Tau Monoclonal Antibody (BT2), Biotin | Invitrogen MN1010B product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tau Monoclonal Antibody (BT2), Biotin

catalog :

MN1010B

quantity :

50 µg

price :

US 391

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

BT2

reactivity :

human, mouse, rat, bovine

application :

western blot, ELISA

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000	Santos R, Correia S, Alves M, Oliveira P, Cardoso S, Carvalho C, et al. Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats. Biochim Biophys Acta. 2014;1842:1154-66 pubmed publisher
western blot; rat; 1:2000	Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed publisher
western blot; human	Karch C, Jeng A, Goate A. Calcium phosphatase calcineurin influences tau metabolism. Neurobiol Aging. 2013;34:374-86 pubmed publisher
western blot; rat; 1:2000	Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed publisher
western blot; mouse western blot; human	Yamada K, Cirrito J, Stewart F, Jiang H, Finn M, Holmes B, et al. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011;31:13110-7 pubmed publisher
	Wang X, Smith K, Pearson M, Hughes A, Cosden M, MARCUS J, et al. Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy. PLoS ONE. 2018;13:e0195486 pubmed publisher
	Gibbons G, Banks R, Kim B, Changolkar L, Riddle D, Leight S, et al. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. J Neuropathol Exp Neurol. 2018;77:216-228 pubmed publisher
	Narasimhan S, Lee V. The use of mouse models to study cell-to-cell transmission of pathological tau. Methods Cell Biol. 2017;141:287-305 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Tau Monoclonal Antibody (BT2), Biotin

Catalog # :

MN1010B

Quantity :

50 µg

Price :

US 391

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Human, Non-human primate, Rat

Applications :

ELISA: Assay-dependent

Species :

Bovine, Human, Non-human primate, Rat

Clone :

BT2

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Immunogen :

Purified bovine Tau

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent

Aliases :

AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)

more info or order :

Invitrogen product webpage