Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Biotin

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Biotin

catalog :

MN1020B

quantity :

50 µg

price :

US 534

clonality :

monoclonal

host :

mouse

conjugate :

biotin

antigen modification :

phosphorylated

clone name :

AT8

reactivity :

hamsters, baboons, African green monkey, human, mouse, rat, chicken, cat, fruit fly , domestic rabbit, roundworm , domestic horse, rhesus macaque

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - free floating section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 447

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig 1j	Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt S, Vieira Saecker A, et al. NLRP3 inflammasome activation drives tau pathology. Nature. 2019;: pubmed publisher
immunohistochemistry - free floating section; mouse; loading ...; fig 5h	Gary C, Lam S, Herard A, Koch J, Petit F, Gipchtein P, et al. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta Neuropathol Commun. 2019;7:126 pubmed publisher
western blot; mouse; 1:200; loading ...; fig 2a	Kubo A, Misonou H, Matsuyama M, Nomori A, Wada Kakuda S, Takashima A, et al. Distribution of endogenous normal tau in the mouse brain. J Comp Neurol. 2019;527:985-998 pubmed publisher
immunohistochemistry; mouse; loading ...; fig 4c	Lang S, Harre U, Purohit P, Dietel K, Kienhöfer D, Hahn J, et al. Neurodegeneration Enhances the Development of Arthritis. J Immunol. 2017;198:2394-2402 pubmed publisher
immunohistochemistry; rat; 1:100; fig 6	Foxton R, Osborne A, Martin K, Ng Y, Shima D. Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism. Cell Death Dis. 2016;7:e2212 pubmed publisher
western blot; mouse; fig 11	Makani V, Jang Y, Christopher K, Judy W, Eckstein J, Hensley K, et al. BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR. PLoS ONE. 2016;11:e0149715 pubmed publisher
immunohistochemistry; human; fig 1	Puvenna V, Engeler M, Banjara M, Brennan C, Schreiber P, Dadas A, et al. Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy. Brain Res. 2016;1630:225-40 pubmed publisher
immunohistochemistry; human; 1:250; fig 6	Tousseyn T, Bajsarowicz K, SÃ¡nchez H, Gheyara A, Oehler A, Geschwind M, et al. Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes. J Neuropathol Exp Neurol. 2015;74:873-88 pubmed publisher
immunohistochemistry; mouse; 1:400; fig 10	Liu P, Paulson J, Forster C, Shapiro S, Ashe K, Zahs K. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS ONE. 2015;10:e0126317 pubmed publisher
immunocytochemistry; human; 1:800	Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, et al. Mutant huntingtin alters Tau phosphorylation and subcellular distribution. Hum Mol Genet. 2015;24:76-85 pubmed publisher
immunohistochemistry; human; 1:1000	Lasagna Reeves C, Sengupta U, Castillo Carranza D, Gerson J, Guerrero Munoz M, Troncoso J, et al. The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathol Commun. 2014;2:56 pubmed publisher
western blot; human; 1:1000 immunohistochemistry; mouse; 1:400	Jiang T, Yu J, Zhu X, Zhang Q, Cao L, Wang H, et al. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. 2014;85:121-30 pubmed publisher
western blot; mouse	Garcia Mesa Y, Pareja Galeano H, Bonet Costa V, Revilla S, Gómez Cabrera M, Gambini J, et al. Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms. Psychoneuroendocrinology. 2014;45:154-66 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:500	Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher
western blot; rat; 1:1000	Lin L, Yang S, Chu J, Wang L, Ning L, Zhang T, et al. Region-specific expression of tau, amyloid-? protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41:1149-63 pubmed publisher
immunohistochemistry; mouse; 1:50 western blot; mouse	Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed publisher
immunohistochemistry; mouse western blot; mouse	Kondadi A, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, et al. Loss of the m-AAA protease subunit AFG?L? causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014;33:1011-26 pubmed publisher
immunohistochemistry; human; 1:200	Pan J, Lee M, Honig L, Vonsattel J, Faust P, Louis E. Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?. Parkinsonism Relat Disord. 2014;20:655-8 pubmed publisher
immunohistochemistry; mouse; 1:100 ELISA; mouse; 1:250 western blot; mouse; 1:1000	Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed publisher
western blot; human; 1:2000	Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed publisher
immunohistochemistry; mouse; 1:1000	Palm R, Chang J, Blair J, Garcia Mesa Y, Lee H, Castellani R, et al. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. J Neurochem. 2014;130:115-25 pubmed publisher
immunohistochemistry; mouse	Kim H, Chang K, Ha T, Kim J, Ha S, Shin K, et al. S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model. PLoS ONE. 2014;9:e88924 pubmed publisher
immunohistochemistry; human; 1:1000	Dalby N, Volbracht C, Helboe L, Larsen P, Jensen H, Egebjerg J, et al. Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy. J Alzheimers Dis. 2014;40:429-42 pubmed publisher
western blot; mouse; 1:1000	Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed publisher
western blot; mouse; 1:200	Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:1000	Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed publisher
western blot; mouse; 1:1000	Torres M, Price S, Fiol deRoque M, Marcilla Etxenike A, Ahyayauch H, Barcelo Coblijn G, et al. Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. Biochim Biophys Acta. 2014;1838:1680-92 pubmed publisher
immunohistochemistry; mouse; 1:200	Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed publisher
western blot; mouse	Pehar M, Ko M, Li M, Scrable H, Puglielli L. P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion. Aging Cell. 2014;13:449-56 pubmed publisher
immunohistochemistry; mouse; 1:50	Huang X, Qian Z, He X, Gong Q, Wu K, Jiang L, et al. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol Aging. 2014;35:1045-54 pubmed publisher
immunohistochemistry; mouse; 1:500 western blot; mouse; 1:500	Graham D, Gray A, Joyce J, Yu D, O Moore J, Carlson G, et al. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014;79:307-13 pubmed publisher
western blot; mouse; 1:250	Trujillo Estrada L, Jimenez S, De Castro V, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology. Acta Neuropathol Commun. 2013;1:73 pubmed publisher
immunohistochemistry; human; 1:2000	Yanagisawa D, Taguchi H, Ibrahim N, Morikawa S, Shiino A, Inubushi T, et al. Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain. J Alzheimers Dis. 2014;39:617-31 pubmed publisher
western blot; human; 1:1000	Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed publisher
immunohistochemistry; human; 1:1000	Blennerhassett R, Lillo P, Halliday G, Hodges J, Kril J. Distribution of pathology in frontal variant Alzheimer's disease. J Alzheimers Dis. 2014;39:63-70 pubmed publisher
immunohistochemistry; human; 1:100	Nölle A, van Haastert E, Zwart R, Hoozemans J, Scheper W. Ubiquilin 2 is not associated with tau pathology. PLoS ONE. 2013;8:e76598 pubmed publisher
immunohistochemistry; mouse; 1:1000	Hensley K, Gabbita S, Venkova K, Hristov A, Johnson M, Eslami P, et al. A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2013;72:955-69 pubmed publisher
western blot; human; 1:1000	Natunen T, Parrado A, Helisalmi S, Pursiheimo J, Sarajärvi T, Mäkinen P, et al. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J Alzheimers Dis. 2013;37:217-32 pubmed publisher
immunohistochemistry; rat; 1:1000	Levarska L, Zilka N, Jadhav S, Neradil P, Novak M. Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease. J Alzheimers Dis. 2013;37:569-77 pubmed publisher
immunohistochemistry; mouse	Mannix R, Meehan W, MANDEVILLE J, Grant P, Gray T, Berglass J, et al. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013;74:65-75 pubmed publisher
immunohistochemistry; human	Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed publisher
immunohistochemistry; human	Anumala U, Gu J, Lo Monte F, Kramer T, Heyny von Haußen R, Hölzer J, et al. Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains. Bioorg Med Chem. 2013;21:5139-44 pubmed publisher
immunohistochemistry; mouse; 1:1000	Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, et al. The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e68722 pubmed publisher
western blot; human; 1:2000	Chen R, Chang W, Lin Y, Cheng P, Chen Y. Alzheimer's amyloid-? oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway. ACS Chem Neurosci. 2013;4:1287-96 pubmed publisher
immunohistochemistry; human; 1:1000	Barron A, Garcia Segura L, Caruso D, Jayaraman A, Lee J, Melcangi R, et al. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci. 2013;33:8891-7 pubmed publisher
immunohistochemistry; human western blot; human	Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, et al. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS ONE. 2013;8:e62459 pubmed publisher
immunohistochemistry; rat; 1:100 ELISA; rat; 1:1000 western blot; rat; 1:1000	Hawkins B, Krishnamurthy S, Castillo Carranza D, Sengupta U, Prough D, Jackson G, et al. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem. 2013;288:17042-50 pubmed publisher
western blot; mouse; 1:200	Tackenberg C, Grinschgl S, Trutzel A, Santuccione A, Frey M, Konietzko U, et al. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 2013;4:e608 pubmed publisher
immunohistochemistry; human; 1:100	Manczak M, Reddy P. Abnormal interaction of oligomeric amyloid-? with phosphorylated tau: implications to synaptic dysfunction and neuronal damage. J Alzheimers Dis. 2013;36:285-95 pubmed publisher
immunohistochemistry; human	Gu J, Anumala U, Heyny von Haußen R, Hölzer J, Goetschy Meyer V, Mall G, et al. Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium. ChemMedChem. 2013;8:891-7 pubmed publisher
immunohistochemistry; human; 1:50 western blot; human; 1:2000	Ando K, Brion J, Stygelbout V, Suain V, Authelet M, Dedecker R, et al. Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 2013;125:861-78 pubmed publisher
immunohistochemistry; human	Iranzo A, Tolosa E, Gelpi E, Molinuevo J, Valldeoriola F, Serradell M, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12:443-53 pubmed publisher
western blot; human	Ozdemir A, Rom I, Kovalevich J, Yen W, Adiga R, Dave R, et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS ONE. 2013;8:e58232 pubmed publisher
immunohistochemistry; human	Varges D, Schulz Schaeffer W, Wemheuer W, Damman I, Schmitz M, Cramm M, et al. Spongiform encephalopathy in siblings with no evidence of protease-resistant prion protein or a mutation in the prion protein gene. J Neurol. 2013;260:1871-9 pubmed publisher
immunohistochemistry; human; 1:1000	Josephs K, Dickson D, Murray M, Senjem M, Parisi J, Petersen R, et al. Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia. Brain Lang. 2013;127:127-34 pubmed publisher
immunohistochemistry; human; 1:2000	Feldengut S, Del Tredici K, Braak H. Paraffin sections of 70-100 ?m: a novel technique and its benefits for studying the nervous system. J Neurosci Methods. 2013;215:241-4 pubmed publisher
western blot; mouse	Geekiyanage H, Upadhye A, Chan C. Inhibition of serine palmitoyltransferase reduces A? and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease. Neurobiol Aging. 2013;34:2037-51 pubmed publisher
western blot; mouse; 1:1000	Alonso E, Vale C, Vieytes M, Botana L. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and ?-amyloid pathology. ACS Chem Neurosci. 2013;4:1062-70 pubmed publisher
immunohistochemistry; human	Bigio E. Making the diagnosis of frontotemporal lobar degeneration. Arch Pathol Lab Med. 2013;137:314-25 pubmed publisher
immunohistochemistry; mouse	Garringer H, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS ONE. 2013;8:e56426 pubmed publisher
immunohistochemistry; mouse; 1:1000	Zufferey V, Vallet P, Moeri M, Moulin Sallanon M, Piotton F, Marin P, et al. Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice. Brain Res Bull. 2013;94:17-22 pubmed publisher
immunohistochemistry; mouse	Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, et al. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013;12:257-68 pubmed publisher
western blot; mouse	Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed publisher
western blot; mouse; 1:1000	Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed publisher
immunohistochemistry; human; 1:200	Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed publisher
immunohistochemistry; human; 1:50	Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed publisher
western blot; mouse	Liu D, Pitta M, Jiang H, Lee J, Zhang G, Chen X, et al. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol Aging. 2013;34:1564-80 pubmed publisher
immunohistochemistry; mouse; 1:500	Yao J, Ho D, Calingasan N, Pipalia N, Lin M, Beal M. Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. J Exp Med. 2012;209:2501-13 pubmed publisher
immunohistochemistry; human; 1:500	Hong Y, Chan C, Kwon I, Li X, Song M, Lee H, et al. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci. 2012;32:17262-72 pubmed publisher
immunohistochemistry; mouse; 1:45	ATTAR A, Ripoli C, Riccardi E, Maiti P, Li Puma D, Liu T, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012;135:3735-48 pubmed publisher
western blot; rat; 0.2 ug/ml	Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid ?-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed publisher
immunohistochemistry; mouse; 1:500 western blot; mouse; 1:1000	Torres M, Jimenez S, Sanchez Varo R, Navarro V, Trujillo Estrada L, Sanchez Mejias E, et al. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Mol Neurodegener. 2012;7:59 pubmed publisher
immunohistochemistry; human; 1:1000	Kovari E, Herrmann F, Hof P, Bouras C. The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease. Neuropathol Appl Neurobiol. 2013;39:498-509 pubmed publisher
western blot; human; 1:1000	Yokota T, Akatsu H, Miyauchi T, Heese K. Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain. FEBS Lett. 2012;586:4357-61 pubmed publisher
immunohistochemistry; mouse	Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönneke H, Jordan S, et al. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS Genet. 2012;8:e1003021 pubmed publisher
western blot; rat; 1:1000	Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed publisher
immunohistochemistry; human	Pirker S, Perju Dumbrava L, Kovacs G, Traub Weidinger T, Asenbaum S, Pirker W. Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration. Parkinsonism Relat Disord. 2013;19:222-6 pubmed publisher
immunoprecipitation; human immunocytochemistry; human western blot; human	López Menéndez C, Gamir Morralla A, Jurado Arjona J, Higuero A, Campanero M, Ferrer I, et al. Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. Hum Mol Genet. 2013;22:466-82 pubmed publisher
immunohistochemistry; human; 1:200 western blot; human; 1:500	Choi S, Aid S, Caracciolo L, Minami S, Niikura T, Matsuoka Y, et al. Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. J Neurochem. 2013;124:59-68 pubmed publisher
immunohistochemistry; human; 1:250	Harris J, Koyama A, Maeda S, Ho K, Devidze N, Dubal D, et al. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS ONE. 2012;7:e45881 pubmed publisher
immunohistochemistry; mouse	Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed publisher
western blot; mouse	Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall G, et al. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. J Nutr Biochem. 2013;24:360-70 pubmed publisher
western blot; human	van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans C. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neurosci Lett. 2012;528:104-9 pubmed publisher
immunohistochemistry; human; 0.5 ug/ml	Britschgi M, Takeda Uchimura Y, Rockenstein E, Johns H, Masliah E, Wyss Coray T. Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice. J Neuroinflammation. 2012;9:220 pubmed publisher
immunohistochemistry; mouse; 1:10	Capsoni S, Carlo A, Vignone D, Amato G, Criscuolo C, Willnow T, et al. SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;33:357-71 pubmed publisher
immunohistochemistry; mouse; 1:500	Mewes A, Franke H, Singer D. Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies. PLoS ONE. 2012;7:e45017 pubmed publisher
immunohistochemistry; human; 1:500	Tang J, Mardini F, Janik L, Garrity S, Li R, Bachlani G, et al. Modulation of murine Alzheimer pathogenesis and behavior by surgery. Ann Surg. 2013;257:439-48 pubmed publisher
immunohistochemistry; human; 1:500	Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, et al. Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice. Hum Mol Genet. 2012;21:5091-105 pubmed publisher
immunohistochemistry; human	Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, et al. Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and ?-amyloid plaques in Alzheimer's disease models. J Med Chem. 2012;55:9170-80 pubmed publisher
western blot; human	Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, et al. Hyperphosphorylation of Tau induced by naturally secreted amyloid-? at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3? signaling pathway. J Biol Chem. 2012;287:35222-33 pubmed publisher
immunohistochemistry; human; 1:200	Gelpi E, Lladó A, Clarimon J, Rey M, Rivera R, Ezquerra M, et al. Phenotypic variability within the inclusion body spectrum of basophilic inclusion body disease and neuronal intermediate filament inclusion disease in frontotemporal lobar degenerations with FUS-positive inclusions. J Neuropathol Exp Neurol. 2012;71:795-805 pubmed publisher
western blot; mouse	Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed publisher
immunohistochemistry; human; 1:200	Gelpi E, Soler Insa J, Parchi P, Saverioni D, Yague J, Nos C, et al. Atypical neuropathological sCJD-MM phenotype with abundant white matter Kuru-type plaques sparing the cerebellar cortex. Neuropathology. 2013;33:204-8 pubmed publisher
immunocytochemistry; human; 1:100	Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed publisher
immunohistochemistry; human; 1:2000	Colom Cadena M, Gelpi E, Marti M, Charif S, Dols Icardo O, Blesa R, et al. MAPT H1 haplotype is associated with enhanced ?-synuclein deposition in dementia with Lewy bodies. Neurobiol Aging. 2013;34:936-42 pubmed publisher
western blot; mouse	Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed publisher
western blot; mouse	Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed publisher
immunohistochemistry; mouse; 1:200	Julien C, Marcouiller F, Bretteville A, El Khoury N, Baillargeon J, Hébert S, et al. Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation. PLoS ONE. 2012;7:e40020 pubmed publisher
western blot; human	Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed publisher
immunohistochemistry; mouse; 1:10	Capsoni S, Marinelli S, Ceci M, Vignone D, Amato G, Malerba F, et al. Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice. PLoS ONE. 2012;7:e37555 pubmed publisher
immunohistochemistry; human; 1:200	Schauer T, Lochner M, Kovacs G. Nigral Tau pathology and striatal amyloid-? deposition does not correlate with striatal dopamine deficit in Alzheimer's disease. J Neural Transm (Vienna). 2012;119:1545-9 pubmed publisher
immunohistochemistry; mouse	Barten D, Fanara P, Andorfer C, Hoque N, Wong P, Husted K, et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci. 2012;32:7137-45 pubmed publisher
western blot; mouse; 1:500	Herzig M, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, et al. High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain. PLoS ONE. 2012;7:e36581 pubmed publisher
western blot; mouse; 1:500	Cancino G, Miller F, Kaplan D. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013;34:387-99 pubmed publisher
immunohistochemistry; human; 1:500	Mustroph M, King M, Klein R, Ramirez J. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behav Brain Res. 2012;233:141-8 pubmed publisher
immunohistochemistry; mouse; 1:50	Petratos S, Ozturk E, Azari M, Kenny R, Lee J, Magee K, et al. Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation. Brain. 2012;135:1794-818 pubmed publisher
western blot; mouse	Chen C, Weng Y, Chien K, Lin K, Yeh T, Cheng Y, et al. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ. 2012;19:1623-33 pubmed publisher
immunohistochemistry; human; 1:200	Kapás I, Majtenyi K, Töro K, Keller E, Voigtlander T, Kovacs G. Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. Metab Brain Dis. 2012;27:231-5 pubmed publisher
western blot; human; 1:500	Van der Jeugd A, HochgrÃ¤fe K, Ahmed T, Decker J, Sydow A, Hofmann A, et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol. 2012;123:787-805 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:200	Joshi Y, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis. 2012;31:167-76 pubmed publisher
western blot; African green monkey	Matsushima T, Saito Y, Elliott J, Iijima Ando K, Nishimura M, Kimura N, et al. Membrane-microdomain localization of amyloid ?-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. J Biol Chem. 2012;287:19715-24 pubmed publisher
immunohistochemistry; human; 1:150	Fodero Tavoletti M, Brockschnieder D, Villemagne V, Martin L, Connor A, Thiele A, et al. In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer. Nucl Med Biol. 2012;39:1042-8 pubmed publisher
immunohistochemistry; human; 1:2000	Braak H, Thal D, Matschke J, Ghebremedhin E, Del Tredici K. Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiol Aging. 2013;34:286-97 pubmed publisher
immunohistochemistry; human; 1:800	Talbot K, Wang H, Kazi H, Han L, Bakshi K, Stucky A, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122:1316-38 pubmed publisher
immunohistochemistry; mouse; 1:1000	Carvalho C, Cardoso S, Correia S, Santos R, Santos M, Baldeiras I, et al. Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes. 2012;61:1234-42 pubmed publisher
immunohistochemistry; human; 1:1000	Clausen A, Xu X, Bi X, Baudry M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J Alzheimers Dis. 2012;30:183-208 pubmed publisher
immunohistochemistry; human; 1:200	Woehrer A, Laszlo L, Finsterer J, Stollberger C, Furtner J, Rinner W, et al. Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia. Acta Neuropathol. 2012;124:583-91 pubmed publisher
western blot; rat; 1:1000	Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed publisher
immunocytochemistry; rat	Zago W, Buttini M, Comery T, Nishioka C, Gardai S, Seubert P, et al. Neutralization of soluble, synaptotoxic amyloid ? species by antibodies is epitope specific. J Neurosci. 2012;32:2696-702 pubmed publisher
immunohistochemistry; human western blot; human	Matsuki T, Zaka M, Guerreiro R, van der Brug M, Cooper J, Cookson M, et al. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PLoS ONE. 2012;7:e31152 pubmed publisher
western blot; human	Löffler T, Flunkert S, Taub N, Schofield E, Ward M, Windisch M, et al. Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci. 2012;47:192-203 pubmed publisher
immunohistochemistry; mouse; 1:300 western blot; mouse; 1:500	Sudduth T, Wilson J, Everhart A, Colton C, Wilcock D. Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS ONE. 2012;7:e31993 pubmed publisher
western blot; human	Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed publisher
immunohistochemistry; mouse; 1:100	Sundaram J, Chan E, Poore C, Pareek T, Cheong W, Shui G, et al. Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. J Neurosci. 2012;32:1020-34 pubmed publisher
immunohistochemistry; human; 1:1000	Lasagna Reeves C, Castillo Carranza D, Sengupta U, Sarmiento J, Troncoso J, Jackson G, et al. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J. 2012;26:1946-59 pubmed publisher
immunohistochemistry; human; 1:500	Giustiniani J, Sineus M, Sardin E, Dounane O, Panchal M, Sazdovitch V, et al. Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17. J Alzheimers Dis. 2012;29:471-83 pubmed publisher
immunohistochemistry; human; 1:200	Venkataramani V, Wirths O, Budka H, Hartig W, Kovacs G, Bayer T. Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-? in a fraction of amyloid-? deposits in Alzheimer's disease without cross-reactivity with other protein aggregates. J Alzheimers Dis. 2012;29:361-71 pubmed publisher
immunohistochemistry; human; 1:200	Stefanits H, Budka H, Kovacs G. Asymmetry of neurodegenerative disease-related pathologies: a cautionary note. Acta Neuropathol. 2012;123:449-52 pubmed publisher
western blot; mouse; 1:1000	Garcia Mesa Y, Gimenez Llort L, Lopez L, Venegas C, Cristofol R, Escames G, et al. Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse. Neurobiol Aging. 2012;33:1124.e13-29 pubmed publisher
immunohistochemistry; human; 1:200	Okamoto Y, Yamamoto T, Kalaria R, Senzaki H, Maki T, Hase Y, et al. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2012;123:381-94 pubmed publisher
western blot; rat	Krüger U, Wang Y, Kumar S, Mandelkow E. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging. 2012;33:2291-305 pubmed publisher
immunohistochemistry; human; 1:100	Perez S, Getova D, He B, Counts S, Geula C, Désiré L, et al. Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease. Am J Pathol. 2012;180:526-40 pubmed publisher
immunocytochemistry; mouse; 1:100	Manaye K, Mouton P, Xu G, Drew A, Lei D, Sharma Y, et al. Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. Age (Dordr). 2013;35:139-47 pubmed publisher
immunohistochemistry; baboons; 1:1000 immunohistochemistry; African green monkey; 1:1000	Ndung u M, Hartig W, Wegner F, Mwenda J, Low R, Akinyemi R, et al. Cerebral amyloid ?(42) deposits and microvascular pathology in ageing baboons. Neuropathol Appl Neurobiol. 2012;38:487-99 pubmed publisher
immunocytochemistry; human; 1:500	Morawski M, Brückner G, Jäger C, Seeger G, Matthews R, Arendt T. Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology. Brain Pathol. 2012;22:547-61 pubmed publisher
western blot; rat; 1:500	Li L, Zhang Z, Holscher C, Gao C, Jiang Y, Liu Y. (Val?) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur J Pharmacol. 2012;674:280-6 pubmed publisher
immunohistochemistry; mouse; 1:1000	Nijholt D, van Haastert E, Rozemuller A, Scheper W, Hoozemans J. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol. 2012;226:693-702 pubmed publisher
immunohistochemistry; human; 1:2000 western blot; human	Kitazawa M, Cheng D, Tsukamoto M, Koike M, Wes P, Vasilevko V, et al. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ?-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011;187:6539-49 pubmed publisher
immunohistochemistry; mouse; 1:50	Cuadrado Tejedor M, Ricobaraza A, Frechilla D, Franco R, Pérez Mediavilla A, Garcia Osta A. Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice. J Alzheimers Dis. 2012;28:567-78 pubmed publisher
immunohistochemistry; human; 1:500 western blot; human; 1:500	Sanchez Varo R, Trujillo Estrada L, Sanchez Mejias E, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus. Acta Neuropathol. 2012;123:53-70 pubmed publisher
immunohistochemistry; rhesus macaque; 1:450	Piccardo P, Cervenak J, Yakovleva O, Gregori L, Pomeroy K, Cook A, et al. Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology. J Comp Pathol. 2012;147:84-93 pubmed publisher
immunohistochemistry; human	Saing T, Dick M, Nelson P, Kim R, Cribbs D, Head E. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012;29:1054-70 pubmed publisher
immunocytochemistry; human; 1:1000 immunohistochemistry; human; 1:1000	Wilhelmus M, de Jager M, Rozemuller A, Brevé J, Bol J, Eckert R, et al. Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies. J Pathol. 2012;226:132-42 pubmed publisher
western blot; mouse; 1:500	Li X, Kumar Y, Zempel H, Mandelkow E, Biernat J, Mandelkow E. Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J. 2011;30:4825-37 pubmed publisher
immunohistochemistry; human; 1:200	Antonell A, Gelpi E, Sanchez Valle R, Martinez R, Molinuevo J, Lladó A. Breakpoint sequence analysis of an A?PP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy. J Alzheimers Dis. 2012;28:303-8 pubmed publisher
immunohistochemistry; human; 1:250	McMillan P, Kraemer B, Robinson L, Leverenz J, Raskind M, Schellenberg G. Truncation of tau at E391 promotes early pathologic changes in transgenic mice. J Neuropathol Exp Neurol. 2011;70:1006-19 pubmed publisher
immunohistochemistry; human; 1:2000	Braak H, Thal D, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol. 2011;70:960-9 pubmed publisher
immunohistochemistry; human; 1:500	Elipenahli C, Stack C, Jainuddin S, Gerges M, Yang L, Starkov A, et al. Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. J Alzheimers Dis. 2012;28:173-82 pubmed publisher
immunohistochemistry; mouse	Castellani R, Gupta Y, Sheng B, Siedlak S, Harris P, Coller J, et al. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Lab Invest. 2011;91:1777-86 pubmed publisher
western blot; human; 1:1000	Ambegaokar S, Jackson G. Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet. 2011;20:4947-77 pubmed publisher
western blot; human; 1:1000	Khandelwal P, Dumanis S, Herman A, Rebeck G, Moussa C. Wild type and P301L mutant Tau promote neuro-inflammation and ?-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci. 2012;49:44-53 pubmed publisher
immunohistochemistry; mouse; 1:1000	Li L, Cheung T, Chen J, Herrup K. A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death. Int J Alzheimers Dis. 2011;2011:171464 pubmed publisher
western blot; human; 1:1000	Alonso E, Vale C, Vieytes M, LaFerla F, Gimenez Llort L, Botana L. 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular A? and hyperphosphorylated tau in vitro. Neurochem Int. 2011;59:1056-65 pubmed publisher
immunohistochemistry; human	Wilhelmus M, Bol J, van Haastert E, Rozemuller A, Bu G, Drukarch B, et al. Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. Am J Pathol. 2011;179:2152-6 pubmed publisher
immunohistochemistry; human; 1:500	Xue Q, Streit W. Microglial pathology in Down syndrome. Acta Neuropathol. 2011;122:455-66 pubmed publisher
immunocytochemistry; human western blot; human	Emmer K, Waxman E, Covy J, Giasson B. E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. J Biol Chem. 2011;286:35104-18 pubmed publisher
western blot; mouse; 1:100	Sheppard O, Plattner F, Rubin A, Slender A, Linehan J, Brandner S, et al. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiol Aging. 2012;33:828.e31-44 pubmed publisher
ELISA; mouse western blot; mouse; 1:1000	Chai X, Wu S, Murray T, Kinley R, Cella C, Sims H, et al. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J Biol Chem. 2011;286:34457-67 pubmed publisher
western blot; human; 1:250	Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, et al. Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J. 2011;25:4063-72 pubmed publisher
western blot; mouse; 1:500	Cho S, Sun B, Zhou Y, Kauppinen T, Halabisky B, Wes P, et al. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem. 2011;286:32713-22 pubmed publisher
immunohistochemistry; mouse; 1:1000	Panaite P, Kielar M, Kraftsik R, Gourdon G, Kuntzer T, Barakat Walter I. Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice. J Neuropathol Exp Neurol. 2011;70:678-85 pubmed publisher
immunohistochemistry; hamsters; 1:20	Gerhauser I, Wohlsein P, Ernst H, Germann P, Baumgartner W. Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters. Neurobiol Aging. 2012;33:1716-9 pubmed publisher
western blot; mouse western blot; human	Minami S, Clifford T, HOE H, Matsuoka Y, Rebeck G. Fyn knock-down increases A?, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012;33:825.e15-24 pubmed publisher
immunocytochemistry; chicken western blot; chicken	Whiteman I, Minamide L, Goh D, Bamburg J, Goldsbury C. Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes. PLoS ONE. 2011;6:e20878 pubmed publisher
immunohistochemistry; human; 1:1000	Kanaan N, Morfini G, LaPointe N, Pigino G, Patterson K, Song Y, et al. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci. 2011;31:9858-68 pubmed publisher
immunohistochemistry; human; 1:200	Martínez Sáez E, Gelpi E, Rey M, Ferrer I, Ribalta T, Botta Orfila T, et al. Hirano body-rich subtypes of Creutzfeldt-Jakob disease. Neuropathol Appl Neurobiol. 2012;38:153-61 pubmed publisher
immunohistochemistry; mouse western blot; mouse	Roe A, Staup M, Serrats J, Sawchenko P, Rissman R. Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci. 2011;34:448-56 pubmed publisher
immunohistochemistry; human; 1:100	Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K. Immunohistochemical characterization of ?-secretase activating protein expression in Alzheimer's disease brains. Neuropathol Appl Neurobiol. 2012;38:132-41 pubmed publisher
immunohistochemistry; human; 1 ug/ml western blot; human; 1:1000	Tran H, LaFerla F, Holtzman D, Brody D. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-? accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011;31:9513-25 pubmed publisher
western blot; human; 1:250	Silva D, Esteves A, Arduino D, Oliveira C, Cardoso S. Amyloid-?-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway. J Alzheimers Dis. 2011;26:565-81 pubmed publisher
immunohistochemistry; human	Rodriguez Diehl R, Rey M, Gironell A, Martínez Sáez E, Ferrer I, Sanchez Valle R, et al. "Preclinical" MSA in definite Creutzfeldt-Jakob disease. Neuropathology. 2012;32:158-63 pubmed publisher
immunohistochemistry; human	Stone J, Siedlak S, Tabaton M, Hirano A, Castellani R, Santocanale C, et al. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. J Neuropathol Exp Neurol. 2011;70:578-87 pubmed publisher
immunocytochemistry; mouse	Goodwin J, Zhang J, Gonzalez D, Albinsson S, Geller D. Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension. J Hypertens. 2011;29:1347-56 pubmed publisher
western blot; mouse; 1:1000	Cuadrado Tejedor M, Hervias I, Ricobaraza A, Puerta E, Pérez Roldán J, García Barroso C, et al. Sildenafil restores cognitive function without affecting ?-amyloid burden in a mouse model of Alzheimer's disease. Br J Pharmacol. 2011;164:2029-41 pubmed publisher
immunohistochemistry; human; 1:1000	Engmann O, Hortobagyi T, Thompson A, Guadagno J, Troakes C, Soriano S, et al. Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease. Biol Psychiatry. 2011;70:159-68 pubmed publisher
immunocytochemistry; human western blot; human	Waxman E, Giasson B. Induction of intracellular tau aggregation is promoted by ?-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. J Neurosci. 2011;31:7604-18 pubmed publisher
western blot; human	Copenhaver P, Anekonda T, Musashe D, Robinson K, Ramaker J, Swanson T, et al. A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug. Dis Model Mech. 2011;4:634-48 pubmed publisher
immunohistochemistry; human; 1:200	Belarbi K, Burnouf S, Fernandez Gomez F, Laurent C, Lestavel S, Figeac M, et al. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiol Dis. 2011;43:486-94 pubmed publisher
immunohistochemistry; human; 1:200	Rusina R, Kovacs G, Fiala J, Hort J, Ridzon P, Holmerová I, et al. FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases. BMC Neurol. 2011;11:50 pubmed publisher
immunohistochemistry; domestic rabbit; 1:500	Sparks D, Ziolkowski C, Lawmaster T, Martin T. Influence of water quality on cholesterol-induced tau pathology: preliminary data. Int J Alzheimers Dis. 2011;2011:987023 pubmed publisher
western blot; human	Orejana L, Barros Miñones L, Jordan J, Puerta E, Aguirre N. Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model. Neurobiol Aging. 2012;33:625.e11-20 pubmed publisher
immunohistochemistry; human; 1:500	Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, et al. Fronto-temporal lobar degeneration: neuropathology in 60 cases. J Neural Transm (Vienna). 2011;118:753-64 pubmed publisher
immunohistochemistry; rat; 1:500 western blot; rat; 1:500	Castro Álvarez J, Gutierrez Vargas J, Darnaudéry M, Cardona Gómez G. ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia. Behav Neurosci. 2011;125:465-72 pubmed publisher
immunohistochemistry; human; 1:200 western blot; human; 1:1000	Chen L, Xiong Y, Kong F, Qu M, Wang Q, Chen X, et al. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012;120:157-64 pubmed publisher
immunohistochemistry; human	Gaig C, Valldeoriola F, Gelpi E, Ezquerra M, Llufriu S, Buongiorno M, et al. Rapidly progressive diffuse Lewy body disease. Mov Disord. 2011;26:1316-23 pubmed publisher
western blot; rat; 1:1000	Ferreira A, Bigio E. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol Med. 2011;17:676-85 pubmed publisher
immunohistochemistry; human; 1:200 western blot; human; 1:500	Kovacs G, Molnár K, Laszlo L, Strobel T, Botond G, Hönigschnabl S, et al. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol. 2011;122:205-22 pubmed publisher
immunohistochemistry; human; 1:300	Hagen M, Murrell J, Delisle M, Andermann E, Andermann F, Guiot M, et al. Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene. Brain Pathol. 2011;21:575-82 pubmed publisher
immunohistochemistry; mouse	Maeda J, Zhang M, Okauchi T, Ji B, Ono M, Hattori S, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci. 2011;31:4720-30 pubmed publisher
immunocytochemistry; rat; 1:200 western blot; rat	Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe D. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011;108:5819-24 pubmed publisher
western blot; mouse; 1:1,000	Koike M, Garcia F, Kitazawa M, Green K, LaFerla F. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011;495:55-9 pubmed publisher
western blot; human; 1:1000	Green K, Khashwji H, Estrada T, LaFerla F. ST101 induces a novel 17 kDa APP cleavage that precludes A? generation in vivo. Ann Neurol. 2011;69:831-44 pubmed publisher
immunohistochemistry; human; 1:250	Jayadev S, Nochlin D, Poorkaj P, Steinbart E, Mastrianni J, Montine T, et al. Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Ann Neurol. 2011;69:712-20 pubmed publisher
immunohistochemistry; human; 1:1000	Glöckner F, Meske V, Lutjohann D, Ohm T. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. J Neuropathol Exp Neurol. 2011;70:292-301 pubmed publisher
immunohistochemistry; human; 1:1000	Talbot K, Louneva N, Cohen J, Kazi H, Blake D, Arnold S. Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS ONE. 2011;6:e16886 pubmed publisher
immunohistochemistry; human; 1:200 western blot; human; 1:3000	Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, et al. Apomorphine treatment in Alzheimer mice promoting amyloid-? degradation. Ann Neurol. 2011;69:248-56 pubmed publisher
immunohistochemistry; mouse; 1:50	Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, et al. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci. 2011;31:2511-25 pubmed publisher
immunocytochemistry; mouse; 1:200	Whittington R, Virag L, Marcouiller F, Papon M, El Khoury N, Julien C, et al. Propofol directly increases tau phosphorylation. PLoS ONE. 2011;6:e16648 pubmed publisher
western blot; mouse; 1:1000	Nunes A, Pressey S, Cooper J, Soriano S. Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis. Neurobiol Dis. 2011;42:349-59 pubmed publisher
western blot; mouse; 1:1000	Shipton O, Leitz J, Dworzak J, Acton C, Tunbridge E, Denk F, et al. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci. 2011;31:1688-92 pubmed publisher
immunohistochemistry; hamsters; 1:2000 western blot; hamsters; 1:500	Stieler J, Bullmann T, Kohl F, Tøien Ø, Brückner M, Hartig W, et al. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS ONE. 2011;6:e14530 pubmed publisher
immunohistochemistry; mouse western blot; mouse	Niikura T, Sidahmed E, Hirata Fukae C, Aisen P, Matsuoka Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS ONE. 2011;6:e16259 pubmed publisher
immunohistochemistry; mouse; 1:50 western blot; mouse; 1:1000	Cuadrado Tejedor M, Ricobaraza A, Del Rio J, Frechilla D, Franco R, Pérez Mediavilla A, et al. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behav Brain Res. 2011;220:338-43 pubmed publisher
immunohistochemistry; mouse; 0.2 ug/mL	Fonseca M, Chu S, Berci A, Benoit M, Peters D, Kimura Y, et al. Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation. 2011;8:4 pubmed publisher
immunohistochemistry; human western blot; human	Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed publisher
immunohistochemistry; rat western blot; rat	Filipcik P, Zilka N, Bugos O, Kučerák J, Koson P, Novak P, et al. First transgenic rat model developing progressive cortical neurofibrillary tangles. Neurobiol Aging. 2012;33:1448-56 pubmed publisher
western blot; mouse	Ando K, Uemura K, Kuzuya A, Maesako M, Asada Utsugi M, Kubota M, et al. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. J Biol Chem. 2011;286:7619-28 pubmed publisher
immunohistochemistry; human western blot; human	Chen J, Cohen M, Lerner A, Yang Y, Herrup K. DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease. Mol Neurodegener. 2010;5:60 pubmed publisher
immunocytochemistry; human; 1:2000	Braak H, Del Tredici K. The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol. 2011;121:171-81 pubmed publisher
immunohistochemistry; human immunohistochemistry; mouse	Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean M, et al. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiol Learn Mem. 2011;95:296-304 pubmed publisher
immunohistochemistry; human; 1:1500	Sepulveda Falla D, Matschke J, Bernreuther C, Hagel C, Puig B, Villegas A, et al. Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease. Brain Pathol. 2011;21:452-63 pubmed publisher
immunohistochemistry; human	Leger F, Fernagut P, Canron M, Leoni S, Vital C, Tison F, et al. Protein aggregation in the aging retina. J Neuropathol Exp Neurol. 2011;70:63-8 pubmed publisher
immunohistochemistry; mouse; 1:500	Boutajangout A, Quartermain D, Sigurdsson E. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci. 2010;30:16559-66 pubmed publisher
immunocytochemistry; human; 1:10 immunohistochemistry; human; 1:1000 western blot; human; 1:100000	Colodner K, Feany M. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci. 2010;30:16102-13 pubmed publisher
immunohistochemistry; mouse; 1:100	Bittner T, Fuhrmann M, Burgold S, Ochs S, Hoffmann N, Mitteregger G, et al. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS ONE. 2010;5:e15477 pubmed publisher
immunohistochemistry; human; 1:250	Ringman J, Gylys K, Medina L, Fox M, Kepe V, Flores D, et al. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neurosci Lett. 2011;487:287-92 pubmed publisher
immunocytochemistry; human; 1:500	Takahashi R, Tobiume M, Sato Y, Sata T, Gouras G, Takahashi H. Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain. Neuropathology. 2011;31:208-14 pubmed publisher
immunohistochemistry; human; 1:2000	Braak H, Thal D, Del Tredici K. Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases. J Neural Transm (Vienna). 2011;118:809-19 pubmed publisher
immunohistochemistry; mouse	Tamayev R, Giliberto L, Li W, d Abramo C, Arancio O, Vidal R, et al. Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. J Neurosci. 2010;30:14915-24 pubmed publisher
immunohistochemistry; mouse; 1:100	Yang D, Xie Z, Stephenson D, Morton D, Hicks C, Brown T, et al. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). Neuroimage. 2011;54:2652-8 pubmed publisher
immunohistochemistry; human western blot; human	Bose A, Mouton Liger F, Paquet C, Mazot P, Vigny M, Gray F, et al. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol. 2011;21:189-200 pubmed publisher
western blot; mouse	Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, et al. Diacylglycerol kinase ? knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE. 2010;5:e13447 pubmed publisher
immunohistochemistry; human; 1:1000	Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobagyi T, Tanila H, et al. WNT signaling in activated microglia is proinflammatory. Glia. 2011;59:119-31 pubmed publisher
immunohistochemistry; human; 1:3000	Kantarci K, Yang C, Schneider J, Senjem M, Reyes D, Lowe V, et al. Antemortem amyloid imaging and ?-amyloid pathology in a case with dementia with Lewy bodies. Neurobiol Aging. 2012;33:878-85 pubmed publisher
immunohistochemistry; mouse; 1:100	Andrews Zwilling Y, Bien Ly N, Xu Q, Li G, Bernardo A, Yoon S, et al. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010;30:13707-17 pubmed publisher
immunohistochemistry; human; 1:1000	Perez S, He B, Muhammad N, Oh K, Fahnestock M, Ikonomovic M, et al. Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice. Neurobiol Dis. 2011;41:338-52 pubmed publisher
immunohistochemistry; rat	Stozicka Z, Zilka N, Novak P, Kovacech B, Bugos O, Novak M. Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease. J Neuroinflammation. 2010;7:64 pubmed publisher
immunohistochemistry; mouse	Chen X, Wagener J, Morgan D, Hui L, Ghribi O, Geiger J. Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet. J Alzheimers Dis. 2010;22:1289-303 pubmed publisher
western blot; mouse; 1:500	Peethumnongsin E, Yang L, Kallhoff Munoz V, Hu L, Takashima A, Pautler R, et al. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010;30:13409-18 pubmed publisher
immunohistochemistry; mouse; 1:200 western blot; mouse; 1:5000	Bhaskar K, Konerth M, Kokiko Cochran O, Cardona A, Ransohoff R, Lamb B. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010;68:19-31 pubmed publisher
western blot; mouse	Minami S, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, et al. Therapeutic versus neuroinflammatory effects of passive immunization is dependent on A?/amyloid burden in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2010;7:57 pubmed publisher
immunohistochemistry; mouse; 1:250	Van Nostrand W, Xu F, Rozemuller A, Colton C. Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. Stroke. 2010;41:S135-8 pubmed publisher
western blot; human; 1:500	Min S, Cho S, Zhou Y, Schroeder S, Haroutunian V, Seeley W, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010;67:953-66 pubmed publisher
immunohistochemistry; mouse; 1:500	Lee S, Varvel N, Konerth M, Xu G, Cardona A, Ransohoff R, et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010;177:2549-62 pubmed publisher
western blot; human; 1:1000	Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, et al. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons. J Mol Neurosci. 2011;43:326-32 pubmed publisher
immunohistochemistry; mouse	Rosario E, Carroll J, Pike C. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res. 2010;1359:281-90 pubmed publisher
immunohistochemistry; mouse western blot; mouse	Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, et al. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. Brain. 2010;133:3323-35 pubmed publisher
immunohistochemistry; human immunohistochemistry; mouse	Hurtado D, Molina Porcel L, Iba M, Aboagye A, Paul S, Trojanowski J, et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol. 2010;177:1977-88 pubmed publisher
immunohistochemistry; mouse; 1:200	Hoftberger R, Fink S, Aboul Enein F, Botond G, Olah J, Berki T, et al. Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis. Glia. 2010;58:1847-57 pubmed publisher
immunohistochemistry; human; 1:1000	Wilhelmus M, Verhaar R, Andringa G, Bol J, Cras P, Shan L, et al. Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain. Brain Pathol. 2011;21:130-9 pubmed publisher
immunohistochemistry; rat; 1:500	Ramirez J, Poulton W, Knelson E, Barton C, King M, Klein R. Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behav Brain Res. 2011;216:332-40 pubmed publisher
immunohistochemistry; human; 1:100 western blot; human; 1:50	Hamilton L, Aumont A, Julien C, Vadnais A, Calon F, Fernandes K. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci. 2010;32:905-20 pubmed publisher
immunohistochemistry; human; 1:2,000	McKee A, Gavett B, Stern R, Nowinski C, Cantu R, Kowall N, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010;69:918-29 pubmed publisher
western blot; rat; 1:500	Zheng Y, Amin N, Hu Y, Rudrabhatla P, Shukla V, Kanungo J, et al. A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. J Biol Chem. 2010;285:34202-12 pubmed publisher
immunohistochemistry; human; 1:500	Blanchard J, Wanka L, Tung Y, Cárdenas Aguayo M, LaFerla F, Iqbal K, et al. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting A? and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010;120:605-21 pubmed publisher
immunohistochemistry; human; 1:1000	Loy C, McCusker E, Kril J, Kwok J, Brooks W, McCann H, et al. Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology. Brain. 2010;133:e158; author reply e159 pubmed publisher
immunohistochemistry; human	Nicholson R, Kusne Y, Nowak L, LaFerla F, Reiman E, Valla J. Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models. Brain Res. 2010;1347:179-85 pubmed publisher
western blot; fruit fly ; 1:50000	Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed publisher
western blot; human	van Eersel J, Ke Y, Liu X, Delerue F, Kril J, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93 pubmed publisher
immunohistochemistry; human; 1:100	Blazquez Llorca L, Garcia Marin V, DeFelipe J. Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients. Front Neuroanat. 2010;4:20 pubmed publisher
immunohistochemistry; human; 1:250	Poorkaj P, Raskind W, Leverenz J, Matsushita M, Zabetian C, Samii A, et al. A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity. Mov Disord. 2010;25:1409-17 pubmed publisher
immunohistochemistry; human; 1:1,000	Josephs K, Whitwell J, Boeve B, Knopman D, Petersen R, Hu W, et al. Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease. Mov Disord. 2010;25:1246-52 pubmed publisher
immunohistochemistry; human; 1:50	Barnett B, Bressler J, Chen T, Hutchins G, Crain B, Kaufmann W. ?B-crystallin negative astrocytic inclusions. Brain Dev. 2011;33:349-52 pubmed publisher
immunohistochemistry; mouse; 1:200	Bhaskar K, Hobbs G, Yen S, Lee G. Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. Neuropathol Appl Neurobiol. 2010;36:462-77 pubmed publisher
western blot; fruit fly	Ambegaokar S, Jackson G. Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster. Genetics. 2010;186:435-42 pubmed publisher
immunohistochemistry; human	Pretnar Oblak J, Zaletel M, Hajnsek T, Meglic B, Hocevar Boltezar I, Popovic M. Isolated bulbar paralysis in a patient with medullar tau pathology: a case report. J Neurol Neurosurg Psychiatry. 2010;81:847-9 pubmed publisher
western blot; human; 1:1000	Parachikova A, Vasilevko V, Cribbs D, LaFerla F, Green K. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010;21:527-42 pubmed publisher
immunocytochemistry; rat; 1:30 western blot; rat; 1:200	Bertrand J, Sénéchal P, Zummo Soucy M, Plouffe V, Leclerc N. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. J Neurochem. 2010;114:1353-67 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:1,000	Rodriguez Navarro J, Rodriguez L, Casarejos M, Solano R, Gomez A, Perucho J, et al. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol Dis. 2010;39:423-38 pubmed publisher
immunohistochemistry; human; 1:500	Morawski M, Bruckner G, Jager C, Seeger G, Arendt T. Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease. Neuroscience. 2010;169:1347-63 pubmed publisher
western blot; human; 1:1000	Koike M, Green K, Blurton Jones M, LaFerla F. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010;177:300-10 pubmed publisher
immunohistochemistry; human; 1:500	Lee H, Lee J, Lee H, Carter J, Chang J, Oh W, et al. Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. Neurobiol Aging. 2012;33:588-602 pubmed publisher
immunohistochemistry; mouse; 1:200	Feuillette S, Deramecourt V, Laquerriere A, Duyckaerts C, Delisle M, Maurage C, et al. Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains. Brain Res. 2010;1345:182-9 pubmed publisher
immunohistochemistry; human; 1:100	Mohorko N, Repovs G, Popovic M, Kovacs G, Bresjanac M. Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples. J Neuropathol Exp Neurol. 2010;69:405-14 pubmed publisher
immunohistochemistry; human; 1:300	Caltagarone J, Hamilton R, Murdoch G, Jing Z, DeFranco D, Bowser R. Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi. J Neuropathol Exp Neurol. 2010;69:356-71 pubmed publisher
immunohistochemistry; mouse; 1:1000	Carroll J, Rosario E, Villamagna A, Pike C. Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology. 2010;151:2713-22 pubmed publisher
western blot; rat; 1:100-1:200	Bertrand J, Plouffe V, Senechal P, Leclerc N. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. 2010;168:323-34 pubmed publisher
immunohistochemistry; human; 1:1000	van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C. Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiol Dis. 2010;39:265-71 pubmed publisher
immunohistochemistry; human; 1:2000	Braak H, Ludolph A, Thal D, Del Tredici K. Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord. Acta Neuropathol. 2010;120:67-74 pubmed publisher
immunohistochemistry; human	Heath J, Siedlak S, Zhu X, Lee H, Thakur A, Yan R, et al. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology. 2010;30:574-9 pubmed publisher
immunohistochemistry; human; 1:200	Lee J, Won S, Suh J, Son S, Moon G, Park U, et al. Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Exp Mol Med. 2010;42:386-94 pubmed
immunohistochemistry; human	Bigio E, Mishra M, Hatanpaa K, White C, Johnson N, Rademaker A, et al. TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease. Acta Neuropathol. 2010;120:43-54 pubmed publisher
immunohistochemistry; human	de Calignon A, Fox L, Pitstick R, Carlson G, Bacskai B, Spires Jones T, et al. Caspase activation precedes and leads to tangles. Nature. 2010;464:1201-4 pubmed publisher
western blot; hamsters; 1:4,000	Wang G, Shi S, Gao C, Zhang B, Tian C, Dong C, et al. Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases. BMC Infect Dis. 2010;10:86 pubmed publisher
immunohistochemistry; mouse; 1:50	Escribano L, Simón A, Gimeno E, Cuadrado Tejedor M, Lopez de Maturana R, Garcia Osta A, et al. Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology. 2010;35:1593-604 pubmed publisher
western blot; mouse; 1:200	Greco S, Bryan K, Sarkar S, Zhu X, Smith M, Ashford J, et al. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;19:1155-67 pubmed publisher
western blot; human; 1:200	Fang H, Zhang L, Meng F, Du X, Zhou J. Acute hypoxia promote the phosphorylation of tau via ERK pathway. Neurosci Lett. 2010;474:173-177 pubmed publisher
immunohistochemistry; human; 1:2000	Del Tredici K, Hawkes C, Ghebremedhin E, Braak H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol. 2010;119:703-13 pubmed publisher
immunocytochemistry; human; 1:250	Dickstein D, Brautigam H, Stockton S, Schmeidler J, Hof P. Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau. Brain Struct Funct. 2010;214:161-79 pubmed publisher
immunohistochemistry; human; 1:200	Silveira Moriyama L, Hughes G, Church A, Ayling H, Williams D, Petrie A, et al. Hyposmia in progressive supranuclear palsy. Mov Disord. 2010;25:570-7 pubmed publisher
western blot; human	Liu X, Liao K, Liu R, Wang H, Zhang Y, Zhang Q, et al. Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2. J Alzheimers Dis. 2010;19:953-62 pubmed publisher
immunohistochemistry; rat; 1:1000	Sharma A, Callahan L, Sul J, Kim T, Barrett L, Kim M, et al. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS ONE. 2010;5:e9002 pubmed publisher
immunohistochemistry; mouse; 1:1000	Pan Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS ONE. 2010;5:e8762 pubmed publisher
immunohistochemistry; mouse; 1:50	Hartig W, Kacza J, Paulke B, Grosche J, Bauer U, Hoffmann A, et al. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur J Neurosci. 2010;31:99-109 pubmed publisher
immunohistochemistry; human; 1:50 western blot; human; 1:1000	Fujimura R, Reiner T, Ma F, Phillips V, de las Pozas A, Dickson D, et al. Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease. J Alzheimers Dis. 2010;19:97-109 pubmed publisher
immunocytochemistry; rat western blot; rat	Maj M, Gartner W, Ilhan A, Neziri D, Attems J, Wagner L. Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin. J Endocrinol. 2010;205:25-36 pubmed publisher
western blot; human; 1:1000	Martinez Coria H, Green K, Billings L, Kitazawa M, Albrecht M, Rammes G, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010;176:870-80 pubmed publisher
immunohistochemistry; mouse; 1:500	Lee J, Jin H, Endo S, Schuchman E, Carter J, Bae J. Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses. Stem Cells. 2010;28:329-43 pubmed publisher
immunohistochemistry; human; 1:1000	Bonda D, Evans T, Santocanale C, Llosá J, Vina J, Bajic V, et al. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Albany NY). 2009;1:382-8 pubmed
immunocytochemistry; human; 1:100 western blot; human immunocytochemistry; mouse; 1:100 western blot; mouse	Vale C, Alonso E, Rubiolo J, Vieytes M, LaFerla F, Gimenez Llort L, et al. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010;30:577-90 pubmed publisher
immunohistochemistry; mouse	Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, et al. Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS ONE. 2009;4:e7931 pubmed publisher
immunohistochemistry; human; 1:1,000	Whitwell J, Jack C, Przybelski S, Parisi J, Senjem M, Boeve B, et al. Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis. Neurobiol Aging. 2011;32:1531-41 pubmed publisher
immunohistochemistry; mouse western blot; mouse; 1:250	Lopes J, Oliveira C, Agostinho P. Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5. Aging Cell. 2010;9:64-77 pubmed publisher
immunohistochemistry; rat	Lecanu L, Rammouz G, McCourty A, Sidahmed E, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010;165:427-35 pubmed publisher
immunohistochemistry; human western blot; chicken	Whiteman I, Gervasio O, Cullen K, Guillemin G, Jeong E, Witting P, et al. Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. J Neurosci. 2009;29:12994-3005 pubmed publisher
immunocytochemistry; human	Campos Peña V, Tapia Ramírez J, Sanchez Torres C, Meraz Rios M. Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane. J Alzheimers Dis. 2009;18:919-33 pubmed publisher
immunohistochemistry; domestic horse; 1:50	Capucchio M, Marquez M, Pregel P, Foradada L, Bravo M, Mattutino G, et al. Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies. J Comp Pathol. 2010;142:61-73 pubmed publisher
immunohistochemistry; human	Soontornniyomkij V, Lynch M, Mermash S, Pomakian J, Badkoobehi H, Clare R, et al. Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy. Brain Pathol. 2010;20:459-67 pubmed publisher
immunohistochemistry; mouse; 1:1000	McConnell G, Rees H, Levey A, Gutekunst C, Gross R, Bellamkonda R. Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration. J Neural Eng. 2009;6:056003 pubmed publisher
immunohistochemistry; human; 1:250 western blot; human; 1:1000	van Eersel J, Bi M, Ke Y, Hodges J, Xuereb J, Gregory G, et al. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna). 2009;116:1243-51 pubmed publisher
immunohistochemistry; human	Rahman A, Ting K, Cullen K, Braidy N, Brew B, Guillemin G. The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS ONE. 2009;4:e6344 pubmed publisher
immunohistochemistry; human	Tang J, LeGros R, Louneva N, Yeh L, Cohen J, Hahn C, et al. Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression. Hum Mol Genet. 2009;18:3851-63 pubmed publisher
immunohistochemistry; human; 1:200	Kovacs G, Murrell J, Horvath S, Haraszti L, Majtenyi K, Molnar M, et al. TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea. Mov Disord. 2009;24:1843-7 pubmed publisher
immunocytochemistry; human; 1:5	Nogalska A, Terracciano C, D Agostino C, King Engel W, Askanas V. p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis. Acta Neuropathol. 2009;118:407-13 pubmed publisher
immunohistochemistry; mouse; 1:250 western blot; mouse; 1:200	Wilcock D, Gharkholonarehe N, Van Nostrand W, Davis J, Vitek M, Colton C. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci. 2009;29:7957-65 pubmed publisher
immunohistochemistry; human; 1:2,000	McKee A, Cantu R, Nowinski C, Hedley Whyte E, Gavett B, Budson A, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009;68:709-35 pubmed publisher
immunohistochemistry; human	Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, et al. Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. FEBS Lett. 2009;583:2194-200 pubmed publisher
western blot; human; 1:200 western blot; mouse; 1:200	Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. J Neuropathol Exp Neurol. 2009;68:503-14 pubmed publisher
blocking or activating experiments; human immunohistochemistry; human; 1:1000 western blot; human; 1:1000	Clavaguera F, Bolmont T, Crowther R, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11:909-13 pubmed publisher
western blot; mouse	Ittner L, Ke Y, Götz J. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem. 2009;284:20909-16 pubmed publisher
immunocytochemistry; mouse; 1:400	Kasher P, De Vos K, Wharton S, Manser C, Bennett E, Bingley M, et al. Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. J Neurochem. 2009;110:34-44 pubmed publisher
western blot; human; 1:200	Greco S, Sarkar S, Casadesus G, Zhu X, Smith M, Ashford J, et al. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neurosci Lett. 2009;455:191-4 pubmed publisher
immunocytochemistry; human	Myung N, Zhu X, Kruman I, Castellani R, Petersen R, Siedlak S, et al. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordr). 2008;30:209-15 pubmed publisher
immunohistochemistry; human; 1:400	Simpson J, Ince P, Haynes L, Theaker R, Gelsthorpe C, Baxter L, et al. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2010;36:25-40 pubmed publisher
immunohistochemistry; mouse	Ohmi K, Kudo L, Ryazantsev S, Zhao H, Karsten S, Neufeld E. Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy. Proc Natl Acad Sci U S A. 2009;106:8332-7 pubmed publisher
immunohistochemistry; human; 1:400 western blot; human; 1:800	Jing Z, Caltagarone J, Bowser R. Altered subcellular distribution of c-Abl in Alzheimer's disease. J Alzheimers Dis. 2009;17:409-22 pubmed publisher
immunohistochemistry; human; 1:400	Lace G, Savva G, Forster G, De Silva R, Brayne C, Matthews F, et al. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain. 2009;132:1324-34 pubmed publisher
western blot; mouse	Planel E, Bretteville A, Liu L, Virag L, Du A, Yu W, et al. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB J. 2009;23:2595-604 pubmed publisher
immunohistochemistry; rat western blot; rat	Filipcik P, Cente M, Krajciova G, Vanicky I, Novak M. Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration. Cell Mol Neurobiol. 2009;29:895-900 pubmed publisher
immunohistochemistry; mouse; 1:200	Bitner R, Nikkel A, Markosyan S, Otte S, Puttfarcken P, Gopalakrishnan M. Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. Brain Res. 2009;1265:65-74 pubmed publisher
immunohistochemistry; mouse	Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, et al. Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice. J Alzheimers Dis. 2009;16:371-88 pubmed publisher
immunohistochemistry; human; 1:3,750	Josephs K, Ahlskog J, Parisi J, Boeve B, Crum B, Giannini C, et al. Rapidly progressive neurodegenerative dementias. Arch Neurol. 2009;66:201-7 pubmed publisher
western blot; human; 1:200	Greco S, Sarkar S, Johnston J, Tezapsidis N. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochem Biophys Res Commun. 2009;380:98-104 pubmed publisher
western blot; mouse	Ricobaraza A, Cuadrado Tejedor M, Pérez Mediavilla A, Frechilla D, Del Rio J, Garcia Osta A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology. 2009;34:1721-32 pubmed publisher
immunocytochemistry; mouse	Liu Y, Yoo M, Savonenko A, Stirling W, Price D, Borchelt D, et al. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2008;28:13805-14 pubmed publisher
western blot; mouse	Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, et al. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008;28:12798-807 pubmed publisher
western blot; rat	Lee H, Zhu X, Casadesus G, Pallas M, Camins A, O Neill M, et al. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Res. 2009;1249:244-50 pubmed publisher
immunohistochemistry; human	Shehadeh L, Mitsi G, Adi N, Bishopric N, Papapetropoulos S. Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects. Mov Disord. 2009;24:204-10 pubmed publisher
western blot; fruit fly ; 1:2,000	Chatterjee S, Sang T, Lawless G, Jackson G. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet. 2009;18:164-77 pubmed publisher
immunocytochemistry; human; 1:1,000	Thakur A, Siedlak S, James S, Bonda D, Rao A, Webber K, et al. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. Int J Clin Exp Pathol. 2008;1:134-46 pubmed
immunohistochemistry; human; 1:500 immunohistochemistry; mouse; 1:500	Takahashi R, Capetillo Zarate E, Lin M, Milner T, Gouras G. Co-occurrence of Alzheimer's disease ß-amyloid and ? pathologies at synapses. Neurobiol Aging. 2010;31:1145-52 pubmed publisher
immunohistochemistry; human; 1:50	Khan T, Alkon D. Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker. Neurobiol Aging. 2010;31:889-900 pubmed publisher
western blot; rat; 1:200	Patil S, Balu D, Melrose J, Chan C. Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease. BMC Res Notes. 2008;1:20 pubmed publisher
immunohistochemistry; human; 1:1000	Wilhelmus M, Grunberg S, Bol J, van Dam A, Hoozemans J, Rozemuller A, et al. Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain. Brain Pathol. 2009;19:612-22 pubmed publisher
immunohistochemistry; human; 1:1,000	Jicha G, Parisi J, Dickson D, Cha R, Johnson K, Smith G, et al. Age and apoE associations with complex pathologic features in Alzheimer's disease. J Neurol Sci. 2008;273:34-9 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:1,000	Rodriguez Navarro J, Gomez A, Rodal I, Perucho J, Martinez A, Furió V, et al. Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. Hum Mol Genet. 2008;17:3128-43 pubmed publisher
immunohistochemistry; mouse; 1:400	Laporte V, Ait Ghezala G, Volmar C, Ganey C, Ganey N, Wood M, et al. CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice. Brain Res. 2008;1231:132-42 pubmed publisher
immunocytochemistry; human; 1:100	Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca F, Catania M, et al. A new function of microtubule-associated protein tau: involvement in chromosome stability. Cell Cycle. 2008;7:1788-94 pubmed
immunohistochemistry; human; 1:200	Sikorska B, Liberski P, Sobow T, Budka H, Ironside J. Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease. Neuropathol Appl Neurobiol. 2009;35:46-59 pubmed publisher
western blot; mouse	Lim J, Balastik M, Lee T, Nakamura K, Liou Y, Sun A, et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008;118:1877-89 pubmed publisher
immunohistochemistry; mouse	Vidal R, Barbeito A, Miravalle L, Ghetti B. Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2. Brain Pathol. 2009;19:58-68 pubmed publisher
immunocytochemistry; rat; 1:30 western blot; rat; 1:250	Resende R, Ferreiro E, Pereira C, Oliveira C. ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation. J Neurosci Res. 2008;86:2091-9 pubmed publisher
immunohistochemistry; mouse; 1:150	Wilcock D, Lewis M, Van Nostrand W, Davis J, Previti M, Gharkholonarehe N, et al. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci. 2008;28:1537-45 pubmed publisher
immunohistochemistry; rat	Hinners I, Hill A, Otto U, Michalsky A, Mack T, Striggow F. Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Mol Cell Neurosci. 2008;37:559-67 pubmed publisher
western blot; mouse	Matsuoka Y, Jouroukhin Y, Gray A, Ma L, Hirata Fukae C, Li H, et al. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther. 2008;325:146-53 pubmed publisher
immunohistochemistry; mouse western blot; mouse	Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, et al. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci. 2007;27:13635-48 pubmed
immunohistochemistry; human; 1:200	Kovacs G, Pittman A, Revesz T, Luk C, Lees A, Kiss E, et al. MAPT S305I mutation: implications for argyrophilic grain disease. Acta Neuropathol. 2008;116:103-18 pubmed
immunohistochemistry; human; 1:200	Preusser M, Kitzwoegerer M, Budka H, Brugger S. Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. Neuropathology. 2007;27:453-6 pubmed
immunohistochemistry; mouse; 1:500	Schrag M, Sharma S, Brown Borg H, Ghribi O. Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus. 2008;18:239-44 pubmed
immunohistochemistry; human; 1:1,000	Josephs K, Whitwell J, Ahmed Z, Shiung M, Weigand S, Knopman D, et al. Beta-amyloid burden is not associated with rates of brain atrophy. Ann Neurol. 2008;63:204-12 pubmed
immunohistochemistry; mouse; 1:40 western blot; mouse; 1:40	Bai F, Xi J, Andley U. Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol Vis. 2007;13:1589-600 pubmed
immunohistochemistry; human	Piggott M, Ballard C, Rowan E, Holmes C, McKeith I, Jaros E, et al. Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline. Synapse. 2007;61:903-11 pubmed
immunohistochemistry; human	Ojala J, Alafuzoff I, Herukka S, van Groen T, Tanila H, Pirttila T. Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiol Aging. 2009;30:198-209 pubmed
immunohistochemistry; human; 1:100	Munoz D, Woulfe J, Kertesz A. Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia. Acta Neuropathol. 2007;114:347-57 pubmed
western blot; rat western blot; roundworm	Brandt R, Gergou A, Wacker I, Fath T, Hutter H. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiol Aging. 2009;30:22-33 pubmed
western blot; mouse; 1:500	Rissman R, Lee K, Vale W, Sawchenko P. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007;27:6552-62 pubmed
immunohistochemistry; human	Moreira P, Siedlak S, Wang X, Santos M, Oliveira C, Tabaton M, et al. Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol. 2007;66:525-32 pubmed
western blot; rat	Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, et al. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007;104:9511-6 pubmed
immunohistochemistry; human	Evans T, Raina A, Delacourte A, Aprelikova O, Lee H, Zhu X, et al. BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. Int J Med Sci. 2007;4:140-5 pubmed
immunohistochemistry; mouse western blot; mouse	Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla F. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007;102:1053-63 pubmed
immunohistochemistry; mouse western blot; mouse	Caccamo A, Oddo S, Tran L, LaFerla F. Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol. 2007;170:1669-75 pubmed
western blot; human; 1:1,000	Green K, Martinez Coria H, Khashwji H, Hall E, Yurko Mauro K, Ellis L, et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci. 2007;27:4385-95 pubmed
immunohistochemistry; human; 1:250	Leverenz J, Yu C, Montine T, Steinbart E, Bekris L, Zabetian C, et al. A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. Brain. 2007;130:1360-74 pubmed
immunohistochemistry; human; 1:40	Magaki S, Raghavan R, Mueller C, Oberg K, Vinters H, Kirsch W. Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias. Neurosci Lett. 2007;418:72-6 pubmed
immunohistochemistry; mouse; 1:500	Planel E, Richter K, Nolan C, Finley J, Liu L, Wen Y, et al. Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci. 2007;27:3090-7 pubmed
immunohistochemistry; human; 1:1,000	Whitwell J, Jack C, Parisi J, Knopman D, Boeve B, Petersen R, et al. Rates of cerebral atrophy differ in different degenerative pathologies. Brain. 2007;130:1148-58 pubmed
western blot; mouse	Leschik J, Welzel A, Weissmann C, Eckert A, Brandt R. Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death. J Neurochem. 2007;101:1303-15 pubmed
immunohistochemistry; human; 1:1,000	Josephs K, Ahmed Z, Katsuse O, Parisi J, Boeve B, Knopman D, et al. Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations. J Neuropathol Exp Neurol. 2007;66:142-51 pubmed
immunohistochemistry; human; 1:200	Sikorska B, Papierz W, Preusser M, Liberski P, Budka H. Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies. Neuropathol Appl Neurobiol. 2007;33:126-9 pubmed
immunohistochemistry; human; 1:1,000	Josephs K, Whitwell J, Parisi J, Knopman D, Boeve B, Geda Y, et al. Argyrophilic grains: a distinct disease or an additive pathology?. Neurobiol Aging. 2008;29:566-73 pubmed
western blot; fruit fly ; 1:50,000	Dias Santagata D, Fulga T, Duttaroy A, Feany M. Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J Clin Invest. 2007;117:236-45 pubmed
immunohistochemistry; human; 1:250	Wahle T, Thal D, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, et al. GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. J Neurosci. 2006;26:12838-46 pubmed
immunohistochemistry; human	Papapetropoulos S, Mash D. Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors. J Neural Transm (Vienna). 2007;114:341-5 pubmed
immunohistochemistry; human; 1:1,000	Barnes L, Schneider J, Boyle P, Bienias J, Bennett D. Memory complaints are related to Alzheimer disease pathology in older persons. Neurology. 2006;67:1581-5 pubmed
immunohistochemistry; mouse western blot; mouse	Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs D, LaFerla F. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006;281:39413-23 pubmed
immunohistochemistry; human; 1:500	Parachikova A, Agadjanyan M, Cribbs D, Blurton Jones M, Perreau V, Rogers J, et al. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging. 2007;28:1821-33 pubmed
immunohistochemistry; human; 1:5000	Ikonomovic M, Abrahamson E, Isanski B, Debnath M, Mathis C, DeKosky S, et al. X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease. Methods Enzymol. 2006;412:123-44 pubmed
immunohistochemistry; human; 1:1,000	Hu W, Murray J, Greenaway M, Parisi J, Josephs K. Cognitive impairment and celiac disease. Arch Neurol. 2006;63:1440-6 pubmed
immunohistochemistry; human; 1:1,000	Boeve B, Baker M, Dickson D, Parisi J, Giannini C, Josephs K, et al. Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain. 2006;129:3103-14 pubmed
immunocytochemistry; human; 1:500	Lee H, Ueda M, Zhu X, Perry G, Smith M. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?. J Neurosci Res. 2006;84:1856-61 pubmed
immunohistochemistry; human	Papapetropoulos S, Mash D. Insular pathology in Parkinson's disease patients with orthostatic hypotension. Parkinsonism Relat Disord. 2007;13:308-11 pubmed
western blot; rat	Farah C, Perreault S, Liazoghli D, Desjardins M, Anton A, Lauzon M, et al. Tau interacts with Golgi membranes and mediates their association with microtubules. Cell Motil Cytoskeleton. 2006;63:710-24 pubmed
immunohistochemistry; mouse western blot; mouse; 1:1,000	Green K, Billings L, Roozendaal B, McGaugh J, LaFerla F. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006;26:9047-56 pubmed
immunohistochemistry; human; 1:200	Gelpi E, Preusser M, Bauer G, Budka H. Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology. Forensic Sci Int. 2007;168:177-82 pubmed
immunohistochemistry; human; 1:1,000	Jicha G, Petersen R, Knopman D, Boeve B, Smith G, Geda Y, et al. Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. J Neuropathol Exp Neurol. 2006;65:602-9 pubmed
western blot; domestic rabbit; 1:100	Ghribi O, Larsen B, Schrag M, Herman M. High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol. 2006;200:460-7 pubmed
immunohistochemistry; human	Jicha G, Parisi J, Dickson D, Johnson K, Cha R, Ivnik R, et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol. 2006;63:674-81 pubmed
immunohistochemistry; human	Petersen R, Parisi J, Dickson D, Johnson K, Knopman D, Boeve B, et al. Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol. 2006;63:665-72 pubmed
immunohistochemistry; cat; 1:500	Gunn Moore D, McVee J, Bradshaw J, Pearson G, Head E, Gunn Moore F. Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. J Feline Med Surg. 2006;8:234-42 pubmed
immunohistochemistry; human	Grudzien A, Shaw P, Weintraub S, Bigio E, Mash D, Mesulam M. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging. 2007;28:327-35 pubmed
immunohistochemistry; human; 1:1000 western blot; human; 1:1000	Griffin W, Liu L, Li Y, Mrak R, Barger S. Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammation. 2006;3:5 pubmed
western blot; rat; 1:100	Oka T, Tamada Y, Nakajima E, Shearer T, Azuma M. Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension. J Neurosci Res. 2006;83:1342-51 pubmed
immunohistochemistry; human; 1:1,000	Halliday G, Song Y, Creasey H, Morris J, Brooks W, Kril J. Neuropathology in the S305S tau gene mutation. Brain. 2006;129:E40 pubmed
immunohistochemistry; human	Piggott M, Ballard C, Dickinson H, McKeith I, Perry R, Perry E. Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia. Int J Neuropsychopharmacol. 2007;10:231-44 pubmed
immunohistochemistry; human	Papapetropoulos S, McCorquodale D, Gonzalez J, Jean Gilles L, Mash D. Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations. Parkinsonism Relat Disord. 2006;12:253-6 pubmed
immunocytochemistry; human immunohistochemistry; human	Quintana C, Bellefqih S, Laval J, Guerquin Kern J, Wu T, Avila J, et al. Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol. 2006;153:42-54 pubmed
immunohistochemistry; human	Obici L, Demarchi A, de Rosa G, Bellotti V, Marciano S, Donadei S, et al. A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy. Ann Neurol. 2005;58:639-44 pubmed
western blot; mouse; 1:1000	Blain J, Sullivan P, Poirier J. A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. Neurobiol Dis. 2006;21:505-14 pubmed
immunohistochemistry; human	Yang W, Ang L, Strong M. Tau protein aggregation in the frontal and entorhinal cortices as a function of aging. Brain Res Dev Brain Res. 2005;156:127-38 pubmed
immunohistochemistry; human	Klos K, Josephs K, Parisi J, Dickson D. Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease. Mov Disord. 2005;20:1515-20 pubmed
immunohistochemistry; human; 1:10,000	Newman J, Rissman R, Sarsoza F, Kim R, Dick M, Bennett D, et al. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005;110:135-44 pubmed
western blot; rat	Sakaue M, Okazaki M, Hara S. Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Toxicology. 2005;213:97-106 pubmed
immunohistochemistry; rhesus macaque	Fukuda T, Shimizu J, Furuhata H, Abe T, Shimizu K, Oishi T, et al. Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates. Acta Neuropathol. 2005;110:145-50 pubmed
immunohistochemistry; rat; 1:200 western blot; rat; 1:200	Patil S, Chan C. Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci Lett. 2005;384:288-93 pubmed
immunohistochemistry; human; 1:1,000	Knopman D, Boeve B, Parisi J, Dickson D, Smith G, Ivnik R, et al. Antemortem diagnosis of frontotemporal lobar degeneration. Ann Neurol. 2005;57:480-8 pubmed
immunohistochemistry; mouse; 1:200	Frasier M, Walzer M, McCarthy L, Magnuson D, Lee J, Haas C, et al. Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. Exp Neurol. 2005;192:274-87 pubmed
immunohistochemistry; rat	Hung K, Hwang S, Liang C, Chen Y, Lee T, Liu J, et al. Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. J Neuropathol Exp Neurol. 2005;64:15-26 pubmed
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	Dong Y, Liang F, Huang L, Fang F, Yang G, Tanzi R, et al. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Commun Biol. 2021;4:560 pubmed publisher
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	Laversenne V, Nazeeruddin S, Källstig E, Colin P, Voize C, Schneider B. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta Neuropathol Commun. 2020;8:198 pubmed publisher
	Gratuze M, Leyns C, Sauerbeck A, St Pierre M, Xiong M, Kim N, et al. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. J Clin Invest. 2020;130:4954-4968 pubmed publisher
	Guillemaud O, Ceyzériat K, Saint Georges T, Cambon K, Petit F, Ben Haim L, et al. Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease. Neurobiol Aging. 2020;90:135-146 pubmed publisher
	Metaxas A, Thygesen C, Briting S, Landau A, Darvesh S, Finsen B. Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients. Front Cell Neurosci. 2019;13:538 pubmed publisher
	Shi Y, Manis M, Long J, Wang K, Sullivan P, Remolina Serrano J, et al. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med. 2019;216:2546-2561 pubmed publisher
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	Christensen K, Beach T, Serrano G, Kanaan N. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta Neuropathol Commun. 2019;7:29 pubmed publisher
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	Murphy K, Llewellyn K, Wakser S, Pontasch J, Samanich N, Flemer M, et al. Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system. J Biol Chem. 2018;293:18242-18269 pubmed publisher
	Leyns C, ULRICH J, Finn M, Stewart F, Koscal L, Remolina Serrano J, et al. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy. Proc Natl Acad Sci U S A. 2017;114:11524-11529 pubmed publisher
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	Takeda S, Wegmann S, Cho H, DeVos S, Commins C, Roe A, et al. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015;6:8490 pubmed publisher
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product information

Product Type :

Antibody

Product Name :

Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Biotin

Catalog # :

MN1020B

Quantity :

50 µg

Price :

US 534

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent

Species :

Human

Clone :

AT8

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Immunogen :

Partially purified human PHF-Tau

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent

Aliases :

AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)

more info or order :

Invitrogen product webpage