IL-6 Monoclonal Antibody (20F3) | Invitrogen MM600C product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-6 Monoclonal Antibody (20F3)

catalog :

MM600C

quantity :

500 µg

price :

US 391

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

20F3

reactivity :

mouse

application :

western blot, ELISA, immunohistochemistry, neutralization, immunoprecipitation, immunohistochemistry - paraffin section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse	Johnson R, Yu H, Kerr M, Slaven J, Karunakaran K, Brunham R. PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice. Infect Immun. 2012;80:2204-11 pubmed publisher
blocking or activating experiments; mouse	Korbelik M, Cecic I, Merchant S, Sun J. Acute phase response induction by cancer treatment with photodynamic therapy. Int J Cancer. 2008;122:1411-7 pubmed
ELISA; mouse	Osaka M, Hagita S, Haraguchi M, Kajimura M, Suematsu M, Yoshida M. Real-time imaging of mechanically injured femoral artery in mice reveals a biphasic pattern of leukocyte accumulation. Am J Physiol Heart Circ Physiol. 2007;292:H1876-82 pubmed
blocking or activating experiments; mouse	Hu Z, Zhao W, Shimamura T. Mechanisms of strain-dependent development of mast cells from mouse splenocytes. Immunol Cell Biol. 2006;84:184-91 pubmed
ELISA; mouse	Derbigny W, Kerr M, Johnson R. Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines. J Immunol. 2005;175:6065-75 pubmed
	Mitchell A, Wanczyk H, JENSEN T, Finck C. Human induced pluripotent stem cells ameliorate hyperoxia-induced lung injury in a mouse model. Am J Transl Res. 2020;12:292-307 pubmed
	Deiters U, Gumenscheimer M, Galanos C, Muhlradt P. Toll-like receptor 2- and 6-mediated stimulation by macrophage-activating lipopeptide 2 induces lipopolysaccharide (LPS) cross tolerance in mice, which results in protection from tumor necrosis factor alpha but in only partial protection from lethal . Infect Immun. 2003;71:4456-62 pubmed
	Cecic I, Korbelik M. Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors. Cancer Lett. 2002;183:43-51 pubmed
	Piec G, Mirkovitch J, Palacio S, Muhlradt P, Felix R. Effect of MALP-2, a lipopeptide from Mycoplasma fermentans, on bone resorption in vitro. Infect Immun. 1999;67:6281-5 pubmed
	Deiters U, Muhlradt P. Mycoplasmal lipopeptide MALP-2 induces the chemoattractant proteins macrophage inflammatory protein 1alpha (MIP-1alpha), monocyte chemoattractant protein 1, and MIP-2 and promotes leukocyte infiltration in mice. Infect Immun. 1999;67:3390-8 pubmed

product information

Product Type :

Antibody

Product Name :

IL-6 Monoclonal Antibody (20F3)

Catalog # :

MM600C

Quantity :

500 µg

Price :

US 391

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Clone :

20F3

Isotype :

IgG1

Storage :

-20°C

Description :

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.

Immunogen :

Recombinant mouse IL-6

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent

Aliases :

B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6

more info or order :

Invitrogen product webpage