IL-1 beta Monoclonal Antibody (1400.24.17) | Invitrogen MM425B product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-1 beta Monoclonal Antibody (1400.24.17)

catalog :

MM425B

quantity :

500 µg

price :

US 441

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1400.24.17

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; fig 5a	Eyre R, Alferez D, Santiago Gómez A, Spence K, McConnell J, Hart C, et al. Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nat Commun. 2019;10:5016 pubmed publisher
blocking or activating experiments; mouse; fig 9	Cohen T, Many G, Fleming B, Gnocchi V, Ghimbovschi S, Mosser D, et al. Upregulated IL-1Î² in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages. Skelet Muscle. 2015;5:24 pubmed publisher
western blot; mouse	Kim H, Jeong J, Kim S, Park S, Chae H, Lee Y. Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-?B/HIF-1? signaling pathway. Sci Rep. 2013;3:1142 pubmed publisher
blocking or activating experiments; mouse	Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, et al. Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation. PLoS ONE. 2012;7:e39823 pubmed publisher
immunohistochemistry; mouse	Miller L, Pietras E, Uricchio L, Hirano K, Rao S, Lin H, et al. Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol. 2007;179:6933-42 pubmed
ELISA; mouse	Johnson D, O Connor J, Dantzer R, Freund G. Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness. Proc Natl Acad Sci U S A. 2005;102:15184-9 pubmed
	Tu H, Zhang D, Barksdale A, Wadman M, Muelleman R, Li Y. Dexamethasone Improves Wound Healing by Decreased Inflammation and Increased Vasculogenesis in Mouse Skin Frostbite Model. Wilderness Environ Med. 2020;31:407-417 pubmed publisher
	Zhang K, Fang Y, He Y, Yin H, Guan X, Pu Y, et al. Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence. Nat Commun. 2019;10:5380 pubmed publisher
	Liang Z, Han L, Sun D, Chen Y, Wu Q, Zhang L, et al. Chemerin-induced macrophages pyroptosis in fetal brain tissue leads to cognitive disorder in offspring of diabetic dams. J Neuroinflammation. 2019;16:226 pubmed publisher
	Incio J, Liu H, Suboj P, Chin S, Chen I, Pinter M, et al. Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov. 2016;6:852-69 pubmed publisher
	Joshi V, Kalvakolanu D, Hebel J, Hasday J, Cross A. Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia. Infect Immun. 2002;70:6896-903 pubmed
	Edberg J, Qin H, Gibson A, Yee A, Redecha P, Indik Z, et al. The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis. J Biol Chem. 2002;277:41287-93 pubmed
	Joshi V, Kalvakolanu D, Hasday J, Hebel R, Cross A. IL-18 levels and the outcome of innate immune response to lipopolysaccharide: importance of a positive feedback loop with caspase-1 in IL-18 expression. J Immunol. 2002;169:2536-44 pubmed
	Cecic I, Korbelik M. Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors. Cancer Lett. 2002;183:43-51 pubmed
	De Boer M, Hu J, Kalvakolanu D, Hasday J, Cross A. IFN-gamma inhibits lipopolysaccharide-induced interleukin-1 beta in primary murine macrophages via a Stat1-dependent pathway. J Interferon Cytokine Res. 2001;21:485-94 pubmed
	Lubberts E, Joosten L, van den Bersselaar L, Helsen M, Bakker A, van Meurs J, et al. Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. J Immunol. 1999;163:4546-56 pubmed
	Cardona A, Restrepo B, Jaramillo J, Teale J. Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells. J Immunol. 1999;162:995-1002 pubmed
	Duong M, Ouellet N, Simard M, Bergeron Y, Olivier M, Bergeron M. Kinetic study of host defense and inflammatory response to Aspergillus fumigatus in steroid-induced immunosuppressed mice. J Infect Dis. 1998;178:1472-82 pubmed
	Geiger T, Towbin H, Cosenti Vargas A, Zingel O, Arnold J, Rordorf C, et al. Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. Clin Exp Rheumatol. 1993;11:515-22 pubmed

product information

Product Type :

Antibody

Product Name :

IL-1 beta Monoclonal Antibody (1400.24.17)

Catalog # :

MM425B

Quantity :

500 µg

Price :

US 441

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Western Blot: 1 µg/mL

Species :

Human, Mouse

Clone :

1400.24.17

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Immunogen :

Recombinant mouse IL-1 beta

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: 1 µg/mL

Aliases :

catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta

more info or order :

Invitrogen product webpage