TCR gamma/delta Monoclonal Antibody (5A6.E9), TRI-COLOR | Invitrogen MHGD06 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR gamma/delta Monoclonal Antibody (5A6.E9), TRI-COLOR

catalog :

MHGD06

quantity :

500 uL

price :

US 620.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5A6.E9

reactivity :

domestic goat, African green monkey, human, mouse, domestic sheep

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig s1f	Mayassi T, Ladell K, Gudjonson H, McLaren J, Shaw D, Tran M, et al. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell. 2019;176:967-981.e19 pubmed publisher
blocking or activating experiments; human; fig 2a	Ribeiro S, Tesio M, Ribot J, Macintyre E, Barata J, Silva Santos B. Casein kinase 2 controls the survival of normal thymic and leukemic ?? T cells via promotion of AKT signaling. Leukemia. 2017;31:1603-1610 pubmed publisher
flow cytometry; human; loading ...; tbl 1	Sumatoh H, Teng K, Cheng Y, Newell E. Optimization of mass cytometry sample cryopreservation after staining. Cytometry A. 2017;91:48-61 pubmed publisher
immunohistochemistry - paraffin section; human	Tanaka T, Yamamoto H, Elsayed A, Satou A, Asano N, Kohno K, et al. Clinicopathologic Spectrum of Gastrointestinal T-cell Lymphoma: Reappraisal Based on T-cell Receptor Immunophenotypes. Am J Surg Pathol. 2016;40:777-85 pubmed publisher
immunohistochemistry - paraffin section; mouse; fig 4	Kim J, Choi Y, Lee B, Song M, Ban C, Kim J, et al. Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells. J Allergy Clin Immunol. 2016;137:1466-1476.e3 pubmed publisher
flow cytometry; human; 2:25; fig 1	Leong M, Newell E. Multiplexed Peptide-MHC Tetramer Staining with Mass Cytometry. Methods Mol Biol. 2015;1346:115-31 pubmed publisher
immunohistochemistry; human; tbl 2	Satou A, Asano N, Kato S, Katsuya H, Ishitsuka K, Elsayed A, et al. FoxP3-positive T cell lymphoma arising in non-HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL-NOS and 2 cases of mycosis fungoides. Histopathology. 2016;68:1099-108 pubmed publisher
immunohistochemistry; human; tbl 2	Tomita S, Kikuti Y, Carreras J, Kojima M, Ando K, Takasaki H, et al. Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. Mod Pathol. 2015;28:1286-96 pubmed publisher
immunohistochemistry - frozen section; human; 1:100; fig 2	Owens G, Erickson K, Malone C, Pan C, Huynh M, Chang J, et al. Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis. J Neuroinflammation. 2015;12:134 pubmed publisher
immunohistochemistry; human; tbl 4	Kato S, Asano N, Miyata Takata T, Takata K, Elsayed A, Satou A, et al. T-cell receptor (TCR) phenotype of nodal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (CTL): a clinicopathologic study of 39 cases. Am J Surg Pathol. 2015;39:462-71 pubmed publisher
flow cytometry; human	Qin G, Mao H, Zheng J, Sia S, Liu Y, Chan P, et al. Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses. J Infect Dis. 2009;200:858-65 pubmed publisher
flow cytometry; domestic goat flow cytometry; domestic sheep	Conrad M, Davis W, Koop B. TCR and CD3 antibody cross-reactivity in 44 species. Cytometry A. 2007;71:925-33 pubmed
flow cytometry; human	Kalmbach Y, Boldt A, Fendel R, Mordmuller B, Kremsner P, Kun J. Increase in annexin V-positive B cells expressing LILRB1/ILT2/CD85j in malaria. Eur Cytokine Netw. 2006;17:175-80 pubmed
flow cytometry; African green monkey	Cairo C, Propp N, Hebbeler A, Colizzi V, Pauza C. The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vgamma2/Jgamma1.2 subset. Immunology. 2005;115:197-205 pubmed
flow cytometry; human	Green A, Lissina A, Hutchinson S, Hewitt R, Temple B, James D, et al. Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin. Clin Exp Immunol. 2004;136:472-82 pubmed
	Daniels J, Doukas P, Escala M, Ringbloom K, Shih D, Yang J, et al. Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas. Nat Commun. 2020;11:1806 pubmed publisher
	Xu D, Robinson A, Ishii T, Duncan D, Alden T, Goings G, et al. Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy. J Exp Med. 2018;215:1169-1186 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TCR gamma/delta Monoclonal Antibody (5A6.E9), TRI-COLOR

Catalog # :

MHGD06

Quantity :

500 uL

Price :

US 620.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

5A6.E9

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR gamma/delta T cell receptor

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@

more info or order :

Invitrogen product webpage