IL-12 p70 Monoclonal Antibody (9A5) | Invitrogen MM120 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-12 p70 Monoclonal Antibody (9A5)

catalog :

MM120

quantity :

500 µg

price :

US 430.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

9A5

reactivity :

mouse

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse	Dewamitta S, Nomura T, Kawamura I, Hara H, Tsuchiya K, Kurenuma T, et al. Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes. Infect Immun. 2010;78:1884-94 pubmed publisher
ELISA; mouse	Kajino K, Nakamura I, Bamba H, Sawai T, Ogasawara K. Involvement of IL-10 in exhaustion of myeloid dendritic cells and rescue by CD40 stimulation. Immunology. 2007;120:28-37 pubmed
immunohistochemistry; mouse; fig 6	Ola T, Williams N. Protection of non-obese diabetic mice from autoimmune diabetes by Escherichia coli heat-labile enterotoxin B subunit. Immunology. 2006;117:262-70 pubmed
immunohistochemistry - paraffin section; mouse ELISA; mouse	Guiducci C, Vicari A, Sangaletti S, Trinchieri G, Colombo M. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res. 2005;65:3437-46 pubmed
	Ahler E, Register A, Chakraborty S, Fang L, Dieter E, Sitko K, et al. A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions. Mol Cell. 2019;74:393-408.e20 pubmed publisher
	Broichhagen J, Schönberger M, Cork S, Frank J, Marchetti P, Bugliani M, et al. Optical control of insulin release using a photoswitchable sulfonylurea. Nat Commun. 2014;5:5116 pubmed publisher
	Belevych A, Ho H, Terentyeva R, Bonilla I, Terentyev D, Carnes C, et al. Dietary omega-3 fatty acids promote arrhythmogenic remodeling of cellular Ca2+ handling in a postinfarction model of sudden cardiac death. PLoS ONE. 2013;8:e78414 pubmed publisher
	Pantazis A, Kohanteb A, Olcese R. Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol. 2010;136:645-57 pubmed publisher
	Savalli N, Kondratiev A, De Quintana S, Toro L, Olcese R. Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol. 2007;130:117-31 pubmed
	Kong J, Meng J, Biser P, Fleming W, Taylor D. Cellular depolarization of neurons in the locus ceruleus region of the guinea pig associated with the development of tolerance to opioids. J Pharmacol Exp Ther. 2001;298:909-16 pubmed
	Blum A, Metwali A, Crawford C, Li J, Qadir K, Elliott D, et al. Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni. FASEB J. 2001;15:950-7 pubmed
	Yeung V, Gieni R, Umetsu D, DeKruyff R. Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses. J Immunol. 1998;161:4146-52 pubmed
	DeKruyff R, Fang Y, Umetsu D. Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production. J Immunol. 1998;160:2231-7 pubmed
	Orange J, Biron C. Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol. 1996;156:4746-56 pubmed
	Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol. 1996;26:659-68 pubmed
	Wilkinson V, Warrier R, Truitt T, Nunes P, Gately M, Presky D. Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA. J Immunol Methods. 1996;189:15-24 pubmed
	Simon F, Leffert H, Ellisman M, Iwahashi M, Deerinck T, Fortune J, et al. Hepatic Na(+)-K(+)-ATPase enzyme activity correlates with polarized beta-subunit expression. Am J Physiol. 1995;269:C69-84 pubmed
	Schenk D, Leffert H. Monoclonal antibodies to rat Na+,K+-ATPase block enzymatic activity. Proc Natl Acad Sci U S A. 1983;80:5281-5 pubmed
	Schenk D, Hubert J, Leffert H. Use of a monoclonal antibody to quantify (Na+,K+)-ATPase activity and sites in normal and regenerating rat liver. J Biol Chem. 1984;259:14941-51 pubmed
	Hubert J, Schenk D, Skelly H, Leffert H. Rat hepatic (Na+, K+)-ATPase: alpha-subunit isolation by immunoaffinity chromatography and structural analysis by peptide mapping. Biochemistry. 1986;25:4156-63 pubmed
	Ariyasu R, Deerinck T, Levinson S, Ellisman M. Distribution of (Na+ + K+)ATPase and sodium channels in skeletal muscle and electroplax. J Neurocytol. 1987;16:511-22 pubmed
	Ting Beall H, Beall H, Hastings D, Friedman M, Ball W. Identification of monoclonal antibody binding domains of Na+,K(+)-ATPase by immunoelectron microscopy. FEBS Lett. 1990;265:121-5 pubmed

product information

Product Type :

Antibody

Product Name :

IL-12 p70 Monoclonal Antibody (9A5)

Catalog # :

MM120

Quantity :

500 µg

Price :

US 430.00

Clonality :

Monoclonal

Purity :

Caprylic acid precipitation

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Clone :

9A5

Isotype :

IgG2b

Storage :

-20°C

Description :

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.

Immunogen :

Recombinant mouse IL-12

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Aliases :

20C2; CLMF; CLMF p35; CLMF p40; CLMF2; cytokine; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; Il12; IL-12; Il-12 p35; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; IL12, subunit p40; Il-12; cytokine; IL12A; IL-12A; IL12A/B; IL12AB; IL12B; Il-12b; IL12P35; IL-12p35; Il12p40; Il-12p40; IL35 subunit; ILN; IMD28; IMD29; Interleukin; interleukin 12 35 kDa subunit; interleukin 12 35kDa subunit; interleukin 12 40 kDa subunit; interleukin 12 40kDa subunit; interleukin 12 p35 subunit; interleukin 12 p40 subunit precursor; interleukin 12 polypeptide 35; interleukin 12, p35; interleukin 12, p40; interleukin 12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 12p35 subunit precursor; interleukin-12 alpha chain; interleukin-12 alpha p40 subunit; interleukin-12 beta chain; interleukin-12 beta p35 subunit; interleukin-12 p35 subunit; interleukin-12 p35 subunit precursor; interleukin-12 p40; interleukin-12 p40 subunit; interleukin-12 p40 subunit precursor; Interleukin-12 p70; interleukin-12 subunit alpha; Interleukin-12 subunit beta; interleukin-23 p40 subunit; Ll12a; MGC151228; MGC151232; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; P35; p40

more info or order :

Invitrogen product webpage