Petry F, Pelletier J, Bretteville A, Morin F, Calon F, Hébert S, et al. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PLoS ONE. 2014;9:e94251 pubmed publisher

Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen T, et al. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022;40:111417 pubmed publisher

Hausrat T, Janiesch P, Breiden P, Lutz D, Hoffmeister Ullerich S, Hermans Borgmeyer I, et al. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Nat Commun. 2022;13:4192 pubmed publisher

Nakamori M, Shimizu H, Ogawa K, Hasuike Y, Nakajima T, Sakurai H, et al. Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1. Brain Commun. 2022;4:fcac154 pubmed publisher

Rauskolb S, Andreska T, Fries S, von Collenberg C, Blum R, Monoranu C, et al. Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment. Acta Neuropathol Commun. 2022;10:68 pubmed publisher

Permanne B, Sand A, Ousson S, N xe9 ny M, Hantson J, Schubert R, et al. O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies. ACS Chem Neurosci. 2022;13:1296-1314 pubmed publisher

Zhou Q, Li S, Li M, Ke D, Wang Q, Yang Y, et al. Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration. EBioMedicine. 2022;78:103970 pubmed publisher

Marengo L, Armbrust F, Schoenherr C, Storck S, Schmitt U, Zampar S, et al. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Cell Mol Life Sci. 2022;79:168 pubmed publisher

Barker S, Raju R, Milman N, Wang J, Davila Velderrain J, Gunter Rahman F, et al. MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration. Sci Transl Med. 2021;13:eabd7695 pubmed publisher

Yuste Checa P, Trinkaus V, Riera Tur I, Imamoglu R, Schaller T, Wang H, et al. The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nat Commun. 2021;12:4863 pubmed publisher

Bampton A, Gatt A, Humphrey J, Cappelli S, Bhattacharya D, Foti S, et al. HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing. Acta Neuropathol. 2021;142:609-627 pubmed publisher

Valencia A, Bieber V, Bajrami B, Marsh G, Hamann S, Wei R, et al. Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice. Front Neurol. 2021;12:624051 pubmed publisher

Zheng J, Tian N, Liu F, Zhang Y, Su J, Gao Y, et al. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal Transduct Target Ther. 2021;6:269 pubmed publisher

Cores A, Abril S, Michalska P, Duarte P, Olives A, Martín M, et al. Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation. Antioxidants (Basel). 2021;10: pubmed publisher

Wu D, Gao D, Yu H, Pi G, Xiong R, Lei H, et al. Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway. Clin Transl Med. 2021;11:e428 pubmed publisher

Sakakibara Y, Hirota Y, Ibaraki K, Takei K, Chikamatsu S, Tsubokawa Y, et al. Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. J Alzheimers Dis. 2021;82:1513-1530 pubmed publisher

Zhang J, Wu N, Wang S, Yao Z, Xiao F, Lu J, et al. Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease. Aging Cell. 2021;20:e13380 pubmed publisher

Subramanian M, Hyeon S, Das T, Suh Y, Kim Y, Lee J, et al. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021;12:3291 pubmed publisher

López Gambero A, Rosell Valle C, Medina Vera D, Navarro J, Vargas A, Rivera P, et al. A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse. Int J Mol Sci. 2021;22: pubmed publisher

Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, et al. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. elife. 2021;10: pubmed publisher

Galán Ganga M, Rodríguez Cueto C, Merchán Rubira J, Hernandez F, Avila J, Posada Ayala M, et al. Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration. Acta Neuropathol Commun. 2021;9:90 pubmed publisher

Dong Y, Liang F, Huang L, Fang F, Yang G, Tanzi R, et al. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Commun Biol. 2021;4:560 pubmed publisher

Tseng J, Ajit A, Tabassum Z, Patel N, Tian X, Chen Y, et al. Tau seeds are subject to aberrant modifications resulting in distinct signatures. Cell Rep. 2021;35:109037 pubmed publisher

Miguel J, Perez S, Malek Ahmadi M, Mufson E. Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease. Front Aging Neurosci. 2021;13:645334 pubmed publisher

Shili C, Habibi M, Sutton J, Barnes J, Burch Konda J, Pezeshki A. Effect of a Phytogenic Water Additive on Growth Performance, Blood Metabolites and Gene Expression of Amino Acid Transporters in Nursery Pigs Fed with Low-Protein/High-Carbohydrate Diets. Animals (Basel). 2021;11: pubmed publisher

Wang X, Kuang N, Chen Y, Liu G, Wang N, Kong F, et al. Transplantation of olfactory ensheathing cells promotes the therapeutic effect of neural stem cells on spinal cord injury by inhibiting necrioptosis. Aging (Albany NY). 2021;13:9056-9070 pubmed publisher

Perez Garcia G, De Gasperi R, Gama Sosa M, Perez G, Otero Pagan A, Pryor D, et al. Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast. Acta Neuropathol Commun. 2021;9:33 pubmed publisher

Sokratian A, Ziaee J, Kelly K, Chang A, Bryant N, Wang S, et al. Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia. Acta Neuropathol. 2021;141:547-564 pubmed publisher

Almeida M, Piehler T, Carstens K, Zhao M, Samadi M, Dudek S, et al. Distinct and dementia-related synaptopathy in the hippocampus after military blast exposures. Brain Pathol. 2021;31:e12936 pubmed publisher

Ly H, Verma N, Sharma S, Kotiya D, Despa S, Abner E, et al. The association of circulating amylin with β-amyloid in familial Alzheimer's disease. Alzheimers Dement (N Y). 2021;7:e12130 pubmed publisher

Choi Y, Dunn Meynell A, Marchese M, Blumberg B, Gaindh D, Dowling P, et al. Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy. Alzheimers Res Ther. 2021;13:32 pubmed publisher

Hondius D, Koopmans F, Leistner C, Pita Illobre D, Peferoen Baert R, Marbus F, et al. The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease. Acta Neuropathol. 2021;141:341-358 pubmed publisher

Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, et al. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:1 pubmed publisher

Zareba Paslawska J, Patra K, Kluzer L, Revesz T, Svenningsson P. Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice. Front Neurol. 2020;11:589471 pubmed publisher

Biechele G, Franzmeier N, Blume T, Ewers M, Luque J, Eckenweber F, et al. Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases. J Neuroinflammation. 2020;17:374 pubmed publisher

Chiu C, Weng Y, Huang Y, Chen R, Liu Y, Yeh T, et al. (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell Death Dis. 2020;11:1018 pubmed publisher

Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed publisher

LeBlang C, Medalla M, Nicoletti N, Hays E, Zhao J, Shattuck J, et al. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 2020;14:285 pubmed publisher

Ma X, Zhu Y, Lu J, Xie J, Li C, Shin W, et al. Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau. elife. 2020;9: pubmed publisher

Hu S, Hu M, Liu J, Zhang B, Zhang Z, Zhou F, et al. Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson's Disease. Neuropsychiatr Dis Treat. 2020;16:651-663 pubmed publisher

Yilmazer Hanke D, Mayer T, Müller H, Neugebauer H, Abaei A, Scheuerle A, et al. Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts. Acta Neuropathol Commun. 2020;8:33 pubmed publisher

Liao X, Cai F, Sun Z, Zhang Y, Wang J, Jiao B, et al. Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene. JCI Insight. 2020;5: pubmed publisher

Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, et al. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. J Neuroinflammation. 2020;17:72 pubmed publisher

Rodriguez Ortiz C, Prieto G, Martini A, Forner S, Trujillo Estrada L, LaFerla F, et al. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13118 pubmed publisher

Schrank S, McDaid J, Briggs C, Mustaly Kalimi S, Brinks D, Houcek A, et al. Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology. Int J Mol Sci. 2020;21: pubmed publisher

Kaalund S, Passamonti L, Allinson K, Murley A, Robbins T, Spillantini M, et al. Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity. Acta Neuropathol Commun. 2020;8:11 pubmed publisher

Bencze J, Szarka M, Bencs V, Szabó R, Módis L, Aarsland D, et al. Lemur Tyrosine Kinase 2 (LMTK2) Level Inversely Correlates with Phospho-Tau in Neuropathological Stages of Alzheimer's Disease. Brain Sci. 2020;10: pubmed publisher

Walker D, Tang T, Mendsaikhan A, Tooyama I, Serrano G, Sue L, et al. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. Int J Mol Sci. 2020;21: pubmed publisher

Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher

Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher

Bowie E, Goetz S. TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. elife. 2020;9: pubmed publisher

Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed publisher

He Z, McBride J, Xu H, Changolkar L, Kim S, Zhang B, et al. Transmission of tauopathy strains is independent of their isoform composition. Nat Commun. 2020;11:7 pubmed publisher

Arenas F, Castro F, Núñez S, Gay G, Garcia Ruiz C, Fernandez Checa J. STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome. Aging (Albany NY). 2020;12:571-592 pubmed publisher

Shafei R, Woollacott I, Mummery C, Bocchetta M, Guerreiro R, Bras J, et al. Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia. Neurobiol Aging. 2020;87:141.e15-141.e20 pubmed publisher

Fan Q, He W, Gayen M, Benoit M, Luo X, Hu X, et al. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. J Neurosci. 2020;40:1133-1144 pubmed publisher

Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed publisher

Pires G, McElligott S, Drusinsky S, Halliday G, Potier M, Wisniewski T, et al. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathol Commun. 2019;7:195 pubmed publisher

Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed publisher

Faraco G, Hochrainer K, Segarra S, Schaeffer S, Santisteban M, Menon A, et al. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019;: pubmed publisher

di Meco A, Pratico D. Early-life exposure to high-fat diet influences brain health in aging mice. Aging Cell. 2019;18:e13040 pubmed publisher

Fiock K, Smith J, Crary J, Hefti M. β-amyloid and tau pathology in the aging feline brain. J Comp Neurol. 2020;528:108-113 pubmed publisher

Kroth H, Oden F, Molette J, Schieferstein H, Capotosti F, Mueller A, et al. Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies. Eur J Nucl Med Mol Imaging. 2019;46:2178-2189 pubmed publisher

Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher

Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, et al. Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nat Commun. 2019;10:2479 pubmed publisher

Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, et al. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging Cell. 2019;18:e12978 pubmed publisher

Libard S, Alafuzoff I. Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease. Acta Neuropathol Commun. 2019;7:3 pubmed publisher

Sartori M, Mendes T, Desai S, Lasorsa A, Herledan A, Malmanche N, et al. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation. Acta Neuropathol. 2019;: pubmed publisher

Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed publisher

Falcon B, Zivanov J, Zhang W, Murzin A, Garringer H, Vidal R, et al. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature. 2019;568:420-423 pubmed publisher

Stejskalova Z, Rohan Z, Rusina R, Tesar A, Kukal J, Kovacs G, et al. Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation. BMC Neurol. 2019;19:42 pubmed publisher

Merezhko M, Brunello C, Yan X, Vihinen H, Jokitalo E, Uronen R, et al. Secretion of Tau via an Unconventional Non-vesicular Mechanism. Cell Rep. 2018;25:2027-2035.e4 pubmed publisher

Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed publisher

Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed publisher

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed publisher

Cramer P, Gentzel R, Tanis K, Vardigan J, Wang Y, Connolly B, et al. Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease. Neurobiol Aging. 2018;64:92-106 pubmed publisher

Brici D, G tz J, Nisbet R. A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles. J Alzheimers Dis. 2018;61:899-905 pubmed publisher

Qu X, Yuan F, Corona C, Pasini S, Pero M, Gundersen G, et al. Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity. J Cell Biol. 2017;216:3161-3178 pubmed publisher

Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher

Siedlak S, Jiang Y, Huntley M, Wang L, Gao J, Xie F, et al. TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease. J Alzheimers Dis. 2017;58:1027-1033 pubmed publisher

Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher

Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed publisher

Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017;8:14740 pubmed publisher

Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed publisher

Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed publisher

Fu H, Rodriguez G, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. 2017;93:533-541.e5 pubmed publisher

Wang P, Joberty G, Buist A, Vanoosthuyse A, Stancu I, Vasconcelos B, et al. Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta Neuropathol. 2017;133:731-749 pubmed publisher

Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed publisher

Yoshida K, Hata Y, Kinoshita K, Takashima S, Tanaka K, Nishida N. Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series. Acta Neuropathol. 2017;133:809-823 pubmed publisher

Stepanov V, Svedberg M, Jia Z, Krasikova R, Lemoine L, Okamura N, et al. Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand. Nucl Med Biol. 2017;46:50-53 pubmed publisher

van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, et al. TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Hum Mutat. 2017;38:297-309 pubmed publisher

Wang A, Jensen E, Rexach J, Vinters H, Hsieh Wilson L. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:15120-15125 pubmed publisher

Lipton S, Rezaie T, Nutter A, Lopez K, Parker J, Kosaka K, et al. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death Dis. 2016;7:e2499 pubmed publisher

Shively S, Edgerton S, Iacono D, Purohit D, Qu B, Haroutunian V, et al. Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain. Acta Neuropathol. 2017;133:353-366 pubmed publisher

Noy S, Krawitz S, Del Bigio M. Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service. J Neuropathol Exp Neurol. 2016;75:1145-1154 pubmed publisher

Ling H, Kovacs G, Vonsattel J, DAVEY K, Mok K, Hardy J, et al. Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. Brain. 2016;139:3237-3252 pubmed

Jan A, Jansonius B, Delaidelli A, Somasekharan S, Bhanshali F, Vandal M, et al. eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response. Acta Neuropathol. 2017;133:101-119 pubmed publisher

Mansuroglu Z, Benhelli Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, et al. Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. Sci Rep. 2016;6:33047 pubmed publisher

Qin Y, Liu Y, Hao W, Decker Y, Tomic I, Menger M, et al. Stimulation of TLR4 Attenuates Alzheimer's Disease-Related Symptoms and Pathology in Tau-Transgenic Mice. J Immunol. 2016;197:3281-3292 pubmed

Zimova I, Brezovakova V, Hromádka T, Weisová P, Cubinkova V, Valachova B, et al. Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy. J Alzheimers Dis. 2016;54:831-43 pubmed publisher

Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed publisher

Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher

Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Rep. 2016;16:1690-1700 pubmed publisher

Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed

Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, et al. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016;15:914-23 pubmed publisher

Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed publisher

Gelpi E, Hoftberger R, Graus F, Ling H, Holton J, Dawson T, et al. Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol. 2016;132:531-43 pubmed publisher

Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed publisher

Adams S, Tilton K, Kozubek J, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2016;75:779-790 pubmed

Fernández Nogales M, Santos Galindo M, Merchán Rubira J, Hoozemans J, Rábano A, Ferrer I, et al. Tau-positive nuclear indentations in P301S tauopathy mice. Brain Pathol. 2017;27:314-322 pubmed publisher

Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed publisher

Herring A, Münster Y, Metzdorf J, Bolczek B, Krüssel S, Krieter D, et al. Late running is not too late against Alzheimer's pathology. Neurobiol Dis. 2016;94:44-54 pubmed publisher

Shively S, Horkayne Szakaly I, Jones R, Kelly J, Armstrong R, Perl D. Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series. Lancet Neurol. 2016;15:944-953 pubmed publisher

Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed publisher

Wang H, Wang R, Carrera I, Xu S, Lakshmana M. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. Eneuro. 2016;3: pubmed publisher

Makioka K, Yamazaki T, Takatama M, Ikeda M, Murayama S, Okamoto K, et al. Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease. J Neurol Sci. 2016;365:101-7 pubmed publisher

Dourlen P, Fernandez Gomez F, Dupont C, Grenier Boley B, Bellenguez C, Obriot H, et al. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Mol Psychiatry. 2017;22:874-883 pubmed publisher

Bouvier D, Jones E, Quesseveur G, Davoli M, A Ferreira T, Quirion R, et al. High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease. Sci Rep. 2016;6:24544 pubmed publisher

Yetman M, Fowler S, Jankowsky J. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS ONE. 2016;11:e0153724 pubmed publisher

Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, et al. Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration. Acta Neuropathol Commun. 2016;4:36 pubmed publisher

Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed publisher

Chanu S, Sarkar S. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 2017;54:2706-2719 pubmed publisher

Merlini M, Wanner D, Nitsch R. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta Neuropathol. 2016;131:737-52 pubmed publisher

Gorsky M, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Sci Rep. 2016;6:22685 pubmed publisher

Piras A, Collin L, Grüninger F, Graff C, Rönnbäck A. Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol Commun. 2016;4:22 pubmed publisher

Maeda S, Djukic B, Taneja P, Yu G, Lo I, Davis A, et al. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016;17:530-51 pubmed publisher

Perez S, Sherwood C, Cranfield M, Erwin J, Mudakikwa A, Hof P, et al. Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol Aging. 2016;39:195-201 pubmed publisher

Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher

Garcia Ratés S, Morrill P, Tu H, Pottiez G, Badin A, Tormo Garcia C, et al. (I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology. 2016;105:487-499 pubmed publisher

Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed publisher

Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, Dearmond S. Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2016;75:256-62 pubmed publisher

Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed publisher

Jiang T, Zhang Y, Chen Q, Gao Q, Zhu X, Zhou J, et al. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. 2016;105:196-206 pubmed publisher

Peng Y, Kim M, Hullinger R, O Riordan K, Burger C, Pehar M, et al. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain. 2016;139:937-52 pubmed publisher

Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher

El Khoury N, Gratuze M, Petry F, Papon M, Julien C, Marcouiller F, et al. Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice. Neurobiol Dis. 2016;88:55-65 pubmed publisher

Liu H, Shi H, Huang F, Peterson K, Wu H, Lan Y, et al. Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway. Sci Rep. 2016;6:19137 pubmed publisher

Rosenberger A, Morrema T, Gerritsen W, van Haastert E, Snkhchyan H, Hilhorst R, et al. Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology. J Neuroinflammation. 2016;13:4 pubmed publisher

Sandoval Hernández A, Buitrago L, Moreno H, Cardona Gómez G, Arboleda G. Role of Liver X Receptor in AD Pathophysiology. PLoS ONE. 2015;10:e0145467 pubmed publisher

Platt T, Beckett T, Kohler K, Niedowicz D, Murphy M. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. 2016;315:162-74 pubmed publisher

Nagamine S, Yamazaki T, Makioka K, Fujita Y, Ikeda M, Takatama M, et al. Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains. Neuropathology. 2016;36:333-45 pubmed publisher

Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed publisher

Chambers J, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, et al. The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun. 2015;3:78 pubmed publisher

Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed publisher

Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, et al. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Mol Brain. 2015;8:82 pubmed publisher

Hromadkova L, Kolarova M, Jankovicova B, Bartos A, Ricny J, Bilkova Z, et al. Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product. J Neuroimmunol. 2015;289:121-9 pubmed publisher

Pamphlett R, Kum Jew S. Locus ceruleus neurons in people with autism contain no histochemically-detectable mercury. Biometals. 2016;29:171-5 pubmed publisher

Sabogal Guáqueta A, Osorio E, Cardona Gómez G. Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice. Neuropharmacology. 2016;102:111-20 pubmed publisher

Chauhan S, Ahmed Z, Bradfute S, Arko Mensah J, Mandell M, Won Choi S, et al. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Nat Commun. 2015;6:8620 pubmed publisher

Yamada K, Patel T, Hochgräfe K, Mahan T, Jiang H, Stewart F, et al. Analysis of in vivo turnover of tau in a mouse model of tauopathy. Mol Neurodegener. 2015;10:55 pubmed publisher

Radford H, Moreno J, Verity N, Halliday M, Mallucci G. PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia. Acta Neuropathol. 2015;130:633-42 pubmed publisher

Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, et al. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol. 2015;130:619-31 pubmed publisher

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18:1584-93 pubmed publisher

Watamura N, Toba J, Yoshii A, Nikkuni M, Ohshima T. Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment. J Neurosci Res. 2016;94:15-26 pubmed publisher

Min S, Chen X, Tracy T, Li Y, Zhou Y, Wang C, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015;21:1154-62 pubmed publisher

Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala M, Sultan A, et al. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiol Dis. 2015;82:540-551 pubmed publisher

Smith P, Hernandez Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, et al. miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Hum Mol Genet. 2015;24:6721-35 pubmed publisher

Richter M, Mewes A, Fritsch M, Krügel U, Hoffmann R, Singer D. Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation. Vaccines (Basel). 2014;2:601-23 pubmed publisher

Henstridge C, Jackson R, Kim J, Herrmann A, Wright A, Harris S, et al. Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse. Acta Neuropathol Commun. 2015;3:53 pubmed publisher

Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher

Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed publisher

Du L, Chang L, Ardiles A, Tapia Rojas C, Araya J, Inestrosa N, et al. Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus. PLoS ONE. 2015;10:e0135499 pubmed publisher

Smolek T, Madari A, Farbáková J, Kandrac O, Jadhav S, Cente M, et al. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. J Comp Neurol. 2016;524:874-95 pubmed publisher

Rábano A, Cuadros R, Merino Serráis P, Rodal I, Benavides Piccione R, Gómez E, et al. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease. Methods Mol Biol. 2016;1303:143-60 pubmed publisher

Lauretti E, Praticò D. Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell. 2015;14:1067-74 pubmed publisher

Zeineh M, Chen Y, Kitzler H, Hammond R, Vogel H, Rutt B. Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiol Aging. 2015;36:2483-500 pubmed publisher

Kim J, Kim S, Lee Y. Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice. Neuroreport. 2015;26:767-72 pubmed publisher

Ziskin J, Greicius M, Zhu W, Okumu A, Adams C, Plowey E. Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia. Acta Neuropathol Commun. 2015;3:43 pubmed publisher

Hamm M, Bailey R, Shaw G, Yen S, Lewis J, Giasson B. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. J Neurosci Res. 2015;93:1567-80 pubmed publisher

Sun L, Ban T, Liu C, Chen Q, Wang X, Yan M, et al. Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation. J Neurochem. 2015;134:1139-51 pubmed publisher

Di Meco A, Joshi Y, Lauretti E, Praticò D. Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry. 2016;21:403-10 pubmed publisher

Iacono D, Geraci Erck M, Peng H, Rabin M, Kurlan R. Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses. Tremor Other Hyperkinet Mov (N Y). 2015;5: pubmed publisher

Wang D, Kinoshita Y, Kinoshita C, Uo T, Sopher B, Cudaback E, et al. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015;138:2005-19 pubmed publisher

Sankaranarayanan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PLoS ONE. 2015;10:e0125614 pubmed publisher

Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed publisher

Kan M, Lee J, Wilson J, Everhart A, Brown C, Hoofnagle A, et al. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci. 2015;35:5969-82 pubmed publisher

Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed publisher

Maphis N, Xu G, Kokiko Cochran O, Jiang S, Cardona A, Ransohoff R, et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015;138:1738-55 pubmed publisher

Erro Aguirre M, Zelaya M, Sánchez Ruiz de Gordoa J, Tuñón M, Lanciego J. Midbrain catecholaminergic neurons co-express α-synuclein and tau in progressive supranuclear palsy. Front Neuroanat. 2015;9:25 pubmed publisher

Aubry S, Shin W, Crary J, Lefort R, Qureshi Y, Lefebvre C, et al. Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression. PLoS ONE. 2015;10:e0120352 pubmed publisher

Filipcik P, Cente M, Zilka N, Smolek T, Hanes J, Kučerák J, et al. Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochim Biophys Acta. 2015;1852:1219-29 pubmed publisher

Li R, Xu D, Ma T. Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience. 2015;294:14-20 pubmed publisher

Tapia Rojas C, Aranguiz F, Varela Nallar L, Inestrosa N. Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease. Brain Pathol. 2016;26:62-74 pubmed publisher

Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed publisher

Collins J, King A, Woodhouse A, Kirkcaldie M, Vickers J. The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease. Exp Neurol. 2015;267:219-29 pubmed publisher

Garza Manero S, Arias C, Bermúdez Rattoni F, Vaca L, Zepeda A. Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease. Front Cell Neurosci. 2015;9:53 pubmed publisher

Jay T, Miller C, Cheng P, Graham L, Bemiller S, Broihier M, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015;212:287-95 pubmed publisher

Reis R, Hennessy E, Murray C, Griffin Ã, Cunningham C. At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei. Neuropathol Appl Neurobiol. 2015;41:780-97 pubmed publisher

Bennett R, Brody D. Array tomography for the detection of non-dilated, injured axons in traumatic brain injury. J Neurosci Methods. 2015;245:25-36 pubmed publisher

Sabogal Guáqueta A, Muñoz Manco J, Ramírez Pineda J, Lamprea Rodriguez M, Osorio E, Cardona Gómez G. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. Neuropharmacology. 2015;93:134-45 pubmed publisher

Spilsbury A, Miwa S, Attems J, Saretzki G. The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro. J Neurosci. 2015;35:1659-74 pubmed publisher

Apostolova L, Zarow C, Biado K, Hurtz S, Boccardi M, Somme J, et al. Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol. Alzheimers Dement. 2015;11:139-50 pubmed publisher

Tian H, Davidowitz E, Lopez P, He P, Schulz P, Moe J, et al. Isolation and characterization of antibody fragments selective for toxic oligomeric tau. Neurobiol Aging. 2015;36:1342-55 pubmed publisher

Yang Y, Shepherd C, Halliday G. Aneuploidy in Lewy body diseases. Neurobiol Aging. 2015;36:1253-60 pubmed publisher

Petraglia A, Plog B, Dayawansa S, Dashnaw M, Czerniecka K, Walker C, et al. The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy. Surg Neurol Int. 2014;5:184 pubmed publisher

Postupna N, Keene C, Crane P, Gonzalez Cuyar L, Sonnen J, Hewitt J, et al. Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE. J Neuropathol Exp Neurol. 2015;74:100-9 pubmed publisher

Serrano F, Tapia Rojas C, Carvajal F, Hancke J, Cerpa W, Inestrosa N. Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice. Mol Neurodegener. 2014;9:61 pubmed publisher

Iliff J, Chen M, Plog B, Zeppenfeld D, Soltero M, Yang L, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. 2014;34:16180-93 pubmed publisher

Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed publisher

Hohsfield L, Daschil N, Orädd G, Strömberg I, Humpel C. Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models. Mol Cell Neurosci. 2014;63:83-95 pubmed

Höllerhage M, Deck R, de Andrade A, Respondek G, Xu H, Rösler T, et al. Piericidin A aggravates Tau pathology in P301S transgenic mice. PLoS ONE. 2014;9:e113557 pubmed publisher

Ohia Nwoko O, Montazari S, Lau Y, Eriksen J. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54 pubmed publisher

Ryu J, Horkayne Szakaly I, Xu L, Pletnikova O, Leri F, Eberhart C, et al. The problem of axonal injury in the brains of veterans with histories of blast exposure. Acta Neuropathol Commun. 2014;2:153 pubmed publisher

Falcon B, Cavallini A, Angers R, Glover S, Murray T, Barnham L, et al. Conformation determines the seeding potencies of native and recombinant Tau aggregates. J Biol Chem. 2015;290:1049-65 pubmed publisher

Huang C, Ho Y, Ng O, Irwin M, Chang R, Wong G. Dexmedetomidine directly increases tau phosphorylation. J Alzheimers Dis. 2015;44:839-50 pubmed publisher

Thomzig A, Wagenführ K, Daus M, Joncic M, Schulz Schaeffer W, Thanheiser M, et al. Decontamination of medical devices from pathological amyloid-?-, tau- and ?-synuclein aggregates. Acta Neuropathol Commun. 2014;2:151 pubmed publisher

Castro Alvarez J, Uribe Arias S, Kosik K, Cardona Gómez G. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Front Aging Neurosci. 2014;6:243 pubmed publisher

Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher

Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer J, Jimenez Sanchez M, et al. PICALM modulates autophagy activity and tau accumulation. Nat Commun. 2014;5:4998 pubmed publisher

Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed publisher

Lue L, Schmitz C, Serrano G, Sue L, Beach T, Walker D. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices. Brain Pathol. 2015;25:469-80 pubmed publisher

Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed publisher

Yarchoan M, Toledo J, Lee E, Arvanitakis Z, Kazi H, Han L, et al. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathol. 2014;128:679-89 pubmed publisher

Collin L, Bohrmann B, Göpfert U, Oroszlan Szovik K, Ozmen L, Grüninger F. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. Brain. 2014;137:2834-46 pubmed publisher

Kohler C, Dinekov M, Götz J. Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and A? amyloidosis. Neurobiol Dis. 2014;71:169-79 pubmed publisher

Polito V, Li H, Martini Stoica H, Wang B, Yang L, Xu Y, et al. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014;6:1142-60 pubmed publisher

Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger J, Zerbinatti C. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE. 2014;9:e103187 pubmed publisher

Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014;76:443-56 pubmed publisher

Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed publisher

Fernández Nogales M, Cabrera J, Santos Galindo M, Hoozemans J, Ferrer I, Rozemuller A, et al. Huntington's disease is a four-repeat tauopathy with tau nuclear rods. Nat Med. 2014;20:881-5 pubmed publisher

Rao M, McBrayer M, Campbell J, Kumar A, Hashim A, Sershen H, et al. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. J Neurosci. 2014;34:9222-34 pubmed publisher

Lasagna Reeves C, Sengupta U, Castillo Carranza D, Gerson J, Guerrero Munoz M, Troncoso J, et al. The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathol Commun. 2014;2:56 pubmed publisher

Jiang T, Yu J, Zhu X, Zhang Q, Cao L, Wang H, et al. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. 2014;85:121-30 pubmed publisher

Xia D, Götz J. Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn. Front Mol Neurosci. 2014;7:40 pubmed publisher

Garcia Mesa Y, Pareja Galeano H, Bonet Costa V, Revilla S, Gómez Cabrera M, Gambini J, et al. Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms. Psychoneuroendocrinology. 2014;45:154-66 pubmed publisher

Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher

Lin L, Yang S, Chu J, Wang L, Ning L, Zhang T, et al. Region-specific expression of tau, amyloid-? protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41:1149-63 pubmed publisher

Hales C, Seyfried N, Dammer E, Duong D, Yi H, Gearing M, et al. U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21. Mol Neurodegener. 2014;9:15 pubmed publisher

Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed publisher

Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3?/?. Eur J Neurosci. 2014;40:2442-53 pubmed publisher

Bit Ivan E, Suh E, Shim H, Weintraub S, Hyman B, Arnold S, et al. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. J Neuropathol Exp Neurol. 2014;73:467-73 pubmed publisher

Kondadi A, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, et al. Loss of the m-AAA protease subunit AFG?L? causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014;33:1011-26 pubmed publisher

Pan J, Lee M, Honig L, Vonsattel J, Faust P, Louis E. Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?. Parkinsonism Relat Disord. 2014;20:655-8 pubmed publisher

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher

Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed publisher

Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed publisher

Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed publisher

Stancu I, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, et al. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB J. 2014;28:2620-31 pubmed publisher

Palm R, Chang J, Blair J, Garcia Mesa Y, Lee H, Castellani R, et al. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. J Neurochem. 2014;130:115-25 pubmed publisher

Kim H, Chang K, Ha T, Kim J, Ha S, Shin K, et al. S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model. PLoS ONE. 2014;9:e88924 pubmed publisher

Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, et al. Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun. 2014;2:14 pubmed publisher

Zhang Y, Lu L, Jia J, Jia L, Geula C, Pei J, et al. A lifespan observation of a novel mouse model: in vivo evidence supports a? oligomer hypothesis. PLoS ONE. 2014;9:e85885 pubmed publisher

Dalby N, Volbracht C, Helboe L, Larsen P, Jensen H, Egebjerg J, et al. Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy. J Alzheimers Dis. 2014;40:429-42 pubmed publisher

Bodi I, Curran O, Selway R, Elwes R, Burrone J, Laxton R, et al. Two cases of multinodular and vacuolating neuronal tumour. Acta Neuropathol Commun. 2014;2:7 pubmed publisher

Chare L, Hodges J, Leyton C, McGinley C, Tan R, Kril J, et al. New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications. J Neurol Neurosurg Psychiatry. 2014;85:865-70 pubmed publisher

Xiong Z, Thangavel R, Kempuraj D, Yang E, Zaheer S, Zaheer A. Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain. J Alzheimers Dis. 2014;40:297-308 pubmed publisher

Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed publisher

Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed publisher

Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed publisher

Ridwan S, Bauer H, Frauenknecht K, Hefti K, von Pein H, Sommer C. Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease. J Anat. 2014;224:377-91 pubmed publisher

Torres M, Price S, Fiol deRoque M, Marcilla Etxenike A, Ahyayauch H, Barcelo Coblijn G, et al. Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. Biochim Biophys Acta. 2014;1838:1680-92 pubmed publisher

Dye J, Rees G, Yang I, Vespa P, Martin N, Vinters H. Neuropathologic analysis of hematomas evacuated from patients with spontaneous intracerebral hemorrhage. Neuropathology. 2014;34:253-60 pubmed publisher

Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed publisher

Pehar M, Ko M, Li M, Scrable H, Puglielli L. P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion. Aging Cell. 2014;13:449-56 pubmed publisher

Sagare A, Bell R, Zhao Z, Ma Q, Winkler E, Ramanathan A, et al. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013;4:2932 pubmed publisher

Huang X, Qian Z, He X, Gong Q, Wu K, Jiang L, et al. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol Aging. 2014;35:1045-54 pubmed publisher

Graham D, Gray A, Joyce J, Yu D, O Moore J, Carlson G, et al. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014;79:307-13 pubmed publisher

Murray P, Kirkwood C, Gray M, Fish K, Ikonomovic M, Hamilton R, et al. Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis. J Alzheimers Dis. 2014;39:759-73 pubmed publisher

Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed publisher

Trujillo Estrada L, Jimenez S, De Castro V, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology. Acta Neuropathol Commun. 2013;1:73 pubmed publisher

Yanagisawa D, Taguchi H, Ibrahim N, Morikawa S, Shiino A, Inubushi T, et al. Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain. J Alzheimers Dis. 2014;39:617-31 pubmed publisher

Wang C, Klechikov A, Gharibyan A, Wärmländer S, Jarvet J, Zhao L, et al. The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade. Acta Neuropathol. 2014;127:507-22 pubmed publisher

Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed publisher

Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, et al. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014;39:191-210 pubmed publisher

Wilson R, Nag S, Boyle P, Hizel L, Yu L, Buchman A, et al. Brainstem aminergic nuclei and late-life depressive symptoms. JAMA Psychiatry. 2013;70:1320-8 pubmed publisher

Hales C, REES H, Seyfried N, Dammer E, Duong D, Gearing M, et al. Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes. J Neuropathol Exp Neurol. 2013;72:1009-15 pubmed publisher

Blennerhassett R, Lillo P, Halliday G, Hodges J, Kril J. Distribution of pathology in frontal variant Alzheimer's disease. J Alzheimers Dis. 2014;39:63-70 pubmed publisher

Nölle A, van Haastert E, Zwart R, Hoozemans J, Scheper W. Ubiquilin 2 is not associated with tau pathology. PLoS ONE. 2013;8:e76598 pubmed publisher

Hensley K, Gabbita S, Venkova K, Hristov A, Johnson M, Eslami P, et al. A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2013;72:955-69 pubmed publisher

Natunen T, Parrado A, Helisalmi S, Pursiheimo J, Sarajärvi T, Mäkinen P, et al. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J Alzheimers Dis. 2013;37:217-32 pubmed publisher

Levarska L, Zilka N, Jadhav S, Neradil P, Novak M. Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease. J Alzheimers Dis. 2013;37:569-77 pubmed publisher

Popova S, Alafuzoff I. Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration. J Alzheimers Dis. 2013;37:603-10 pubmed publisher

Mannix R, Meehan W, MANDEVILLE J, Grant P, Gray T, Berglass J, et al. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013;74:65-75 pubmed publisher

Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed publisher

Perez S, Raghanti M, Hof P, Kramer L, Ikonomovic M, Lacor P, et al. Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla). J Comp Neurol. 2013;521:4318-38 pubmed publisher

Mizukami K, Abrahamson E, Mi Z, Ishikawa M, Watanabe K, Kinoshita S, et al. Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology. Neuropathology. 2014;34:11-8 pubmed publisher

Anumala U, Gu J, Lo Monte F, Kramer T, Heyny von Haußen R, Hölzer J, et al. Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains. Bioorg Med Chem. 2013;21:5139-44 pubmed publisher

Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, et al. The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e68722 pubmed publisher

Chen R, Chang W, Lin Y, Cheng P, Chen Y. Alzheimer's amyloid-? oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway. ACS Chem Neurosci. 2013;4:1287-96 pubmed publisher

Barron A, Garcia Segura L, Caruso D, Jayaraman A, Lee J, Melcangi R, et al. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci. 2013;33:8891-7 pubmed publisher

Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, et al. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS ONE. 2013;8:e62459 pubmed publisher

Clippinger A, D Alton S, Lin W, Gendron T, Howard J, Borchelt D, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathol. 2013;126:39-50 pubmed publisher

Hawkins B, Krishnamurthy S, Castillo Carranza D, Sengupta U, Prough D, Jackson G, et al. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem. 2013;288:17042-50 pubmed publisher

Tackenberg C, Grinschgl S, Trutzel A, Santuccione A, Frey M, Konietzko U, et al. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 2013;4:e608 pubmed publisher

Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, et al. Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Mol Ther. 2013;21:1358-68 pubmed publisher

Manczak M, Reddy P. Abnormal interaction of oligomeric amyloid-? with phosphorylated tau: implications to synaptic dysfunction and neuronal damage. J Alzheimers Dis. 2013;36:285-95 pubmed publisher

Gu J, Anumala U, Heyny von Haußen R, Hölzer J, Goetschy Meyer V, Mall G, et al. Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium. ChemMedChem. 2013;8:891-7 pubmed publisher

Ando K, Brion J, Stygelbout V, Suain V, Authelet M, Dedecker R, et al. Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 2013;125:861-78 pubmed publisher

Iranzo A, Tolosa E, Gelpi E, Molinuevo J, Valldeoriola F, Serradell M, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12:443-53 pubmed publisher

Ozdemir A, Rom I, Kovalevich J, Yen W, Adiga R, Dave R, et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS ONE. 2013;8:e58232 pubmed publisher

Varges D, Schulz Schaeffer W, Wemheuer W, Damman I, Schmitz M, Cramm M, et al. Spongiform encephalopathy in siblings with no evidence of protease-resistant prion protein or a mutation in the prion protein gene. J Neurol. 2013;260:1871-9 pubmed publisher

Josephs K, Dickson D, Murray M, Senjem M, Parisi J, Petersen R, et al. Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia. Brain Lang. 2013;127:127-34 pubmed publisher

Feldengut S, Del Tredici K, Braak H. Paraffin sections of 70-100 ?m: a novel technique and its benefits for studying the nervous system. J Neurosci Methods. 2013;215:241-4 pubmed publisher

Geekiyanage H, Upadhye A, Chan C. Inhibition of serine palmitoyltransferase reduces A? and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease. Neurobiol Aging. 2013;34:2037-51 pubmed publisher

Alonso E, Vale C, Vieytes M, Botana L. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and ?-amyloid pathology. ACS Chem Neurosci. 2013;4:1062-70 pubmed publisher

Howlett D, Hortobagyi T, Francis P. Clusterin associates specifically with A?40 in Alzheimer's disease brain tissue. Brain Pathol. 2013;23:623-32 pubmed publisher

Wu T, Lu Y, Chuang C, Wu C, Chiang A, Krantz D, et al. Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. Acta Neuropathol. 2013;125:711-25 pubmed publisher

Bigio E. Making the diagnosis of frontotemporal lobar degeneration. Arch Pathol Lab Med. 2013;137:314-25 pubmed publisher

Garringer H, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS ONE. 2013;8:e56426 pubmed publisher

Barros Miñones L, Martín de Saavedra D, Perez Alvarez S, Orejana L, Suquía V, Goni Allo B, et al. Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. Biochim Biophys Acta. 2013;1832:705-17 pubmed publisher

Zufferey V, Vallet P, Moeri M, Moulin Sallanon M, Piotton F, Marin P, et al. Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice. Brain Res Bull. 2013;94:17-22 pubmed publisher

Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, et al. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013;12:257-68 pubmed publisher

Dobson Stone C, Luty A, Thompson E, Blumbergs P, Brooks W, Short C, et al. Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis. Acta Neuropathol. 2013;125:523-33 pubmed publisher

Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed publisher

Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed publisher

Sarnat H, Flores Sarnat L, Crino P, Hader W, Bello Espinosa L. Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis. Folia Neuropathol. 2012;50:330-45 pubmed

Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed publisher

Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, et al. Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-? peptide injection in rats. PLoS ONE. 2013;8:e53117 pubmed publisher

Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed publisher

Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed publisher

Liu D, Pitta M, Jiang H, Lee J, Zhang G, Chen X, et al. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol Aging. 2013;34:1564-80 pubmed publisher

Morcinek K, Kohler C, Götz J, Schröder H. Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Res. 2013;1497:73-84 pubmed publisher

Leboucher A, Laurent C, Fernandez Gomez F, Burnouf S, Troquier L, Eddarkaoui S, et al. Detrimental effects of diet-induced obesity on ? pathology are independent of insulin resistance in ? transgenic mice. Diabetes. 2013;62:1681-8 pubmed publisher

Yao J, Ho D, Calingasan N, Pipalia N, Lin M, Beal M. Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. J Exp Med. 2012;209:2501-13 pubmed publisher

Hong Y, Chan C, Kwon I, Li X, Song M, Lee H, et al. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci. 2012;32:17262-72 pubmed publisher

ATTAR A, Ripoli C, Riccardi E, Maiti P, Li Puma D, Liu T, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012;135:3735-48 pubmed publisher

Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid ?-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed publisher

Torres M, Jimenez S, Sanchez Varo R, Navarro V, Trujillo Estrada L, Sanchez Mejias E, et al. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Mol Neurodegener. 2012;7:59 pubmed publisher

Kovari E, Herrmann F, Hof P, Bouras C. The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease. Neuropathol Appl Neurobiol. 2013;39:498-509 pubmed publisher

Yokota T, Akatsu H, Miyauchi T, Heese K. Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain. FEBS Lett. 2012;586:4357-61 pubmed publisher

Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönneke H, Jordan S, et al. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS Genet. 2012;8:e1003021 pubmed publisher

Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed publisher

Pirker S, Perju Dumbrava L, Kovacs G, Traub Weidinger T, Asenbaum S, Pirker W. Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration. Parkinsonism Relat Disord. 2013;19:222-6 pubmed publisher

López Menéndez C, Gamir Morralla A, Jurado Arjona J, Higuero A, Campanero M, Ferrer I, et al. Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. Hum Mol Genet. 2013;22:466-82 pubmed publisher

Choi S, Aid S, Caracciolo L, Minami S, Niikura T, Matsuoka Y, et al. Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. J Neurochem. 2013;124:59-68 pubmed publisher

Chambers J, Uchida K, Harada T, Tsuboi M, Sato M, Kubo M, et al. Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats. PLoS ONE. 2012;7:e46452 pubmed publisher

Harris J, Koyama A, Maeda S, Ho K, Devidze N, Dubal D, et al. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS ONE. 2012;7:e45881 pubmed publisher

Soontornniyomkij V, Moore D, Gouaux B, Soontornniyomkij B, Tatro E, Umlauf A, et al. Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers. AIDS. 2012;26:2327-35 pubmed publisher

Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed publisher

Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall G, et al. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. J Nutr Biochem. 2013;24:360-70 pubmed publisher

van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans C. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neurosci Lett. 2012;528:104-9 pubmed publisher

Britschgi M, Takeda Uchimura Y, Rockenstein E, Johns H, Masliah E, Wyss Coray T. Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice. J Neuroinflammation. 2012;9:220 pubmed publisher

Capsoni S, Carlo A, Vignone D, Amato G, Criscuolo C, Willnow T, et al. SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;33:357-71 pubmed publisher

Mewes A, Franke H, Singer D. Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies. PLoS ONE. 2012;7:e45017 pubmed publisher

Tang J, Mardini F, Janik L, Garrity S, Li R, Bachlani G, et al. Modulation of murine Alzheimer pathogenesis and behavior by surgery. Ann Surg. 2013;257:439-48 pubmed publisher

Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, et al. Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice. Hum Mol Genet. 2012;21:5091-105 pubmed publisher

Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, et al. Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and ?-amyloid plaques in Alzheimer's disease models. J Med Chem. 2012;55:9170-80 pubmed publisher

Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, et al. Hyperphosphorylation of Tau induced by naturally secreted amyloid-? at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3? signaling pathway. J Biol Chem. 2012;287:35222-33 pubmed publisher

Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K. Dystrophic neurites express C9orf72 in Alzheimer's disease brains. Alzheimers Res Ther. 2012;4:33 pubmed publisher

Gelpi E, Lladó A, Clarimon J, Rey M, Rivera R, Ezquerra M, et al. Phenotypic variability within the inclusion body spectrum of basophilic inclusion body disease and neuronal intermediate filament inclusion disease in frontotemporal lobar degenerations with FUS-positive inclusions. J Neuropathol Exp Neurol. 2012;71:795-805 pubmed publisher

Magnaudeix A, Wilson C, Page G, Bauvy C, Codogno P, Leveque P, et al. PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging. 2013;34:770-90 pubmed publisher

Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed publisher

Gelpi E, Soler Insa J, Parchi P, Saverioni D, Yague J, Nos C, et al. Atypical neuropathological sCJD-MM phenotype with abundant white matter Kuru-type plaques sparing the cerebellar cortex. Neuropathology. 2013;33:204-8 pubmed publisher

Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed publisher

Colom Cadena M, Gelpi E, Marti M, Charif S, Dols Icardo O, Blesa R, et al. MAPT H1 haplotype is associated with enhanced ?-synuclein deposition in dementia with Lewy bodies. Neurobiol Aging. 2013;34:936-42 pubmed publisher

Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed publisher

Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed publisher

Julien C, Marcouiller F, Bretteville A, El Khoury N, Baillargeon J, Hébert S, et al. Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation. PLoS ONE. 2012;7:e40020 pubmed publisher

Bretteville A, Marcouiller F, Julien C, El Khoury N, Petry F, Poitras I, et al. Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors. Sci Rep. 2012;2:480 pubmed publisher

Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed publisher

Capsoni S, Marinelli S, Ceci M, Vignone D, Amato G, Malerba F, et al. Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice. PLoS ONE. 2012;7:e37555 pubmed publisher

Schauer T, Lochner M, Kovacs G. Nigral Tau pathology and striatal amyloid-? deposition does not correlate with striatal dopamine deficit in Alzheimer's disease. J Neural Transm (Vienna). 2012;119:1545-9 pubmed publisher

Barten D, Fanara P, Andorfer C, Hoque N, Wong P, Husted K, et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci. 2012;32:7137-45 pubmed publisher

Herzig M, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, et al. High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain. PLoS ONE. 2012;7:e36581 pubmed publisher

Cancino G, Miller F, Kaplan D. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013;34:387-99 pubmed publisher

Mustroph M, King M, Klein R, Ramirez J. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behav Brain Res. 2012;233:141-8 pubmed publisher

Fine J, Baillargeon A, Renner D, Hoerster N, Tokarev J, Colton S, et al. Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1?, and phosphorylates GSK3? in P301L tau transgenic mice. Exp Brain Res. 2012;219:381-90 pubmed publisher

Petratos S, Ozturk E, Azari M, Kenny R, Lee J, Magee K, et al. Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation. Brain. 2012;135:1794-818 pubmed publisher

Chen C, Weng Y, Chien K, Lin K, Yeh T, Cheng Y, et al. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ. 2012;19:1623-33 pubmed publisher

Kapás I, Majtenyi K, Töro K, Keller E, Voigtlander T, Kovacs G. Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. Metab Brain Dis. 2012;27:231-5 pubmed publisher

Van der Jeugd A, Hochgräfe K, Ahmed T, Decker J, Sydow A, Hofmann A, et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol. 2012;123:787-805 pubmed publisher

Joshi Y, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis. 2012;31:167-76 pubmed publisher

Matsushima T, Saito Y, Elliott J, Iijima Ando K, Nishimura M, Kimura N, et al. Membrane-microdomain localization of amyloid ?-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. J Biol Chem. 2012;287:19715-24 pubmed publisher

Fodero Tavoletti M, Brockschnieder D, Villemagne V, Martin L, Connor A, Thiele A, et al. In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer. Nucl Med Biol. 2012;39:1042-8 pubmed publisher

Braak H, Thal D, Matschke J, Ghebremedhin E, Del Tredici K. Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiol Aging. 2013;34:286-97 pubmed publisher

Talbot K, Wang H, Kazi H, Han L, Bakshi K, Stucky A, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122:1316-38 pubmed publisher

Zhang Q, Gao T, Luo Y, Chen X, Gao G, Gao X, et al. Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease. PLoS ONE. 2012;7:e33722 pubmed publisher

Soontornniyomkij V, Soontornniyomkij B, Moore D, Gouaux B, Masliah E, Tung S, et al. Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2012;7:579-90 pubmed publisher

Carvalho C, Cardoso S, Correia S, Santos R, Santos M, Baldeiras I, et al. Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes. 2012;61:1234-42 pubmed publisher

Clausen A, Xu X, Bi X, Baudry M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J Alzheimers Dis. 2012;30:183-208 pubmed publisher

Woehrer A, Laszlo L, Finsterer J, Stollberger C, Furtner J, Rinner W, et al. Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia. Acta Neuropathol. 2012;124:583-91 pubmed publisher

Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed publisher

Zago W, Buttini M, Comery T, Nishioka C, Gardai S, Seubert P, et al. Neutralization of soluble, synaptotoxic amyloid ? species by antibodies is epitope specific. J Neurosci. 2012;32:2696-702 pubmed publisher

Matsuki T, Zaka M, Guerreiro R, van der Brug M, Cooper J, Cookson M, et al. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PLoS ONE. 2012;7:e31152 pubmed publisher

Löffler T, Flunkert S, Taub N, Schofield E, Ward M, Windisch M, et al. Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci. 2012;47:192-203 pubmed publisher

Caesar I, Jonson M, Nilsson K, Thor S, Hammarstrom P. Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. PLoS ONE. 2012;7:e31424 pubmed publisher

Sudduth T, Wilson J, Everhart A, Colton C, Wilcock D. Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS ONE. 2012;7:e31993 pubmed publisher

Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed publisher

Troquier L, Caillierez R, Burnouf S, Fernandez Gomez F, Grosjean M, Zommer N, et al. Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Curr Alzheimer Res. 2012;9:397-405 pubmed

Sundaram J, Chan E, Poore C, Pareek T, Cheong W, Shui G, et al. Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. J Neurosci. 2012;32:1020-34 pubmed publisher

Lasagna Reeves C, Castillo Carranza D, Sengupta U, Sarmiento J, Troncoso J, Jackson G, et al. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J. 2012;26:1946-59 pubmed publisher

Giustiniani J, Sineus M, Sardin E, Dounane O, Panchal M, Sazdovitch V, et al. Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17. J Alzheimers Dis. 2012;29:471-83 pubmed publisher

Venkataramani V, Wirths O, Budka H, Hartig W, Kovacs G, Bayer T. Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-? in a fraction of amyloid-? deposits in Alzheimer's disease without cross-reactivity with other protein aggregates. J Alzheimers Dis. 2012;29:361-71 pubmed publisher

Stefanits H, Budka H, Kovacs G. Asymmetry of neurodegenerative disease-related pathologies: a cautionary note. Acta Neuropathol. 2012;123:449-52 pubmed publisher

Filipcik P, Novak P, Mravec B, Ondicova K, Krajciova G, Novak M, et al. Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress. Cell Mol Neurobiol. 2012;32:837-45 pubmed publisher

Garcia Mesa Y, Gimenez Llort L, Lopez L, Venegas C, Cristofol R, Escames G, et al. Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse. Neurobiol Aging. 2012;33:1124.e13-29 pubmed publisher

Okamoto Y, Yamamoto T, Kalaria R, Senzaki H, Maki T, Hase Y, et al. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2012;123:381-94 pubmed publisher

Krüger U, Wang Y, Kumar S, Mandelkow E. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging. 2012;33:2291-305 pubmed publisher

Elobeid A, Soininen H, Alafuzoff I. Hyperphosphorylated tau in young and middle-aged subjects. Acta Neuropathol. 2012;123:97-104 pubmed publisher

Perez S, Getova D, He B, Counts S, Geula C, Désiré L, et al. Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease. Am J Pathol. 2012;180:526-40 pubmed publisher

Manaye K, Mouton P, Xu G, Drew A, Lei D, Sharma Y, et al. Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. Age (Dordr). 2013;35:139-47 pubmed publisher

Ndung u M, Hartig W, Wegner F, Mwenda J, Low R, Akinyemi R, et al. Cerebral amyloid ?(42) deposits and microvascular pathology in ageing baboons. Neuropathol Appl Neurobiol. 2012;38:487-99 pubmed publisher

Morawski M, Brückner G, Jäger C, Seeger G, Matthews R, Arendt T. Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology. Brain Pathol. 2012;22:547-61 pubmed publisher

Li L, Zhang Z, Holscher C, Gao C, Jiang Y, Liu Y. (Val?) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur J Pharmacol. 2012;674:280-6 pubmed publisher

Nijholt D, van Haastert E, Rozemuller A, Scheper W, Hoozemans J. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol. 2012;226:693-702 pubmed publisher

Kitazawa M, Cheng D, Tsukamoto M, Koike M, Wes P, Vasilevko V, et al. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ?-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011;187:6539-49 pubmed publisher

Maarouf C, Daugs I, Kokjohn T, Walker D, Hunter J, Kruchowsky J, et al. Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging. PLoS ONE. 2011;6:e27291 pubmed publisher

Cuadrado Tejedor M, Ricobaraza A, Frechilla D, Franco R, Pérez Mediavilla A, Garcia Osta A. Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice. J Alzheimers Dis. 2012;28:567-78 pubmed publisher

Sanchez Varo R, Trujillo Estrada L, Sanchez Mejias E, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus. Acta Neuropathol. 2012;123:53-70 pubmed publisher

Piccardo P, Cervenak J, Yakovleva O, Gregori L, Pomeroy K, Cook A, et al. Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology. J Comp Pathol. 2012;147:84-93 pubmed publisher

Saing T, Dick M, Nelson P, Kim R, Cribbs D, Head E. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012;29:1054-70 pubmed publisher

Wilhelmus M, de Jager M, Rozemuller A, Brevé J, Bol J, Eckert R, et al. Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies. J Pathol. 2012;226:132-42 pubmed publisher

Li X, Kumar Y, Zempel H, Mandelkow E, Biernat J, Mandelkow E. Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J. 2011;30:4825-37 pubmed publisher

Antonell A, Gelpi E, Sanchez Valle R, Martinez R, Molinuevo J, Lladó A. Breakpoint sequence analysis of an A?PP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy. J Alzheimers Dis. 2012;28:303-8 pubmed publisher

McMillan P, Kraemer B, Robinson L, Leverenz J, Raskind M, Schellenberg G. Truncation of tau at E391 promotes early pathologic changes in transgenic mice. J Neuropathol Exp Neurol. 2011;70:1006-19 pubmed publisher

Braak H, Thal D, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol. 2011;70:960-9 pubmed publisher

Elipenahli C, Stack C, Jainuddin S, Gerges M, Yang L, Starkov A, et al. Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. J Alzheimers Dis. 2012;28:173-82 pubmed publisher

Castellani R, Gupta Y, Sheng B, Siedlak S, Harris P, Coller J, et al. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Lab Invest. 2011;91:1777-86 pubmed publisher

Ambegaokar S, Jackson G. Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet. 2011;20:4947-77 pubmed publisher

Khandelwal P, Dumanis S, Herman A, Rebeck G, Moussa C. Wild type and P301L mutant Tau promote neuro-inflammation and ?-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci. 2012;49:44-53 pubmed publisher

Chen S, Wang J, Irwin R, Yao J, Liu L, Brinton R. Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. PLoS ONE. 2011;6:e24293 pubmed publisher

Li L, Cheung T, Chen J, Herrup K. A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death. Int J Alzheimers Dis. 2011;2011:171464 pubmed publisher

Alonso E, Vale C, Vieytes M, LaFerla F, Gimenez Llort L, Botana L. 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular A? and hyperphosphorylated tau in vitro. Neurochem Int. 2011;59:1056-65 pubmed publisher

Wilhelmus M, Bol J, van Haastert E, Rozemuller A, Bu G, Drukarch B, et al. Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. Am J Pathol. 2011;179:2152-6 pubmed publisher

Xue Q, Streit W. Microglial pathology in Down syndrome. Acta Neuropathol. 2011;122:455-66 pubmed publisher

Emmer K, Waxman E, Covy J, Giasson B. E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. J Biol Chem. 2011;286:35104-18 pubmed publisher

Sheppard O, Plattner F, Rubin A, Slender A, Linehan J, Brandner S, et al. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiol Aging. 2012;33:828.e31-44 pubmed publisher

Chai X, Wu S, Murray T, Kinley R, Cella C, Sims H, et al. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J Biol Chem. 2011;286:34457-67 pubmed publisher

Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, et al. Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J. 2011;25:4063-72 pubmed publisher

Cho S, Sun B, Zhou Y, Kauppinen T, Halabisky B, Wes P, et al. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem. 2011;286:32713-22 pubmed publisher

Panaite P, Kielar M, Kraftsik R, Gourdon G, Kuntzer T, Barakat Walter I. Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice. J Neuropathol Exp Neurol. 2011;70:678-85 pubmed publisher

Gerhauser I, Wohlsein P, Ernst H, Germann P, Baumgartner W. Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters. Neurobiol Aging. 2012;33:1716-9 pubmed publisher

Minami S, Clifford T, HOE H, Matsuoka Y, Rebeck G. Fyn knock-down increases A?, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012;33:825.e15-24 pubmed publisher

Whiteman I, Minamide L, Goh D, Bamburg J, Goldsbury C. Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes. PLoS ONE. 2011;6:e20878 pubmed publisher

Martínez Sáez E, Gelpi E, Rey M, Ferrer I, Ribalta T, Botta Orfila T, et al. Hirano body-rich subtypes of Creutzfeldt-Jakob disease. Neuropathol Appl Neurobiol. 2012;38:153-61 pubmed publisher

Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K. Immunohistochemical characterization of ?-secretase activating protein expression in Alzheimer's disease brains. Neuropathol Appl Neurobiol. 2012;38:132-41 pubmed publisher

Tran H, LaFerla F, Holtzman D, Brody D. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-? accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011;31:9513-25 pubmed publisher

Silva D, Esteves A, Arduino D, Oliveira C, Cardoso S. Amyloid-?-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway. J Alzheimers Dis. 2011;26:565-81 pubmed publisher

Rodriguez Diehl R, Rey M, Gironell A, Martínez Sáez E, Ferrer I, Sanchez Valle R, et al. "Preclinical" MSA in definite Creutzfeldt-Jakob disease. Neuropathology. 2012;32:158-63 pubmed publisher

Stone J, Siedlak S, Tabaton M, Hirano A, Castellani R, Santocanale C, et al. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. J Neuropathol Exp Neurol. 2011;70:578-87 pubmed publisher

Goodwin J, Zhang J, Gonzalez D, Albinsson S, Geller D. Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension. J Hypertens. 2011;29:1347-56 pubmed publisher

Ploia C, Antoniou X, Sclip A, Grande V, Cardinetti D, Colombo A, et al. JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models. J Alzheimers Dis. 2011;26:315-29 pubmed publisher

Cuadrado Tejedor M, Hervias I, Ricobaraza A, Puerta E, Pérez Roldán J, García Barroso C, et al. Sildenafil restores cognitive function without affecting ?-amyloid burden in a mouse model of Alzheimer's disease. Br J Pharmacol. 2011;164:2029-41 pubmed publisher

Engmann O, Hortobagyi T, Thompson A, Guadagno J, Troakes C, Soriano S, et al. Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease. Biol Psychiatry. 2011;70:159-68 pubmed publisher

Waxman E, Giasson B. Induction of intracellular tau aggregation is promoted by ?-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. J Neurosci. 2011;31:7604-18 pubmed publisher

Copenhaver P, Anekonda T, Musashe D, Robinson K, Ramaker J, Swanson T, et al. A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug. Dis Model Mech. 2011;4:634-48 pubmed publisher

Belarbi K, Burnouf S, Fernandez Gomez F, Laurent C, Lestavel S, Figeac M, et al. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiol Dis. 2011;43:486-94 pubmed publisher

Rusina R, Kovacs G, Fiala J, Hort J, Ridzon P, Holmerová I, et al. FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases. BMC Neurol. 2011;11:50 pubmed publisher

Sparks D, Ziolkowski C, Lawmaster T, Martin T. Influence of water quality on cholesterol-induced tau pathology: preliminary data. Int J Alzheimers Dis. 2011;2011:987023 pubmed publisher

Orejana L, Barros Miñones L, Jordan J, Puerta E, Aguirre N. Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model. Neurobiol Aging. 2012;33:625.e11-20 pubmed publisher

Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, et al. Fronto-temporal lobar degeneration: neuropathology in 60 cases. J Neural Transm (Vienna). 2011;118:753-64 pubmed publisher

Hartikainen P, Pikkarainen M, Hanninen T, Soininen H, Alafuzoff I. Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions. Neuropathology. 2012;32:60-8 pubmed publisher

Castro Álvarez J, Gutierrez Vargas J, Darnaudéry M, Cardona Gómez G. ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia. Behav Neurosci. 2011;125:465-72 pubmed publisher

Chen L, Xiong Y, Kong F, Qu M, Wang Q, Chen X, et al. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012;120:157-64 pubmed publisher

Gaig C, Valldeoriola F, Gelpi E, Ezquerra M, Llufriu S, Buongiorno M, et al. Rapidly progressive diffuse Lewy body disease. Mov Disord. 2011;26:1316-23 pubmed publisher

Ferreira A, Bigio E. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol Med. 2011;17:676-85 pubmed publisher

Kovacs G, Molnár K, Laszlo L, Strobel T, Botond G, Hönigschnabl S, et al. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol. 2011;122:205-22 pubmed publisher

Hagen M, Murrell J, Delisle M, Andermann E, Andermann F, Guiot M, et al. Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene. Brain Pathol. 2011;21:575-82 pubmed publisher

Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe D. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011;108:5819-24 pubmed publisher

Green K, Khashwji H, Estrada T, LaFerla F. ST101 induces a novel 17 kDa APP cleavage that precludes A? generation in vivo. Ann Neurol. 2011;69:831-44 pubmed publisher

Glöckner F, Meske V, Lutjohann D, Ohm T. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. J Neuropathol Exp Neurol. 2011;70:292-301 pubmed publisher

Talbot K, Louneva N, Cohen J, Kazi H, Blake D, Arnold S. Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS ONE. 2011;6:e16886 pubmed publisher

Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, et al. Apomorphine treatment in Alzheimer mice promoting amyloid-? degradation. Ann Neurol. 2011;69:248-56 pubmed publisher

To A, Ribe E, Chuang T, Schroeder J, Lovestone S. The ?3 and ?4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice. PLoS ONE. 2011;6:e16991 pubmed publisher

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, et al. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci. 2011;31:2511-25 pubmed publisher

Kudo L, Parfenova L, Ren G, Vi N, Hui M, Ma Z, et al. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Hum Mol Genet. 2011;20:1820-33 pubmed publisher

Whittington R, Virag L, Marcouiller F, Papon M, El Khoury N, Julien C, et al. Propofol directly increases tau phosphorylation. PLoS ONE. 2011;6:e16648 pubmed publisher

Nunes A, Pressey S, Cooper J, Soriano S. Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis. Neurobiol Dis. 2011;42:349-59 pubmed publisher

Shipton O, Leitz J, Dworzak J, Acton C, Tunbridge E, Denk F, et al. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci. 2011;31:1688-92 pubmed publisher

Stieler J, Bullmann T, Kohl F, Tøien Ø, Brückner M, Hartig W, et al. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS ONE. 2011;6:e14530 pubmed publisher

Song Y, Huang Y, Halliday G. Clinical correlates of similar pathologies in parkinsonian syndromes. Mov Disord. 2011;26:499-506 pubmed publisher

Dusonchet J, Kochubey O, Stafa K, Young S, Zufferey R, Moore D, et al. A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2. J Neurosci. 2011;31:907-12 pubmed publisher

Cuadrado Tejedor M, Ricobaraza A, Del Rio J, Frechilla D, Franco R, Pérez Mediavilla A, et al. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behav Brain Res. 2011;220:338-43 pubmed publisher

Fonseca M, Chu S, Berci A, Benoit M, Peters D, Kimura Y, et al. Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation. 2011;8:4 pubmed publisher

Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed publisher

Filipcik P, Zilka N, Bugos O, Kučerák J, Koson P, Novak P, et al. First transgenic rat model developing progressive cortical neurofibrillary tangles. Neurobiol Aging. 2012;33:1448-56 pubmed publisher

Ando K, Uemura K, Kuzuya A, Maesako M, Asada Utsugi M, Kubota M, et al. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. J Biol Chem. 2011;286:7619-28 pubmed publisher

Chen J, Cohen M, Lerner A, Yang Y, Herrup K. DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease. Mol Neurodegener. 2010;5:60 pubmed publisher

Braak H, Del Tredici K. The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol. 2011;121:171-81 pubmed publisher

Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean M, et al. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiol Learn Mem. 2011;95:296-304 pubmed publisher

Sepulveda Falla D, Matschke J, Bernreuther C, Hagel C, Puig B, Villegas A, et al. Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease. Brain Pathol. 2011;21:452-63 pubmed publisher

Leger F, Fernagut P, Canron M, Leoni S, Vital C, Tison F, et al. Protein aggregation in the aging retina. J Neuropathol Exp Neurol. 2011;70:63-8 pubmed publisher

Boutajangout A, Quartermain D, Sigurdsson E. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci. 2010;30:16559-66 pubmed publisher

Colodner K, Feany M. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci. 2010;30:16102-13 pubmed publisher

Bittner T, Fuhrmann M, Burgold S, Ochs S, Hoffmann N, Mitteregger G, et al. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS ONE. 2010;5:e15477 pubmed publisher

Roltsch E, Holcomb L, Young K, Marks A, Zimmer D. PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation. J Neuroinflammation. 2010;7:78 pubmed publisher

Braak H, Thal D, Del Tredici K. Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases. J Neural Transm (Vienna). 2011;118:809-19 pubmed publisher

Tamayev R, Giliberto L, Li W, d Abramo C, Arancio O, Vidal R, et al. Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. J Neurosci. 2010;30:14915-24 pubmed publisher

Bose A, Mouton Liger F, Paquet C, Mazot P, Vigny M, Gray F, et al. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol. 2011;21:189-200 pubmed publisher

Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, et al. Diacylglycerol kinase ? knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE. 2010;5:e13447 pubmed publisher

Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobagyi T, Tanila H, et al. WNT signaling in activated microglia is proinflammatory. Glia. 2011;59:119-31 pubmed publisher

Kantarci K, Yang C, Schneider J, Senjem M, Reyes D, Lowe V, et al. Antemortem amyloid imaging and ?-amyloid pathology in a case with dementia with Lewy bodies. Neurobiol Aging. 2012;33:878-85 pubmed publisher

Perez S, He B, Muhammad N, Oh K, Fahnestock M, Ikonomovic M, et al. Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice. Neurobiol Dis. 2011;41:338-52 pubmed publisher

Chen X, Wagener J, Morgan D, Hui L, Ghribi O, Geiger J. Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet. J Alzheimers Dis. 2010;22:1289-303 pubmed publisher

Bhaskar K, Konerth M, Kokiko Cochran O, Cardona A, Ransohoff R, Lamb B. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010;68:19-31 pubmed publisher

Minami S, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, et al. Therapeutic versus neuroinflammatory effects of passive immunization is dependent on A?/amyloid burden in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2010;7:57 pubmed publisher

Van Nostrand W, Xu F, Rozemuller A, Colton C. Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. Stroke. 2010;41:S135-8 pubmed publisher

Min S, Cho S, Zhou Y, Schroeder S, Haroutunian V, Seeley W, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010;67:953-66 pubmed publisher

Lee S, Varvel N, Konerth M, Xu G, Cardona A, Ransohoff R, et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010;177:2549-62 pubmed publisher

Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, et al. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons. J Mol Neurosci. 2011;43:326-32 pubmed publisher

Rosario E, Carroll J, Pike C. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res. 2010;1359:281-90 pubmed publisher

Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, et al. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. Brain. 2010;133:3323-35 pubmed publisher

Hurtado D, Molina Porcel L, Iba M, Aboagye A, Paul S, Trojanowski J, et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol. 2010;177:1977-88 pubmed publisher

Hoftberger R, Fink S, Aboul Enein F, Botond G, Olah J, Berki T, et al. Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis. Glia. 2010;58:1847-57 pubmed publisher

Wilhelmus M, Verhaar R, Andringa G, Bol J, Cras P, Shan L, et al. Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain. Brain Pathol. 2011;21:130-9 pubmed publisher

Hamilton L, Aumont A, Julien C, Vadnais A, Calon F, Fernandes K. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci. 2010;32:905-20 pubmed publisher

Zheng Y, Amin N, Hu Y, Rudrabhatla P, Shukla V, Kanungo J, et al. A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. J Biol Chem. 2010;285:34202-12 pubmed publisher

Blanchard J, Wanka L, Tung Y, Cárdenas Aguayo M, LaFerla F, Iqbal K, et al. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting A? and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010;120:605-21 pubmed publisher

Loy C, McCusker E, Kril J, Kwok J, Brooks W, McCann H, et al. Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology. Brain. 2010;133:e158; author reply e159 pubmed publisher

Nicholson R, Kusne Y, Nowak L, LaFerla F, Reiman E, Valla J. Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models. Brain Res. 2010;1347:179-85 pubmed publisher

Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed publisher

van Eersel J, Ke Y, Liu X, Delerue F, Kril J, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93 pubmed publisher

Barnett B, Bressler J, Chen T, Hutchins G, Crain B, Kaufmann W. ?B-crystallin negative astrocytic inclusions. Brain Dev. 2011;33:349-52 pubmed publisher

Bhaskar K, Hobbs G, Yen S, Lee G. Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. Neuropathol Appl Neurobiol. 2010;36:462-77 pubmed publisher

Liang B, Duan B, Zhou X, Gong J, Luo Z. Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Biol Chem. 2010;285:27737-44 pubmed publisher

Ambegaokar S, Jackson G. Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster. Genetics. 2010;186:435-42 pubmed publisher

Pretnar Oblak J, Zaletel M, Hajnsek T, Meglic B, Hocevar Boltezar I, Popovic M. Isolated bulbar paralysis in a patient with medullar tau pathology: a case report. J Neurol Neurosurg Psychiatry. 2010;81:847-9 pubmed publisher

Parachikova A, Vasilevko V, Cribbs D, LaFerla F, Green K. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010;21:527-42 pubmed publisher

Bertrand J, Sénéchal P, Zummo Soucy M, Plouffe V, Leclerc N. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. J Neurochem. 2010;114:1353-67 pubmed publisher

Morawski M, Bruckner G, Jager C, Seeger G, Arendt T. Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease. Neuroscience. 2010;169:1347-63 pubmed publisher

Koike M, Green K, Blurton Jones M, LaFerla F. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010;177:300-10 pubmed publisher

Lee H, Lee J, Lee H, Carter J, Chang J, Oh W, et al. Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. Neurobiol Aging. 2012;33:588-602 pubmed publisher

Feuillette S, Deramecourt V, Laquerriere A, Duyckaerts C, Delisle M, Maurage C, et al. Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains. Brain Res. 2010;1345:182-9 pubmed publisher

Caltagarone J, Hamilton R, Murdoch G, Jing Z, DeFranco D, Bowser R. Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi. J Neuropathol Exp Neurol. 2010;69:356-71 pubmed publisher

Berg I, Nilsson K, Thor S, Hammarstrom P. Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses. Nat Protoc. 2010;5:935-44 pubmed publisher

Carroll J, Rosario E, Villamagna A, Pike C. Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology. 2010;151:2713-22 pubmed publisher

Bertrand J, Plouffe V, Senechal P, Leclerc N. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. 2010;168:323-34 pubmed publisher

van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C. Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiol Dis. 2010;39:265-71 pubmed publisher

Braak H, Ludolph A, Thal D, Del Tredici K. Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord. Acta Neuropathol. 2010;120:67-74 pubmed publisher

Heath J, Siedlak S, Zhu X, Lee H, Thakur A, Yan R, et al. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology. 2010;30:574-9 pubmed publisher

Lee J, Won S, Suh J, Son S, Moon G, Park U, et al. Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Exp Mol Med. 2010;42:386-94 pubmed

de Calignon A, Fox L, Pitstick R, Carlson G, Bacskai B, Spires Jones T, et al. Caspase activation precedes and leads to tangles. Nature. 2010;464:1201-4 pubmed publisher

Escribano L, Simón A, Gimeno E, Cuadrado Tejedor M, Lopez de Maturana R, Garcia Osta A, et al. Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology. 2010;35:1593-604 pubmed publisher

Greco S, Bryan K, Sarkar S, Zhu X, Smith M, Ashford J, et al. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;19:1155-67 pubmed publisher

Fang H, Zhang L, Meng F, Du X, Zhou J. Acute hypoxia promote the phosphorylation of tau via ERK pathway. Neurosci Lett. 2010;474:173-177 pubmed publisher

Del Tredici K, Hawkes C, Ghebremedhin E, Braak H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol. 2010;119:703-13 pubmed publisher

Dickstein D, Brautigam H, Stockton S, Schmeidler J, Hof P. Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau. Brain Struct Funct. 2010;214:161-79 pubmed publisher

Silveira Moriyama L, Hughes G, Church A, Ayling H, Williams D, Petrie A, et al. Hyposmia in progressive supranuclear palsy. Mov Disord. 2010;25:570-7 pubmed publisher

Liu X, Liao K, Liu R, Wang H, Zhang Y, Zhang Q, et al. Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2. J Alzheimers Dis. 2010;19:953-62 pubmed publisher

Sharma A, Callahan L, Sul J, Kim T, Barrett L, Kim M, et al. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS ONE. 2010;5:e9002 pubmed publisher

Ma J, Huang Y, Chen S, Halliday G. Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease. Neuropathol Appl Neurobiol. 2010;36:312-9 pubmed publisher

Pan Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS ONE. 2010;5:e8762 pubmed publisher

Hartig W, Kacza J, Paulke B, Grosche J, Bauer U, Hoffmann A, et al. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur J Neurosci. 2010;31:99-109 pubmed publisher

Fujimura R, Reiner T, Ma F, Phillips V, de las Pozas A, Dickson D, et al. Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease. J Alzheimers Dis. 2010;19:97-109 pubmed publisher

Maj M, Gartner W, Ilhan A, Neziri D, Attems J, Wagner L. Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin. J Endocrinol. 2010;205:25-36 pubmed publisher

Martinez Coria H, Green K, Billings L, Kitazawa M, Albrecht M, Rammes G, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010;176:870-80 pubmed publisher

Lee J, Jin H, Endo S, Schuchman E, Carter J, Bae J. Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses. Stem Cells. 2010;28:329-43 pubmed publisher

Bonda D, Evans T, Santocanale C, Llosá J, Vina J, Bajic V, et al. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Albany NY). 2009;1:382-8 pubmed

Vale C, Alonso E, Rubiolo J, Vieytes M, LaFerla F, Gimenez Llort L, et al. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010;30:577-90 pubmed publisher

Lecanu L, Rammouz G, McCourty A, Sidahmed E, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010;165:427-35 pubmed publisher

Whiteman I, Gervasio O, Cullen K, Guillemin G, Jeong E, Witting P, et al. Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. J Neurosci. 2009;29:12994-3005 pubmed publisher

Pandey N, Sultan K, Twomey E, Sparks D. Phospholipids block nuclear factor-kappa B and tau phosphorylation and inhibit amyloid-beta secretion in human neuroblastoma cells. Neuroscience. 2009;164:1744-53 pubmed publisher

Hall E, Lee S, Mairuae N, Simmons Z, Connor J. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011;32:1409-19 pubmed publisher

Campos Peña V, Tapia Ramírez J, Sanchez Torres C, Meraz Rios M. Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane. J Alzheimers Dis. 2009;18:919-33 pubmed publisher

McConnell G, Rees H, Levey A, Gutekunst C, Gross R, Bellamkonda R. Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration. J Neural Eng. 2009;6:056003 pubmed publisher

van Eersel J, Bi M, Ke Y, Hodges J, Xuereb J, Gregory G, et al. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna). 2009;116:1243-51 pubmed publisher

Tang J, LeGros R, Louneva N, Yeh L, Cohen J, Hahn C, et al. Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression. Hum Mol Genet. 2009;18:3851-63 pubmed publisher

Kovacs G, Murrell J, Horvath S, Haraszti L, Majtenyi K, Molnar M, et al. TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea. Mov Disord. 2009;24:1843-7 pubmed publisher

Kim H, Sul D, Lim J, Lee D, Joo S, Hwang K, et al. Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation. Biosci Biotechnol Biochem. 2009;73:1685-9 pubmed

Nogalska A, Terracciano C, D Agostino C, King Engel W, Askanas V. p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis. Acta Neuropathol. 2009;118:407-13 pubmed publisher

Wilcock D, Gharkholonarehe N, Van Nostrand W, Davis J, Vitek M, Colton C. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci. 2009;29:7957-65 pubmed publisher

McKee A, Cantu R, Nowinski C, Hedley Whyte E, Gavett B, Budson A, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009;68:709-35 pubmed publisher

Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, et al. Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. FEBS Lett. 2009;583:2194-200 pubmed publisher

Savica R, Bower J, Maraganore D, Grossardt B, Rocca W. Bell's palsy preceding Parkinson's disease: a case-control study. Mov Disord. 2009;24:1530-3 pubmed publisher

Halliday G, Herrero M, Murphy K, McCann H, Ros Bernal F, Barcia C, et al. No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism. Mov Disord. 2009;24:1519-23 pubmed publisher

Clavaguera F, Bolmont T, Crowther R, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11:909-13 pubmed publisher

Kasher P, De Vos K, Wharton S, Manser C, Bennett E, Bingley M, et al. Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. J Neurochem. 2009;110:34-44 pubmed publisher

Greco S, Sarkar S, Casadesus G, Zhu X, Smith M, Ashford J, et al. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neurosci Lett. 2009;455:191-4 pubmed publisher

Jing Z, Caltagarone J, Bowser R. Altered subcellular distribution of c-Abl in Alzheimer's disease. J Alzheimers Dis. 2009;17:409-22 pubmed publisher

Leem Y, Lim H, Shim S, Cho J, Kim B, Han P. Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. J Neurosci Res. 2009;87:2561-70 pubmed publisher

Lace G, Savva G, Forster G, De Silva R, Brayne C, Matthews F, et al. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain. 2009;132:1324-34 pubmed publisher

Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer P. TDP-43 pathology in familial British dementia. Acta Neuropathol. 2009;118:303-11 pubmed publisher

Planel E, Bretteville A, Liu L, Virag L, Du A, Yu W, et al. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB J. 2009;23:2595-604 pubmed publisher

Filipcik P, Cente M, Krajciova G, Vanicky I, Novak M. Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration. Cell Mol Neurobiol. 2009;29:895-900 pubmed publisher

Greco S, Sarkar S, Johnston J, Tezapsidis N. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochem Biophys Res Commun. 2009;380:98-104 pubmed publisher

Ricobaraza A, Cuadrado Tejedor M, Pérez Mediavilla A, Frechilla D, Del Rio J, Garcia Osta A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology. 2009;34:1721-32 pubmed publisher

Sul D, Kim H, Lee D, Joo S, Hwang K, Park S. Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation. Life Sci. 2009;84:257-62 pubmed publisher

Liu Y, Yoo M, Savonenko A, Stirling W, Price D, Borchelt D, et al. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2008;28:13805-14 pubmed publisher

Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, et al. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008;28:12798-807 pubmed publisher

Lee H, Zhu X, Casadesus G, Pallas M, Camins A, O Neill M, et al. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Res. 2009;1249:244-50 pubmed publisher

Sul D, Kim H, Cho E, Lee M, Kim H, Jung W, et al. 2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation. Toxicology. 2009;255:65-71 pubmed publisher

Huang Y, Song Y, Murphy K, Holton J, Lashley T, Revesz T, et al. LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions. Acta Neuropathol. 2008;116:639-46 pubmed publisher

Khan T, Alkon D. Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker. Neurobiol Aging. 2010;31:889-900 pubmed publisher

Luty A, Kwok J, Thompson E, Blumbergs P, Brooks W, Loy C, et al. Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9. BMC Neurol. 2008;8:32 pubmed publisher

Patil S, Balu D, Melrose J, Chan C. Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease. BMC Res Notes. 2008;1:20 pubmed publisher

Wilhelmus M, Grunberg S, Bol J, van Dam A, Hoozemans J, Rozemuller A, et al. Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain. Brain Pathol. 2009;19:612-22 pubmed publisher

Kanungo J, Zheng Y, Amin N, Pant H. The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins. J Neurochem. 2008;106:2236-48 pubmed publisher

Laporte V, Ait Ghezala G, Volmar C, Ganey C, Ganey N, Wood M, et al. CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice. Brain Res. 2008;1231:132-42 pubmed publisher

Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca F, Catania M, et al. A new function of microtubule-associated protein tau: involvement in chromosome stability. Cell Cycle. 2008;7:1788-94 pubmed

Park S, Kim H, Cho E, Kwon B, Phark S, Hwang K, et al. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem Toxicol. 2008;46:2881-7 pubmed publisher

Hu M, Waring J, Gopalakrishnan M, Li J. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem. 2008;106:1371-7 pubmed publisher

Rosen R, Farberg A, Gearing M, Dooyema J, Long P, Anderson D, et al. Tauopathy with paired helical filaments in an aged chimpanzee. J Comp Neurol. 2008;509:259-70 pubmed publisher

Vidal R, Barbeito A, Miravalle L, Ghetti B. Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2. Brain Pathol. 2009;19:58-68 pubmed publisher

Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, et al. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci. 2007;27:13635-48 pubmed

Kovacs G, Pittman A, Revesz T, Luk C, Lees A, Kiss E, et al. MAPT S305I mutation: implications for argyrophilic grain disease. Acta Neuropathol. 2008;116:103-18 pubmed

Carroll J, Rosario E, Chang L, Stanczyk F, Oddo S, LaFerla F, et al. Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci. 2007;27:13357-65 pubmed

Schrag M, Sharma S, Brown Borg H, Ghribi O. Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus. 2008;18:239-44 pubmed

Bai F, Xi J, Andley U. Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol Vis. 2007;13:1589-600 pubmed

Rissman R, Lee K, Vale W, Sawchenko P. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007;27:6552-62 pubmed

Moreira P, Siedlak S, Wang X, Santos M, Oliveira C, Tabaton M, et al. Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol. 2007;66:525-32 pubmed

Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla F. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007;102:1053-63 pubmed

Magaki S, Raghavan R, Mueller C, Oberg K, Vinters H, Kirsch W. Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias. Neurosci Lett. 2007;418:72-6 pubmed

Planel E, Richter K, Nolan C, Finley J, Liu L, Wen Y, et al. Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci. 2007;27:3090-7 pubmed

Leschik J, Welzel A, Weissmann C, Eckert A, Brandt R. Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death. J Neurochem. 2007;101:1303-15 pubmed

Sikorska B, Papierz W, Preusser M, Liberski P, Budka H. Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies. Neuropathol Appl Neurobiol. 2007;33:126-9 pubmed

Zhu H, Guo H, Hou H, Liu Y, Sheng S, Zhou J. Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease. Hum Pathol. 2007;38:426-34 pubmed

Papapetropoulos S, Mash D. Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors. J Neural Transm (Vienna). 2007;114:341-5 pubmed

Ikonomovic M, Abrahamson E, Isanski B, Debnath M, Mathis C, DeKosky S, et al. X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease. Methods Enzymol. 2006;412:123-44 pubmed

Lee H, Ueda M, Zhu X, Perry G, Smith M. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?. J Neurosci Res. 2006;84:1856-61 pubmed

Papapetropoulos S, Mash D. Insular pathology in Parkinson's disease patients with orthostatic hypotension. Parkinsonism Relat Disord. 2007;13:308-11 pubmed

Gelpi E, Preusser M, Bauer G, Budka H. Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology. Forensic Sci Int. 2007;168:177-82 pubmed

Lagalwar S, Guillozet Bongaarts A, Berry R, Binder L. Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease. J Neuropathol Exp Neurol. 2006;65:455-64 pubmed

Griffin W, Liu L, Li Y, Mrak R, Barger S. Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammation. 2006;3:5 pubmed

Quintana C, Bellefqih S, Laval J, Guerquin Kern J, Wu T, Avila J, et al. Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol. 2006;153:42-54 pubmed

Obici L, Demarchi A, de Rosa G, Bellotti V, Marciano S, Donadei S, et al. A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy. Ann Neurol. 2005;58:639-44 pubmed

Blain J, Sullivan P, Poirier J. A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. Neurobiol Dis. 2006;21:505-14 pubmed

Klos K, Josephs K, Parisi J, Dickson D. Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease. Mov Disord. 2005;20:1515-20 pubmed

Patil S, Chan C. Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci Lett. 2005;384:288-93 pubmed

Hung K, Hwang S, Liang C, Chen Y, Lee T, Liu J, et al. Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. J Neuropathol Exp Neurol. 2005;64:15-26 pubmed

Wang Y, Chen G, Hu X, Lu Y, Zhou J, Liu R. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Brain Res. 2005;1031:101-8 pubmed

Takahashi S, Kulkarni A. Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25. J Neurochem. 2004;88:1295-304 pubmed

Takahashi S, Saito T, Hisanaga S, Pant H, Kulkarni A. Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem. 2003;278:10506-15 pubmed

Forno L, Langston J, Herrick M, Wilson J, Murayama S. Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type. Acta Neuropathol. 2002;103:599-606 pubmed

Rapoport M, Ferreira A. PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons. J Neurochem. 2000;74:125-33 pubmed

Yu Q, Du F, Belli I, Gomes P, Sotiropoulos I, Waites C. Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain. Cell Death Dis. 2024;15:73 pubmed publisher

Warfield A, Gupta P, Ruhmann M, Jeffs Q, Guidone G, Rhymes H, et al. A brainstem to circadian system circuit links Tau pathology to sundowning-related disturbances in an Alzheimer's disease mouse model. Nat Commun. 2023;14:5027 pubmed publisher

Garland E, Dennett O, Lau L, Chatelet D, Bottlaender M, Nicoll J, et al. The mitochondrial protein TSPO in Alzheimer's disease: relation to the severity of AD pathology and the neuroinflammatory environment. J Neuroinflammation. 2023;20:186 pubmed publisher

Kang Y, Diep Y, Tran M, Tran V, Ambrin G, Ngo H, et al. Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration. Nat Protoc. 2023;18:2838-2867 pubmed publisher

Giannini L, Mol M, Rajicic A, van Buuren R, Sarkar L, Arezoumandan S, et al. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta Neuropathol Commun. 2023;11:126 pubmed publisher

Romero Fernandez W, Carvajal Tapia C, Prusky A, Katdare K, Wang E, Shostak A, et al. Detection, visualization and quantification of protein complexes in human Alzheimer's disease brains using proximity ligation assay. Sci Rep. 2023;13:11948 pubmed publisher

Abou El Hassan H, Rezende R, Izzy S, Gabriely G, Yahya T, Tatematsu B, et al. Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males. Nat Commun. 2023;14:4286 pubmed publisher

Lee Gosselin A, Jury Garfe N, You Y, Dabin L, Soni D, Dutta S, et al. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. Cells. 2023;12: pubmed publisher

Sola M, Rendon Angel A, Rojo Martinez V, Sgrignani J, Magrin C, Piovesana E, et al. Tau protein binds to the P53 E3 ubiquitin ligase MDM2. Sci Rep. 2023;13:10208 pubmed publisher

Williams T, Bathe T, Vo Q, Sacilotto P, McFarland K, Ruiz A, et al. Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy. Acta Neuropathol Commun. 2023;11:99 pubmed publisher

Zwang T, Woost B, Bailey J, Hoglund Z, Richardson D, Bennett R, et al. Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging. Brain Commun. 2023;5:fcad130 pubmed publisher

Hussong S, Banh A, Van Skike C, Dorigatti A, Hernandez S, Hart M, et al. Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy. Nat Commun. 2023;14:2367 pubmed publisher

Zhong S, Ye J, Deng Y, Zhang M, Zou M, Yao X, et al. Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice. Molecules. 2023;28: pubmed publisher

Gatto R, Carlos A, Reichard R, Lowe V, Whitwell J, Josephs K. Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients. PLoS ONE. 2023;18:e0284182 pubmed publisher

Cheng C, Liu Y, Yang Y, Lin K, Wu D, Liu Y, et al. Plasmon-activated water as a therapeutic strategy in Alzheimer's disease by altering gut microbiota. Aging (Albany NY). 2023;15:3715-3737 pubmed publisher

Mamais A, Sanyal A, Fajfer A, Zykoski C, Guldin M, Riley DiPaolo A, et al. The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neurons. bioRxiv. 2023;: pubmed publisher

Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, et al. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. 2023;26:106375 pubmed publisher

Dong Q, Pt xe1 x10d ek L, Fu Y. Mutant β1-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy. Proc Natl Acad Sci U S A. 2023;120:e2221686120 pubmed publisher

Jadiya P, Cohen H, Kolmetzky D, Kadam A, Tomar D, Elrod J. Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline. iScience. 2023;26:106296 pubmed publisher

Cecon E, Oishi A, Luka M, Ndiaye Lobry D, Fran xe7 ois A, Lescuyer M, et al. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. elife. 2023;12: pubmed publisher

Michaud J, Plu I, Parai J, Bourgault A, Tanguay C, Seilhean D, et al. Ballooned neurons in semi-recent severe traumatic brain injury. Acta Neuropathol Commun. 2023;11:37 pubmed publisher

Beckmann A, Ramirez P, Gamez M, Gonzalez E, De Mange J, Bieniek K, et al. Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease. iScience. 2023;26:106152 pubmed publisher

Williams D, Yan B, Wang H, Negm L, Sackmann C, Verkuyl C, et al. Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation. Sci Rep. 2023;13:2337 pubmed publisher

Walker J, Goette W, Farrell K, Iida M, Karlovich E, White C, et al. The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration. Alzheimers Dement. 2023;19:3158-3170 pubmed publisher

Saha I, Yuste Checa P, da Silva Padilha M, Guo Q, K xf6 rner R, Holthusen H, et al. The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nat Commun. 2023;14:560 pubmed publisher

Shih N, Kurniawan N, Cabeen R, Korobkova L, Wong E, Chui H, et al. Microstructural mapping of dentate gyrus pathology in Alzheimer's disease: A 16.4 Tesla MRI study. Neuroimage Clin. 2023;37:103318 pubmed publisher

Wang E, Brown G, Lewis M, Jellen L, Pu C, Johnson M, et al. Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta. Mov Disord. 2023;38:464-473 pubmed publisher

Ballesteros xc1 lvarez J, Nguyen W, Sivapatham R, Rane A, Andersen J. Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease. GeroScience. 2023;45:1095-1113 pubmed publisher

Park G, Xu K, Chea L, Kim K, Safarta L, Song K, et al. Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation. J Biol Chem. 2023;299:102821 pubmed publisher

Batenburg K, Kasri N, Heine V, Scheper W. Intraneuronal tau aggregation induces the integrated stress response in astrocytes. J Mol Cell Biol. 2023;14: pubmed publisher

Malarte M, Gillberg P, Kumar A, Bogdanovic N, Lemoine L, Nordberg A. Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains. Mol Psychiatry. 2023;28:1272-1283 pubmed publisher

Brandimarti R, Irollo E, Meucci O. The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities. Mol Neurobiol. 2022;: pubmed publisher

Chen S, Chang Y, Li L, Acosta D, Li Y, Guo Q, et al. Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease. Acta Neuropathol Commun. 2022;10:188 pubmed publisher

Manet C, Mansuroglu Z, Conquet L, Bortolin V, Comptdaer T, Segrt H, et al. Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response. J Neuroinflammation. 2022;19:307 pubmed publisher

Fathy Y, Jonkman L, Bol J, Timmermans E, Jonker A, Rozemuller A, et al. Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies. Transl Neurodegener. 2022;11:52 pubmed publisher

Lee H, Yoon S, Lee J, Park K, Jung Y, Cho I, et al. Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models. Alzheimers Res Ther. 2022;14:177 pubmed publisher

Delic V, Karp J, Guzman M, Arismendi G, Stalnaker K, Burton J, et al. Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson's-like pathology burden. Acta Neuropathol Commun. 2022;10:170 pubmed publisher

Gil L, Chi Ahumada E, Ni xf1 o S, Capdeville G, M xe9 ndez Torres A, Guerrero C, et al. Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer's Patients: A Biphasic Regulation of Neurogenesis. Int J Mol Sci. 2022;23: pubmed publisher

Fern xe1 ndez Albarral J, Salobrar Garc xed a E, Matamoros J, Fern xe1 ndez Mend xed vil C, Del Sastre E, Chen L, et al. Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy. Antioxidants (Basel). 2022;11: pubmed publisher

Rodrigues F, Papanikolaou A, Holeniewska J, Phillips K, Saleem A, Solomon S. Altered low-frequency brain rhythms precede changes in gamma power during tauopathy. iScience. 2022;25:105232 pubmed publisher

Rickner H, Jiang L, Hong R, O Neill N, Mojica C, Snyder B, et al. Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model. Nat Commun. 2022;13:6275 pubmed publisher

Sabui A, Biswas M, Somvanshi P, Kandagiri P, Gorla M, Mohammed F, et al. Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons. Front Mol Neurosci. 2022;15:927195 pubmed publisher

Zaharija B, Odor x10d i x107 M, Hart A, Samard x17e ija B, Marreiros R, Prikulis I, et al. TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein. Int J Mol Sci. 2022;23: pubmed publisher

van den Berg M, Adhikari M, Verschuuren M, Pintelon I, Vasilkovska T, Van Audekerke J, et al. Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer's disease in TgF344-AD rats. Alzheimers Res Ther. 2022;14:148 pubmed publisher

Luo Z, Wang Y, Pang S, Gao S, Liu N, Gao X, et al. Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice. Drug Des Devel Ther. 2022;16:3285-3296 pubmed publisher

de Fisenne M, Yilmaz Z, De Decker R, Suain V, Bu xe9 e L, Ando K, et al. Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models. Neurobiol Dis. 2022;174:105875 pubmed publisher

Li L, Miao J, Chu D, Jin N, Tung Y, Dai C, et al. Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation. CNS Neurosci Ther. 2022;28:2245-2259 pubmed publisher

Andersen O, B xf8 gh N, Landau A, Pl xf8 en G, Jensen A, Monti G, et al. A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency. Cell Rep Med. 2022;3:100740 pubmed publisher

Giannini L, Ohm D, Rozemuller A, Dratch L, Suh E, Van Deerlin V, et al. Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathol. 2022;144:1065-1084 pubmed publisher

Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, et al. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Mol Neurodegener. 2022;17:58 pubmed publisher

Farrell K, Iida M, Cherry J, Casella A, Stein T, Bieniek K, et al. Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2022;81:781-789 pubmed publisher

Jiang J, Yang C, Ai J, Zhang Q, Cai X, Tu T, et al. Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation. Front Aging Neurosci. 2022;14:926904 pubmed publisher

Mate V, Smolek T, Kazmerova Z, Jadhav S, Brezovakova V, Jurkanin B, et al. Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy. Front Aging Neurosci. 2022;14:935973 pubmed publisher

Moreno Valladares M, Moncho Amor V, Bernal Simon I, Agirre Iturrioz E, xc1 lvarez Satta M, Matheu A. Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment. Int J Mol Sci. 2022;23: pubmed publisher

McCann H, Bahar A, Burkhardt K, Gardner A, Halliday G, Iverson G, et al. Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank. Brain Commun. 2022;4:fcac189 pubmed publisher

Guo T, Pan X, Jiang G, Zhang D, Qi J, Shao L, et al. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. J Neurosci. 2022;42:7309-17 pubmed publisher

Wander C, Tsujimoto T, Ervin J, Wang C, Maranto S, Bhat V, et al. Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. Acta Neuropathol Commun. 2022;10:110 pubmed publisher

Kumar S, Orlov E, Gowda P, Bose C, Swerdlow R, Lahiri D, et al. Synaptosome microRNAs regulate synapse functions in Alzheimer's disease. NPJ Genom Med. 2022;7:47 pubmed publisher

Parekh P, Mu Q, Badachhape A, Bhavane R, Srivastava M, Devkota L, et al. A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging. Theranostics. 2022;12:5504-5521 pubmed publisher

Tejada Moreno J, Villegas Lanau A, Madrigal Zapata L, Baena Pineda A, Velez Hernandez J, Campo Nieto O, et al. Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family. PLoS ONE. 2022;17:e0269955 pubmed publisher

Tan B, Babür E, Toy N, G xfc nayd x131 n B, Dursun N, S xfc er C. Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism. Int J Dev Neurosci. 2022;82:654-663 pubmed publisher

Butler M, Dixon E, Stein T, Alvarez V, HUBER B, Buckland M, et al. Tau Pathology in Chronic Traumatic Encephalopathy is Primarily Neuronal. J Neuropathol Exp Neurol. 2022;81:773-780 pubmed publisher

Hendrickx J, Adams C, Sieben A, Laukens K, Van Dam D, De Meyer G. Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy. Biomedicines. 2022;10: pubmed publisher

Otero García M, Mahajani S, Wakhloo D, Tang W, Xue Y, Morabito S, et al. Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease. Neuron. 2022;110:2929-2948.e8 pubmed publisher

Lopez Toledo G, Silva Lucero M, Herrera D xed az J, Garc xed a D, Arias Monta xf1 o J, Cárdenas Aguayo M. Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer's Disease Pathology, Constitute a Potential Object for Early Diagnosis. Front Aging Neurosci. 2022;14:921573 pubmed publisher

Sepulveda Falla D, Sanchez J, Almeida M, Boassa D, Acosta Uribe J, Vila Castelar C, et al. Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia. Acta Neuropathol. 2022;144:589-601 pubmed publisher

Paidas M, Cosio D, Ali S, Kenyon N, Jayakumar A. Long-Term Sequelae of COVID-19 in Experimental Mice. Mol Neurobiol. 2022;59:5970-5986 pubmed publisher

Wu H, Qiu W, Zhu X, Li X, Xie Z, Carreras I, et al. The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer's Pathogenesis via Specific Pathways. Front Aging Neurosci. 2022;14:912709 pubmed publisher

Yu Y, Yang M, Zhuang X, Pan J, Zhao Y, Yu Y. Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia. Brain Behav. 2022;12:e2702 pubmed publisher

Di Liberto G, Egervari K, Kreutzfeldt M, Sch xfc rch C, Hewer E, Wagner I, et al. Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV. Brain. 2022;145:2730-2741 pubmed publisher

Suzuki C, Yamaguchi J, Sanada T, Oliva Trejo J, Kakuta S, Shibata M, et al. Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins. Sci Rep. 2022;12:11662 pubmed publisher

Larson T, Khandelwal V, Weber M, Leidinger M, Meyerholz D, Narayanan N, et al. Mice expressing P301S mutant human tau have deficits in interval timing. Behav Brain Res. 2022;432:113967 pubmed publisher

Xia D, Lianoglou S, Sandmann T, Calvert M, Suh J, Thomsen E, et al. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Mol Neurodegener. 2022;17:41 pubmed publisher

Zinnen A, Vichich J, Metzger J, Gambardella J, Bondarenko V, Simmons H, et al. Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum. PLoS ONE. 2022;17:e0269190 pubmed publisher

Capano L, Sato C, Ficulle E, Yu A, Horie K, Kwon J, et al. Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons. Cell Stem Cell. 2022;29:918-932.e8 pubmed publisher

Sathler M, Doolittle M, Cockrell J, Nadalin I, Hofmann F, Vandewoude S, et al. HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation. J Cell Sci. 2022;135: pubmed publisher

Ackermans N, Varghese M, Williams T, Grimaldi N, Selmanovic E, Alipour A, et al. Evidence of traumatic brain injury in headbutting bovids. Acta Neuropathol. 2022;144:5-26 pubmed publisher

Ferrer I, Andr xe9 s Benito P, Garcia Esparcia P, L xf3 pez Gonzalez I, Valiente D, Jord xe1 n Pirla M, et al. Differences in Tau Seeding in Newborn and Adult Wild-Type Mice. Int J Mol Sci. 2022;23: pubmed publisher

Wang S, Guo Y, Ervin J, Lusk J, Luo S. Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old. Acta Neuropathol. 2022;144:45-57 pubmed publisher

Taddei R, Sanchez Mico M, Bonnar O, Connors T, Gaona A, Denbow D, et al. Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages. Acta Neuropathol Commun. 2022;10:72 pubmed publisher

Melikyan Z, Corrada M, Leiby A, Sajjadi S, Bukhari S, Montine T, et al. Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study. Neurobiol Aging. 2022;116:12-15 pubmed publisher

Farhadi A, Totonchi M, Nabavi S, Baharvand H, Pakdaman H, Hajizadeh Saffar E, et al. P38 initiates degeneration of midbrain GABAergic and glutamatergic neurons in diabetes models. Eur J Neurosci. 2022;56:3755-3778 pubmed publisher

Steuer E, Kemper L, Hlynialuk C, Leinonen Wright K, Montonye M, Lapcinski I, et al. Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia. J Neurosci. 2022;42:4737-4754 pubmed publisher

Iacono D, Murphy E, Sherman P, Chapapas H, Cerqueira B, Christensen C, et al. High altitude is associated with pTau deposition, neuroinflammation, and myelin loss. Sci Rep. 2022;12:6839 pubmed publisher

Samluk L, Ostapczuk P, Dziembowska M. Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis. Mol Biol Cell. 2022;33:ar67 pubmed publisher

Miyahara H, Akagi A, Riku Y, Sone J, Otsuka Y, Sakai M, et al. Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies. Brain Pathol. 2022;32:e13069 pubmed publisher

Kang S, Meng L, Zhang X, Wu Z, Mancieri A, Xie B, et al. Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation. Nat Struct Mol Biol. 2022;29:292-305 pubmed publisher

Jankovska N, Rusina R, Keller J, Kukal J, Bruzova M, Parobkova E, et al. Biomarkers Analysis and Clinical Manifestations in Comorbid Creutzfeldt-Jakob Disease: A Retrospective Study in 215 Autopsy Cases. Biomedicines. 2022;10: pubmed publisher

Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs G, Arzberger T, et al. Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Commun. 2022;13:1362 pubmed publisher

Tsolaki E, Csincsik L, Xue J, Lengyel I, Bertazzo S. Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau. Acta Biomater. 2022;143:138-144 pubmed publisher

Liu A, Lusk J, Ervin J, Burke J, O BRIEN R, Wang S. Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation. Acta Neuropathol Commun. 2022;10:27 pubmed publisher

Authiat M, Gruz Gibelli E, Colas J, Bianchi E, Garcia Arauzo M, Marin P, et al. Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models. Neural Plast. 2022;2022:3172861 pubmed publisher

Xiong J, Kang S, Wang Z, Liu X, Kuo T, Korkmaz F, et al. FSH blockade improves cognition in mice with Alzheimer's disease. Nature. 2022;603:470-476 pubmed publisher

Wu C, Vinton E, PEARSE R, Heo K, Aylward A, Hsieh Y, et al. APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons. Mol Psychiatry. 2022;27:1970-1989 pubmed publisher

Latimer C, Stair J, Hincks J, Currey H, Bird T, Keene C, et al. TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans. Dis Model Mech. 2022;15: pubmed publisher

Roqanian S, Ahmadian S, Nabavi S, Pakdaman H, Shafiezadeh M, Goudarzi G, et al. Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion. J Neurosci Res. 2022;100:1084-1104 pubmed publisher

Walker J, Kazempour Dehkordi S, Fracassi A, Vanschoiack A, Pavenko A, Taglialatela G, et al. Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling. Acta Neuropathol Commun. 2022;10:23 pubmed publisher

Curtis M, Smith T, Yu D, Pratic xf2 D. Association of Retromer Deficiency and Tau Pathology in Down Syndrome. Ann Neurol. 2022;91:561-567 pubmed publisher

Peris L, Parato J, Qu X, Soleilhac J, Lanté F, Kumar A, et al. Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease. Brain. 2022;: pubmed publisher

Vagenknecht P, Luzgin A, Ono M, Ji B, Higuchi M, Noain D, et al. Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography. Eur J Nucl Med Mol Imaging. 2022;49:2137-2152 pubmed publisher

Mu xf1 oz Castro C, Noori A, Magdamo C, Li Z, Marks J, Frosch M, et al. Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease. J Neuroinflammation. 2022;19:30 pubmed publisher

Manos J, Preiss C, Venkat N, Tamm J, Reinhardt P, Kwon T, et al. Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model. iScience. 2022;25:103658 pubmed publisher

Dahl M, Mather M, Werkle Bergner M, Kennedy B, Guzman S, Hurth K, et al. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiol Aging. 2022;112:39-54 pubmed publisher

Fagan S, Béchet S, Dev K. Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. Mol Neurobiol. 2022;59:1882-1895 pubmed publisher

Zhu X, Liu L, Dai W, Ma T. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural Regen Res. 2022;17:1841-1849 pubmed publisher

Danis C, Dupré E, Zejneli O, Caillierez R, Arrial A, Bégard S, et al. Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment. Mol Ther. 2022;30:1484-1499 pubmed publisher

Xie C, Zhuang X, Niu Z, Ai R, Lautrup S, Zheng S, et al. Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nat Biomed Eng. 2022;6:76-93 pubmed publisher

Xu S, Yang P, Qian K, Li Y, Guo Q, Wang P, et al. Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease. Bioact Mater. 2022;11:300-316 pubmed publisher

Zhang Y, Chen H, Long X, Xu T. Three-dimensional-engineered bioprinted in vitro human neural stem cell self-assembling culture model constructs of Alzheimer's disease. Bioact Mater. 2022;11:192-205 pubmed publisher

Senejani A, Maghsoudlou J, El Zohiry D, Gaur G, Wawrzeniak K, Caravaglia C, et al. Borrelia burgdorferi Co-Localizing with Amyloid Markers in Alzheimer's Disease Brain Tissues. J Alzheimers Dis. 2022;85:889-903 pubmed publisher

Saroja S, Sharma A, Hof P, Pereira A. Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease. Alzheimers Dement. 2022;18:1602-1615 pubmed publisher

Kindler D, Maschio C, Ni R, Zerbi V, Razansky D, Klohs J. Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy. J Cereb Blood Flow Metab. 2022;42:686-693 pubmed publisher

Smith A, DAVEY K, Tsartsalis S, Khozoie C, Fancy N, Tang S, et al. Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology. Acta Neuropathol. 2022;143:75-91 pubmed publisher

Zhang H, Yuan C, Liu K, Yang Q, Zhao J, Li H, et al. Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy. Neural Regen Res. 2022;17:152-162 pubmed publisher

Lyons C, Zhou X, Razzoli M, Chen M, Xia W, Ashe K, et al. Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice. Eur J Neurosci. 2022;55:2971-2985 pubmed publisher

Dehkordi S, Walker J, Sah E, Bennett E, Atrian F, Frost B, et al. Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology. Nat Aging. 2021;1:1107-1116 pubmed publisher

Javonillo D, Tran K, Phan J, Hingco E, Kram xe1 r E, da Cunha C, et al. Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease. Front Neurosci. 2021;15:785276 pubmed publisher

Pitera A, Hartnell I, Scullard L, Williamson K, Boche D, O Connor V, et al. Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies. J Alzheimers Dis Rep. 2021;5:855-869 pubmed publisher

Omoluabi T, Torraville S, Maziar A, Ghosh A, Power K, Reinhardt C, et al. Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects. Alzheimers Dement (N Y). 2021;7:e12231 pubmed publisher

Filippone A, Smith T, Pratico D. Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau. J Inflamm Res. 2021;14:7455-7465 pubmed publisher

Ba L, Huang L, He Z, Deng S, Xie Y, Zhang M, et al. Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?. Front Aging Neurosci. 2021;13:759983 pubmed publisher

Puigdell xed vol M, Milde S, Vilalta A, Cockram T, Allendorf D, Lee J, et al. The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration. Cell Rep. 2021;37:110148 pubmed publisher

Woelfle S, Boeckers T. Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including the Stratum lucidum. Front Cell Neurosci. 2021;15:789903 pubmed publisher

Jankovska N, Matej R, Olejár T. Extracellular Prion Protein Aggregates in Nine Gerstmann-Sträussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data. Int J Mol Sci. 2021;22: pubmed publisher

Jaillard C, Ouechtati F, Cl xe9 rin E, Millet Puel G, Corsi M, A xef t Ali N, et al. The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function. Redox Biol. 2021;48:102198 pubmed publisher

Ravikumar S, Wisse L, Lim S, Ittyerah R, Xie L, Bedard M, et al. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta Neuropathol Commun. 2021;9:173 pubmed publisher

Sato H, Takado Y, Toyoda S, Tsukamoto Yasui M, Minatohara K, Takuwa H, et al. Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model. Sci Adv. 2021;7:eabd5046 pubmed publisher

Vega A, Chkheidze R, Jarmale V, Shang P, Foong C, Diamond M, et al. Deep learning reveals disease-specific signatures of white matter pathology in tauopathies. Acta Neuropathol Commun. 2021;9:170 pubmed publisher

Ahmad F, Mein H, Jing Y, Zhang H, Liu P. Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study. Int J Mol Sci. 2021;22: pubmed publisher

Wang W, Cao Q, Tan T, Yang F, Williams J, Yan Z. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging Cell. 2021;20:e13456 pubmed publisher

Delpech J, Pathak D, Varghese M, Kalavai S, Hays E, Hof P, et al. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci Transl Med. 2021;13:eabe8455 pubmed publisher

Herrmann F, Hessmann M, Schaertl S, Berg Rosseburg K, Brown C, Bursow G, et al. Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates. Sci Rep. 2021;11:17977 pubmed publisher

Winslow W, McDonough I, Tallino S, Decker A, Vural A, Velázquez R. IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer's Disease Associated With Brain Weight. Front Aging Neurosci. 2021;13:720214 pubmed publisher

Taylor H, Emptage N, Jeans A. Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau. Cell Rep. 2021;36:109638 pubmed publisher

Blumenstock S, Schulz Trieglaff E, Voelkl K, Bolender A, Lapios P, Lindner J, et al. Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. EMBO J. 2021;40:e107260 pubmed publisher

Evans A, Park H, Saw N, Singhal K, Ogawa G, Leib R, et al. Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice. Neurobiol Aging. 2021;106:241-256 pubmed publisher

Chen C, Zhou Y, Wang H, Alam A, Kang S, Ahn E, et al. Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease. EMBO J. 2021;40:e106320 pubmed publisher

Bichmann M, Prat Oriol N, Ercan Herbst E, Sch xf6 ndorf D, Gomez Ramos B, Schw xe4 rzler V, et al. SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease. Mol Neurodegener. 2021;16:46 pubmed publisher

Raha Chowdhury R, Raha A, Henderson J, Ghaffari S, Grigorova M, Beresford Webb J, et al. Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia. J Clin Med. 2021;10: pubmed publisher

Tran V, Kang Y, Kim H, Kim H, Cho H. Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform. Int J Mol Sci. 2021;22: pubmed publisher

Xu Y, Propson N, Du S, Xiong W, Zheng H. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher

Kahriman A, Bouley J, Smith T, Bosco D, Woerman A, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature. Acta Neuropathol Commun. 2021;9:118 pubmed publisher

Mol M, Wong T, Melhem S, Basu S, Viscusi R, Galjart N, et al. Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia. Neurol Genet. 2021;7:e596 pubmed publisher

Na H, Tian H, Zhang Z, Li Q, Yang J, Mcparland L, et al. Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model. Am J Alzheimers Dis Other Demen. 2021;36:15333175211012867 pubmed publisher

Kazim S, Sharma A, Saroja S, Seo J, Larson C, Ramakrishnan A, et al. Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures. Biol Psychiatry. 2021;: pubmed publisher

Sun X, Li L, Dong Q, Zhu J, Huang Y, Hou S, et al. Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease. J Neuroinflammation. 2021;18:131 pubmed publisher

Cornblath E, Li H, Changolkar L, Zhang B, Brown H, Gathagan R, et al. Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor. Sci Adv. 2021;7: pubmed publisher

Lee C, Latimer C, Henriksen J, Blazes M, Larson E, Crane P, et al. Application of deep learning to understand resilience to Alzheimer's disease pathology. Brain Pathol. 2021;31:e12974 pubmed publisher

Raha A, Ghaffari S, Henderson J, Chakraborty S, Allinson K, Friedland R, et al. Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation. Front Aging Neurosci. 2021;13:653591 pubmed publisher

Liu X, Qi X, Fang H, Zhou K, Wang Q, Chen G. Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease. Front Aging Neurosci. 2021;13:639318 pubmed publisher

Dickson J, Yoon H, Frosch M, Hyman B. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. J Neuropathol Exp Neurol. 2021;80:530-540 pubmed publisher

Takamura R, Mizuta K, Sekine Y, Islam T, Saito T, Sato M, et al. Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice. J Neurosci. 2021;41:5315-5329 pubmed publisher

de Pablo Fern xe1 ndez E, Courtney R, Rockliffe A, Gentleman S, Holton J, Warner T. Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology. Neuropathol Appl Neurobiol. 2021;47:1080-1091 pubmed publisher

Hashem J, Hu M, Zhang J, Gao F, Chen C. Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2021;58:4122-4133 pubmed publisher

Lyra e Silva N, Gonçalves R, Pascoal T, Lima Filho R, Resende E, Vieira E, et al. Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease. Transl Psychiatry. 2021;11:251 pubmed publisher

Kang S, Ahn E, Liu X, Bryson M, Miller G, Weinshenker D, et al. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta Neuropathol. 2021;142:139-158 pubmed publisher

Bourdenx M, Martín Segura A, Scrivo A, Rodriguez Navarro J, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696-2714.e25 pubmed publisher

Lester E, Ooi F, Bakkar N, Ayers J, Woerman A, Wheeler J, et al. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021;109:1675-1691.e9 pubmed publisher

Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Marcilla I, Martí Andrés G, Caballero M, et al. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun. 2021;9:64 pubmed publisher

Miki Y, Tsushima E, Foti S, Strand K, Asi Y, Yamamoto A, et al. Identification of multiple system atrophy mimicking Parkinson's disease or progressive supranuclear palsy. Brain. 2021;144:1138-1151 pubmed publisher

Xia F, Ha Y, Shi S, Li Y, Li S, Luisi J, et al. Early alterations of neurovascular unit in the retina in mouse models of tauopathy. Acta Neuropathol Commun. 2021;9:51 pubmed publisher

Latina V, Giacovazzo G, Cordella F, Balzamino B, Micera A, Varano M, et al. Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta Neuropathol Commun. 2021;9:38 pubmed publisher

Wang Z, Xia Y, Liu P, Liu X, Edgington Mitchell L, Lei K, et al. ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2021;202:102032 pubmed publisher

Miller L, Mukadam A, Durrant C, Vaysburd M, Katsinelos T, Tuck B, et al. Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Acta Neuropathol Commun. 2021;9:41 pubmed publisher

McMurray L, Macdonald J, Ramakrishnan N, Zhao Y, Williamson D, Tietz O, et al. Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models. ACS Chem Neurosci. 2021;12:1885-1893 pubmed publisher

Jankovska N, Olejár T, Matej R. Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer's and Creutzfeldt-Jakob Disease: A Micromorphological Pilot Study on 20 Brains. Int J Mol Sci. 2021;22: pubmed publisher

Guennewig B, Lim J, Marshall L, McCorkindale A, Paasila P, Patrick E, et al. Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology. Sci Rep. 2021;11:4865 pubmed publisher

Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Commun. 2021;3:fcab011 pubmed publisher

Gerrits E, Brouwer N, Kooistra S, Woodbury M, Vermeiren Y, Lambourne M, et al. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta Neuropathol. 2021;141:681-696 pubmed publisher

Gulfo J, Pérez de San Román J, Ledda A, Junyent F, Ramirez M, Gil Bea F, et al. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus. PLoS ONE. 2021;16:e0246930 pubmed publisher

Sandusky Beltran L, Kovalenko A, Placides D, Ratnasamy K, Ma C, Hunt J, et al. Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology. J Clin Invest. 2021;131: pubmed publisher

Chiocchetti R, Hitrec T, Giancola F, Sadeghinezhad J, Squarcio F, Galiazzo G, et al. Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor. Cell Tissue Res. 2021;384:287-299 pubmed publisher

Chambraud B, Daguinot C, Guillemeau K, Genet M, Dounane O, Meduri G, et al. Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. Autophagy. 2021;:1-20 pubmed publisher

Shin J, Park S, Lee H, Kim Y. Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model. Sci Rep. 2021;11:1617 pubmed publisher

Kang S, Kim J, Chang K. Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model. Sci Rep. 2021;11:1334 pubmed publisher

Bettencourt C, Miki Y, Piras I, de Silva R, Foti S, Talboom J, et al. MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis. Neuropathol Appl Neurobiol. 2021;47:640-652 pubmed publisher

Walker J, Richardson T, Farrell K, Iida M, Foong C, Shang P, et al. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021;80:102-111 pubmed publisher

Walker C, Greathouse K, Boros B, Poovey E, Clearman K, Ramdas R, et al. Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice. Neuroscience. 2021;455:195-211 pubmed publisher

von Maydell D, Jorfi M. A Synergistic Engineering Approach to Build Human Brain Spheroids. Methods Mol Biol. 2021;2258:151-169 pubmed publisher

Waller R, Narramore R, Simpson J, Heath P, Verma N, Tinsley M, et al. Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies. Brain Pathol. 2021;31:e12928 pubmed publisher

Sundermann E, Bondi M, Campbell L, Gouaux B, Moore R, Soontornniyomkij V, et al. Distinguishing Amnestic Mild Cognitive Impairment From HIV-Associated Neurocognitive Disorders. J Infect Dis. 2021;224:435-442 pubmed publisher

Stojakovic A, Chang S, Nesbitt J, Pichurin N, Ostroot M, Aikawa T, et al. Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice. J Alzheimers Dis. 2021;79:335-353 pubmed publisher

Soto Mercado V, Mendivil Perez M, Jimenez Del Rio M, Velez Pardo C. Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor. J Alzheimers Dis. 2021;82:S359-S378 pubmed publisher

Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii Kitahara A, Muraoka S, Bhatt N, et al. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain. 2021;144:288-309 pubmed publisher

Briel N, Pratsch K, Roeber S, Arzberger T, Herms J. Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration. Brain Pathol. 2021;31:e12914 pubmed publisher

Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, et al. RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death Differ. 2021;28:337-348 pubmed publisher

Abey A, Davies D, Goldsbury C, Buckland M, Valenzuela M, Duncan T. Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies. Brain Pathol. 2021;31:144-162 pubmed publisher

Reimer L, Betzer C, Kofoed R, Volbracht C, Fog K, Kurhade C, et al. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain Pathol. 2021;31:103-119 pubmed publisher

Gomaa A, Makboul R, El Mokhtar M, Abdel Rahman E, Ahmed E, Nicola M. Evaluation of the neuroprotective effect of donepezil in type 2 diabetic rats. Fundam Clin Pharmacol. 2021;35:97-112 pubmed publisher

Gao Y, Zheng J, Jiang T, Pi G, Sun F, Xiong R, et al. Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy. Front Cell Dev Biol. 2020;8:633725 pubmed publisher

Muñoz Mayorga D, Rissman R, Morales T. Reproductive status impact on tau phosphorylation induced by chronic stress. Neurobiol Stress. 2020;13:100241 pubmed publisher

Wu Z, Liu X, Cheng L, Ye K. Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice. Cell Death Dis. 2020;11:1058 pubmed publisher

Cao Q, Wang W, Williams J, Yang F, Wang Z, Yan Z. Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher

Guo X, Liu Y, Morgan D, Zhao L. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging Dis. 2020;11:1423-1443 pubmed publisher

Vanan S, Zeng X, Chia S, Varnas K, Jiang M, Zhang K, et al. Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice. Mol Brain. 2020;13:164 pubmed publisher

Zuliani I, Lanzillotta C, Tramutola A, Francioso A, Pagnotta S, Barone E, et al. The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome. Neurotherapeutics. 2020;: pubmed publisher

S Narasimhan K, Devarajan A, Karan G, Sundaram S, Wang Q, van Groen T, et al. Reductive stress promotes protein aggregation and impairs neurogenesis. Redox Biol. 2020;37:101739 pubmed publisher

McMillan P, Wheeler J, Gatlin R, Taylor L, Strovas T, Baum M, et al. Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice. Acta Neuropathol Commun. 2020;8:200 pubmed publisher

Giarratana A, Zheng C, Reddi S, Teng S, Berger D, Adler D, et al. APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes. Sci Rep. 2020;10:19919 pubmed publisher

Alsema A, Jiang Q, Kracht L, Gerrits E, Dubbelaar M, Miedema A, et al. Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue. Front Mol Neurosci. 2020;13:134 pubmed publisher

Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, et al. Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. Mol Neurodegener. 2020;15:66 pubmed publisher

Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis M, Liu C, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nat Commun. 2020;11:5540 pubmed publisher

Pérez Rando M, Dujardin S, Bennett R, Commins C, Nibhanupudy T, Hyman B. Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathol Commun. 2020;8:168 pubmed publisher

Murphy E, Iacono D, Pan H, Grimes J, Parks S, Raiciulescu S, et al. Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences. Sci Rep. 2020;10:17446 pubmed publisher

Ni R, Chen Z, Gerez J, Shi G, Zhou Q, Riek R, et al. Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy. Biomed Opt Express. 2020;11:4989-5002 pubmed publisher

Sandberg A, Ling H, Gearing M, Dombroski B, Cantwell L, R Bibo L, et al. Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R. Neurobiol Dis. 2020;146:105079 pubmed publisher

Roda A, Montoliu Gaya L, Serra Mir G, Villegas S. Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice. Int J Mol Sci. 2020;21: pubmed publisher

Chiasseu M, Fesharaki Zadeh A, Saito T, Saido T, Strittmatter S. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiol Dis. 2020;145:105059 pubmed publisher

Chen C, Ahn E, Kang S, Liu X, Alam A, Ye K. Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model. Sci Adv. 2020;6:eaba0466 pubmed publisher

Mankhong S, Kim S, Moon S, Lee K, Jeon H, Hwang B, et al. Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion. Int J Mol Sci. 2020;21: pubmed publisher

Ye J, Yin Y, Yin Y, Zhang H, Wan H, Wang L, et al. Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration. Aging Cell. 2020;:e13209 pubmed publisher

Briner A, Götz J, Polanco J. Fyn Kinase Controls Tau Aggregation In Vivo. Cell Rep. 2020;32:108045 pubmed publisher

Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M, et al. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain. 2020;143:2803-2817 pubmed publisher

Landa J, Gaig C, Plagum xe0 J, Saiz A, Antonell A, Sanchez Valle R, et al. Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration. Ann Neurol. 2020;88:1023-1027 pubmed publisher

Dominguez Meijide A, Vasili E, König A, Cima Omori M, Ibañez de Opakua A, Leonov A, et al. Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Sci Rep. 2020;10:12827 pubmed publisher

Yang Y, Tan H, Boukhali M, Khatri A, Yu Y, Hua F, et al. Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice. Anesthesiology. 2020;133:595-610 pubmed publisher

Katsikoudi A, Ficulle E, Cavallini A, Sharman G, Guyot A, Zagnoni M, et al. Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures. J Biol Chem. 2020;295:13079-13093 pubmed publisher

Yadikar H, Torres I, Aiello G, Kurup M, Yang Z, Lin F, et al. Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization. PLoS ONE. 2020;15:e0224952 pubmed publisher

Nam E, Lee Y, Moon C, Chang K. Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression. Int J Mol Sci. 2020;21: pubmed publisher

Eckenweber F, Medina Luque J, Blume T, Sacher C, Biechele G, Wind K, et al. Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning. J Neuroinflammation. 2020;17:208 pubmed publisher

Neddens J, Daurer M, Flunkert S, Beutl K, Loeffler T, Walker L, et al. Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models. PLoS ONE. 2020;15:e0235543 pubmed publisher

Perez M, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, et al. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids. Mol Psychiatry. 2020;: pubmed publisher

Martins S, Müller Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, et al. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. Int J Mol Sci. 2020;21: pubmed publisher

Wander C, Tseng J, Song S, Al Housseiny H, Tart D, Ajit A, et al. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. 2020;23:101255 pubmed publisher

Ghosh A, Mizuno K, Tiwari S, Proitsi P, Gomez Perez Nievas B, Glennon E, et al. Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Transl Psychiatry. 2020;10:192 pubmed publisher

Pontecorvo M, Keene C, Beach T, Montine T, Arora A, Devous M, et al. Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study. EJNMMI Res. 2020;10:65 pubmed publisher

Wen X, An P, Li H, Zhou Z, Sun Y, Wang J, et al. Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS. Neurosci Bull. 2020;: pubmed publisher

Venkataraman L, He P, Schulz P, Sierks M. Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants. Neurobiol Aging. 2020;94:7-14 pubmed publisher

Nachman E, Wentink A, Madiona K, Bousset L, Katsinelos T, Allinson K, et al. Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species. J Biol Chem. 2020;295:9676-9690 pubmed publisher

Soto Mercado V, Mendivil Perez M, Velez Pardo C, Lopera F, Jimenez Del Rio M. Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications. PLoS ONE. 2020;15:e0221669 pubmed publisher

Bourdenx M, Nioche A, Dovero S, Arotcarena M, Camus S, Porras G, et al. Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates. Sci Adv. 2020;6:eaaz9165 pubmed publisher

Liaudanskaya V, Chung J, Mizzoni C, Rouleau N, Berk A, Wu L, et al. Modeling Controlled Cortical Impact Injury in 3D Brain-Like Tissue Cultures. Adv Healthc Mater. 2020;9:e2000122 pubmed publisher

Lee J, Han S, Park M, Song I, Choi M, Yu E, et al. N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease. Nat Commun. 2020;11:2358 pubmed publisher

Miki Y, Foti S, Hansen D, Strand K, Asi Y, Tsushima E, et al. Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy. Brain. 2020;143:1798-1810 pubmed publisher

Kovacs G, Lukić M, Irwin D, Arzberger T, Respondek G, Lee E, et al. Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathol. 2020;140:99-119 pubmed publisher

Yang M, Lian N, Yu Y, Wang Y, Xie K, Yu Y. Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Mol Med Rep. 2020;22:445-453 pubmed publisher

Puangmalai N, Bhatt N, Montalbano M, Sengupta U, Gaikwad S, Ventura F, et al. Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies. Cell Death Dis. 2020;11:314 pubmed publisher

Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, et al. Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model. J Neurosci. 2020;40:3491-3501 pubmed publisher

Colas J, Chessel N, Ouared A, Gruz Gibelli E, Marin P, Herrmann F, et al. Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways. Neural Plast. 2020;2020:9369815 pubmed publisher

Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, et al. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ Vaccines. 2020;5:28 pubmed publisher

Garc xed a Arriaza J, Mar xed n M, Merch xe1 n Rubira J, Mascaraque S, Medina M, xc1 vila J, et al. Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins. Vaccines (Basel). 2020;8: pubmed publisher

Bevan Jones W, Cope T, Jones P, Kaalund S, Passamonti L, Allinson K, et al. Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. Brain. 2020;143:1010-1026 pubmed publisher

Trejo Lopez J, Sorrentino Z, Riffe C, Prokop S, Dickson D, Yachnis A, et al. Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2020;79:407-418 pubmed publisher

Krishnan M, Hwang J, Kim M, Kim Y, Seo J, Jung J, et al. β-hydroxybutyrate Impedes the Progression of Alzheimer's Disease and Atherosclerosis in ApoE-Deficient Mice. Nutrients. 2020;12: pubmed publisher

Das R, Balmik A, Chinnathambi S. Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology. Int J Biol Macromol. 2020;152:30-39 pubmed publisher

Crowe A, Henderson M, Anderson J, Titus S, Zakharov A, Simeonov A, et al. Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays. J Biol Chem. 2020;295:4001-4013 pubmed publisher

van Olst L, Verhaege D, Franssen M, Kamermans A, Roucourt B, Carmans S, et al. Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model. Neurobiol Aging. 2020;89:89-98 pubmed publisher

Ornelas A, Adler C, Serrano G, Curry J, Shill H, Kopyov O, et al. Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report. Parkinsonism Relat Disord. 2020;71:36-39 pubmed publisher

Zheng J, Li H, Tian N, Liu F, Wang L, Yin Y, et al. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell Stem Cell. 2020;26:331-345.e6 pubmed publisher

Hou T, Zhou Y, Zhu L, Wang X, Pang P, Wang D, et al. Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease. J Neurochem. 2020;154:441-457 pubmed publisher

Ling H, Gelpi E, DAVEY K, Jaunmuktane Z, Mok K, Jabbari E, et al. Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates. Acta Neuropathol. 2020;139:717-734 pubmed publisher

Töpperwien M, van der Meer F, Stadelmann C, Salditt T. Correlative x-ray phase-contrast tomography and histology of human brain tissue affected by Alzheimer's disease. Neuroimage. 2020;210:116523 pubmed publisher

Furcila D, Domínguez Alvaro M, DeFelipe J, Alonso Nanclares L. Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease. Front Neuroanat. 2019;13:99 pubmed publisher

Koller E, Gonzalez De La Cruz E, Weinrich M, Williams T, Cruz P, Ryu D, et al. Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. Mol Neurobiol. 2020;: pubmed publisher

Mendsaikhan A, Tooyama I, Bellier J, Serrano G, Sue L, Lue L, et al. Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun. 2019;7:215 pubmed publisher

Hesse R, Hurtado M, Jackson R, Eaton S, Herrmann A, Colom Cadena M, et al. Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype. Acta Neuropathol Commun. 2019;7:214 pubmed publisher

Kurihara M, Mano T, Saito Y, Murayama S, Toda T, Iwata A. Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. Brain Sci. 2019;10: pubmed publisher

Iacono D, Lee P, Edlow B, Gray N, Fischl B, Kenney K, et al. Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity. J Neuropathol Exp Neurol. 2020;79:144-162 pubmed publisher

Scarpelli E, Trinh V, Tashnim Z, Krans J, Keller L, Colodner K. Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation. PLoS ONE. 2019;14:e0226380 pubmed publisher

Giarratana A, Teng S, Reddi S, Zheng C, Adler D, Thakker Varia S, et al. BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes. Front Neurol. 2019;10:1175 pubmed publisher

Lauretti E, Nenov M, Dincer O, Iuliano L, Pratico D. Extra virgin olive oil improves synaptic activity, short-term plasticity, memory, and neuropathology in a tauopathy model. Aging Cell. 2020;19:e13076 pubmed publisher

Henderson M, Sengupta M, Trojanowski J, Lee V. Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta Neuropathol Commun. 2019;7:183 pubmed publisher

Guarascio R, Salih D, Yasvoina M, Edwards F, Cheetham M, van der Spuy J. Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment. Hum Mol Genet. 2020;29:80-96 pubmed publisher

Ahn E, Kang S, Liu X, Chen G, Zhang Z, Chandrasekharan B, et al. Initiation of Parkinson's disease from gut to brain by δ-secretase. Cell Res. 2020;30:70-87 pubmed publisher

Aulston B, Liu Q, Mante M, Florio J, Rissman R, Yuan S. Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain. J Alzheimers Dis. 2019;72:575-585 pubmed publisher

Wang S, Cho Y. Yeast surface display of full-length human microtubule-associated protein tau. Biotechnol Prog. 2020;36:e2920 pubmed publisher

Dunn Meynell A, Dowling P, Marchese M, Rodriguez E, Blumberg B, Choi Y, et al. In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy. Front Aging Neurosci. 2019;11:252 pubmed publisher

Chiu C, Yeh T, Chen R, Chen H, Huang Y, Weng Y, et al. Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Front Cell Neurosci. 2019;13:399 pubmed publisher

Ajit D, Trzeciakiewicz H, Tseng J, Wander C, Chen Y, Ajit A, et al. A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation. J Biol Chem. 2019;294:16698-16711 pubmed publisher