Fetal Hemoglobin Monoclonal Antibody (HBF-1), PE | Invitrogen MHFH04-4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Fetal Hemoglobin Monoclonal Antibody (HBF-1), PE

catalog :

MHFH04-4

quantity :

2 mL

price :

US 1772.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

HBF-1

reactivity :

human

application :

flow cytometry

citations: 6

Reference
De Souza D, Hebert N, Esrick E, Ciuculescu M, Archer N, Armant M, et al. Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling. Nat Commun. 2023;14:5850 pubmed publisher
Iftikhar F, Rahman S, Khan M, Khan K, Khan M, Uddin R, et al. In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene Induction by Adhatoda vasica: A Pre-Clinical Study of HbF Inducers for β-Thalassemia. Front Pharmacol. 2022;13:797853 pubmed publisher
Zhang Y, Paikari A, Sumazin P, Ginter Summarell C, Crosby J, Boerwinkle E, et al. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Blood. 2018;132:321-333 pubmed publisher
Krivega I, Byrnes C, de Vasconcellos J, Lee Y, Kaushal M, Dean A, et al. Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/Î³-globin looping. Blood. 2015;126:665-72 pubmed publisher
Fong E, Finlayson J, Robins F, Davies J, Joseph J, Rossi E, et al. Evaluation of a new rapid anti-HbF FITC assay, Trillium QuikQuant, for detection and quantitation of foetomaternal haemorrhage. Int J Lab Hematol. 2013;35:106-10 pubmed publisher
Kennedy G, Shaw R, Just S, Bryson G, Battistutta F, Rowell J, et al. Quantification of feto-maternal haemorrhage (FMH) by flow cytometry: anti-fetal haemoglobin labelling potentially underestimates massive FMH in comparison to labelling with anti-D. Transfus Med. 2003;13:25-33 pubmed

product information

Product Type :

Antibody

Product Name :

Fetal Hemoglobin Monoclonal Antibody (HBF-1), PE

Catalog # :

MHFH04-4

Quantity :

2 mL

Price :

US 1772.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

HBF-1

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects. Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells have been termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin. Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells. Several clinical conditions have been described with increased levels of F cells. These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.

Immunogen :

Human Fetal Hemoglobin (HbF)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

A-gamma globin; alpha-1 globin; gamma A hemoglobin; gamma globin; gamma-1-globin; Hb F Agamma; HBG1; HBGA; HBGR; HBG-T2; hemoglobin alpha 1; Hemoglobin gamma-1 chain; hemoglobin gamma-a chain; hemoglobin subunit gamma 1; hemoglobin subunit gamma-1; hemoglobin, gamma A; hemoglobin, gamma, regulator of; HSGGL1; PRO2979