Fetal Hemoglobin Monoclonal Antibody (HBF-1), FITC | Invitrogen MHFH01 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Fetal Hemoglobin Monoclonal Antibody (HBF-1), FITC

catalog :

MHFH01

quantity :

500 uL

price :

US 504.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

HBF-1

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 2	Shearstone J, Golonzhka O, Chonkar A, Tamang D, Van Duzer J, Jones S, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS ONE. 2016;11:e0153767 pubmed publisher
flow cytometry; human; fig 2	Li H, Xie W, Gore E, Montoute M, Bee W, Zappacosta F, et al. Development of phenotypic screening assays for ?-globin induction using primary human bone marrow day 7 erythroid progenitor cells. J Biomol Screen. 2013;18:1212-22 pubmed publisher
flow cytometry; human	Huang X, Shah S, Wang J, Ye Z, Dowey S, Tsang K, et al. Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors. Mol Ther. 2014;22:451-463 pubmed publisher
	Peretz S, Livshits L, Pretorius E, Makhro A, Bogdanova A, Gassmann M, et al. The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism. Front Physiol. 2022;13:796837 pubmed publisher
	Vinjamur D, Yao Q, Cole M, McGuckin C, Ren C, Zeng J, et al. ZNF410 represses fetal globin by singular control of CHD4. Nat Genet. 2021;53:719-728 pubmed publisher
	Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu J, et al. Transcription factor competition at the γ-globin promoters controls hemoglobin switching. Nat Genet. 2021;53:511-520 pubmed publisher
	Liu S, Wu M, Lancelot M, Deng J, Gao Y, Roback J, et al. BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells. Mol Ther. 2021;: pubmed publisher
	Tolu S, Reyes Gil M, Ogu U, Thomas M, Bouhassira E, Minniti C. Hemoglobin F mitigation of sickle cell complications decreases with aging. Am J Hematol. 2020;95:E122-E125 pubmed publisher
	Krishnamoorthy S, Pace B, Gupta D, Sturtevant S, Li B, Makala L, et al. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease. JCI Insight. 2017;2: pubmed publisher
	. Abstracts of the 16th meeting of the Clinical Cytometry Society. Clinical applications of cytometry. November 11-13, 2001. Orlando, Florida, USA. Cytometry. 2001;46:310-28 pubmed

product information

Product Type :

Antibody

Product Name :

Fetal Hemoglobin Monoclonal Antibody (HBF-1), FITC

Catalog # :

MHFH01

Quantity :

500 uL

Price :

US 504.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

HBF-1

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects. Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells have been termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin. Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells. Several clinical conditions have been described with increased levels of F cells. These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.

Immunogen :

Human Fetal Hemoglobin (HbF)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

A-gamma globin; alpha-1 globin; gamma A hemoglobin; gamma globin; gamma-1-globin; Hb F Agamma; HBG1; HBGA; HBGR; HBG-T2; hemoglobin alpha 1; Hemoglobin gamma-1 chain; hemoglobin gamma-a chain; hemoglobin subunit gamma 1; hemoglobin subunit gamma-1; hemoglobin, gamma A; hemoglobin, gamma, regulator of; HSGGL1; PRO2979

more info or order :

Invitrogen product webpage