IL-10 Monoclonal Antibody (2A5) | Invitrogen MM010 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-10 Monoclonal Antibody (2A5)

catalog :

MM010

quantity :

500 µg

price :

US 450.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

2A5

reactivity :

mouse

application :

western blot, ELISA, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse	Imtiyaz H, Williams E, Hickey M, Patel S, Durham A, Yuan L, et al. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest. 2010;120:2699-714 pubmed publisher
ELISA; mouse	Nemeth K, Keane Myers A, Brown J, Metcalfe D, Gorham J, Gorham J, et al. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci U S A. 2010;107:5652-7 pubmed publisher
	Agarwal S, Baccam P, Aggarwal R, Veerapu N. Novel Synthesis and Phenotypic Analysis of Mutant Clouds for Hepatitis E Virus Genotype 1. J Virol. 2018;92: pubmed publisher
	Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, et al. An in vitro model of murine middle ear epithelium. Dis Model Mech. 2016;9:1405-1417 pubmed
	NÃ©meth K, Leelahavanichkul A, Yuen P, Mayer B, Parmelee A, Doi K, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med. 2009;15:42-9 pubmed publisher
	Ato M, Iwabuchi K, Shimada S, Mukaida N, Onoe K. Augmented expression of tumour necrosis factor-alpha induced by lipopolysaccharide in spleen of human monocyte chemoattractant protein-1 transgenic mouse enhances the lipopolysaccharide sensitivity of the marginal zone macrophages. Immunology. 2002;106:554-63 pubmed
	Oberholzer A, Oberholzer C, Bahjat K, Ungaro R, Tannahill C, Murday M, et al. Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells. J Immunol. 2002;168:3412-8 pubmed
	Gao W, Wortis H, Pereira M. The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretion. Int Immunol. 2002;14:299-308 pubmed
	Maeda H, Fujimoto S, Greene M. Suppressor T cells regulate the nonanergic cell population that remains after peripheral tolerance is induced to the Mls-1 antigen in T cell receptor Vbeta 8.1 transgenic mice. Proc Natl Acad Sci U S A. 2000;97:13257-62 pubmed
	Samsom J, Annema A, Geertsma M, Langermans J, Groeneveld P, De Heer E, et al. Interleukin-10 has different effects on proliferation of Listeria monocytogenes in livers and spleens of mice. Infect Immun. 2000;68:4666-72 pubmed
	Matsumoto T, Sakurai M, Kiyohara H, Yamada H. Orally administered decoction of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver. Immunopharmacology. 2000;46:149-61 pubmed
	Shibata Y, Foster L, Bradfield J, Myrvik Q. Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse. J Immunol. 2000;164:1314-21 pubmed
	Tang B, Brand D, Chiang T, Stuart J, Kang A, Myers L. Immunogenicity and arthritogenicity of recombinant CB10 in B10.RIII mice. J Immunol. 2000;164:481-7 pubmed
	Schmidt Weber C, Alexander S, Henault L, James L, Lichtman A. IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement. J Immunol. 1999;162:238-44 pubmed
	Assenmacher M, Lohning M, Scheffold A, Richter A, Miltenyi S, Schmitz J, et al. Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10: selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4. J Immunol. 1998;161:2825-32 pubmed
	Nishigori C, Yarosh D, O CONNOR A, Shreedhar V, Ullrich S, Cox P, et al. HindIII liposomes suppress delayed-type hypersensitivity responses in vivo and induce epidermal IL-10 in vitro. J Immunol. 1998;161:2684-91 pubmed
	D Orazio T, Niederkorn J. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol. 1998;160:2089-98 pubmed
	Maguire H, Ketcha K, Lattime E. Neutralizing anti-IL-10 antibody upregulates the induction and elicitation of contact hypersensitivity. J Interferon Cytokine Res. 1997;17:763-8 pubmed
	Reichmann G, Dlugonska H, Fischer H. T cell receptor specificities of Toxoplasma gondii-reactive mouse CD4+ T lymphocytes and Th1 clones. Med Microbiol Immunol. 1997;186:25-30 pubmed
	Goedert S, Germann T, Hoehn P, Koelsch S, Palm N, Rude E, et al. Th1 development of naive CD4+ T cells is inhibited by co-activation with anti-CD4 monoclonal antibodies. J Immunol. 1996;157:566-73 pubmed
	Bohn E, Autenrieth I. IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-gamma production in NK cells and CD4+ T cells. J Immunol. 1996;156:1458-68 pubmed
	Khan I, Matsuura T, Fonseka S, Kasper L. Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice. J Immunol. 1996;156:636-43 pubmed
	Ullrich S. Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J Immunol. 1994;152:3410-6 pubmed
	Valensi J, Carlson J, Van Nest G. Systemic cytokine profiles in BALB/c mice immunized with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants. J Immunol. 1994;153:4029-39 pubmed
	Giovarelli M, Musiani P, Modesti A, Dellabona P, Casorati G, Allione A, et al. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J Immunol. 1995;155:3112-23 pubmed

product information

Product Type :

Antibody

Product Name :

IL-10 Monoclonal Antibody (2A5)

Catalog # :

MM010

Quantity :

500 µg

Price :

US 450.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Rat

Reactivity :

Mouse

Applications :

Western Blot: Assay-dependent

Species :

Mouse

Clone :

2A5

Isotype :

IgG1

Storage :

-20°C

Description :

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Immunogen :

Recombinant mouse IL-10

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay-dependent

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF

more info or order :

Invitrogen product webpage