| Published Application/Species/Sample/Dilution | Reference |
|---|
- flow cytometry; mouse; 1:100; loading ...; fig 5a
| James O, Vandereyken M, Marchingo J, Singh F, Bray S, Wilson J, et al. IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun. 2021;12:4290 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 7j
| Bonilla W, Kirchhammer N, Marx A, Kallert S, Krzyzaniak M, Lu M, et al. Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack. Cell Rep Med. 2021;2:100209 pubmed publisher |
- flow cytometry; human; loading ...; fig s1g
| Mayassi T, Ladell K, Gudjonson H, McLaren J, Shaw D, Tran M, et al. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell. 2019;176:967-981.e19 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 6f
| Jensen I, Winborn C, Fosdick M, Shao P, Tremblay M, Shan Q, et al. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathog. 2018;14:e1007405 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 4b
| Harker J, Wong K, Dallari S, Bao P, Dolgoter A, Jo Y, et al. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. J Virol. 2018;92: pubmed publisher |
- flow cytometry; human; fig 1b
| Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher |
- flow cytometry; rhesus macaque; fig 4d
| Hu X, Valentin A, Dayton F, Kulkarni V, Alicea C, Rosati M, et al. DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV. J Immunol. 2016;197:3999-4013 pubmed |
- flow cytometry; human; loading ...; fig 4a
| Chandele A, Sewatanon J, Gunisetty S, Singla M, Onlamoon N, Akondy R, et al. Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India. J Virol. 2016;90:11259-11278 pubmed |
- flow cytometry; mouse; loading ...; fig 5f
| Lewis G, Wehrens E, Labarta Bajo L, Streeck H, Zuniga E. TGF-? receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016;126:3799-3813 pubmed publisher |
- flow cytometry; human; 1:100; fig 3
| Marafini I, Monteleone I, Di Fusco D, Sedda S, Cupi M, Fina D, et al. Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells. PLoS ONE. 2016;11:e0155103 pubmed publisher |
| Hu Z, Blackman M, Kaye K, Usherwood E. Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68. J Immunol. 2015;194:2746-56 pubmed publisher |
| Triplett T, Tucker C, Triplett K, Alderman Z, Sun L, Ling L, et al. STAT3 Signaling Is Required for Optimal Regression of Large Established Tumors in Mice Treated with Anti-OX40 and TGFβ Receptor Blockade. Cancer Immunol Res. 2015;3:526-35 pubmed publisher |
| Penaloza MacMaster P, Kamphorst A, Wieland A, Araki K, Iyer S, West E, et al. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med. 2014;211:1905-18 pubmed publisher |
| Vargas A, Zhou S, Ethier Chiasson M, Flipo D, Lafond J, Gilbert C, et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB J. 2014;28:3703-19 pubmed publisher |
| Pick J, Arra A, Lingel H, Hegel J, Huber M, Nishanth G, et al. CTLA-4 (CD152) enhances the Tc17 differentiation program. Eur J Immunol. 2014;44:2139-52 pubmed publisher |
| Ntranos A, Hall O, Robinson D, Grishkan I, Schott J, Tosi D, et al. FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. J Neuroimmunol. 2014;270:13-21 pubmed publisher |
| Hagn M, Blackwell S, Beyer T, Ebel V, Fabricius D, Lindner S, et al. B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21. Int Immunol. 2014;26:383-95 pubmed publisher |
- flow cytometry; rhesus macaque
| Kulkarni V, Valentin A, Rosati M, Alicea C, Singh A, Jalah R, et al. Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques. PLoS ONE. 2014;9:e86254 pubmed publisher |
- flow cytometry; human; fig 2
| Mellor Heineke S, Villanueva J, Jordan M, Marsh R, Zhang K, Bleesing J, et al. Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis. Front Immunol. 2013;4:72 pubmed publisher |
| Penaloza MacMaster P, Provine N, Ra J, Borducchi E, McNally A, Simmons N, et al. Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors. J Virol. 2013;87:1373-84 pubmed publisher |
- flow cytometry; rhesus macaque; fig 4
| Jalah R, Patel V, Kulkarni V, Rosati M, Alicea C, Ganneru B, et al. IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques. Hum Vaccin Immunother. 2012;8:1620-9 pubmed publisher |
- flow cytometry; mouse; 1:50; fig 2
| Walsh K, Teijaro J, Zuniga E, Welch M, Fremgen D, Blackburn S, et al. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe. 2012;11:643-53 pubmed publisher |
- flow cytometry; mouse; fig 2
| Salti S, Hammelev E, Grewal J, Reddy S, Zemple S, Grossman W, et al. Granzyme B regulates antiviral CD8+ T cell responses. J Immunol. 2011;187:6301-9 pubmed publisher |
- flow cytometry; human; fig 3
| Mahnke Y, Saqr A, Hazenfeld S, Brady R, Roederer M, Subbramanian R. Age-related changes in durability and function of vaccine-elicited influenza-specific CD4(+) T-cell responses. Vaccine. 2011;29:8606-14 pubmed publisher |
- flow cytometry; mouse; fig 1
| Hsieh S, Lin J, Huang J, Wu S, Chu C, Kung J, et al. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun. 2011;79:4493-502 pubmed publisher |
- flow cytometry; mouse; fig 3
| Desmarets M, Mylvaganam G, Waller E, Josephson C, Pack C, Lukacher A, et al. Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector function. Am J Transplant. 2011;11:1825-34 pubmed publisher |
- flow cytometry; human; fig 2
| D Eliseo D, Manzi L, Merendino N, Velotti F. Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression. J Nutr Biochem. 2012;23:452-7 pubmed publisher |
- flow cytometry; mouse; fig 2
| Haque A, Best S, Amante F, Ammerdorffer A, de Labastida F, Pereira T, et al. High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8(+) T cell-mediated immune pathology. Infect Immun. 2011;79:1882-8 pubmed publisher |
- flow cytometry; mouse; fig 4
| Kallies A, Carotta S, Huntington N, Bernard N, Tarlinton D, Smyth M, et al. A role for Blimp1 in the transcriptional network controlling natural killer cell maturation. Blood. 2011;117:1869-79 pubmed publisher |
- flow cytometry; mouse; fig 5, 6
| Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, et al. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med. 2010;207:2561-8 pubmed publisher |
- flow cytometry; mouse; fig 4
| Klages K, Mayer C, Lahl K, Loddenkemper C, Teng M, Ngiow S, et al. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res. 2010;70:7788-99 pubmed publisher |
- flow cytometry; human; fig 4
| Cairo C, Armstrong C, Cummings J, Deetz C, Tan M, Lu C, et al. Impact of age, gender, and race on circulating ?? T cells. Hum Immunol. 2010;71:968-75 pubmed publisher |
- flow cytometry; rhesus macaque; fig 5
| Reeves R, Gillis J, Wong F, Yu Y, Connole M, Johnson R. CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection. Blood. 2010;115:4439-46 pubmed publisher |
- flow cytometry; human; fig 1
| Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, et al. Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J Immunol. 2009;183:1838-45 pubmed publisher |
| Ribeiro de Almeida C, Heath H, Krpic S, Dingjan G, van Hamburg J, Bergen I, et al. Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol. 2009;182:999-1010 pubmed |
- flow cytometry; human; fig 1
| Cummings J, Cairo C, Armstrong C, Davis C, Pauza C. Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS. J Leukoc Biol. 2008;84:371-9 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:50; fig 1
| Chiarle R, Martinengo C, Mastini C, Ambrogio C, D Escamard V, Forni G, et al. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med. 2008;14:676-80 pubmed publisher |
| Sridhar S, Reyes Sandoval A, Draper S, Moore A, Gilbert S, Gao G, et al. Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A. J Virol. 2008;82:3822-33 pubmed publisher |
| Wagner C, Stegmaier S, Hänsch G. Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro. Mol Immunol. 2008;45:1761-6 pubmed |
- flow cytometry; human; fig 1
| Chan K, Kaur A. Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques. J Immunol Methods. 2007;325:20-34 pubmed |
- flow cytometry; human; fig 3
| Romagnani C, Juelke K, Falco M, Morandi B, D Agostino A, Costa R, et al. CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation. J Immunol. 2007;178:4947-55 pubmed |
- flow cytometry; mouse; fig 4
| Tao J, Gao Y, Li M, He W, Chen L, Harvev B, et al. JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Eur J Immunol. 2007;37:818-29 pubmed |
- flow cytometry; human; 1:200; fig 3A
| Yang Z, Novak A, Ziesmer S, Witzig T, Ansell S. Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma. Cancer Res. 2006;66:10145-52 pubmed |
- flow cytometry; rhesus macaque
| Macchia I, Gauduin M, Kaur A, Johnson R. Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes. Immunology. 2006;119:232-42 pubmed |
- flow cytometry; human; fig 2
| McIlroy D, Meyer L, Dudoit Y, Samri A, Delfraissy J, Autran B, et al. Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection. Int J Immunogenet. 2006;33:73-9 pubmed |
- flow cytometry; mouse; fig 4
| Zhao D, Thornton A, DiPaolo R, Shevach E. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood. 2006;107:3925-32 pubmed |
- flow cytometry; human; tbl 1
| Gopcsa L, Banyai A, Jakab K, Kormos L, Tamaska J, Matolcsy A, et al. Extensive flow cytometric characterization of plasmacytoid dendritic cell leukemia cells. Eur J Haematol. 2005;75:346-51 pubmed |
- flow cytometry; human; fig 5
| Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, et al. MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors. Mol Immunol. 2006;43:1129-43 pubmed |
| Grossman W, Radhi M, Schauer D, Gerday E, Grose C, Goldman F. Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8. Blood. 2005;106:1203-6 pubmed |
- flow cytometry; mouse; fig 5
| Lang A, Nikolich Zugich J. Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection. J Immunol. 2005;174:2919-25 pubmed |
- flow cytometry; mouse; fig 3A
| Quemeneur L, Beloeil L, Michallet M, Angelov G, Tomkowiak M, Revillard J, et al. Restriction of de novo nucleotide biosynthesis interferes with clonal expansion and differentiation into effector and memory CD8 T cells. J Immunol. 2004;173:4945-52 pubmed |
- flow cytometry; human; fig 1
| Metkar S, Froelich C. Human neutrophils lack granzyme A, granzyme B, and perforin. Blood. 2004;104:905-6; author reply 907-8 pubmed |
- flow cytometry; human; 1:400
- flow cytometry; mouse; 1:400
| Grossman W, Verbsky J, Tollefsen B, Kemper C, Atkinson J, Ley T. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood. 2004;104:2840-8 pubmed |
- flow cytometry; mouse; fig 1
| Byers A, Kemball C, Moser J, Lukacher A. Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells. J Immunol. 2003;171:17-21 pubmed |
- flow cytometry; human; 10 ug/ml
| McIlroy D, Cartron P, Tuffery P, Dudoit Y, Samri A, Autran B, et al. A triple-mutated allele of granzyme B incapable of inducing apoptosis. Proc Natl Acad Sci U S A. 2003;100:2562-7 pubmed |
| Pandit H, Valentin A, Angel M, Deléage C, Bergamaschi C, Bear J, et al. Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes. iScience. 2023;26:105929 pubmed publisher |
| Tsui C, Kretschmer L, Rapelius S, Gabriel S, Chisanga D, Kn xf6 pper K, et al. MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature. 2022;609:354-360 pubmed publisher |
| Castellanos C, Ren X, Gonzalez S, Li H, Schroeder A, Liang H, et al. Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1. Sci Immunol. 2021;6:eabh0707 pubmed publisher |
| Marinaik C, Kingstad Bakke B, Lee W, Hatta M, Sonsalla M, Larsen A, et al. Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants. Cell Rep Med. 2020;1:100095 pubmed publisher |
| Tao L, Farooq M, Gao Y, Zhang L, Niu C, Ajmal I, et al. CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells. Cancers (Basel). 2020;12: pubmed publisher |
| Sandu I, Cerletti D, Oetiker N, Borsa M, Wagen F, Spadafora I, et al. Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection. Cell Rep. 2020;32:108078 pubmed publisher |
| Utzschneider D, Gabriel S, Chisanga D, Gloury R, Gubser P, Vasanthakumar A, et al. Early precursor T cells establish and propagate T cell exhaustion in chronic infection. Nat Immunol. 2020;21:1256-1266 pubmed publisher |
| Beltra J, Manne S, Abdel Hakeem M, Kurachi M, Giles J, Chen Z, et al. Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Immunity. 2020;52:825-841.e8 pubmed publisher |
| Lin W, Xu D, Austin C, Caplazi P, Senger K, Sun Y, et al. Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer. Front Immunol. 2019;10:2019 pubmed publisher |
| Petitdemange C, Kasturi S, Kozlowski P, Nabi R, Quarnstrom C, Reddy P, et al. Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques. JCI Insight. 2019;4: pubmed publisher |
| Hu X, Lu Z, Valentin A, Rosati M, Broderick K, Sardesai N, et al. Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques. Hum Vaccin Immunother. 2018;14:2163-2177 pubmed publisher |
| Canter R, Grossenbacher S, Foltz J, Sturgill I, Park J, Luna J, et al. Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial. J Immunother Cancer. 2017;5:98 pubmed publisher |
| Danahy D, Anthony S, Jensen I, Hartwig S, Shan Q, Xue H, et al. Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog. 2017;13:e1006569 pubmed publisher |
| Ban Y, Oh S, Seo S, Kim S, Choi I, Greenberg P, et al. miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation. Cell Rep. 2017;20:2598-2611 pubmed publisher |
| Locafaro G, Andolfi G, Russo F, Cesana L, Spinelli A, Camisa B, et al. IL-10-Engineered Human CD4+ Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism. Mol Ther. 2017;25:2254-2269 pubmed publisher |
| Dolina J, Cechova S, Rudy C, Sung S, Tang W, Lee J, et al. Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression. J Immunol. 2017;198:2341-2351 pubmed publisher |
| Martins M, Tully D, Cruz M, Power K, Veloso de Santana M, Bean D, et al. Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection. J Virol. 2015;89:10802-20 pubmed publisher |
| Elavazhagan S, Fatehchand K, Santhanam V, Fang H, Ren L, Gautam S, et al. Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity. J Immunol. 2015;194:2786-95 pubmed publisher |
| Haque A, Best S, Montes De Oca M, James K, Ammerdorffer A, Edwards C, et al. Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity. J Clin Invest. 2014;124:2483-96 pubmed publisher |
| Olson J, McDonald Hyman C, Jameson S, Hamilton S. Effector-like CD8? T cells in the memory population mediate potent protective immunity. Immunity. 2013;38:1250-60 pubmed publisher |
| Altin J, Goodnow C, Cook M. IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation. J Immunol. 2012;188:5478-88 pubmed publisher |
| Hersperger A, Siciliano N, Eisenlohr L. Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity. J Virol. 2012;86:7298-309 pubmed publisher |
