowinski C, Cantu R, Kowall N, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010;69:918-29 pubmed publisher
  • western blot; rat; 1:500
Zheng Y, Amin N, Hu Y, Rudrabhatla P, Shukla V, Kanungo J, et al. A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. J Biol Chem. 2010;285:34202-12 pubmed publisher
  • immunohistochemistry; human; 1:200
Desai M, Mastrangelo M, Ryan D, Sudol K, Narrow W, Bowers W. Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target. Am J Pathol. 2010;177:1422-35 pubmed publisher
  • western blot; fruit fly ; 1:2000
Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed publisher
  • immunohistochemistry; human; 1:100
Blazquez Llorca L, Garcia Marin V, DeFelipe J. Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients. Front Neuroanat. 2010;4:20 pubmed publisher
  • immunohistochemistry; human; 1:250
Poorkaj P, Raskind W, Leverenz J, Matsushita M, Zabetian C, Samii A, et al. A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity. Mov Disord. 2010;25:1409-17 pubmed publisher
  • immunohistochemistry; human; 1:1,000
Josephs K, Whitwell J, Boeve B, Knopman D, Petersen R, Hu W, et al. Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease. Mov Disord. 2010;25:1246-52 pubmed publisher
  • western blot; human; 1:1000
Parachikova A, Vasilevko V, Cribbs D, LaFerla F, Green K. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010;21:527-42 pubmed publisher
  • immunohistochemistry; human; 1:500
Ryan D, Mastrangelo M, Narrow W, Sullivan M, Federoff H, Bowers W. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Mol Ther. 2010;18:1471-81 pubmed publisher
  • immunocytochemistry; rat; 1:10
  • western blot; rat; 1:75
Bertrand J, Sénéchal P, Zummo Soucy M, Plouffe V, Leclerc N. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. J Neurochem. 2010;114:1353-67 pubmed publisher
  • immunohistochemistry; mouse; 1:100
  • western blot; mouse; 1:1,000
Rodriguez Navarro J, Rodriguez L, Casarejos M, Solano R, Gomez A, Perucho J, et al. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol Dis. 2010;39:423-38 pubmed publisher
  • western blot; human; fig 5
Shiryaev N, Jouroukhin Y, Gozes I. 3R tau expression modifies behavior in transgenic mice. J Neurosci Res. 2010;88:2727-35 pubmed publisher
  • immunohistochemistry; mouse; 1:1,400-1:2,400
Kohler C, Bista P, Gotz J, Schroder H. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain Res. 2010;1347:111-24 pubmed publisher
  • western blot; human; 1:1000
Koike M, Green K, Blurton Jones M, LaFerla F. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010;177:300-10 pubmed publisher
  • immunohistochemistry; human; 1:100
Mohorko N, Repovs G, Popovic M, Kovacs G, Bresjanac M. Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples. J Neuropathol Exp Neurol. 2010;69:405-14 pubmed publisher
  • western blot; rat; 1:100-1:200
Bertrand J, Plouffe V, Senechal P, Leclerc N. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. 2010;168:323-34 pubmed publisher
  • immunohistochemistry; human
Bigio E, Mishra M, Hatanpaa K, White C, Johnson N, Rademaker A, et al. TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease. Acta Neuropathol. 2010;120:43-54 pubmed publisher
  • western blot; hamsters; 1:4,000
Wang G, Shi S, Gao C, Zhang B, Tian C, Dong C, et al. Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases. BMC Infect Dis. 2010;10:86 pubmed publisher
  • western blot; fruit fly
Iijima Ando K, Zhao L, Gatt A, Shenton C, Iijima K. A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Hum Mol Genet. 2010;19:1930-8 pubmed publisher
  • immunohistochemistry; rat; 1:200
Silverberg G, Miller M, Machan J, Johanson C, Caralopoulos I, Pascale C, et al. Amyloid and Tau accumulate in the brains of aged hydrocephalic rats. Brain Res. 2010;1317:286-96 pubmed publisher
  • western blot; human; 1:1000
Martinez Coria H, Green K, Billings L, Kitazawa M, Albrecht M, Rammes G, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010;176:870-80 pubmed publisher
  • immunohistochemistry; mouse
Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, et al. Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS ONE. 2009;4:e7931 pubmed publisher
  • immunohistochemistry; human; 1:1,000
Whitwell J, Jack C, Przybelski S, Parisi J, Senjem M, Boeve B, et al. Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis. Neurobiol Aging. 2011;32:1531-41 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; mouse; 1:250
Lopes J, Oliveira C, Agostinho P. Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5. Aging Cell. 2010;9:64-77 pubmed publisher
  • western blot; mouse
Grueninger F, Bohrmann B, Czech C, Ballard T, Frey J, Weidensteiner C, et al. Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. Neurobiol Dis. 2010;37:294-306 pubmed publisher
  • immunohistochemistry; domestic horse; 1:50
Capucchio M, Marquez M, Pregel P, Foradada L, Bravo M, Mattutino G, et al. Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies. J Comp Pathol. 2010;142:61-73 pubmed publisher
  • immunohistochemistry; human
Soontornniyomkij V, Lynch M, Mermash S, Pomakian J, Badkoobehi H, Clare R, et al. Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy. Brain Pathol. 2010;20:459-67 pubmed publisher
  • western blot; human; 1:1000
van Eersel J, Bi M, Ke Y, Hodges J, Xuereb J, Gregory G, et al. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna). 2009;116:1243-51 pubmed publisher
  • immunohistochemistry; human
Rahman A, Ting K, Cullen K, Braidy N, Brew B, Guillemin G. The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS ONE. 2009;4:e6344 pubmed publisher
  • western blot; mouse; 1:500
Wilcock D, Gharkholonarehe N, Van Nostrand W, Davis J, Vitek M, Colton C. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci. 2009;29:7957-65 pubmed publisher
  • immunohistochemistry; human; 1:2,000
McKee A, Cantu R, Nowinski C, Hedley Whyte E, Gavett B, Budson A, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009;68:709-35 pubmed publisher
  • western blot; human; 1:200
  • western blot; mouse; 1:200
Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. J Neuropathol Exp Neurol. 2009;68:503-14 pubmed publisher
  • western blot; mouse
Ittner L, Ke Y, Götz J. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem. 2009;284:20909-16 pubmed publisher
  • immunocytochemistry; human
Myung N, Zhu X, Kruman I, Castellani R, Petersen R, Siedlak S, et al. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordr). 2008;30:209-15 pubmed publisher
  • immunohistochemistry; human; 1:400
Simpson J, Ince P, Haynes L, Theaker R, Gelsthorpe C, Baxter L, et al. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2010;36:25-40 pubmed publisher
  • immunohistochemistry; mouse
Ohmi K, Kudo L, Ryazantsev S, Zhao H, Karsten S, Neufeld E. Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy. Proc Natl Acad Sci U S A. 2009;106:8332-7 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Bitner R, Nikkel A, Markosyan S, Otte S, Puttfarcken P, Gopalakrishnan M. Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. Brain Res. 2009;1265:65-74 pubmed publisher
  • immunohistochemistry; mouse
Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, et al. Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice. J Alzheimers Dis. 2009;16:371-88 pubmed publisher
  • immunohistochemistry; human; 1:3,750
Josephs K, Ahlskog J, Parisi J, Boeve B, Crum B, Giannini C, et al. Rapidly progressive neurodegenerative dementias. Arch Neurol. 2009;66:201-7 pubmed publisher
  • western blot; hamsters; 1:1000
Stieler J, Bullmann T, Kohl F, Barnes B, Arendt T. PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation. J Neural Transm (Vienna). 2009;116:345-50 pubmed publisher
  • immunohistochemistry; human
Shehadeh L, Mitsi G, Adi N, Bishopric N, Papapetropoulos S. Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects. Mov Disord. 2009;24:204-10 pubmed publisher
  • western blot; human; fig 4
Ojala J, Sutinen E, Salminen A, Pirttila T. Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells. J Neuroimmunol. 2008;205:86-93 pubmed publisher
  • western blot; fruit fly ; 1:2,000
Chatterjee S, Sang T, Lawless G, Jackson G. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet. 2009;18:164-77 pubmed publisher
  • immunocytochemistry; human; 1:1,000
Thakur A, Siedlak S, James S, Bonda D, Rao A, Webber K, et al. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. Int J Clin Exp Pathol. 2008;1:134-46 pubmed
  • immunohistochemistry; mouse; 1:500
  • immunohistochemistry; human; 1:500
Takahashi R, Capetillo Zarate E, Lin M, Milner T, Gouras G. Co-occurrence of Alzheimer's disease ß-amyloid and ? pathologies at synapses. Neurobiol Aging. 2010;31:1145-52 pubmed publisher
  • immunohistochemistry; human; 1:1,000
Jicha G, Parisi J, Dickson D, Cha R, Johnson K, Smith G, et al. Age and apoE associations with complex pathologic features in Alzheimer's disease. J Neurol Sci. 2008;273:34-9 pubmed publisher
  • immunohistochemistry; mouse; 1:100
  • western blot; mouse; 1:1,000
Rodriguez Navarro J, Gomez A, Rodal I, Perucho J, Martinez A, Furió V, et al. Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. Hum Mol Genet. 2008;17:3128-43 pubmed publisher
  • immunohistochemistry; human; 1:200
Sikorska B, Liberski P, Sobow T, Budka H, Ironside J. Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease. Neuropathol Appl Neurobiol. 2009;35:46-59 pubmed publisher
  • western blot; mouse
Lim J, Balastik M, Lee T, Nakamura K, Liou Y, Sun A, et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008;118:1877-89 pubmed publisher
  • immunocytochemistry; rat; 1:30
  • western blot; rat; 1:250
Resende R, Ferreiro E, Pereira C, Oliveira C. ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation. J Neurosci Res. 2008;86:2091-9 pubmed publisher
  • immunohistochemistry; mouse; 1:150
Wilcock D, Lewis M, Van Nostrand W, Davis J, Previti M, Gharkholonarehe N, et al. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci. 2008;28:1537-45 pubmed publisher
  • immunohistochemistry; rat
Hinners I, Hill A, Otto U, Michalsky A, Mack T, Striggow F. Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Mol Cell Neurosci. 2008;37:559-67 pubmed publisher
  • western blot; mouse
Matsuoka Y, Jouroukhin Y, Gray A, Ma L, Hirata Fukae C, Li H, et al. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther. 2008;325:146-53 pubmed publisher
  • western blot; mouse
Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, et al. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci. 2007;27:13635-48 pubmed
  • immunohistochemistry; human; 1:200
Preusser M, Kitzwoegerer M, Budka H, Brugger S. Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. Neuropathology. 2007;27:453-6 pubmed
  • immunohistochemistry; human; 1:1,000
Josephs K, Whitwell J, Ahmed Z, Shiung M, Weigand S, Knopman D, et al. Beta-amyloid burden is not associated with rates of brain atrophy. Ann Neurol. 2008;63:204-12 pubmed
  • immunohistochemistry; human
Piggott M, Ballard C, Rowan E, Holmes C, McKeith I, Jaros E, et al. Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline. Synapse. 2007;61:903-11 pubmed
  • immunohistochemistry; human
Ojala J, Alafuzoff I, Herukka S, van Groen T, Tanila H, Pirttila T. Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiol Aging. 2009;30:198-209 pubmed
  • immunohistochemistry; human; 1:100
Munoz D, Woulfe J, Kertesz A. Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia. Acta Neuropathol. 2007;114:347-57 pubmed
  • immunohistochemistry; human; fig 2B
Wiedau Pazos M, Wong E, Solomon E, Alarcon M, Geschwind D. Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice. Neurobiol Aging. 2009;30:14-21 pubmed
  • western blot; roundworm
  • western blot; rat
Brandt R, Gergou A, Wacker I, Fath T, Hutter H. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiol Aging. 2009;30:22-33 pubmed
  • western blot; rat
Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, et al. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007;104:9511-6 pubmed
  • immunohistochemistry; human
Evans T, Raina A, Delacourte A, Aprelikova O, Lee H, Zhu X, et al. BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. Int J Med Sci. 2007;4:140-5 pubmed
  • immunohistochemistry; mouse
  • western blot; mouse
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla F. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007;102:1053-63 pubmed
  • immunohistochemistry; mouse
  • western blot; mouse
Caccamo A, Oddo S, Tran L, LaFerla F. Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol. 2007;170:1669-75 pubmed
  • western blot; human; 1:1,000
Green K, Martinez Coria H, Khashwji H, Hall E, Yurko Mauro K, Ellis L, et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci. 2007;27:4385-95 pubmed
  • immunohistochemistry; human; 1:250
Leverenz J, Yu C, Montine T, Steinbart E, Bekris L, Zabetian C, et al. A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. Brain. 2007;130:1360-74 pubmed
  • immunohistochemistry; human; 1:1,000
Whitwell J, Jack C, Parisi J, Knopman D, Boeve B, Petersen R, et al. Rates of cerebral atrophy differ in different degenerative pathologies. Brain. 2007;130:1148-58 pubmed
  • immunohistochemistry; human; 1:1,000
Josephs K, Ahmed Z, Katsuse O, Parisi J, Boeve B, Knopman D, et al. Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations. J Neuropathol Exp Neurol. 2007;66:142-51 pubmed
  • immunohistochemistry; human; 1:1,000
Josephs K, Whitwell J, Parisi J, Knopman D, Boeve B, Geda Y, et al. Argyrophilic grains: a distinct disease or an additive pathology?. Neurobiol Aging. 2008;29:566-73 pubmed
  • western blot; fruit fly ; 1:50,000
Dias Santagata D, Fulga T, Duttaroy A, Feany M. Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J Clin Invest. 2007;117:236-45 pubmed
  • immunohistochemistry; human; 1:250
Wahle T, Thal D, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, et al. GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. J Neurosci. 2006;26:12838-46 pubmed
  • immunohistochemistry; human; 1:1,000
Barnes L, Schneider J, Boyle P, Bienias J, Bennett D. Memory complaints are related to Alzheimer disease pathology in older persons. Neurology. 2006;67:1581-5 pubmed
  • immunohistochemistry; mouse
  • western blot; mouse
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs D, LaFerla F. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006;281:39413-23 pubmed
  • immunohistochemistry; human; 1:500
Parachikova A, Agadjanyan M, Cribbs D, Blurton Jones M, Perreau V, Rogers J, et al. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging. 2007;28:1821-33 pubmed
  • immunohistochemistry; human; 1:1,000
Hu W, Murray J, Greenaway M, Parisi J, Josephs K. Cognitive impairment and celiac disease. Arch Neurol. 2006;63:1440-6 pubmed
  • immunohistochemistry; human; 1:1,000
Boeve B, Baker M, Dickson D, Parisi J, Giannini C, Josephs K, et al. Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain. 2006;129:3103-14 pubmed
  • western blot; rat
Farah C, Perreault S, Liazoghli D, Desjardins M, Anton A, Lauzon M, et al. Tau interacts with Golgi membranes and mediates their association with microtubules. Cell Motil Cytoskeleton. 2006;63:710-24 pubmed
  • immunohistochemistry; mouse
  • western blot; mouse; 1:1,000
Green K, Billings L, Roozendaal B, McGaugh J, LaFerla F. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006;26:9047-56 pubmed
  • immunohistochemistry; human; 1:1,000
Jicha G, Petersen R, Knopman D, Boeve B, Smith G, Geda Y, et al. Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. J Neuropathol Exp Neurol. 2006;65:602-9 pubmed
  • western blot; domestic rabbit; 1:100
Ghribi O, Larsen B, Schrag M, Herman M. High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol. 2006;200:460-7 pubmed
  • immunohistochemistry; human
Jicha G, Parisi J, Dickson D, Johnson K, Cha R, Ivnik R, et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol. 2006;63:674-81 pubmed
  • immunohistochemistry; human
Petersen R, Parisi J, Dickson D, Johnson K, Knopman D, Boeve B, et al. Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol. 2006;63:665-72 pubmed
  • western blot; human
Galas M, Dourlen P, Bégard S, Ando K, Blum D, Hamdane M, et al. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem. 2006;281:19296-304 pubmed
  • immunohistochemistry; cat; 1:500
Gunn Moore D, McVee J, Bradshaw J, Pearson G, Head E, Gunn Moore F. Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. J Feline Med Surg. 2006;8:234-42 pubmed
  • immunohistochemistry; human
Grudzien A, Shaw P, Weintraub S, Bigio E, Mash D, Mesulam M. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging. 2007;28:327-35 pubmed
  • western blot; rat; 1:100
Oka T, Tamada Y, Nakajima E, Shearer T, Azuma M. Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension. J Neurosci Res. 2006;83:1342-51 pubmed
  • immunohistochemistry; human; 1:1,000
Halliday G, Song Y, Creasey H, Morris J, Brooks W, Kril J. Neuropathology in the S305S tau gene mutation. Brain. 2006;129:E40 pubmed
  • immunohistochemistry; human
Piggott M, Ballard C, Dickinson H, McKeith I, Perry R, Perry E. Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia. Int J Neuropsychopharmacol. 2007;10:231-44 pubmed
  • immunohistochemistry; human
Papapetropoulos S, McCorquodale D, Gonzalez J, Jean Gilles L, Mash D. Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations. Parkinsonism Relat Disord. 2006;12:253-6 pubmed
  • immunocytochemistry; human
  • immunohistochemistry; human
Quintana C, Bellefqih S, Laval J, Guerquin Kern J, Wu T, Avila J, et al. Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol. 2006;153:42-54 pubmed
  • immunohistochemistry; human
Yang W, Ang L, Strong M. Tau protein aggregation in the frontal and entorhinal cortices as a function of aging. Brain Res Dev Brain Res. 2005;156:127-38 pubmed
  • immunohistochemistry; human; 1:10,000
Newman J, Rissman R, Sarsoza F, Kim R, Dick M, Bennett D, et al. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005;110:135-44 pubmed
  • western blot; rat
Sakaue M, Okazaki M, Hara S. Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Toxicology. 2005;213:97-106 pubmed
  • immunohistochemistry; rhesus macaque
Fukuda T, Shimizu J, Furuhata H, Abe T, Shimizu K, Oishi T, et al. Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates. Acta Neuropathol. 2005;110:145-50 pubmed
  • immunohistochemistry; human; 1:1,000
Knopman D, Boeve B, Parisi J, Dickson D, Smith G, Ivnik R, et al. Antemortem diagnosis of frontotemporal lobar degeneration. Ann Neurol. 2005;57:480-8 pubmed
  • immunohistochemistry; mouse; 1:200
Frasier M, Walzer M, McCarthy L, Magnuson D, Lee J, Haas C, et al. Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. Exp Neurol. 2005;192:274-87 pubmed
Delizannis A, Nonneman A, Tsering W, de Bondt A, van den Wyngaert I, Zhang B, et al. Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice. Acta Neuropathol Commun. 2021;9:150 pubmed publisher
Ismail M, Hassan M, Moawad S, Okba M, Ashour R, Fayek N, et al. Exploring the Antivirulence Activity of Pulverulentone A, a Phloroglucinol-Derivative from Callistemon citrinus Leaf Extract, against Multi-Drug Resistant Pseudomonas aeruginosa. Antibiotics (Basel). 2021;10: pubmed publisher
Zilova L, Weinhardt V, Tavhelidse T, Schlagheck C, Thumberger T, Wittbrodt J. Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development. elife. 2021;10: pubmed publisher
McMillan P, Strovas T, Baum M, Mitchell B, Eck R, Hendricks N, et al. Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease. Acta Neuropathol Commun. 2021;9:117 pubmed publisher
Costa S, Oliveira V, Serrano M, Pomba C, Couto I. Phenotypic and Molecular Traits of Staphylococcus coagulans Associated with Canine Skin Infections in Portugal. Antibiotics (Basel). 2021;10: pubmed publisher
Xia F, Ha Y, Shi S, Li Y, Li S, Luisi J, et al. Early alterations of neurovascular unit in the retina in mouse models of tauopathy. Acta Neuropathol Commun. 2021;9:51 pubmed publisher
Chan L, Gandhirajan A, Carias L, Dietrich M, Vadas O, Visentin R, et al. Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b. Nat Commun. 2021;12:1538 pubmed publisher
Lin Y, Liu C, Lee H, Chou M, Ke L, Chen C, et al. Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice. Sci Rep. 2021;11:6013 pubmed publisher
Bajracharya R, Brici D, Bodea L, Janowicz P, Götz J, Nisbet R. Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice. Acta Neuropathol Commun. 2021;9:42 pubmed publisher
Scheu A, Lim S, Metzner F, Mohammed S, Howarth M. NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins. Nat Commun. 2021;12:717 pubmed publisher
Stojakovic A, Chang S, Nesbitt J, Pichurin N, Ostroot M, Aikawa T, et al. Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice. J Alzheimers Dis. 2021;79:335-353 pubmed publisher
Wang Y, Liu Y, Nham A, Sherbaf A, Quach D, Yahya E, et al. Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment. Sci Adv. 2020;6: pubmed publisher
Yang T, Liu H, Tran K, Leng A, Massa S, Longo F. Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice. Acta Neuropathol Commun. 2020;8:156 pubmed publisher
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Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed publisher
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Ajit D, Trzeciakiewicz H, Tseng J, Wander C, Chen Y, Ajit A, et al. A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation. J Biol Chem. 2019;294:16698-16711 pubmed publisher
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón Sandoval J, et al. CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice. Brain. 2019;142:3243-3264 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
Phospho-Tau (Thr231) Monoclonal Antibody (AT180)
Catalog # :
MN1040
Quantity :
100 µg
Price :
US 536
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human, Rat
Applications :
ELISA: 2-10 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Western Blot: 1-5 µg/mL
Species :
Human, Rat
Clone :
AT180
Isotype :
IgG1, kappa
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Immunogen :
Partially purified human PHF-Tau
Format :
Liquid
Applications w/Dilutions :
ELISA: 2-10 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Western Blot: 1-5 µg/mL
Aliases :
AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA