product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Fetal Hemoglobin Monoclonal Antibody (HBF-1), APC
catalog :
MHFH05
quantity :
500 uL
price :
US 694.00
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
HBF-1
reactivity :
human
application :
immunocytochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 18
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 2a
Grevet J, Lan X, Hamagami N, Edwards C, Sankaranarayanan L, Ji X, et al. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science. 2018;361:285-290 pubmed publisher
  • flow cytometry; human; loading ...; fig st1
Canver M, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern E, et al. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet. 2017;49:625-634 pubmed publisher
  • immunocytochemistry; human; fig 6
Deng W, Rupon J, Krivega I, Breda L, Motta I, Jahn K, et al. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell. 2014;158:849-860 pubmed publisher
  • flow cytometry; human; 5 ul; fig 1
Shi L, Cui S, Engel J, Tanabe O. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med. 2013;19:291-4 pubmed publisher
  • flow cytometry; human; fig 3
Mundee Y, Bigelow N, Davis B, Porter J. Simplified flow cytometric method for fetal hemoglobin containing red blood cells. Cytometry. 2000;42:389-93 pubmed
  • flow cytometry; human
  • immunocytochemistry; human; fig 3
Chen J, Bigelow N, Davis B. Proposed flow cytometric reference method for the determination of erythroid F-cell counts. Cytometry. 2000;42:239-46 pubmed
  • flow cytometry; human
Thorpe S, Thein S, Sampietro M, Craig J, Mahon B, Huehns E. Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis. Br J Haematol. 1994;87:125-32 pubmed
  • flow cytometry; human
Nance S, Nelson J, Arndt P, Lam H, Garratty G. Quantitation of fetal-maternal hemorrhage by flow cytometry. A simple and accurate method. Am J Clin Pathol. 1989;91:288-92 pubmed
Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, et al. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun. 2023;14:23 pubmed publisher
Lyu J, Liu Y, Gong L, Chen M, Madanat Y, Zhang Y, et al. Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. Cancer Discov. 2023;13:170-193 pubmed publisher
Woodard K, Doerfler P, Mayberry K, Sharma A, Levine R, Yen J, et al. Limitations of mouse models for sickle cell disease conferred by their human globin transgene configurations. Dis Model Mech. 2022;15: pubmed publisher
Qin K, Huang P, Feng R, Keller C, Peslak S, Khandros E, et al. Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nat Genet. 2022;54:874-884 pubmed publisher
Devaraju N, Rajendiran V, Ravi N, Mohankumar K. Genome Engineering of Hematopoietic Stem Cells Using CRISPR/Cas9 System. Methods Mol Biol. 2022;2429:307-331 pubmed publisher
Ravi N, Wienert B, Wyman S, Bell H, George A, Mahalingam G, et al. Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. elife. 2022;11: pubmed publisher
Peslak S, Khandros E, Huang P, Lan X, Geronimo C, Grevet J, et al. HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation. Blood Adv. 2020;4:4560-4572 pubmed publisher
Boontanrart M, Schröder M, Stehli G, Banović M, Wyman S, Lew R, et al. ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin. Cell Rep. 2020;32:107993 pubmed publisher
Khandros E, Huang P, Peslak S, Sharma M, Abdulmalik O, Giardine B, et al. Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts. Blood. 2020;135:1957-1968 pubmed publisher
Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, et al. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest. 2015;125:1243-54 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Fetal Hemoglobin Monoclonal Antibody (HBF-1), APC
Catalog # :
MHFH05
Quantity :
500 uL
Price :
US 694.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: Assay-dependent
Species :
Human
Clone :
HBF-1
Isotype :
IgG1
Storage :
4 C
Description :
Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects. Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells have been termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin. Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells. Several clinical conditions have been described with increased levels of F cells. These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.
Immunogen :
Human Fetal Hemoglobin (HbF).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-dependent
Aliases :
A-gamma globin; alpha-1 globin; gamma A hemoglobin; gamma globin; gamma-1-globin; Hb F Agamma; HBG1; HBGA; HBGR; HBG-T2; hemoglobin alpha 1; Hemoglobin gamma-1 chain; hemoglobin gamma-a chain; hemoglobin subunit gamma 1; hemoglobin subunit gamma-1; hemoglobin, gamma A; hemoglobin, gamma, regulator of; HSGGL1; PRO2979
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA