product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IFN gamma Monoclonal Antibody (XMG1.2)
catalog :
MM700
quantity :
500 µg
price :
US 412
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
XMG1.2
reactivity :
jirds, human, mouse
application :
western blot, ELISA, immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 396
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2a
Rajendran R, Rajendran V, Giraldo Velasquez M, Megalofonou F, Gurski F, Stadelmann C, et al. Oligodendrocyte-Specific Deletion of FGFR1 Reduces Cerebellar Inflammation and Neurodegeneration in MOG35-55-Induced EAE. Int J Mol Sci. 2021;22: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 5b, 5d
Moreira T, Mangani D, Cox L, Leibowitz J, Lobo E, Oliveira M, et al. PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nat Commun. 2021;12:4907 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4d
Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, et al. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • flow cytometry; mouse; loading ...
Yang C, Kwon D, Kim M, Im S, Lee Y. Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia. Front Immunol. 2021;12:645741 pubmed publisher
  • ELISA; mouse; loading ...; fig 2c
Nian Y, Iske J, Maenosono R, Minami K, Heinbokel T, Quante M, et al. Targeting age-specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival. Aging Cell. 2021;20:e13299 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 4c
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 3a
Jensen I, Jensen S, Sjaastad F, Gibson Corley K, Dileepan T, Griffith T, et al. Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 6
Piersma S, Poursine Laurent J, Yang L, Barber G, Parikh B, Yokoyama W. Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Harbour S, DiToro D, Witte S, Zindl C, Gao M, Schoeb T, et al. TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. Sci Immunol. 2020;5: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4g
Svensson M, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody K, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020;6:eaba4353 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 7d
Donaldson D, Bradford B, Else K, Mabbott N. Accelerated onset of CNS prion disease in mice co-infected with a gastrointestinal helminth pathogen during the preclinical phase. Sci Rep. 2020;10:4554 pubmed publisher
  • flow cytometry; mouse; fig 3h
Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2c
Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019;576:143-148 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2c, 6e
Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, et al. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019;5:eaax1608 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 3d
Ma L, Dichwalkar T, Chang J, Cossette B, Garafola D, Zhang A, et al. Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor. Science. 2019;365:162-168 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Pan X, Ma B, You X, Chen S, Wu J, Wang T, et al. Synthesized natural peptides from amphibian skin secretions increase the efficacy of a therapeutic vaccine by recruiting more T cells to the tumour site. BMC Complement Altern Med. 2019;19:163 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3d
Khan O, Giles J, McDonald S, Manne S, Ngiow S, Patel K, et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. Nature. 2019;: pubmed publisher
  • flow cytometry; human; loading ...; fig 2b
Kawalkowska J, Ogbechi J, Venables P, Williams R. cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs. Sci Adv. 2019;5:eaaw5422 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Kumar P, Rajasekaran K, Nanbakhsh A, Gorski J, Thakar M, Malarkannan S. IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection. Sci Rep. 2019;9:4984 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Qian L, Bajana S, Georgescu C, Peng V, Wang H, Adrianto I, et al. Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors. J Exp Med. 2019;216:884-899 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d
Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, et al. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med. 2019;: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Salerno F, Guislain A, Freen van Heeren J, Nicolet B, Young H, Wolkers M. Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells. Oncoimmunology. 2019;8:e1532762 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b, 2c
Karmaus P, Chen X, Lim S, Herrada A, Nguyen T, Xu B, et al. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. Nature. 2019;565:101-105 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3d
Bern M, Parikh B, Yang L, Beckman D, Poursine Laurent J, Yokoyama W. Inducible down-regulation of MHC class I results in natural killer cell tolerance. J Exp Med. 2019;216:99-116 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin G, Shurin M, et al. Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation. Proc Natl Acad Sci U S A. 2019;116:1361-1369 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Mastroianni J, Stickel N, Andrlova H, Hanke K, Melchinger W, Duquesne S, et al. miR-146a Controls Immune Response in the Melanoma Microenvironment. Cancer Res. 2019;79:183-195 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Lee Y, Ju J, Shon W, Oh S, Min C, Kang M, et al. Skewed Dendritic Cell Differentiation of MyD88-Deficient Donor Bone Marrow Cells, Instead of Massive Expansion as Myeloid-Derived Suppressor Cells, Aggravates GVHD. Immune Netw. 2018;18:e44 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Li J, He Y, Hao J, Ni L, Dong C. High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells. Front Immunol. 2018;9:2981 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4d
Atretkhany K, Mufazalov I, Dunst J, Kuchmiy A, Gogoleva V, Andruszewski D, et al. Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018;115:13051-13056 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4f
Jensen I, Winborn C, Fosdick M, Shao P, Tremblay M, Shan Q, et al. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathog. 2018;14:e1007405 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Song M, Sandoval T, Chae C, Chopra S, Tan C, Rutkowski M, et al. IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature. 2018;562:423-428 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6d
Brun P, Scarpa M, Marchiori C, Conti J, Kotsafti A, Porzionato A, et al. Herpes Simplex Virus Type 1 Engages Toll Like Receptor 2 to Recruit Macrophages During Infection of Enteric Neurons. Front Microbiol. 2018;9:2148 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Cheng Y, Zhu X, Wang X, Zhuang Q, Huyan X, Sun X, et al. Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Front Immunol. 2018;9:1566 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Poffenberger M, Metcalfe Roach A, Aguilar E, Chen J, Hsu B, Wong A, et al. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science. 2018;361:406-411 pubmed publisher
  • flow cytometry; human; 1:300; loading ...; fig 1i
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher
  • flow cytometry; mouse; 1:500; loading ...; fig s4a
Zhang C, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun. 2018;9:2745 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Jogdand G, Sengupta S, Bhattacharya G, Singh S, Barik P, Devadas S. Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection. Front Immunol. 2018;9:1041 pubmed publisher
  • flow cytometry; mouse; loading ...; fig e4b
Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen H, Bastian D, Zhang M, et al. PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest. 2018;128:2787-2801 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3e
Yu F, Sharma S, Jankovic D, Gurram R, Su P, Hu G, et al. The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination. J Exp Med. 2018;215:1813-1821 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Harker J, Wong K, Dallari S, Bao P, Dolgoter A, Jo Y, et al. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. J Virol. 2018;92: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Nadafi R, Koning J, Veninga H, Stachtea X, Konijn T, Zwiers A, et al. Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude. Front Immunol. 2018;9:206 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Fontaine M, Vogel I, Van Eycke Y, Galuppo A, Ajouaou Y, Decaestecker C, et al. Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells. EMBO J. 2018;37:398-412 pubmed publisher
  • flow cytometry; human; loading ...; fig 2c
Ibrahim M, Scozzi D, Toth K, Ponti D, Kreisel D, Menna C, et al. Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion. J Immunol. 2018;200:847-856 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a, 2d
  • ELISA; mouse; loading ...; fig 3a
Johnson R, Yu H, Strank N, Karunakaran K, Zhu Y, Brunham R. B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4?13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters. Infect Immun. 2018;86: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2b
Kwak J, Laskowski J, Li H, McSharry M, Sippel T, Bullock B, et al. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018;78:143-156 pubmed publisher
  • flow cytometry; mouse; fig 5a
Wasiuk A, Testa J, Weidlick J, Sisson C, Vitale L, Widger J, et al. CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy. J Immunol. 2017;199:4110-4123 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Bern M, Beckman D, Ebihara T, Taffner S, Poursine Laurent J, White J, et al. Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor. Proc Natl Acad Sci U S A. 2017;114:E8440-E8447 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1e
Danahy D, Anthony S, Jensen I, Hartwig S, Shan Q, Xue H, et al. Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog. 2017;13:e1006569 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Zimmermann J, Durek P, Kuhl A, Schattenberg F, Maschmeyer P, Siracusa F, et al. The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice. Eur J Immunol. 2018;48:161-167 pubmed publisher
  • flow cytometry; mouse; 1:1000; loading ...; fig s3d
Yi W, Gupta S, Ricker E, Manni M, Jessberger R, Chinenov Y, et al. The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity. Nat Commun. 2017;8:254 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4d
Seifert H, Benedek G, Liang J, Nguyen H, Kent G, Vandenbark A, et al. Sex differences in regulatory cells in experimental stroke. Cell Immunol. 2017;318:49-54 pubmed publisher
  • flow cytometry; human; loading ...; fig 2b
  • flow cytometry; mouse; loading ...; fig 2b
Li C, Leng Y, Zhao B, Gao C, Du F, Jin N, et al. Human iPSC-MSC-Derived Xenografts Modulate Immune Responses by Inhibiting the Cleavage of Caspases. Stem Cells. 2017;35:1719-1732 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7d
Garg G, Nikolouli E, Hardtke Wolenski M, Toker A, Ohkura N, Beckstette M, et al. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget. 2017;8:35542-35557 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Chien C, Yu H, Chen S, Chiang B. Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells. Sci Rep. 2017;7:46348 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Shrestha B, You D, Saravia J, Siefker D, Jaligama S, Lee G, et al. IL-4R? on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. J Leukoc Biol. 2017;102:153-161 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8a
Lehmann C, Baranska A, Heidkamp G, Heger L, Neubert K, Lühr J, et al. DC subset-specific induction of T cell responses upon antigen uptake via Fc? receptors in vivo. J Exp Med. 2017;214:1509-1528 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
van der Vlugt L, Obieglo K, Ozir Fazalalikhan A, Sparwasser T, Haeberlein S, Smits H. Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function. Int J Parasitol. 2017;47:545-554 pubmed publisher
  • flow cytometry; mouse; fig s2b
Bruce D, Stefanski H, Vincent B, Dant T, Reisdorf S, Bommiasamy H, et al. Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease. J Clin Invest. 2017;127:1813-1825 pubmed publisher
  • flow cytometry; mouse; fig 5c
Klein J, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, et al. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017;8:14600 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3c
Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
  • flow cytometry; mouse; 1:500; loading ...; fig s1d
Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, et al. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 2017;8:14715 pubmed publisher
  • flow cytometry; mouse; fig 5a
Vaitaitis G, Yussman M, Waid D, Wagner D. Th40 cells (CD4+CD40+ Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells. PLoS ONE. 2017;12:e0172037 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Leech J, Lacey K, Mulcahy M, Medina E, McLoughlin R. IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections. J Immunol. 2017;198:2352-2365 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Vander Lugt B, Riddell J, Khan A, Hackney J, Lesch J, DeVoss J, et al. Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation. J Cell Biol. 2017;216:779-792 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2g
van Nieuwenhuijze A, Dooley J, Humblet Baron S, Sreenivasan J, Koenders M, Schlenner S, et al. Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice. Cell Mol Life Sci. 2017;74:2095-2106 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1k
Xu X, Han L, Zhao G, Xue S, Gao Y, Xiao J, et al. LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 2017;214:209-226 pubmed publisher
  • ELISA; mouse; loading ...; fig s7a
Griffiths K, Ahmed M, Das S, Gopal R, Horne W, Connell T, et al. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun. 2016;7:13894 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3f
Hammer A, Yang G, Friedrich J, Kovacs A, Lee D, Grave K, et al. Role of the receptor Mas in macrophage-mediated inflammation in vivo. Proc Natl Acad Sci U S A. 2016;113:14109-14114 pubmed
  • flow cytometry; mouse; loading ...; fig 1f
Escalante N, Lemire P, Cruz Tleugabulova M, Prescott D, Mortha A, Streutker C, et al. The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility. J Exp Med. 2016;213:2841-2850 pubmed
  • flow cytometry; mouse; loading ...; fig 5e
Theisen E, Sauer J. Listeria monocytogenes-Induced Cell Death Inhibits the Generation of Cell-Mediated Immunity. Infect Immun. 2017;85: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Shifrin N, Kissiov D, Ardolino M, Joncker N, Raulet D. Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness. J Immunol. 2016;197:4127-4136 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig 3a
Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, et al. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016;126:4417-4429 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5B
Alves da Costa T, Di Gangi R, Thomé R, Barreto Felisbino M, Pires Bonfanti A, Lumi Watanabe Ishikawa L, et al. Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. PLoS ONE. 2016;11:e0164745 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Butcher M, Filipowicz A, Waseem T, McGary C, Crow K, Magilnick N, et al. Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFN?+ Th1/Tregs. Circ Res. 2016;119:1190-1203 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1f
Lewis G, Wehrens E, Labarta Bajo L, Streeck H, Zuniga E. TGF-? receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016;126:3799-3813 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Guo H, Cranert S, Lu Y, Zhong M, Zhang S, Chen J, et al. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016;213:2187-207 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6f
Lund A, Wagner M, Fankhauser M, Steinskog E, Broggi M, Spranger S, et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest. 2016;126:3389-402 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Hwang S, Cobb D, Bhadra R, Youngblood B, Khan I. Blimp-1-mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis. J Exp Med. 2016;213:1799-818 pubmed publisher
  • blocking or activating experiments; mouse; loading ...; fig 6b
Chow K, Delconte R, Huntington N, Tarlinton D, Sutherland R, Zhan Y, et al. Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells. J Immunol. 2016;197:2000-8 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5B
Veinotte L, Gebremeskel S, Johnston B. CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFN? production and tumor control. Oncoimmunology. 2016;5:e1160979 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5e
Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s3
Rackov G, Hernandez Jimenez E, Shokri R, Carmona Rodríguez L, Manes S, Alvarez Mon M, et al. p21 mediates macrophage reprogramming through regulation of p50-p50 NF-?B and IFN-?. J Clin Invest. 2016;126:3089-103 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3h
Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
  • flow cytometry; mouse
Keil M, Sonner J, Lanz T, Oezen I, Bunse T, Bittner S, et al. General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation. J Neuroimmunol. 2016;297:117-26 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4d
Sujino T, London M, Hoytema van Konijnenburg D, Rendon T, Buch T, Silva H, et al. Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science. 2016;352:1581-6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Lim J, Im K, Lee E, Kim N, Nam Y, Jeon Y, et al. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis. Sci Rep. 2016;6:26851 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s11a
Chu H, Khosravi A, Kusumawardhani I, Kwon A, Vasconcelos A, Cunha L, et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016;352:1116-20 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Contreras F, Prado C, Gonzalez H, Franz D, Osorio Barrios F, Osorio F, et al. Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity. J Immunol. 2016;196:4143-9 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Xu A, Bhanumathy K, Wu J, Ye Z, Freywald A, Leary S, et al. IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia. Cell Biosci. 2016;6:30 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Jackson S, Jacobs H, Arkatkar T, Dam E, Scharping N, Kolhatkar N, et al. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016;213:733-50 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 2a
Martin B, Wang C, Zhang C, Kang Z, Gulen M, Zepp J, et al. T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. 2016;17:583-92 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4e
Gabunia K, Ellison S, Kelemen S, Kako F, Cornwell W, Rogers T, et al. IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages. Am J Pathol. 2016;186:1361-74 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5a
Roffê E, Marino A, Weaver J, Wan W, de Araújo F, Hoffman V, et al. Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice. Infect Immun. 2016;84:1123-1136 pubmed publisher
  • flow cytometry; mouse; loading ...; tbl 1
Goldberg G, Cornish A, Murphy J, Pang E, Lim L, Campbell I, et al. G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis. Am J Pathol. 2016;186:172-84 pubmed publisher
  • flow cytometry; mouse; fig 4
Zhang Z, Wu N, Lu Y, Davidson D, Colonna M, Veillette A. DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015;212:2165-82 pubmed publisher
  • flow cytometry; mouse; fig 2b
Alam M, Gaida M, Bergmann F, Lasitschka F, Giese T, Giese N, et al. Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med. 2015;21:1337-43 pubmed publisher
  • flow cytometry; mouse; fig 1C
Deppisch N, Ruf P, Eissler N, Neff F, Buhmann R, Lindhofer H, et al. Efficacy and Tolerability of a GD2-Directed Trifunctional Bispecific Antibody in a Preclinical Model: Subcutaneous Administration Is Superior to Intravenous Delivery. Mol Cancer Ther. 2015;14:1877-83 pubmed publisher
  • flow cytometry; mouse; fig 6e
Peske J, Thompson E, Gemta L, Baylis R, Fu Y, Engelhard V. Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat Commun. 2015;6:7114 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5e
Becker P, Hervouet C, Mason G, KWON S, Klavinskis L. Skin vaccination with live virus vectored microneedle arrays induce long lived CD8(+) T cell memory. Vaccine. 2015;33:4691-8 pubmed publisher
  • flow cytometry; mouse
Sakala I, Chaudhri G, Eldi P, Buller R, Karupiah G. Deficiency in Th2 cytokine responses exacerbate orthopoxvirus infection. PLoS ONE. 2015;10:e0118685 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Bertin S, Lozano Ruiz B, Bachiller V, García Martínez I, Herdman S, Zapater P, et al. Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice. Mucosal Immunol. 2015;8:505-15 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Dai M, Yip Y, Hellstrom I, Hellstrom K. Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies. Clin Cancer Res. 2015;21:1127-38 pubmed publisher
  • flow cytometry; mouse
Smith N, Wissink E, Wang J, Pinello J, Davenport M, Grimson A, et al. Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life. J Immunol. 2014;193:177-84 pubmed publisher
  • ELISA; mouse
Newton M, Askeland E, Andresen E, Chehval V, Wang X, Askeland R, et al. Anti-interleukin-10R1 monoclonal antibody in combination with bacillus Calmette--Guérin is protective against bladder cancer metastasis in a murine orthotopic tumour model and demonstrates systemic specific anti-tumour immunity. Clin Exp Immunol. 2014;177:261-8 pubmed publisher
  • ELISA; jirds
Kushwaha V, Kumar V, Verma S, Sharma R, Siddiqi M, Murthy P. Disorganized muscle protein-1 (DIM-1) of filarial parasite Brugia malayi: cDNA cloning, expression, purification, structural modeling and its potential as vaccine candidate for human filarial infection. Vaccine. 2014;32:1693-9 pubmed publisher
  • ELISA; mouse
Johnson R, Kerr M, Slaven J. An atypical CD8 T-cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin-13. Immunology. 2014;142:248-57 pubmed publisher
  • flow cytometry; mouse; fig 5
Furuya Y, Kirimanjeswara G, Roberts S, Metzger D. Increased susceptibility of IgA-deficient mice to pulmonary Francisella tularensis live vaccine strain infection. Infect Immun. 2013;81:3434-41 pubmed publisher
  • ELISA; mouse
Johnson R, Kerr M, Slaven J. Perforin is detrimental to controlling [corrected] C. muridarum replication in vitro, but not in vivo. PLoS ONE. 2013;8:e63340 pubmed publisher
  • flow cytometry; mouse
Mandal M, Donnelly R, Elkabes S, Zhang P, Davini D, David B, et al. Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring. Brain Behav Immun. 2013;33:33-45 pubmed publisher
  • flow cytometry; mouse; fig 1
Walker J, Raué H, Slifka M. Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine. J Virol. 2012;86:13735-44 pubmed publisher
  • ELISA; mouse; fig 3
Jin X, Uchiyama M, Zhang Q, Hirai T, Niimi M. Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice. Evid Based Complement Alternat Med. 2012;2012:689810 pubmed publisher
  • ELISA; mouse; 2 ug/ml
Kao F, Mahmuda S, Pinto R, Triccas J, West N, Britton W. The secreted lipoprotein, MPT83, of Mycobacterium tuberculosis is recognized during human tuberculosis and stimulates protective immunity in mice. PLoS ONE. 2012;7:e34991 pubmed publisher
  • ELISA; mouse; fig 3
Uchiyama M, Jin X, Zhang Q, Hirai T, Amano A, Bashuda H, et al. Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells. J Cardiothorac Surg. 2012;7:26 pubmed publisher
  • ELISA; mouse
Johnson R, Yu H, Kerr M, Slaven J, Karunakaran K, Brunham R. PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice. Infect Immun. 2012;80:2204-11 pubmed publisher
  • immunohistochemistry; mouse
Yokogawa M, Takaishi M, Nakajima K, Kamijima R, DiGiovanni J, Sano S. Imiquimod attenuates the growth of UVB-induced SCC in mice through Th1/Th17 cells. Mol Carcinog. 2013;52:760-9 pubmed publisher
  • flow cytometry; mouse; fig 5
Mathieu M, Cotta Grand N, Daudelin J, Boulet S, Lapointe R, Labrecque N. CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells. PLoS ONE. 2012;7:e30139 pubmed publisher
  • ELISA; mouse
Johnson R, Kerr M, Slaven J. Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract. J Immunol. 2012;188:1896-904 pubmed publisher
  • ELISA; mouse
Joseph S, Verma S, Sahoo M, Dixit S, Verma A, Kushwaha V, et al. Sensitization with anti-inflammatory BmAFI of Brugia malayi allows L3 development in the hostile peritoneal cavity of Mastomys coucha. Acta Trop. 2011;120:191-205 pubmed publisher
  • flow cytometry; mouse; fig s3
Mota B, Gallardo Romero N, Trindade G, Keckler M, Karem K, Carroll D, et al. Adverse events post smallpox-vaccination: insights from tail scarification infection in mice with Vaccinia virus. PLoS ONE. 2011;6:e18924 pubmed publisher
  • ELISA; mouse
Liu W, Chen X, Evanoff D, Luo Y. Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells. Mucosal Immunol. 2011;4:428-37 pubmed publisher
  • ELISA; mouse
Erikçi E, Gursel M, Gursel I. Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes. Biomaterials. 2011;32:1715-23 pubmed publisher
  • flow cytometry; mouse; fig 6, 7
Gibbert K, Dietze K, Zelinskyy G, Lang K, Barchet W, Kirschning C, et al. Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol. 2010;185:6179-89 pubmed publisher
  • blocking or activating experiments; mouse
Thümmler K, Leipe J, Ramming A, Schulze Koops H, Skapenko A. Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions. J Leukoc Biol. 2010;88:1041-50 pubmed publisher
  • ELISA; mouse; 0.4 ug/ml
Hanafi L, Bolduc M, Gagné M, Dufour F, Langelier Y, Boulassel M, et al. Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes. Vaccine. 2010;28:5617-26 pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml
Ramming A, Thümmler K, Schulze Koops H, Skapenko A. Homotypic T-cell/T-cell interaction induces T-cell activation, proliferation, and differentiation. Hum Immunol. 2009;70:873-81 pubmed publisher
  • flow cytometry; mouse; fig 1
Tseng K, Chung C, H ng W, Wang S. Early infection termination affects number of CD8+ memory T cells and protective capacities in listeria monocytogenes-infected mice upon rechallenge. J Immunol. 2009;182:4590-600 pubmed publisher
  • flow cytometry; human
  • flow cytometry; mouse
Nowell M, Williams A, Carty S, Scheller J, Hayes A, Jones G, et al. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J Immunol. 2009;182:613-22 pubmed
  • flow cytometry; mouse
Leppkes M, Becker C, Ivanov I, Hirth S, Wirtz S, Neufert C, et al. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 2009;136:257-67 pubmed publisher
  • ELISA; mouse
West N, Wozniak T, Valenzuela J, Feng C, Sher A, Ribeiro J, et al. Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine. 2008;26:3853-9 pubmed publisher
  • flow cytometry; mouse; fig 6
Richards H, Longhi M, Wright K, Gallimore A, Ager A. CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity. J Immunol. 2008;180:198-206 pubmed
  • ELISA; mouse; 10 ug/ml
Tian C, Ansari M, Paez Cortez J, Bagley J, Godwin J, Donnarumma M, et al. Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy. J Immunol. 2007;179:6762-9 pubmed
  • flow cytometry; mouse
Allard E, Hardy M, Leignadier J, Marquis M, Rooney J, Lehoux D, et al. Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation. Eur J Immunol. 2007;37:3069-77 pubmed
  • immunohistochemistry; mouse; 1:100
Kim Y, Kim Y, Lee K, Kwon H, Kim D, Kim T. Improvement of atopic dermatitis in NC/Nga mice by topical application of CpG phosphodiester-ODN. Int Arch Allergy Immunol. 2007;144:315-24 pubmed
  • blocking or activating experiments; mouse; fig 3
Iwabuchi N, Takahashi N, Xiao J, Miyaji K, Iwatsuki K. In vitro Th1 cytokine-independent Th2 suppressive effects of bifidobacteria. Microbiol Immunol. 2007;51:649-60 pubmed
  • ELISA; mouse
Tsunetsugu Yokota Y, Ishige M, Murakami M. Oral attenuated Salmonella enterica serovar Typhimurium vaccine expressing codon-optimized HIV type 1 Gag enhanced intestinal immunity in mice. AIDS Res Hum Retroviruses. 2007;23:278-86 pubmed
  • flow cytometry; mouse; fig 1
Chang S, Wang K, Lu Y, Yang L, Chen W, Lin Y, et al. Characterization of early gamma interferon (IFN-gamma) expression during murine listeriosis: identification of NK1.1+ CD11c+ cells as the primary IFN-gamma-expressing cells. Infect Immun. 2007;75:1167-76 pubmed
  • ELISA; mouse; fig 2
Hewitson J, Jenkins G, Hamblin P, Mountford A. CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFN-gamma but not IL-4. J Immunol. 2006;177:3209-17 pubmed
  • ELISA; mouse
Raikwar H, Muthian G, Rajasingh J, Johnson C, Bright J. PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. J Neuroimmunol. 2006;178:76-86 pubmed
  • blocking or activating experiments; mouse
Parent M, Wilhelm L, Kummer L, Szaba F, Mullarky I, Smiley S. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun. 2006;74:3381-6 pubmed
  • ELISA; mouse; 0.2 ug/ml
Muthian G, Pradeep C, Sargapradeep K, Kaleysaraj R, Bright J. Setaria digitata secreted filarial lipids modulate IL-12 signaling through JAK-STAT pathway leading to the development of Th1 response. Exp Parasitol. 2006;114:193-203 pubmed
  • ELISA; mouse
Muthian G, Raikwar H, Rajasingh J, Bright J. 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis. J Neurosci Res. 2006;83:1299-309 pubmed
  • ELISA; mouse
Muthian G, Raikwar H, Johnson C, Rajasingh J, Kalgutkar A, Marnett L, et al. COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis. J Clin Immunol. 2006;26:73-85 pubmed
  • ELISA; mouse
Yamamoto K, Kawamura I, Tominaga T, Nomura T, Kohda C, Ito J, et al. Listeriolysin O, a cytolysin derived from Listeria monocytogenes, inhibits generation of ovalbumin-specific Th2 immune response by skewing maturation of antigen-specific T cells into Th1 cells. Clin Exp Immunol. 2005;142:268-74 pubmed
  • flow cytometry; mouse
Irwin S, Izzo A, Dow S, Skeiky Y, Reed S, Alderson M, et al. Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein. Infect Immun. 2005;73:5809-16 pubmed
  • ELISA; mouse
Roach D, Briscoe H, Saunders B, Britton W. Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection. Infect Immun. 2005;73:4787-92 pubmed
  • flow cytometry; mouse; fig 1
Beadling C, Slifka M. Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood. 2005;105:1179-86 pubmed
  • flow cytometry; mouse; 1:50; fig 3
Freyschmidt E, Alonso A, Hartmann G, Gissmann L. Activation of dendritic cells and induction of T cell responses by HPV 16 L1/E7 chimeric virus-like particles are enhanced by CpG ODN or sorbitol. Antivir Ther. 2004;9:479-89 pubmed
  • flow cytometry; mouse; fig 1
Chen B, Cui X, Sempowski G, Domen J, Chao N. Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood. 2004;103:4344-52 pubmed
  • ELISA; mouse; fig 4
Aramaki O, Shirasugi N, Takayama T, Shimazu M, Kitajima M, Ikeda Y, et al. Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. Transplantation. 2004;77:6-12 pubmed
  • flow cytometry; mouse; fig 4
Hogg K, Kumkate S, Mountford A. IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine. Int Immunol. 2003;15:1451-9 pubmed
  • flow cytometry; mouse
Drappa J, Kamen L, Chan E, Georgiev M, Ashany D, Marti F, et al. Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice. J Exp Med. 2003;198:809-21 pubmed
  • blocking or activating experiments; mouse; 5 ug/ml
Goñi O, Alcaide P, Fresno M. Immunosuppression during acute Trypanosoma cruzi infection: involvement of Ly6G (Gr1(+))CD11b(+ )immature myeloid suppressor cells. Int Immunol. 2002;14:1125-34 pubmed
  • flow cytometry; mouse
Turner J, Frank A, Orme I. Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells. Infect Immun. 2002;70:4628-37 pubmed
  • flow cytometry; mouse
Chen B, Liu C, Cui X, Fidler J, Chao N. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000;70:1442-7 pubmed
  • flow cytometry; mouse
Price G, Ou R, Jiang H, Huang L, Moskophidis D. Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia. J Exp Med. 2000;191:1853-67 pubmed
  • blocking or activating experiments; mouse; 10 ug/ml
Angulo I, de las Heras F, Garcia Bustos J, Gargallo D, Munoz Fernandez M, Fresno M. Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice. Blood. 2000;95:212-20 pubmed
  • flow cytometry; mouse
Gett A, Hodgkin P. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. Proc Natl Acad Sci U S A. 1998;95:9488-93 pubmed
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Cherwinski H, Schumacher J, Brown K, Mosmann T. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med. 1987;166:1229-44 pubmed
Yue R, Wei X, Zhao J, Zhou Z, Zhong W. Essential Role of IFN-γ in Regulating Gut Antimicrobial Peptides and Microbiota to Protect Against Alcohol-Induced Bacterial Translocation and Hepatic Inflammation in Mice. Front Physiol. 2020;11:629141 pubmed publisher
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Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov I, et al. Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier. Acta Neuropathol. 2020;140:549-567 pubmed publisher
Martin M, Sompallae R, Winborn C, Harty J, Badovinac V. Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross. Cell Rep. 2020;31:107508 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
IFN gamma Monoclonal Antibody (XMG1.2)
Catalog # :
MM700
Quantity :
500 µg
Price :
US 412
Clonality :
Monoclonal
Purity :
protein A
Host :
Rat
Reactivity :
Mouse
Applications :
ELISA: 1 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Clone :
XMG1.2
Isotype :
IgG1
Storage :
-20°C
Description :
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
Immunogen :
Recombinant mouse IFN gamma
Format :
Liquid
Applications w/Dilutions :
ELISA: 1 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent
Aliases :
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA