Perforin Monoclonal Antibody (dG9), Alexa Fluor 647 | Invitrogen MHPERF21 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Perforin Monoclonal Antibody (dG9), Alexa Fluor 647

catalog :

MHPERF21

quantity :

500 uL

price :

US 455.00

clonality :

monoclonal

host :

mouse

conjugate :

AF647

clone name :

dG9

The same clone is also sold as:

BioLegend: 308133, 308126, 308111, 308132, 308120, 308108, 308131, 308135, 308119, 308105, 308102, 308113, 308117, 308106, 308112, 308128, 308130, 308121, 308127, 308109, 308122, 308125, 308104, 308118, 308103, 308124, 308114, 308110, 308129
Bio-Rad: MCA6138
OriGene: AM00176RP-N
Exbio: 11-765-C100, 1P-765-T100, 11-765-C025, 1P-765-T025

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Liu D, Meckel T, Long E. Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells. PLoS ONE. 2010;5:e12870 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Perforin Monoclonal Antibody (dG9), Alexa Fluor 647

Catalog # :

MHPERF21

Quantity :

500 uL

Price :

US 455.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent

Species :

Human

Clone :

dG9

Isotype :

IgG2b

Storage :

4 C

Description :

Perforin is one of the major cytolytic proteins of cytolytic granules. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Moreover, perforin is involved in immune defense against tumors and virus infections as mediated by cytotoxic lymphocytes. Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, and has a molecular weight of 70 to 75 kD. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9, and homology between perforin and C9 have been demonstrated. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested. Perforin is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.

Immunogen :

Human Perforin.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

Cyta; Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1; perforin 1 (pore forming protein); Perforin1; perforin-1; Pfn; PFN1; Pfp; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; pore-forming protein; PRF1; Prf-1; PRF1 (pore forming protein 1); RATCYTA; RP11-710A11.3