| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; tbl 1
- immunocytochemistry; human; 1:100; tbl 2
- western blot; mouse
| Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed publisher |
- immunohistochemistry knockout validation; human; fig 2
- immunohistochemistry - paraffin section; human; fig 2
| Fernández Nogales M, Santos Galindo M, Merchán Rubira J, Hoozemans J, Rábano A, Ferrer I, et al. Tau-positive nuclear indentations in P301S tauopathy mice. Brain Pathol. 2017;27:314-322 pubmed publisher |
- western blot; mouse; loading ...; fig 1a
| Wu D, Gao D, Yu H, Pi G, Xiong R, Lei H, et al. Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway. Clin Transl Med. 2021;11:e428 pubmed publisher |
- western blot; human; loading ...; fig 3f
| Bennett R, Hu M, Fernandes A, Pérez Rando M, Robbins A, Kamath T, et al. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathol Commun. 2020;8:137 pubmed publisher |
- immunohistochemistry; mouse; 1:500; loading ...; fig 2g
| Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed publisher |
- immunoprecipitation; human; 1 ug/ml; loading ...; fig 1a
| Sola M, Magrin C, Pedrioli G, Pinton S, Salvade A, Papin S, et al. Tau affects P53 function and cell fate during the DNA damage response. Commun Biol. 2020;3:245 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 4j
| Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, et al. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. J Neuroinflammation. 2020;17:72 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4m
- western blot; mouse; 1:1000; loading ...; fig 4k
| Rodriguez Ortiz C, Prieto G, Martini A, Forner S, Trujillo Estrada L, LaFerla F, et al. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13118 pubmed publisher |
- immunohistochemistry; human; 1:500; loading ...; fig 3a
| Liu Y, Zhang S, Li X, Liu E, Wang X, Zhou Q, et al. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Biosci Rep. 2020;40: pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher |
- immunohistochemistry; human; 1:50; loading ...; fig 5
- western blot; human; 1:200-1:2000; loading ...; fig 5, 6
| Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher |
- immunohistochemistry; mouse; 1:500; loading ...; fig 1, 2, 4, 5, 6, 7, 8
| He Z, McBride J, Xu H, Changolkar L, Kim S, Zhang B, et al. Transmission of tauopathy strains is independent of their isoform composition. Nat Commun. 2020;11:7 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1m, 2f
| Ye J, Yin Y, Liu H, Fang L, Tao X, Wei L, et al. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 2020;19:e13055 pubmed publisher |
- ELISA; human; loading ...; fig 5a
| Ercan Herbst E, Ehrig J, Schöndorf D, Behrendt A, Klaus B, Gomez Ramos B, et al. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta Neuropathol Commun. 2019;7:192 pubmed publisher |
- immunohistochemistry; rat; 1:500; loading ...; fig 1d1
| Ghosh A, Torraville S, Mukherjee B, Walling S, Martin G, Harley C, et al. An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development. Alzheimers Res Ther. 2019;11:59 pubmed publisher |
- western blot; rhesus macaque; 1:1000; loading ...; fig 4b
| Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, et al. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging Cell. 2019;18:e12978 pubmed publisher |
- immunohistochemistry - frozen section; mouse; loading ...; fig 2a
| Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson M. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiol Aging. 2018;70:160-169 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 1a
- western blot; mouse; 1:1000; loading ...; fig 5g
| Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed publisher |
- western blot; mouse; loading ...; fig 4
| Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed publisher |
| Nobuhara C, DeVos S, Commins C, Wegmann S, Moore B, Roe A, et al. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017;187:1399-1412 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 4c
- western blot; mouse; fig 4a
| Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher |
- western blot; human; 1:1000; fig 3i
| Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017;8:14740 pubmed publisher |
- western blot; human; 0.2 ug/ml; loading ...; fig 1b
| Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed publisher |
- immunocytochemistry; human; loading ...; fig s2a
- western blot; human; loading ...; fig s1
| McEwan W, Falcon B, Vaysburd M, Clift D, Oblak A, Ghetti B, et al. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proc Natl Acad Sci U S A. 2017;114:574-579 pubmed publisher |
- western blot; mouse; loading ...
| Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed publisher |
- immunocytochemistry; human; 1:1000; loading ...; fig 3d
| Kuan W, Bennett N, He X, Skepper J, Martynyuk N, Wijeyekoon R, et al. ?-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function. Exp Neurol. 2016;285:72-81 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, et al. Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION. J Biol Chem. 2016;291:22714-22720 pubmed |
- western blot; rat; 1:1000; fig 7
| Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed publisher |
- immunohistochemistry; mouse; 1:300; loading ...; fig 3c
- western blot; mouse; 1:200; loading ...; fig 3a
| di Meco A, Li J, Blass B, Abou Gharbia M, Lauretti E, Praticò D. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81:92-100 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Kim H, Lee K, Kim A, Choi M, Choi K, Kang M, et al. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech. 2016;9:839-48 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1a
- immunocytochemistry; human; loading ...; fig 4b
- western blot; human; loading ...; fig 1c
| Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Rep. 2016;16:1690-1700 pubmed publisher |
- western blot; mouse; 1:3000; fig 6
| Velázquez R, Shaw D, Caccamo A, Oddo S. Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease. Mol Neurodegener. 2016;11:52 pubmed publisher |
- western blot; human; fig 2
| Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed publisher |
- blocking or activating experiments; human; fig 3
| Takeda S, Commins C, DeVos S, Nobuhara C, Wegmann S, Roe A, et al. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016;80:355-67 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Yin Y, Gao D, Wang Y, Wang Z, Wang X, Ye J, et al. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A. 2016;113:E3773-81 pubmed publisher |
- western blot; rat; 1:1000; fig 1
| Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, et al. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Sci Rep. 2016;6:27283 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; fig 5
| Cabrera J, Lucas J. MAP2 Splicing is Altered in Huntington's Disease. Brain Pathol. 2017;27:181-189 pubmed publisher |
- western blot; human; 1:2000; fig 4
| Gorsky M, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Sci Rep. 2016;6:22685 pubmed publisher |
- western blot; human; 1:2000; fig 1
| Gurdziel K, Vogt K, Walton K, Schneider G, Gumucio D. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016;245:614-26 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:500; fig 1
| Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed publisher |
- western blot; human; fig s2
| GarcÃa Ayllón M, Botella López A, Cuchillo Ibañez I, Rábano A, Andreasen N, Blennow K, et al. HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain. Mol Neurobiol. 2017;54:188-199 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
| Platt T, Beckett T, Kohler K, Niedowicz D, Murphy M. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. 2016;315:162-74 pubmed publisher |
- western blot; mouse; 1:1000; fig 3
| Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed publisher |
- western blot; human; 1:3000; fig 5
| Caccamo A, Branca C, Talboom J, Shaw D, Turner D, Ma L, et al. Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:14042-56 pubmed publisher |
- western blot; human; 1:5000; fig 3
| Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, et al. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol. 2015;130:619-31 pubmed publisher |
- immunohistochemistry; mouse; 1:500; fig 1
- western blot; mouse; 1:500; fig 5
| Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18:1584-93 pubmed publisher |
- immunohistochemistry - free floating section; mouse; fig 2
| Min S, Chen X, Tracy T, Li Y, Zhou Y, Wang C, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015;21:1154-62 pubmed publisher |
- western blot; mouse; 1:200; fig 3
| Di Meco A, Joshi Y, Lauretti E, Praticò D. Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry. 2016;21:403-10 pubmed publisher |
- immunocytochemistry; mouse; 1:500; fig 1,2,3
| Brelstaff J, Ossola B, Neher J, Klingstedt T, Nilsson K, Goedert M, et al. The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Front Neurosci. 2015;9:184 pubmed publisher |
- western blot; human; 1:3000
| Guerreiro P, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro T, Eckermann K. LRRK2 Promotes Tau Accumulation, Aggregation and Release. Mol Neurobiol. 2016;53:3124-3135 pubmed publisher |
- ELISA; human; 1-2.5 ug/ml
| Sankaranarayanan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PLoS ONE. 2015;10:e0125614 pubmed publisher |
- western blot; human; fig 1a
| Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed publisher |
- western blot; mouse; 1:1000
| Xu H, Rösler T, Carlsson T, de Andrade A, Fiala O, Höllerhage M, et al. Tau silencing by siRNA in the P301S mouse model of tauopathy. Curr Gene Ther. 2014;14:343-51 pubmed |
- immunohistochemistry - paraffin section; mouse; 1:100
- western blot; mouse; 1:200
| Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed publisher |
- western blot; mouse; 1:1000
| Höllerhage M, Deck R, de Andrade A, Respondek G, Xu H, Rösler T, et al. Piericidin A aggravates Tau pathology in P301S transgenic mice. PLoS ONE. 2014;9:e113557 pubmed publisher |
| Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S. Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40. Mol Neurodegener. 2014;9:52 pubmed publisher |
- immunocytochemistry; human; 1:500; fig 6
- western blot; human; 1:2500; fig 4
| Falcon B, Cavallini A, Angers R, Glover S, Murray T, Barnham L, et al. Conformation determines the seeding potencies of native and recombinant Tau aggregates. J Biol Chem. 2015;290:1049-65 pubmed publisher |
- immunocytochemistry; human; 1:1000
- western blot; human; 1:5000
| Saidi L, Polydoro M, Kay K, Sanchez L, Mandelkow E, Hyman B, et al. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. J Alzheimers Dis. 2015;44:937-47 pubmed publisher |
- western blot; human; fig 4
| Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed publisher |
| Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger J, Zerbinatti C. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE. 2014;9:e103187 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200
| Fernández Nogales M, Cabrera J, Santos Galindo M, Hoozemans J, Ferrer I, Rozemuller A, et al. Huntington's disease is a four-repeat tauopathy with tau nuclear rods. Nat Med. 2014;20:881-5 pubmed publisher |
- western blot; human; 1:2000
| Xia D, Götz J. Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn. Front Mol Neurosci. 2014;7:40 pubmed publisher |
- western blot; mouse; 1:500
| Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher |
| Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3?/?. Eur J Neurosci. 2014;40:2442-53 pubmed publisher |
- immunohistochemistry; mouse; 1:400
- ELISA; mouse; 1:1000
| Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed publisher |
- western blot; mouse; 1:200
| di Meco A, Joshi Y, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging. 2014;35:1813-20 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Choi B, Cho W, Kim J, Lee H, Chung C, Jeon W, et al. Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease. Exp Mol Med. 2014;46:e75 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Chabrier M, Cheng D, Castello N, Green K, LaFerla F. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiol Dis. 2014;64:107-17 pubmed publisher |
- western blot; mouse; 1:1000
| Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed publisher |
- western blot; mouse; 1:1000
| Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed publisher |
- immunoprecipitation; mouse
- immunohistochemistry; mouse
- western blot; mouse
| Borghgraef P, Menuet C, Theunis C, Louis J, Devijver H, Maurin H, et al. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PLoS ONE. 2013;8:e84442 pubmed publisher |
- immunoprecipitation; mouse
| Graham D, Gray A, Joyce J, Yu D, O Moore J, Carlson G, et al. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014;79:307-13 pubmed publisher |
- immunohistochemistry - free floating section; mouse
- western blot; mouse
| Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed publisher |
- immunohistochemistry; mouse; 1:1000
- western blot; mouse; 1:1000
| Rice R, Berchtold N, Cotman C, Green K. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014;35:1002-11 pubmed publisher |
- western blot; human; 1:5000
| Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed publisher |
| Meredith J, Sankaranarayanan S, Guss V, Lanzetti A, Berisha F, Neely R, et al. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. PLoS ONE. 2013;8:e76523 pubmed publisher |
- western blot; human; 1:50000
| Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, et al. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013;587:3722-8 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:300
- immunocytochemistry; mouse; 1:300
- immunohistochemistry; mouse; 1:300
| Pristerà A, Saraulli D, Farioli Vecchioli S, Strimpakos G, Costanzi M, Di Certo M, et al. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiol Aging. 2013;34:2551-63 pubmed publisher |
- immunohistochemistry; mouse
| Maurin H, Seymour C, Lechat B, Borghgraef P, Devijver H, Jaworski T, et al. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PLoS ONE. 2013;8:e63589 pubmed publisher |
| Roher A, Cribbs D, Kim R, Maarouf C, Whiteside C, Kokjohn T, et al. Bapineuzumab alters a? composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS ONE. 2013;8:e59735 pubmed publisher |
| Ozdemir A, Rom I, Kovalevich J, Yen W, Adiga R, Dave R, et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS ONE. 2013;8:e58232 pubmed publisher |
| Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed publisher |
- western blot; mouse; 1:5000
| Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed publisher |
- western blot; human; 1:40000
- western blot; mouse; 1:40,000; loading ...; tbl 1
| Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed publisher |
| Kokjohn T, Maarouf C, Daugs I, Hunter J, Whiteside C, Malek Ahmadi M, et al. Neurochemical profile of dementia pugilistica. J Neurotrauma. 2013;30:981-97 pubmed publisher |
- immunohistochemistry; mouse; 1:400
| Morcinek K, Kohler C, Götz J, Schröder H. Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Res. 2013;1497:73-84 pubmed publisher |
- immunohistochemistry; mouse; 1:1000
| ATTAR A, Ripoli C, Riccardi E, Maiti P, Li Puma D, Liu T, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012;135:3735-48 pubmed publisher |
| Lund H, Cowburn R, Gustafsson E, Strömberg K, Svensson A, Dahllund L, et al. Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. Brain Pathol. 2013;23:378-89 pubmed publisher |
- immunohistochemistry; mouse
- western blot; mouse
| Kopeikina K, Polydoro M, Tai H, Yaeger E, Carlson G, Pitstick R, et al. Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2013;521:1334-53 pubmed publisher |
- immunohistochemistry; human; 1:1000
| Harris J, Koyama A, Maeda S, Ho K, Devidze N, Dubal D, et al. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS ONE. 2012;7:e45881 pubmed publisher |
- western blot; mouse
- immunohistochemistry; human; 1:200
| Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed publisher |
- western blot; human; 1:2000
| Deramecourt V, Lebert F, Maurage C, Fernandez Gomez F, Dujardin S, Colin M, et al. Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S. J Alzheimers Dis. 2012;31:741-9 pubmed publisher |
| Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed publisher |
| Fine J, Baillargeon A, Renner D, Hoerster N, Tokarev J, Colton S, et al. Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1?, and phosphorylates GSK3? in P301L tau transgenic mice. Exp Brain Res. 2012;219:381-90 pubmed publisher |
- western blot; African green monkey
| Matsushima T, Saito Y, Elliott J, Iijima Ando K, Nishimura M, Kimura N, et al. Membrane-microdomain localization of amyloid ?-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. J Biol Chem. 2012;287:19715-24 pubmed publisher |
| Zhang B, Carroll J, Trojanowski J, Yao Y, Iba M, Potuzak J, et al. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci. 2012;32:3601-11 pubmed publisher |
- immunohistochemistry; human; 1:4000
| Clausen A, Xu X, Bi X, Baudry M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J Alzheimers Dis. 2012;30:183-208 pubmed publisher |
- immunohistochemistry; mouse; 1:1000
- western blot; mouse; 1:5000
| de Calignon A, Polydoro M, Suarez Calvet M, William C, Adamowicz D, Kopeikina K, et al. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 2012;73:685-97 pubmed publisher |
| Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed publisher |
- western blot; mouse; 1:2000
| Burnouf S, Belarbi K, Troquier L, Derisbourg M, Demeyer D, Leboucher A, et al. Hippocampal BDNF expression in a tau transgenic mouse model. Curr Alzheimer Res. 2012;9:406-10 pubmed |
| Takahashi M, Chin Y, Nonaka T, Hasegawa M, Watanabe N, Arai T. Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells. Neurosci Lett. 2012;510:48-52 pubmed publisher |
- immunohistochemistry; human; 1:2000
- western blot; human
| Kitazawa M, Cheng D, Tsukamoto M, Koike M, Wes P, Vasilevko V, et al. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ?-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011;187:6539-49 pubmed publisher |
| Maarouf C, Daugs I, Kokjohn T, Walker D, Hunter J, Kruchowsky J, et al. Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging. PLoS ONE. 2011;6:e27291 pubmed publisher |
- immunohistochemistry; human
| Saing T, Dick M, Nelson P, Kim R, Cribbs D, Head E. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012;29:1054-70 pubmed publisher |
- western blot; human; 1:1000
| Khandelwal P, Dumanis S, Herman A, Rebeck G, Moussa C. Wild type and P301L mutant Tau promote neuro-inflammation and ?-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci. 2012;49:44-53 pubmed publisher |
- immunohistochemistry; mouse; 1:500
| Gong E, Park H, Kim M, Piao S, Lee E, Jo D, et al. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiol Dis. 2011;44:223-30 pubmed publisher |
- immunohistochemistry; mouse; 1:3000
- western blot; mouse; 1:3000
| Tang J, Mardini F, Caltagarone B, Garrity S, Li R, Bianchi S, et al. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement. 2011;7:521-531.e1 pubmed publisher |
- immunohistochemistry; human; 0.2 ug/mL
| Tran H, LaFerla F, Holtzman D, Brody D. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-? accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011;31:9513-25 pubmed publisher |
- western blot; mouse; 1:5000
| Medeiros R, Kitazawa M, Caccamo A, Baglietto Vargas D, Estrada Hernandez T, Cribbs D, et al. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol. 2011;179:980-91 pubmed publisher |
- immunohistochemistry; human; 1:1000
| Lasagna Reeves C, Castillo Carranza D, Sengupta U, Clos A, Jackson G, Kayed R. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener. 2011;6:39 pubmed publisher |
| Silveyra M, García Ayllón M, de Barreda E, Small D, Martinez S, Avila J, et al. Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice. Neurobiol Aging. 2012;33:624.e23-34 pubmed publisher |
- immunohistochemistry; human; 1:100
| Kovacs G, Molnár K, Laszlo L, Strobel T, Botond G, Hönigschnabl S, et al. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol. 2011;122:205-22 pubmed publisher |
| Wu G, Sankaranarayanan S, Hsieh S, Simon A, Savage M. Decrease in brain soluble amyloid precursor protein ? (sAPP?) in Alzheimer's disease cortex. J Neurosci Res. 2011;89:822-32 pubmed publisher |
- immunohistochemistry; mouse
| Barten D, Cadelina G, Hoque N, DeCarr L, Guss V, Yang L, et al. Tau transgenic mice as models for cerebrospinal fluid tau biomarkers. J Alzheimers Dis. 2011;24 Suppl 2:127-41 pubmed publisher |
- immunoprecipitation; human
| Coffman K, Brodney M, Cook J, Lanyon L, Pandit J, Sakya S, et al. 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3? inhibitors. Bioorg Med Chem Lett. 2011;21:1429-33 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed publisher |
| Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean M, et al. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiol Learn Mem. 2011;95:296-304 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, et al. Nuclear tau, a key player in neuronal DNA protection. J Biol Chem. 2011;286:4566-75 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Bittner T, Fuhrmann M, Burgold S, Ochs S, Hoffmann N, Mitteregger G, et al. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS ONE. 2010;5:e15477 pubmed publisher |
- immunohistochemistry; human; 1:3000
- western blot; human; 1:3000
| Medina D, Caccamo A, Oddo S. Methylene blue reduces a? levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol. 2011;21:140-9 pubmed publisher |
- immunohistochemistry; human; 1:200
- western blot; human; 1:1000
| Hamilton L, Aumont A, Julien C, Vadnais A, Calon F, Fernandes K. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci. 2010;32:905-20 pubmed publisher |
- immunohistochemistry; human; 1:200
| Desai M, Mastrangelo M, Ryan D, Sudol K, Narrow W, Bowers W. Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target. Am J Pathol. 2010;177:1422-35 pubmed publisher |
- immunohistochemistry; human
| Larionov S, Wielgat P, Wang Y, Thal D, Neumann H. Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer. J Neurosci Methods. 2010;192:127-37 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Ittner L, Ke Y, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010;142:387-97 pubmed publisher |
- flow cytometry; human
- immunocytochemistry; human
- western blot; human
| van Eersel J, Ke Y, Liu X, Delerue F, Kril J, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93 pubmed publisher |
- immunohistochemistry; mouse; 1:400
| Kohler C, Bista P, Gotz J, Schroder H. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain Res. 2010;1347:111-24 pubmed publisher |
- western blot; human; 1:1000
| Li Y, Duffy K, Ottinger M, Ray B, Bailey J, Holloway H, et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis. 2010;19:1205-19 pubmed publisher |
| Krupka N, Strappe P, Götz J, Ittner L. Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid. 2010;63:155-60 pubmed publisher |
- western blot; human; 1:5000
| Martinez Coria H, Green K, Billings L, Kitazawa M, Albrecht M, Rammes G, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010;176:870-80 pubmed publisher |
- immunocytochemistry; mouse; 1:200
- western blot; mouse
- immunocytochemistry; human; 1:200
- western blot; human
| Vale C, Alonso E, Rubiolo J, Vieytes M, LaFerla F, Gimenez Llort L, et al. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010;30:577-90 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Campos Peña V, Tapia Ramírez J, Sanchez Torres C, Meraz Rios M. Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane. J Alzheimers Dis. 2009;18:919-33 pubmed publisher |
| Nonaka T, Hasegawa M. A cellular model to monitor proteasome dysfunction by alpha-synuclein. Biochemistry. 2009;48:8014-22 pubmed publisher |
- blocking or activating experiments; human
- western blot; human; 1:1000
| Clavaguera F, Bolmont T, Crowther R, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11:909-13 pubmed publisher |
| Maarouf C, Daugs I, Spina S, Vidal R, Kokjohn T, Patton R, et al. Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations. Mol Neurodegener. 2008;3:20 pubmed publisher |
| Resende R, Ferreiro E, Pereira C, Oliveira C. ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation. J Neurosci Res. 2008;86:2091-9 pubmed publisher |
| Tremblay C, Pilote M, Phivilay A, Emond V, Bennett D, Calon F. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2007;12:377-90 pubmed |
| Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, et al. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007;104:9511-6 pubmed |
- immunohistochemistry; mouse
- western blot; mouse
| Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla F. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007;102:1053-63 pubmed |
| Yamamori H, Khatoon S, Grundke Iqbal I, Blennow K, Ewers M, Hampel H, et al. Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification. Neurosci Lett. 2007;418:186-9 pubmed |
| Clayton K, Delpech J, Herron S, Iwahara N, Ericsson M, Saito T, et al. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021;16:18 pubmed publisher |
| Miller L, Mukadam A, Durrant C, Vaysburd M, Katsinelos T, Tuck B, et al. Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Acta Neuropathol Commun. 2021;9:41 pubmed publisher |
| Iacono D, Murphy E, Avantsa S, Perl D, Day R. Reduction of pTau and APP levels in mammalian brain after low-dose radiation. Sci Rep. 2021;11:2215 pubmed publisher |
| Habekost M, Qvist P, Denham M, Holm I, Jørgensen A. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Mol Neurobiol. 2021;: pubmed publisher |
| Stojakovic A, Chang S, Nesbitt J, Pichurin N, Ostroot M, Aikawa T, et al. Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice. J Alzheimers Dis. 2021;79:335-353 pubmed publisher |
| Lemke N, Melis V, Lauer D, Magbagbeolu M, Neumann B, Harrington C, et al. Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. J Biol Chem. 2020;295:18508-18523 pubmed publisher |
| Murphy E, Iacono D, Pan H, Grimes J, Parks S, Raiciulescu S, et al. Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences. Sci Rep. 2020;10:17446 pubmed publisher |
| Roda A, Esquerda Canals G, Martí Clúa J, Villegas S. Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer's Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation. Pharmaceutics. 2020;12: pubmed publisher |
| Roda A, Montoliu Gaya L, Serra Mir G, Villegas S. Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice. Int J Mol Sci. 2020;21: pubmed publisher |
| Huang H, Camats Perna J, Medeiros R, Anggono V, Widagdo J. Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer's Disease. Eneuro. 2020;7: pubmed publisher |
| Triana Baltzer G, Van Kolen K, Theunis C, Moughadam S, Slemmon R, Mercken M, et al. Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid. J Alzheimers Dis. 2020;77:1417-1430 pubmed publisher |
| Ye J, Yin Y, Yin Y, Zhang H, Wan H, Wang L, et al. Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration. Aging Cell. 2020;:e13209 pubmed publisher |
| Lo Cascio F, Garcia S, Montalbano M, Puangmalai N, McAllen S, Pace A, et al. Modulating disease-relevant tau oligomeric strains by small molecules. J Biol Chem. 2020;295:14807-14825 pubmed publisher |
| Dominguez Meijide A, Vasili E, König A, Cima Omori M, Ibañez de Opakua A, Leonov A, et al. Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Sci Rep. 2020;10:12827 pubmed publisher |
| Perez M, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, et al. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids. Mol Psychiatry. 2020;: pubmed publisher |
| Martins S, Müller Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, et al. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. Int J Mol Sci. 2020;21: pubmed publisher |
| Nachman E, Wentink A, Madiona K, Bousset L, Katsinelos T, Allinson K, et al. Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species. J Biol Chem. 2020;295:9676-9690 pubmed publisher |
| Fiock K, Smalley M, Crary J, Pasca A, Hefti M. Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. Eneuro. 2020;7: pubmed publisher |
| Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, et al. Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model. J Neurosci. 2020;40:3491-3501 pubmed publisher |
| Nakata S, Price A, Eberhart C, Morris M. Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration. J Neuropathol Exp Neurol. 2020;79:493-499 pubmed publisher |
| Alquezar C, Felix J, McCandlish E, Buckley B, Caparros Lefebvre D, Karch C, et al. Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons. Sci Rep. 2020;10:569 pubmed publisher |
| Iacono D, Lee P, Edlow B, Gray N, Fischl B, Kenney K, et al. Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity. J Neuropathol Exp Neurol. 2020;79:144-162 pubmed publisher |
| Saijo E, Metrick M, Koga S, Parchi P, Litvan I, Spina S, et al. 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. Acta Neuropathol. 2020;139:63-77 pubmed publisher |
| Kurihara M, Mano T, Saito Y, Murayama S, Toda T, Iwata A. Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. Brain Sci. 2019;10: pubmed publisher |
| Chadchankar J, Korboukh V, Conway L, Wobst H, Walker C, Doig P, et al. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells. PLoS ONE. 2019;14:e0225145 pubmed publisher |
| Hill E, Karikari T, Moffat K, Richardson M, Wall M. Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity. Eneuro. 2019;6: pubmed publisher |
| Jadiya P, Kolmetzky D, Tomar D, di Meco A, Lombardi A, Lambert J, et al. Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease. Nat Commun. 2019;10:3885 pubmed publisher |
| Weisová P, Cehlar O, Skrabana R, Zilkova M, Filipcik P, Kovacech B, et al. Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans. Acta Neuropathol Commun. 2019;7:129 pubmed publisher |
| Evans H, Benetatos J, van Roijen M, Bodea L, Götz J. Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling. EMBO J. 2019;38:e101174 pubmed publisher |
| Yu A, Fox S, Cavallini A, Kerridge C, O Neill M, Wolak J, et al. Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network. J Biol Chem. 2019;294:7917-7930 pubmed publisher |
| Li J, Chiu J, Pratico D. Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35. Mol Psychiatry. 2019;: pubmed publisher |
| Paonessa F, Evans L, Solanki R, Larrieu D, Wray S, Hardy J, et al. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia. Cell Rep. 2019;26:582-593.e5 pubmed publisher |
| Butler V, Salazar D, Soriano Castell D, Alves Ferreira M, Dennissen F, Vohra M, et al. Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Hum Mol Genet. 2019;28:1498-1514 pubmed publisher |
| Kraus A, Saijo E, Metrick M, Newell K, Sigurdson C, Zanusso G, et al. Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease. Acta Neuropathol. 2019;137:585-598 pubmed publisher |
| Gangolli M, Benetatos J, Esparza T, Fountain E, Seneviratne S, Brody D. Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology. J Neurotrauma. 2019;36:735-755 pubmed publisher |
| Mendsaikhan A, Takeuchi S, Walker D, Tooyama I. Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin. Front Mol Neurosci. 2018;11:470 pubmed publisher |
| Keene C, Wilson A, Kilgore M, Bruner L, Postupna N, Darvas M. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest. 2018;: pubmed publisher |
| Yu K, Kwan P, Cheung S, Ho A, Baum L. Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice. Transl Neurosci. 2018;9:54-60 pubmed publisher |
| Chen H, Liu P, Auger P, Lee S, Adolfsson O, Rey Bellet L, et al. Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression. Sci Rep. 2018;8:16725 pubmed publisher |
| Dumbacher M, van Dooren T, Princen K, De Witte K, Farinelli M, Lievens S, et al. Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease. Mol Neurodegener. 2018;13:50 pubmed publisher |
| Bussian T, Aziz A, Meyer C, Swenson B, van Deursen J, Baker D. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature. 2018;562:578-582 pubmed publisher |
| Hopp S, Lin Y, Oakley D, Roe A, DeVos S, Hanlon D, et al. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. J Neuroinflammation. 2018;15:269 pubmed publisher |
| Brelstaff J, Tolkovsky A, Ghetti B, Goedert M, Spillantini M. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell Rep. 2018;24:1939-1948.e4 pubmed publisher |
| Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, et al. Phosphorylation of different tau sites during progression of Alzheimer's disease. Acta Neuropathol Commun. 2018;6:52 pubmed publisher |
| Li C, Götz J. Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn. J Alzheimers Dis. 2018;64:205-221 pubmed publisher |
| di Meco A, Li J, Barrero C, Merali S, Pratico D. Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy. Mol Psychiatry. 2018;: pubmed publisher |
| Wang X, Smith K, Pearson M, Hughes A, Cosden M, MARCUS J, et al. Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy. PLoS ONE. 2018;13:e0195486 pubmed publisher |
| Young J, Fong L, Frankowski H, Petsko G, Small S, Goldstein L. Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. Stem Cell Reports. 2018;10:1046-1058 pubmed publisher |
| Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska K, Bennett R, Dujardin S, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. EMBO J. 2018;37: pubmed publisher |
| Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, et al. Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions. PLoS Genet. 2018;14:e1007169 pubmed publisher |
| Falcon B, Noad J, McMahon H, Randow F, Goedert M. Galectin-8-mediated selective autophagy protects against seeded tau aggregation. J Biol Chem. 2018;293:2438-2451 pubmed publisher |
| Lauretti E, Pratico D. Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease. Sci Rep. 2017;7:17134 pubmed publisher |
| Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, et al. Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. J Biol Chem. 2018;293:1781-1793 pubmed publisher |
| Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott G, et al. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. Sci Rep. 2017;7:13556 pubmed publisher |
| Drouin Ouellet J, Pircs K, Barker R, Jakobsson J, Parmar M. Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?. Front Neurosci. 2017;11:530 pubmed publisher |
| Huang R, Iacob R, Sankaranarayanan S, Yang L, Ahlijanian M, Tao L, et al. Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry. J Am Soc Mass Spectrom. 2018;29:174-182 pubmed publisher |
| Wang C, Ward M, Chen R, Liu K, Tracy T, Chen X, et al. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017;9:1221-1233 pubmed publisher |
| Lauretti E, Iuliano L, Pratico D. Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol. 2017;4:564-574 pubmed publisher |
| Branca C, Shaw D, Belfiore R, Gokhale V, Shaw A, Foley C, et al. Dyrk1 inhibition improves Alzheimer's disease-like pathology. Aging Cell. 2017;16:1146-1154 pubmed publisher |
| Fitzpatrick A, Falcon B, He S, Murzin A, Murshudov G, Garringer H, et al. Cryo-EM structures of tau filaments from Alzheimer's disease. Nature. 2017;547:185-190 pubmed publisher |
| Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, et al. Tau deletion promotes brain insulin resistance. J Exp Med. 2017;214:2257-2269 pubmed publisher |
| Drouin Ouellet J, Lau S, Brattås P, Rylander Ottosson D, Pircs K, Grassi D, et al. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017;9:1117-1131 pubmed publisher |
| Kim Y, Jeong E, Nah J, Yoo S, Lee W, Kim Y, et al. Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy. J Neurochem. 2017;142:734-746 pubmed publisher |
| Haure Mirande J, Audrain M, Fanutza T, Kim S, Klein W, Glabe C, et al. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathol. 2017;134:769-788 pubmed publisher |
| Nicholls S, DeVos S, Commins C, Nobuhara C, Bennett R, Corjuc D, et al. Characterization of TauC3 antibody and demonstration of its potential to block tau propagation. PLoS ONE. 2017;12:e0177914 pubmed publisher |
| Ising C, Gallardo G, Leyns C, Wong C, Jiang H, Stewart F, et al. AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy. J Exp Med. 2017;214:1227-1238 pubmed publisher |
| Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed publisher |
| Roher A, Maarouf C, Kokjohn T, Belden C, Serrano G, Sabbagh M, et al. Chemical and neuropathological analyses of an Alzheimer's disease patient treated with solanezumab. Am J Neurodegener Dis. 2016;5:158-170 pubmed |
| Chen W, Abud E, Yeung S, Lakatos A, Nassi T, Wang J, et al. Increased tauopathy drives microglia-mediated clearance of beta-amyloid. Acta Neuropathol Commun. 2016;4:63 pubmed publisher |
| Schoch K, DeVos S, Miller R, Chun S, Norrbom M, Wozniak D, et al. Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model. Neuron. 2016;90:941-7 pubmed publisher |
| Tracy T, Sohn P, Minami S, Wang C, Min S, Li Y, et al. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016;90:245-60 pubmed publisher |
| Maeda S, Djukic B, Taneja P, Yu G, Lo I, Davis A, et al. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016;17:530-51 pubmed publisher |
| Barone E, Di Domenico F, Cassano T, Arena A, Tramutola A, Lavecchia M, et al. Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radic Biol Med. 2016;91:127-42 pubmed publisher |
| Usenovic M, Niroomand S, Drolet R, Yao L, Gaspar R, Hatcher N, et al. Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells. J Neurosci. 2015;35:14234-50 pubmed publisher |
| Takeda S, Wegmann S, Cho H, DeVos S, Commins C, Roe A, et al. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015;6:8490 pubmed publisher |
| Day R, Mason M, Thomas C, Poon W, Rohn T. Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain. PLoS ONE. 2015;10:e0132637 pubmed publisher |
| Mikhail F, Calingasan N, Parolari L, Subramanian A, Yang L, Flint Beal M. Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau. Hum Mol Genet. 2015;24:3545-56 pubmed publisher |
| Roher A, Maarouf C, Malek Ahmadi M, Wilson J, Kokjohn T, Daugs I, et al. Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations. Am J Neurodegener Dis. 2013;2:187-207 pubmed |
| Theunis C, Crespo Biel N, Gafner V, Pihlgren M, López Deber M, Reis P, et al. Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy. PLoS ONE. 2013;8:e72301 pubmed publisher |
| Santa Maria I, Díaz Ruiz C, Ksiezak Reding H, Chen A, Ho L, Wang J, et al. GSPE interferes with tau aggregation in vivo: implication for treating tauopathy. Neurobiol Aging. 2012;33:2072-81 pubmed publisher |
| Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem. 2010;285:13107-20 pubmed publisher |
