IL-4 Monoclonal Antibody (24G2) | Invitrogen MM450D product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-4 Monoclonal Antibody (24G2)

catalog :

MM450D

quantity :

500 µg

price :

US 441

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

24G2

reactivity :

mouse

application :

western blot, ELISA, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse; fig 3	Jin X, Uchiyama M, Zhang Q, Hirai T, Niimi M. Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice. Evid Based Complement Alternat Med. 2012;2012:689810 pubmed publisher
ELISA; mouse; fig 3	Uchiyama M, Jin X, Zhang Q, Hirai T, Amano A, Bashuda H, et al. Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells. J Cardiothorac Surg. 2012;7:26 pubmed publisher
immunohistochemistry - frozen section; mouse	Silverio J, de Oliveira Pinto L, da Silva A, de Oliveira G, Lannes Vieira J. Perforin-expressing cytotoxic cells contribute to chronic cardiomyopathy in Trypanosoma cruzi infection. Int J Exp Pathol. 2010;91:72-86 pubmed publisher
ELISA; mouse; 10 ug/ml	Tian C, Ansari M, Paez Cortez J, Bagley J, Godwin J, Donnarumma M, et al. Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy. J Immunol. 2007;179:6762-9 pubmed
flow cytometry; mouse	Walsh C, Smith P, Fallon P. Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice. Parasite Immunol. 2007;29:293-308 pubmed
flow cytometry; mouse	Kubota K. A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection. J Immunol. 2006;176:7576-88 pubmed
flow cytometry; mouse	Mangan N, Van Rooijen N, McKenzie A, Fallon P. Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness. J Immunol. 2006;176:138-47 pubmed
ELISA; mouse; fig 4	Al Qaoud K, Abdel Hafez S. Humoral and cytokine response during protection of mice against secondary hydatidosis caused by Echinococcus granulosus. Parasitol Res. 2005;98:54-60 pubmed
ELISA; mouse	Boldogh I, Bacsi A, Choudhury B, Dharajiya N, Alam R, Hazra T, et al. ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest. 2005;115:2169-79 pubmed
flow cytometry; mouse; fig 8	Mangan N, Fallon R, Smith P, Van Rooijen N, McKenzie A, Fallon P. Helminth infection protects mice from anaphylaxis via IL-10-producing B cells. J Immunol. 2004;173:6346-56 pubmed
ELISA; mouse; fig 4	Aramaki O, Shirasugi N, Takayama T, Shimazu M, Kitajima M, Ikeda Y, et al. Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. Transplantation. 2004;77:6-12 pubmed
	McAllister F, Mc Allister F, Steele C, Zheng M, Young E, Shellito J, et al. T cytotoxic-1 CD8+ T cells are effector cells against pneumocystis in mice. J Immunol. 2004;172:1132-8 pubmed
	Smith R, Harris S, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol. 2002;184:1132-9 pubmed
	Yamamoto N, Suzuki S, Suzuki Y, Shirai A, Nakazawa M, Suzuki M, et al. Immune response induced by airway sensitization after influenza A virus infection depends on timing of antigen exposure in mice. J Virol. 2001;75:499-505 pubmed
	Yeung V, Gieni R, Umetsu D, DeKruyff R. Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses. J Immunol. 1998;161:4146-52 pubmed
	Assenmacher M, Lohning M, Scheffold A, Richter A, Miltenyi S, Schmitz J, et al. Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10: selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4. J Immunol. 1998;161:2825-32 pubmed
	DeKruyff R, Fang Y, Umetsu D. Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production. J Immunol. 1998;160:2231-7 pubmed
	Goedert S, Germann T, Hoehn P, Koelsch S, Palm N, Rude E, et al. Th1 development of naive CD4+ T cells is inhibited by co-activation with anti-CD4 monoclonal antibodies. J Immunol. 1996;157:566-73 pubmed
	Lu P, Urban J, Zhou X, Chen S, Madden K, Moorman M, et al. CD40-mediated stimulation contributes to lymphocyte proliferation, antibody production, eosinophilia, and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 production. J Immunol. 1996;156:3327-33 pubmed
	Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol. 1996;26:659-68 pubmed
	Bogen S, Fogelman I, Abbas A. Analysis of IL-2, IL-4, and IFN-gamma-producing cells in situ during immune responses to protein antigens. J Immunol. 1993;150:4197-205 pubmed
	Finkelman F, Madden K, Morris S, Holmes J, Boiani N, Katona I, et al. Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J Immunol. 1993;151:1235-44 pubmed
	Yamaya H, Basaki Y, Togawa M, Kojima M, Kiniwa M, Matsuura N. Down-regulation of Th2 cell-mediated murine peritoneal eosinophilia by antiallergic agents. Life Sci. 1995;56:1647-54 pubmed
	Aoki I, Kinzer C, Shirai A, Paul W, Klinman D. IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice. Proc Natl Acad Sci U S A. 1995;92:2534-8 pubmed

product information

Product Type :

Antibody

Product Name :

IL-4 Monoclonal Antibody (24G2)

Catalog # :

MM450D

Quantity :

500 µg

Price :

US 441

Clonality :

Monoclonal

Purity :

protein A

Host :

Rat

Reactivity :

Mouse

Applications :

Western Blot: Assay-dependent

Species :

Mouse

Clone :

24G2

Isotype :

IgG1

Storage :

-20°C

Description :

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

Immunogen :

Recombinant mouse IL-4

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay-dependent

Aliases :

B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra

more info or order :

Invitrogen product webpage