IL-10 Monoclonal Antibody (16E3) | Invitrogen MM011 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-10 Monoclonal Antibody (16E3)

catalog :

MM011

quantity :

500 ug

price :

US 471.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1.60E+04

reactivity :

mouse

application :

western blot, ELISA

citations: 9

Reference
Redpath S, Van Der Werf N, MacDonald A, Maizels R, Taylor M. Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase. Infect Immun. 2015;83:3881-9 pubmed publisher
Gao W, Wortis H, Pereira M. The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretion. Int Immunol. 2002;14:299-308 pubmed
Matsumoto T, Sakurai M, Kiyohara H, Yamada H. Orally administered decoction of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver. Immunopharmacology. 2000;46:149-61 pubmed
Tang B, Brand D, Chiang T, Stuart J, Kang A, Myers L. Immunogenicity and arthritogenicity of recombinant CB10 in B10.RIII mice. J Immunol. 2000;164:481-7 pubmed
Schmidt Weber C, Alexander S, Henault L, James L, Lichtman A. IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement. J Immunol. 1999;162:238-44 pubmed
Reichmann G, Dlugonska H, Fischer H. T cell receptor specificities of Toxoplasma gondii-reactive mouse CD4+ T lymphocytes and Th1 clones. Med Microbiol Immunol. 1997;186:25-30 pubmed
Ullrich S. Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J Immunol. 1994;152:3410-6 pubmed
Valensi J, Carlson J, Van Nest G. Systemic cytokine profiles in BALB/c mice immunized with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants. J Immunol. 1994;153:4029-39 pubmed
Giovarelli M, Musiani P, Modesti A, Dellabona P, Casorati G, Allione A, et al. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J Immunol. 1995;155:3112-23 pubmed

product information

Product Type :

Antibody

Product Name :

IL-10 Monoclonal Antibody (16E3)

Catalog # :

MM011

Quantity :

500 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Western Blot: 1:1000

Species :

Mouse

Clone :

1.60E+04

Isotype :

IgG2b

Storage :

-20 C

Description :

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Immunogen :

Recombinant mouse IL-10

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: 1:1000

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF