IL-12 p70 Monoclonal Antibody (C17-8), Biotin | Invitrogen MM121B product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-12 p70 Monoclonal Antibody (C17-8), Biotin

catalog :

MM121B

quantity :

250 µg

price :

US 450.00

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

C17-8

reactivity :

mouse

application :

western blot, ELISA, flow cytometry

more info or order :

Invitrogen product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse	Zhao X, Ross E, Wang Y, Horwitz B. Nfkb1 inhibits LPS-induced IFN-? and IL-12 p40 production in macrophages by distinct mechanisms. PLoS ONE. 2012;7:e32811 pubmed publisher
western blot; mouse	Zwiers A, Fuss I, Seegers D, Konijn T, Garcia Vallejo J, Samsom J, et al. A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation. J Immunol. 2011;186:3572-80 pubmed publisher
ELISA; mouse	Dewamitta S, Nomura T, Kawamura I, Hara H, Tsuchiya K, Kurenuma T, et al. Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes. Infect Immun. 2010;78:1884-94 pubmed publisher
ELISA; mouse	Biedroń R, Ciszek M, Tokarczyk M, Bobek M, Kurnyta M, Słomińska E, et al. 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Arch Immunol Ther Exp (Warsz). 2008;56:127-34 pubmed publisher
ELISA; mouse	Setiawan T, Metwali A, Blum A, Ince M, Urban J, Elliott D, et al. Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine. Infect Immun. 2007;75:4655-63 pubmed
ELISA; mouse	Bryniarski K, Szczepanik M, Ptak M, Ptak W. The influence of collagenase treatment on the production of TNF-alpha, IL-6 and IL-10 by testicular macrophages. J Immunol Methods. 2005;301:186-9 pubmed
ELISA; mouse	Bryniarski K, Szczepanik M, Ptak M, Ptak W. Modulation of testicular macrophage activity by collagenase. Folia Histochem Cytobiol. 2005;43:37-41 pubmed
ELISA; mouse; 0.5 ug/ml	Bryniarski K, Maresz K, Szczepanik M, Ptak M, Ptak W. Modulation of macrophage activity by proteolytic enzymes. Differential regulation of IL-6 and reactive oxygen intermediates (ROIs) synthesis as a possible homeostatic mechanism in the control of inflammation. Inflammation. 2003;27:333-40 pubmed
flow cytometry; mouse ELISA; mouse	Fujimoto N, Ishida H, Nakamura I, Ogasawara K, Itoh Y. Quantities of interleukin-12p40 in mature CD8alpha negative dendritic cells correlate with strength of TCR signal and determine Th cell development. Microbiol Immunol. 2003;47:1017-24 pubmed
	Lin Y, Jamin A, Wolfheimer S, Fiedler A, Junker A, Goretzki A, et al. A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages. Front Immunol. 2023;14:1136669 pubmed publisher
	Lin Y, Flaczyk A, Wolfheimer S, Goretzki A, Jamin A, Wangorsch A, et al. The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE2 from Epithelial Cells. Cells. 2021;10: pubmed publisher
	Conaway E, de Oliveira D, McInnis C, Snapper S, Horwitz B. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017;198:2906-2915 pubmed publisher
	Kim A, Noh Y, Kim K, Jang Y, Choe Y, Lim J. Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination. Exp Mol Med. 2004;36:428-43 pubmed
	Kirby A, Sundquist M, Wick M. In vivo compartmentalization of functionally distinct, rapidly responsive antigen-specific T-cell populations in DNA-immunized or Salmonella enterica serovar Typhimurium-infected mice. Infect Immun. 2004;72:6390-400 pubmed
	Elliott D, Setiawan T, Metwali A, Blum A, Urban J, Weinstock J. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur J Immunol. 2004;34:2690-8 pubmed
	Tomczak M, Erdman S, Poutahidis T, Rogers A, Holcombe H, Plank B, et al. NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40. J Immunol. 2003;171:1484-92 pubmed
	Das S, Khar A. Regulation of NK cell function in vivo by the dose of tumour transplanted in the peritoneum. Immunol Lett. 2002;83:133-42 pubmed
	Blum A, Metwali A, Crawford C, Li J, Qadir K, Elliott D, et al. Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni. FASEB J. 2001;15:950-7 pubmed
	Yeung V, Gieni R, Umetsu D, DeKruyff R. Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses. J Immunol. 1998;161:4146-52 pubmed
	Flamand V, Donckier V, Demoor F, Le Moine A, Matthys P, Vanderhaeghen M, et al. CD40 ligation prevents neonatal induction of transplantation tolerance. J Immunol. 1998;160:4666-9 pubmed
	DeKruyff R, Fang Y, Umetsu D. Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production. J Immunol. 1998;160:2231-7 pubmed
	Taneichi M, Horino A, Naito S, Sakurai S, Komuro K, Uchida T. Differential stimulation requirements for IL-12 production among clones of macrophage hybridomas. J Interferon Cytokine Res. 1997;17:603-7 pubmed
	Orange J, Biron C. Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol. 1996;156:4746-56 pubmed
	Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol. 1996;26:659-68 pubmed

product information

Product Type :

Antibody

Product Name :

IL-12 p70 Monoclonal Antibody (C17-8), Biotin

Catalog # :

MM121B

Quantity :

250 µg

Price :

US 450.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Clone :

C17-8

Isotype :

IgG2a

Storage :

-20°C

Description :

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.

Immunogen :

Recombinant mouse IL-12

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Aliases :

20C2; CLMF; CLMF p35; CLMF p40; CLMF2; cytokine; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; Il12; IL-12; Il-12 p35; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; IL12, subunit p40; Il-12; cytokine; IL12A; IL-12A; IL12A/B; IL12AB; IL12B; Il-12b; IL12P35; IL-12p35; Il12p40; Il-12p40; IL35 subunit; ILN; IMD28; IMD29; Interleukin; interleukin 12 35 kDa subunit; interleukin 12 35kDa subunit; interleukin 12 40 kDa subunit; interleukin 12 40kDa subunit; interleukin 12 p35 subunit; interleukin 12 p40 subunit precursor; interleukin 12 polypeptide 35; interleukin 12, p35; interleukin 12, p40; interleukin 12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 12p35 subunit precursor; interleukin-12 alpha chain; interleukin-12 alpha p40 subunit; interleukin-12 beta chain; interleukin-12 beta p35 subunit; interleukin-12 p35 subunit; interleukin-12 p35 subunit precursor; interleukin-12 p40; interleukin-12 p40 subunit; interleukin-12 p40 subunit precursor; Interleukin-12 p70; interleukin-12 subunit alpha; Interleukin-12 subunit beta; interleukin-23 p40 subunit; Ll12a; MGC151228; MGC151232; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; P35; p40

more info or order :

Invitrogen product webpage